Abstract:
:In the bone marrow (BM), memory plasma cells (PCs) survive for long time periods in dedicated microenvironmental survival niches, resting in terms of proliferation. Several cell types, such as eosinophils and reticular stromal cells, have been reported to contribute to the survival niche of memory PCs. However, until now it has not been demonstrated whether the niche is formed by a fixed cellular microenvironment. By intravital microscopy, we provide for the first time evidence that the direct contacts formed between PCs and reticular stromal cells are stable in vivo, and thus the PCs are sessile in their niches. The majority (∼ 80%) of PCs directly contact reticular stromal cells in a non-random fashion. The mesenchymal reticular stromal cells in contact with memory PCs are not proliferating. On the other hand, we show here that eosinophils in the vicinity of long-lived PCs are vigorously proliferating cells and represent a dynamic component of the survival niche. In contrast, if eosinophils are depleted by irradiation, newly generated eosinophils localize in the vicinity of radiation-resistant PCs and the stromal cells. These results suggest that memory PC niches may provide attraction for eosinophils to maintain stability with fluctuating yet essential accessory cells.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Zehentmeier S,Roth K,Cseresnyes Z,Sercan Ö,Horn K,Niesner RA,Chang HD,Radbruch A,Hauser AEdoi
10.1002/eji.201344313subject
Has Abstractpub_date
2014-08-01 00:00:00pages
2306-17issue
8eissn
0014-2980issn
1521-4141journal_volume
44pub_type
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