Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes.

abstract：:DT9301-0229737 the TcR are believed to provide the peptide fragments bound to major histocompatibility (MHC) molecules. TcR have an immunoglobulin (Ig)-like structure and, in an analogous manner to antigen recognition by Ig, the third complementarity determining regions (CDR3) of the TcR are believed to provide the pr...

journal_title：European journal of immunology

authors： Jones CM,Lake RA,Lamb JR,Faith A

更新日期：1994-05-01 00:00:00

abstract：:We recently constructed IL-15 transgenic (Tg) mice using cDNA encoding a secretable isoform of the IL-15 precursor protein under the control of an MHC class I promoter. The IL-15 Tg mice exhibited resistance against a primary infection with Listeria monocytogenes. The numbers of memory CD8(+) T cells were markedly inc...

journal_title：European journal of immunology

authors： Yajima T,Nishimura H,Ishimitsu R,Yamamura K,Watase T,Busch DH,Pamer EG,Kuwano H,Yoshikai Y

更新日期：2001-03-01 00:00:00

abstract：:Studies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen-specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correl...

journal_title：European journal of immunology

authors： Wilkinson KA,Wilkinson RJ

更新日期：2010-08-01 00:00:00

abstract：:Maintenance of homeostasis at body barriers that are constantly challenged by microbes, toxins and potentially bioactive (macro)molecules requires complex, highly orchestrated mechanisms of protection. Recent discoveries in respiratory research have shed light on the unprecedented role of airway epithelial cells (AEC)...

journal_title：European journal of immunology

authors： Smole U,Kratzer B,Pickl WF

更新日期：2020-05-01 00:00:00

abstract：:The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...

journal_title：European journal of immunology

authors： Rückert R,Brandt K,Bulanova E,Mirghomizadeh F,Paus R,Bulfone-Paus S

更新日期：2003-12-01 00:00:00

abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

journal_title：European journal of immunology

authors： Nordin AA

更新日期：1978-11-01 00:00:00

abstract：:Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the ...

journal_title：European journal of immunology

authors： Ghofrani J,Lucar O,Dugan H,Reeves RK,Jost S

更新日期：2019-08-01 00:00:00

abstract：:The induction of B cell tolerance to 2,4-dinitrophenyl conjugates of polysaccharide antigens (levan or dextran) was studied in mice primed with keyhole limpet hemocyanin (KLH) or 2,4,6-trinitrophenylated KLH. The relationship of the epitope density of the tolerogen with avidity of B cell receptors (as judged indirectl...

journal_title：European journal of immunology

authors： Desaymard C,Pearce B,Feldmann M

更新日期：1976-09-01 00:00:00

abstract：:Macrophages provide a first line of defense against bacterial infection by engulfing and killing invading bacteria, but intracellular bacteria such as Listeria monocytogenes (LM) can survive in macrophages by various mechanisms of evasion. Complement receptor of the immunoglobulin (CRIg), a C3b receptor, binds to C3b ...

journal_title：European journal of immunology

authors： Kim KH,Choi BK,Song KM,Cha KW,Kim YH,Lee H,Han IS,Kwon BS

更新日期：2013-03-01 00:00:00

abstract：:The thymus is the primary organ for T-cell differentiation and maturation. Unlike other major organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost complete atrophy followed by rapid restoration. The process of thymic atrophy, or involution, results in decreased thymopoiesis and emigrat...

journal_title：European journal of immunology

authors： Dooley J,Liston A

更新日期：2012-05-01 00:00:00

abstract：:The requirement for cell interactions in T cell activation has been studied with two continuously in vitro growing T cell clones. These clones are specific for minor histocompatibility antigens, are H-2K restricted, and one clone is functionally a cytolytic T lymphocyte. Both can proliferate when interleukin 2 is adde...

journal_title：European journal of immunology

authors： Di Pauli R,Brückner T

更新日期：1984-10-01 00:00:00

abstract：:Cholera toxin (CT) can function as a potent adjuvant in the mucosal immune response. However, we have found that treatment of A20-HL murine B lymphoma cells with CT severely inhibits the presentation of ovalbumin (OVA) to cells of the T cell clone 42-6A specific for OVA(323-339)/I-Ad, whereas it does not affect the pr...

journal_title：European journal of immunology

authors： Tanaka Y,Nakano H,Ishikawa F,Yoshida M,Gyotoku Y,Kakiuchi T

更新日期：1999-05-01 00:00:00

abstract：:5'-Nucleotidase/CD73 is a key enzyme in the regulation of purinergic signaling, hydrolyzing extracellular AMP to produce adenosine, which is critical in the blood vascular system and in immunosuppression. CD73 is expressed by both blood endothelial cells and lymphatic endothelial cells. Although the role of CD73 on bl...

journal_title：European journal of immunology

authors： Sidibé A,Imhof BA

更新日期：2015-02-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:Inhibitory anti-antibodies induced in patients by xenogeneic or even by humanized anti-T cell antibodies remain an unresolved problem. Mice also produce anti-antibodies following injection of xeno- or allogeneic anti-T cell antibodies. Here we report a principle based on sequentially applied anti-T cell antibodies gen...

