Functional diversity and clonal frequencies of reactivity in the available antibody repertoire.

abstract：:Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (Th2) or Th1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant Th2 response, sub-threshold levels of...

journal_title：European journal of immunology

authors： Bancroft AJ,Else KJ,Grencis RK

更新日期：1994-12-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II products are specialized to present antigens via different intracellular processing routes. Peptides originating from proteins in the cytoplasm can gain access to class I peptide-binding grooves, most likely in the rough endoplasmic reticulum. Peptides from protein...

journal_title：European journal of immunology

authors： Zaghouani H,Kuzu Y,Kuzu H,Brumeanu TD,Swiggard WJ,Steinman RM,Bona CA

更新日期：1993-11-01 00:00:00

abstract：:Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA). Anti-CD 28 mAb can substitute for the action of TPA in the anti-CD 2-induced proliferative respons...

journal_title：European journal of immunology

authors： Pierrès A,Lopez M,Cerdan C,Nunes J,Olive D,Mawas C

更新日期：1988-05-01 00:00:00

abstract：:Intravenous immunoglobulins (IVIgs) efficiently suppress a variety of autoimmune diseases. Over the past few years several potential mechanisms underlying this antiinflammatory activity have become apparent. Among these, terminal sialic acid residues in the sugar moiety of the immunoglobulin G constant fragment have b...

journal_title：European journal of immunology

authors： Schwab I,Seeling M,Biburger M,Aschermann S,Nitschke L,Nimmerjahn F

更新日期：2012-12-01 00:00:00

abstract：:The activating NK cell receptor NKG2D binds to numerous stress-induced cell surface glycoproteins with MHC class I-related ectodomains. In humans, NKG2D ligands (NKG2DL) are members of the MHC-encoded MIC and non-MHC-encoded ULBP families of proteins. The redundancy of NKG2DL raises questions about unique features ass...

journal_title：European journal of immunology

authors： Wittenbrink M,Spreu J,Steinle A

更新日期：2009-06-01 00:00:00

abstract：:The lone CX3C chemokine, fractalkine (FK), is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. We now show that FK is associated with dendritic cells (DC) in epidermis and lymphoid organs. In normal human skin, dual-color fl...

journal_title：European journal of immunology

authors： Papadopoulos EJ,Sassetti C,Saeki H,Yamada N,Kawamura T,Fitzhugh DJ,Saraf MA,Schall T,Blauvelt A,Rosen SD,Hwang ST

更新日期：1999-08-01 00:00:00

abstract：:Polypeptides synthesized in a rabbit reticulocyte lysate system directed by mRNA from the T cell line LH8-105, obtained by radiation leukemia virus-induced transformation of hen egg-white lysozyme (HEL)-specific suppressor T lymphocytes, are able, when injected into mice, to specifically suppress the antibody response...

journal_title：European journal of immunology

authors： Ricciardi-Castagnoli P,Robbiati F,Barbanti E,Colizzi V,Pini C,De Santis R,Doria G,Adorini L

更新日期：1985-04-01 00:00:00

abstract：:Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts fo...

journal_title：European journal of immunology

authors： Anderson S,Shires VL,Wilson RA,Mountford AP

更新日期：1998-09-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class II region is assumed to influence autoimmune diseases such as rheumatoid arthritis. In the mouse, the H-2q haplotype is associated with susceptibility to collagen-induced arthritis, while the H-2p haplotype is not. The class II A molecules of these haplotypes differ by ...

journal_title：European journal of immunology

authors： Brunsberg U,Gustafsson K,Jansson L,Michaëlsson E,Ahrlund-Richter L,Pettersson S,Mattsson R,Holmdahl R

更新日期：1994-07-01 00:00:00

abstract：:The causative agents of Lyme disease, Borrelia burgdorferi s.s., B. garinii, and B. afzelii, differ in their susceptibility to complement-mediated lysis. This phenomenon apparently depends on the expression of proteins termed complement regulator-acquiring surface proteins (CRASP) and their binding to the inhibitory p...

journal_title：European journal of immunology

authors： Kraiczy P,Hellwage J,Skerka C,Kirschfink M,Brade V,Zipfel PF,Wallich R

更新日期：2003-03-01 00:00:00

abstract：:CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...

journal_title：European journal of immunology

authors： Armitage RJ,Tough TW,Macduff BM,Fanslow WC,Spriggs MK,Ramsdell F,Alderson MR

更新日期：1993-09-01 00:00:00

abstract：:Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide ...

journal_title：European journal of immunology

authors： Reske K,Weitzel R

更新日期：1985-12-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:Following immunization with a complex antigen, a B cell internalizes this antigen through an interaction between its surface immunoglobulins and an epitope of the antigen. Enzymatic processing of the antigen frees one or more short peptide determinants (TD) which bind to class II molecules of the B cell. If the comple...

journal_title：European journal of immunology

authors： Sarobe P,Lasarte JJ,Golvano J,Gullón A,Civeira MP,Prieto J,Borrás-Cuesta F

更新日期：1991-06-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein that was 77% identical to human IL 1Ra. The cellular and tissue dist...

