Abstract:
:The invariant chain (Ii) is a chaperone that regulates assembly and transport of class II MHC molecules. In the absence of the lysosomal protease cathepsin S (CatS), degradation of Ii is impaired and an Ii remnant that extends from the N terminus to about residue 110 accumulates in class II MHC-positive endosomal compartments, which are enlarged in size and lack multivesicular morphology. In primary B cells examined in vitro and in lymph nodes examined by immuno-electron microscopy, CatS controls architecture of class II-positive endosomal compartments. In a compound mutant mouse that lacks both CatS and Ii, the normal size of endosomes in class II-positive cells is restored, although internal endosomal membranes are absent. Proper degradation of Ii is thus essential for normal endosomal morphology in antigen-presenting cells in vivo.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Boes M,van der Wel N,Peperzak V,Kim YM,Peters PJ,Ploegh Hdoi
10.1002/eji.200526323keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
2552-62issue
9eissn
0014-2980issn
1521-4141journal_volume
35pub_type
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