journal_title：European journal of immunology

authors： Mysliwietz J,Thierfelder S,Mocikat R,Kremmer E

更新日期：1994-10-01 00:00:00

abstract：:The study of the immunology of schistosomiasis has allowed a clear understanding of the basic mechanisms of resistance, emphasizing the important role played by cellular and humoral factors. Whereas the production of polyclonal or monoclonal antibodies and the precise inventory of immune effector mechanisms in the rat...

journal_title：European journal of immunology

authors： Auriault C,Damonneville M,Joseph M,Capron M,Verwaerde C,Billaut P,Capron A

更新日期：1985-12-01 00:00:00

abstract：:The murine monoclonal antibody (mAb) CB43, raised against the K-562 erythroleukemia line, reacts with monocytes, tissue macrophages, thymocytes and with all the human lines tested but not with resting lymphocytes, large granular lymphocytes, granulocytes and erythrocytes. However, activated lymphocytes and natural kil...

journal_title：European journal of immunology

authors： Bellone G,Alloatti G,Levi R,Geuna M,Tetta C,Peruzzi L,Letarte M,Malavasi F

更新日期：1989-01-01 00:00:00

abstract：:Central and peripheral tolerance mechanisms are expected to hamper the generation of effective immunity against tumors. To break self tolerance against malignant gliomas, we assessed the therapeutic potential of self/foreign antigen cross-reactivity in an immunocompetent rat glioma model. Immunotherapy of tumors using...

journal_title：European journal of immunology

authors： Sioud M,Sørensen D

更新日期：2003-01-01 00:00:00

abstract：:High-dose infusion of IgG (IVIG) is used to treat autoimmune and inflammatory diseases, including Kawasaki disease (KD). Although the immunomodulatory effects of IVIG on blood cells such as macrophages have been well studied, its effects on tissue cells remain unclear. Here, we show that high-dose IgG specifically and...

journal_title：European journal of immunology

authors： Matsuda A,Morita H,Unno H,Saito H,Matsumoto K,Hirao Y,Munechika K,Abe J

更新日期：2012-08-01 00:00:00

abstract：:A diabetes-associated peptide in the glutamic acid decarboxylase 65 (GAD65) molecule, p524-543, activates two distinct populations of T cells, which apparently play opposite roles in the development of diabetes in NOD mice. By comparing the fine specificity of these two T cell repertoires using a nested set of truncat...

journal_title：European journal of immunology

authors： Dai YD,Jensen KP,Marrero I,Li N,Quinn A,Sercarz EE

更新日期：2008-04-01 00:00:00

abstract：:We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph ...

journal_title：European journal of immunology

authors： Maloy KJ,Donachie AM,Mowat AM

更新日期：1995-10-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:There is an antigen presenting cell (APC) in the lymphoid organs capable of presenting exogenous antigen (Ag) with major histocompatibility complex (MHC) class I molecules. This study was initiated to isolate clones of these APC to definitively establish their phenotype and to further study their properties. Murine bo...

journal_title：European journal of immunology

authors： Kovacsovics-Bankowski M,Rock KL

更新日期：1994-10-01 00:00:00

abstract：:C3 is the central component of the complement system. Upon activation, C3 sequentially generates various proteolytic fragments, C3a, C3b, iC3b, C3dg, each of them exposing novel surfaces, which are sites of interaction with other proteins. C3 and its fragments are therapeutic targets and markers of complement activati...

journal_title：European journal of immunology

authors： Subías Hidalgo M,Yébenes H,Rodríguez-Gallego C,Martín-Ambrosio A,Domínguez M,Tortajada A,Rodríguez de Córdoba S,Llorca O

更新日期：2017-03-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00

abstract：:Cells of the innate immune system build immunological memory via epigenetic reprogramming after stimulations with microbial ligands. This functional readjustment allows for enhanced nonspecific inflammatory responses upon secondary challenges, a process termed "trained immunity." The epigenomic blueprint of trained mo...

journal_title：European journal of immunology

authors： Crișan TO,Netea MG,Joosten LA

更新日期：2016-04-01 00:00:00

abstract：:The invariant chain (Ii) is a chaperone that regulates assembly and transport of class II MHC molecules. In the absence of the lysosomal protease cathepsin S (CatS), degradation of Ii is impaired and an Ii remnant that extends from the N terminus to about residue 110 accumulates in class II MHC-positive endosomal comp...

journal_title：European journal of immunology

authors： Boes M,van der Wel N,Peperzak V,Kim YM,Peters PJ,Ploegh H

更新日期：2005-09-01 00:00:00

abstract：:The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII. Treatment of mouse antigen-presenting cells (APC) with the pharmacological Hsp90 inhibi...

journal_title：European journal of immunology

authors： Rajagopal D,Bal V,Mayor S,George A,Rath S

更新日期：2006-04-01 00:00:00

abstract：:Regulatory T cells (Treg) provide protection from autoimmune disease, graft-versus-host disease, transplant rejection and overwhelming tissue destruction during infections. Conversely, high Treg numbers enable cancer cells to evade the host immune response. Thus, Treg are seen as an important tool to manipulate the im...

journal_title：European journal of immunology

authors： Banham AH,Powrie FM,Suri-Payer E

更新日期：2006-11-01 00:00:00

abstract：:Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...

journal_title：European journal of immunology

authors： Schirmbeck R,Böhm W,Reimann J

更新日期：1997-08-01 00:00:00