Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta.

abstract：:The major role of cells of the dendritic family in immunity and tolerance has been amply documented. Since their discovery in 1973, these cells have gained increasing interest from immunologists, as they are able to detect infectious agents, migrate to secondary lymphoid tissue, and prime naive T lymphocytes, thereby ...

journal_title：European journal of immunology

authors： Hespel C,Moser M

更新日期：2012-10-01 00:00:00

abstract：:The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the clea...

journal_title：European journal of immunology

authors： Groettrup M,Kraft R,Kostka S,Standera S,Stohwasser R,Kloetzel PM

更新日期：1996-04-01 00:00:00

abstract：:CD82, a member of tetraspan family (tetraspanin), is a multifunctional molecule that is involved in cell activation, costimulation, and cell spreading of T cells. Here we show that immobilized anti-CD82 monoclonal antibody (mAb) as well as anti-alpha4beta1 integrin mAb induced tyrosine phosphorylation of pp105/Crk-ass...

journal_title：European journal of immunology

authors： Iwata S,Kobayashi H,Miyake-Nishijima R,Sasaki T,Souta-Kuribara A,Nori M,Hosono O,Kawasaki H,Tanaka H,Morimoto C

更新日期：2002-05-01 00:00:00

abstract：:When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...

journal_title：European journal of immunology

authors： Lee SK,Singh J,Taylor RB

更新日期：1975-04-01 00:00:00

abstract：:Cathelicidins are a family of host defence peptides that are known to selectively alter innate immunity in response to infection and other changes in immune status. A study in this issue of the European Journal of Immunology elucidates a new role for mouse cathelin-related antimicrobial peptide in the adaptive immune ...

journal_title：European journal of immunology

authors： Wuerth K,Hancock RE

更新日期：2011-10-01 00:00:00

abstract：:The expression of interferon (IFN) β is highly induced in immune and nonimmune cells in response to virus infection. This upregulation is mediated at both transcriptional and posttranscriptional levels. Whereas the signaling pathways triggered by innate virus receptors leading to transcription factor activation have b...

journal_title：European journal of immunology

authors： Takeuchi O

更新日期：2015-05-01 00:00:00

abstract：:The studies described in this report were designed to investigate factors that could influence the behavior of erythrocytes following their interaction with monoclonal antibodies (mAb) in a fully homologous experimental opsonization system in vivo. The clearance profiles and tissue distribution of target erythrocytes ...

journal_title：European journal of immunology

authors： Yousaf N,Howard JC,Williams BD

更新日期：1991-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

journal_title：European journal of immunology

authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

更新日期：2007-02-01 00:00:00

abstract：:Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...

journal_title：European journal of immunology

authors： Kelly KA,Scollay R

更新日期：1992-02-01 00:00:00

abstract：:Carbon monoxide (CO) treatment improves pathogenic outcome of autoimmune diseases by promoting tolerance. However, the mechanism behind this protective tolerance is not yet defined. Here, we show in a transgenic mouse model for autoimmune diabetes that ex vivo gaseous CO (gCO)-treated DCs loaded with pancreatic β-cell...

journal_title：European journal of immunology

authors： Simon T,Pogu S,Tardif V,Rigaud K,Rémy S,Piaggio E,Bach JM,Anegon I,Blancou P

更新日期：2013-01-01 00:00:00

abstract：:The stimulatory as well as the inhibitory capacity of alloantisera has been investigated with respect to rat mast cell functions. Alloantibody against alloantigens coded for by the major histocompatibility (H-1) gene region promoted histamine release from purified LEW mast cells. This process was found to be complemen...

journal_title：European journal of immunology

authors： Mossmann H,Lauer W,Vortisch U,Gunther E,Bazin H,Hammer DK

更新日期：1976-08-01 00:00:00

abstract：:F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

journal_title：European journal of immunology

authors： Schofield JP,Vijayakumar RK,Oliveira DB

更新日期：1991-05-01 00:00:00

abstract：:Human papillomavirus (HPV) infections account for more than 50% of infection-linked cancers in women worldwide. The immune system controls, at least partially, viral infection and around 90% of HPV-infected women clear the virus within two years. However, it remains unclear which immune cells are implicated in this pr...

journal_title：European journal of immunology

authors： Renoux VM,Bisig B,Langers I,Dortu E,Clémenceau B,Thiry M,Deroanne C,Colige A,Boniver J,Delvenne P,Jacobs N

更新日期：2011-11-01 00:00:00

abstract：:Studies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen-specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correl...

journal_title：European journal of immunology

authors： Wilkinson KA,Wilkinson RJ

更新日期：2010-08-01 00:00:00

abstract：:Cyclosporin A (CSA), an immunosuppressive agent used in organ transplantation and to treat some autoimmune diseases, blocks the Ca2+-dependent steps involved in T cell receptor triggering leading to interleukin (IL)-2 production. Considering that the early steps of T cell activation are insensitive to CSA, we asked wh...