journal_title：European journal of immunology

authors： Shuck ME,Eessalu TE,Tracey DE,Bienkowski MJ

更新日期：1991-11-01 00:00:00

abstract：:In the present study, interleukin 1 (IL 1)-containing media from different sources, namely a murine macrophage cell line (P388D1), rabbit peritoneal macrophages, and human peripheral blood mononuclear cells, were compared for their effect on thymocyte proliferation and on collagenase and PGE2 secretion by chondrocytes...

journal_title：European journal of immunology

authors： Evêquoz V,Bettens F,Kristensen F,Trechsel U,Stadler BM,Dayer JM,De Weck AL,Fleisch H

更新日期：1984-06-01 00:00:00

abstract：:The inheritance of responsiveness to lipopolysaccharide (LPS), and of a marker recognized in LPS-reactive cells by a heterologous antiserum, was studied in crosses between C3H/HeJ (nonresponder) and C3H/Tif (high responder) mice. F1 hybrid mice show codominant expression of these traits: (a) LPS-reactive cells are onl...

journal_title：European journal of immunology

authors： Coutinho A,Forni L,Watanabe T

更新日期：1978-01-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:C3 is the central component of the complement system. Upon activation, C3 sequentially generates various proteolytic fragments, C3a, C3b, iC3b, C3dg, each of them exposing novel surfaces, which are sites of interaction with other proteins. C3 and its fragments are therapeutic targets and markers of complement activati...

journal_title：European journal of immunology

authors： Subías Hidalgo M,Yébenes H,Rodríguez-Gallego C,Martín-Ambrosio A,Domínguez M,Tortajada A,Rodríguez de Córdoba S,Llorca O

更新日期：2017-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) are playing important roles in stimulating the innate immune response and intensifying adaptive immune response against invading pathogens. Appropriate regulation of TLR activation is important to maintain a balance between preventing tumor activation and inhibiting autoimmunity. Toll-like r...

journal_title：European journal of immunology

authors： Kim TW,Hong S,Talukder AH,Pascual V,Liu YJ

更新日期：2016-03-01 00:00:00

abstract：:Mouse thymus-leukemia antigen (TL), like other major histocompatibility complex (MHC) class I-b antigens, displays signs of a specialized function. It is normally expressed at high levels on immature thymocytes and at moderate levels on gut epithelium and activated mature T cells. A promoter/enhancer region unique amo...

journal_title：European journal of immunology

authors： Rodgers JR,Mehta V,Cook RG

更新日期：1995-04-01 00:00:00

abstract：:The identification of soluble factors involved in stem cell renewal is a major goal in the assessment of the BM niche. We have previously shown that human endothelial cell (EC) supernatants can induce the proliferation of hematopoietic progenitor cells (HPCs), especially after stimulation with IL-1β. To identify new p...

journal_title：European journal of immunology

authors： Moldenhauer A,Futschik M,Lu H,Helmig M,Götze P,Bal G,Zenke M,Han W,Salama A

更新日期：2011-06-01 00:00:00

abstract：:Beta1 integrins can provide T cell co-stimulation, but little is known concerning their downstream signaling pathways. We found that Pyk2, a focal adhesion kinase-related tyrosine kinase, is regulated by beta1 integrin signaling in human T cells. Stimulation of Jurkat T cells with the alpha4beta1 integrin ligand VCAM-...

journal_title：European journal of immunology

authors： van Seventer GA,Mullen MM,van Seventer JM

更新日期：1998-11-01 00:00:00

abstract：:The HIV-1 Tat protein plays a critical role in the pathogenesis of HIV and has been considered as a candidate vaccine antigen. In an effort to design a non-invasive vaccination strategy against HIV-1 that stimulates the induction of systemic and mucosal immune responses, we studied the transcutaneous delivery of a syn...

journal_title：European journal of immunology

authors： Partidos CD,Moreau E,Chaloin O,Tunis M,Briand JP,Desgranges C,Muller S

更新日期：2004-12-01 00:00:00

abstract：:The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and d...

journal_title：European journal of immunology

authors： Behrens EM,Gadue P,Gong SY,Garrett S,Stein PL,Cohen PL

更新日期：2003-08-01 00:00:00

abstract：:The immune system relies on homeostatic mechanisms in order to adapt to the changing requirements encountered during steady-state existence and activation by antigen. For T cells, this involves maintenance of a diverse repertoire of naïve cells, rapid elimination of effector cells after pathogen clearance, and long-te...

journal_title：European journal of immunology

authors： Boyman O,Létourneau S,Krieg C,Sprent J

更新日期：2009-08-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:Genetic control has been studied of the response to the encephalitogenic nonapeptide (NP) determinant of myelin basic protein (BP) in inbred guinea pigs of strains resistant or susceptible to induction of experimental autoimmune encephalomyelitis (EAE). By studying bone marrow-reconstituted animals, we found that susc...

journal_title：European journal of immunology

authors： Ben-Nun A,Otmy H,Cohen IR

更新日期：1981-04-01 00:00:00