Abstract:
:Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT) recipients. Adoptive immunotherapy is a promising therapeutic avenue for the treatment of opportunistic infections, including herpesviruses. While T-cell immunotherapy can successfully control CMV and EBV reactivations in BMT recipients, such therapy is not available for HHV-6 infections, in part due to a lack of identified protective CD8(+) T-cell epitopes. Our goal was to identify CD8(+) T-cell viral epitopes derived from the HHV-6B immediate-early protein I and presented by common human leukocyte Ag (HLA) class I alleles including HLA-A*02, HLA-A*03, and HLA-B*07. These epitopes were functionally tested for their ability to induce CD8(+) T-cell expansion and kill HHV-6-infected autologous cells. Cross-reactivity of specific HHV-6B-expanded T cells against HHV-6A-infected cells was also confirmed for a conserved epitope presented by HLA-A*02 molecule. Our findings will help push forward the field of adoptive immunotherapy for the treatment and/or the prevention of HHV-6 reactivation in BMT recipients.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Iampietro M,Morissette G,Gravel A,Dubuc I,Rousseau M,Hasan A,O'Reilly RJ,Flamand Ldoi
10.1002/eji.201444931subject
Has Abstractpub_date
2014-12-01 00:00:00pages
3573-84issue
12eissn
0014-2980issn
1521-4141journal_volume
44pub_type
临床试验,杂志文章abstract::The expression of interleukin (IL)-1 beta, IL-6 and their respective receptors has been studied in the rat brain before and up to 24 h after injury. Messenger RNA transcripts of these four genes were detected by in situ hybridization (ISH) in different structures of the intact brain. The distribution was very similar ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221131
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abstract::The simultaneous detection of Ig and theta on the surface of mouse lymphocytes permits the detection of four cell types (Ig-theta-, Ig-theta+, Ig+theta-, and Ig+theta+) which also have distinct electrophoretic profiles. All types are present in variable proportions in all lymphoid organs studied. Results obtained in c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830050211
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journal_title:European journal of immunology
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doi:10.1002/eji.1830150321
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060414
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journal_title:European journal of immunology
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pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201344313
更新日期:2014-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231117
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190630
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150214
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830261211
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200911
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
pub_type: 评论,杂志文章
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130308
更新日期:1983-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737342
更新日期:2008-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190704
更新日期:1989-07-01 00:00:00
abstract::Protein antigens with both allergenic and immunoprotective properties represent appropriate molecules to study IgE and IgG regulation. We have established a panel of T cell clones specific to bee venom phospholipase A2 (PLA) from human individuals allergic, hyposensitized or immune (protected) to bee sting. All clones...
journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
abstract::Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, the two rat strains have...
journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
abstract::The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engag...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141404
更新日期:2011-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199903)29:03<872::AID-IMMU
更新日期:1999-03-01 00:00:00