journal_title：European journal of immunology

authors： Bemer V,Truffa-Bachi P

更新日期：1996-07-01 00:00:00

abstract：:The generation of effective type 1 T helper (Th1)-cell responses is required for immunity against intracellular bacteria. However, some intracellular bacteria require interleukin (IL)-17 to drive Th1-cell immunity and subsequent protective host immunity. Here, in a model of Mycobacterium bovis Bacille Calmette-Guerin ...

journal_title：European journal of immunology

authors： Gopal R,Lin Y,Obermajer N,Slight S,Nuthalapati N,Ahmed M,Kalinski P,Khader SA

更新日期：2012-02-01 00:00:00

abstract：:Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was show...

journal_title：European journal of immunology

authors： Amagai T,Cinader B

更新日期：1981-11-01 00:00:00

abstract：:A simple and efficient procedure for the construction of bifunctional molecules is described and their use in a variety of applications documented. This procedure is based on our observation that mouse IgG1 monoclonal antibodies, when mixed with equimolar amounts of a high-affinity rat monoclonal antibody specific for...

journal_title：European journal of immunology

authors： Lansdorp PM,Aalberse RC,Bos R,Schutter WG,Van Bruggen EF

更新日期：1986-06-01 00:00:00

abstract：:Recombinant vaccinia viruses (VV)-encoding murine interferon-gamma (IFN-gamma) were constructed and the effect of virus-encoded IFN-gamma on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN-gamma expression by VV enabled the mice to recover from th...

journal_title：European journal of immunology

authors： Kohonen-Corish MR,King NJ,Woodhams CE,Ramshaw IA

更新日期：1990-01-01 00:00:00

abstract：:Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

journal_title：European journal of immunology

authors： Picarella D,Serunian LA,Rosenberg N

更新日期：1991-01-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:GITR (glucocorticoid-induced TNFR family related gene) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes. Because of a high homology in its cytoplasmic region with other known costimulatory members of the TNFRSF, we investigated whether GITR played a costim...

journal_title：European journal of immunology

authors： Ronchetti S,Zollo O,Bruscoli S,Agostini M,Bianchini R,Nocentini G,Ayroldi E,Riccardi C

更新日期：2004-03-01 00:00:00

abstract：:Foxp3-expressing Tregs play a non-redundant role in protecting against immune pathologies. Foxp3(+) Tregs can arise intra- and extra-thymically, however, the signals directing their differentiation and maintenance in the periphery are not well understood. We show that stimulation of mouse naïve CD4(+) T cells in vitro...

journal_title：European journal of immunology

authors： Gabryšová L,Christensen JR,Wu X,Kissenpfennig A,Malissen B,O'Garra A

更新日期：2011-05-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

journal_title：European journal of immunology

authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

更新日期：2006-03-01 00:00:00

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the com...

journal_title：European journal of immunology

authors： Mahnke YD,Brodie TM,Sallusto F,Roederer M,Lugli E

更新日期：2013-11-01 00:00:00

abstract：:Tumor-associated macrophages play an important role in tumorigenesis and metastasis. Trafficking of macrophages to the proximity of tumors is mediated by CSF-1, a growth factor. In this study, we investigated the role of PKB/Akt in CSF-1-induced macrophage migration. Disruption of Akt2 expression by small interference...

journal_title：European journal of immunology

authors： Zhang B,Ma Y,Guo H,Sun B,Niu R,Ying G,Zhang N

更新日期：2009-03-01 00:00:00

abstract：:The expression of human leukocyte function-associated antigens (HLFA, equivalents of murine LFA-1) was studied on early lympho-hemopoietic cells in infant thymus and normal bone marrow by double immunofluorescence methods, cell sorting and colony-forming assays. Monoclonal antibodies MHM-24 recognizing the alpha chain...

journal_title：European journal of immunology

authors： Campana D,Sheridan B,Tidman N,Hoffbrand AV,Janossy G

更新日期：1986-05-01 00:00:00

abstract：:Previous work has shown that the primary IgM plaque-forming cell response of inbred mice to xenogeneic red blood cells (RBC) including sheep, horse and chicken RBC is under the control of two polymorphic genes or sets of genes, one linked to the Igh linkage group and the other of unknown linkage but unlinked to H-2 an...

journal_title：European journal of immunology

authors： Saizawa KM,Melchers I,Eichmann K

更新日期：1985-02-01 00:00:00

abstract：:The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subsequent extravasation to the tissues is a key step during different physiological and pathological processes. In certain of these pathologies the oxygen tension becomes very low, leading to reduced cellular oxidative statu...

journal_title：European journal of immunology

authors： Montoya MC,Luscinskas FW,del Pozo MA,Aragonés J,de Landázuri MO

更新日期：1997-08-01 00:00:00