当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation.

CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation.

Abstract：

:The role of CD8(+) T cells in the development of allergic airway disease is controversial. On the one hand, CD8(+) T cells are known to inhibit the development of airway hyperreactivity (AHR) in murine models of asthma. In humans, IL-10-producing CD8(+) T cells were shown to act as regulatory cells, inhibiting both proliferation and cytokine secretion of T cells. On the other hand, CD8(+) T cells can promote IL-5-mediated eosinophilic airway inflammation and the development of AHR in animal models. To examine this, we investigated the role of CD8(+) T cells during the induction of allergen-induced AHR and demonstrated a protective effect of CD8(+) T cells. Depletion of CD8(+) T cells prior to the immunization led to increased Th2 responses and increased allergic airway disease. However, after development of AHR, CD8(+) T cells that infiltrated the lungs secreted high levels of IL-4, IL-5 and IL-10, but little IFN-gamma, whereas CD8(+) T cells in the peribronchial lymph nodes or spleen produced high levels of IFN-gamma, but little or no Th2 cytokines. These data demonstrate protective effects of CD8(+)T cells against the induction of immune responses and show a functional diversity of CD8(+) T cells in different compartments of sensitized mice.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Stock P,Kallinich T,Akbari O,Quarcoo D,Gerhold K,Wahn U,Umetsu DT,Hamelmann E

doi

10.1002/eji.200324623

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

1817-27

issue

7

eissn

0014-2980

issn

1521-4141

journal_volume

34

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions.

    abstract：:Although originally described in tumor-bearing hosts, myeloid-derived suppressor cells (MDSC) have been detected under numerous pathological situations that cause enhanced demand of myeloid cells. Thus, MDSC might be part of a conserved response to different endogenous and exogenous stress signals, including inflammat...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.200939892

    authors： Bronte V

    更新日期：2009-10-01 00:00:00

  • Dominance of the BV17 element in nickel-specific human T cell receptors relates to severity of contact sensitivity.

    abstract：:Hypersensitivity to nickel (Ni) represents the most common manifestation of contact allergy in humans. The role of metal-specific T cells in this disease is well established, but the molecular interactions involved in their activation are poorly understood. We examined the T cell receptor (TCR) repertoire in T cells a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270808

    authors： Vollmer J,Fritz M,Dormoy A,Weltzien HU,Moulon C

    更新日期：1997-08-01 00:00:00

  • Temperature and cellular regulation of spontaneous cytotoxicity in the shark.

    abstract：:Spontaneous cytolytic activity of shark peripheral blood leukocytes is observed only during periods of decreased environmental temperature (less than 23 degrees C). The effector cell is adherent to glass and is phagocytic. Leukocytes tested during warmer periods (26-31 degrees C) exhibit no spontaneous activity; howev...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830130208

    authors： Pettey CL,McKinney EC

    更新日期：1983-02-01 00:00:00

  • Vitamin A notches up CD11b hi DC development.

    abstract：:Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103(+) DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tiss...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.201343631

    authors： Stock AT,Bedoui S

    更新日期：2013-06-01 00:00:00

  • The invariant chains of mouse class II antigens: biochemical properties and molecular relationship.

    abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830140606

    authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

    更新日期：1984-06-01 00:00:00

  • Nonrandom TRG gamma variable gene rearrangement in normal human T cells and T cell leukemias.

    abstract：:To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearra...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830180126

    authors： Migone N,Casorati G,Di Celle PF,Lusso P,Foa R,Lefranc MP

    更新日期：1988-01-01 00:00:00

  • Immunological approach to inhibit formation of anti-antibodies to allo- and xenogeneic anti-T cell immunoglobulin.

    abstract：:Inhibitory anti-antibodies induced in patients by xenogeneic or even by humanized anti-T cell antibodies remain an unresolved problem. Mice also produce anti-antibodies following injection of xeno- or allogeneic anti-T cell antibodies. Here we report a principle based on sequentially applied anti-T cell antibodies gen...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830241010

    authors： Mysliwietz J,Thierfelder S,Mocikat R,Kremmer E

    更新日期：1994-10-01 00:00:00

  • Analysis of the T cell repertoire for myelin basic protein in thymus-grafted and other types of chimera: evidence that major histocompatibility complex molecules on accessory cells rather than T cell specificity mainly regulate susceptibility to autoimmun

    abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200934

    authors： Matsumoto Y,Kawai K,Fujiwara M

    更新日期：1990-09-01 00:00:00

  • CD45RB expression defines two interconvertible subsets of human CD4+ T cells with memory function.

    abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240536

    authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

    更新日期：1994-05-01 00:00:00

  • Comparative study of VH gene family usage by newborn xid and non-xid mice, newborn NZB and adult NZB mice, and by splenic and peritoneal cavity B cell compartments.

    abstract：:RNA from 170 different Ig-secreting hybridomas was hybridized with VH gene probes 7183, QUPC52, S107, J558, J606, 36-60, V31, X-24 and V-GAM 3.8, with the aim of comparing xid to non-xid mice, neonatal NZB to adult NZB, and the peritoneal cavity with the splenic compartments for VH gene family expression. Our results ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830181217

    authors： Dighiero G,Lim A,Lembezat MP,Kaushik A,Andrade L,Freitas A

    更新日期：1988-12-01 00:00:00

  • Allelic exclusion of membrane but not secreted immunoglobulin in a mature B cell line.

    abstract：:Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210110

    authors： Picarella D,Serunian LA,Rosenberg N

    更新日期：1991-01-01 00:00:00

  • Enzymatic modification of lymphocyte receptors for antigen. III. Resistance of receptors to trypsin at the peak of the immune response.

    abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050612

    authors： Ashman RF

    更新日期：1976-06-01 00:00:00

  • Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77.

    abstract：:Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridom...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200106)31:6<1757::aid-immu1757>3

    authors： Liu W,Youn HD,Liu JO

    更新日期：2001-06-01 00:00:00

  • Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.

    abstract：:Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830261008

    authors： Webb LM,Walmsley MJ,Feldmann M

    更新日期：1996-10-01 00:00:00

  • Galectin-1 supports survival of naive T cells without promoting cell proliferation.

    abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425340

    authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

    更新日期：2005-01-01 00:00:00

  • Human B cell activation and cell cycle progression: stimulation with anti-mu and Staphylococcus aureus Cowan strain I.

    abstract：:The responses of resting human B lymphocytes to a variety of activation signals were studied. Human tonsillar B lymphocytes were separated according to size by countercurrent elutriation. The small B lymphocytes were then stimulated in vitro with various concentrations of anti-mu antibody in the presence or absence of...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830140203

    authors： Kehrl JH,Muraguchi A,Fauci AS

    更新日期：1984-02-01 00:00:00

  • Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice.

    abstract：:The lymphoid cell composition of milky spots was analyzed in unprimed mice before and after i.p. immunization with sheep red blood cells. Milky spots contained surface immunoglobulin-positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge the number of lymphocytes i...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160828

    authors： Dux K,Rouse RV,Kyewski B

    更新日期：1986-08-01 00:00:00

  • Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice.

    abstract：:The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199812)28:12<4138::AID-IMM

    authors： Siegrist CA,Barrios C,Martinez X,Brandt C,Berney M,Córdova M,Kovarik J,Lambert PH

    更新日期：1998-12-01 00:00:00

  • P- and L-selectin mediate binding of T cells to chronically inflamed human airway endothelium.

    abstract：:The inflammatory process that underlies allergic diseases such as asthma is characterized by tissue infiltration of eosinophils and T cells. We have used the Stamper-Woodruff frozen-section assay to characterize the receptors involved in adhesion of human peripheral blood T cells to nasal polyp endothelium (NPE) as a ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199904)29:04<1324::AID-IMM

    authors： Symon FA,McNulty CA,Wardlaw AJ

    更新日期：1999-04-01 00:00:00

  • C1q, the collagen-like subcomponent of the first component of complement C1, is a membrane protein of guinea pig macrophages.

    abstract：:C1q, a subcomponent of C1--the first component of complement, is synthesized by macrophages (M phi). Immunofluorescence and immunoperoxidase studies first indicated the presence of C1q on the surface of guinea pig (gp) and human peritoneal M phi (Loos, M., Storz, R., Müller, W. and Lemmel, E. M., Immunobiology 1981. 1...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830230918

    authors： Kaul M,Loos M

    更新日期：1993-09-01 00:00:00

  • CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity.

    abstract：:Treg subsets play a role in sustaining peripheral tolerance, are characterized by markers such as forkhead winged-helix transcription factor (FOXP3) and CD25, and produce suppressive cytokines, such as IL-10 and TGF-β. Glucocorticoid-induced TNF receptor family-related (GITR) protein has been suggested to regulate Tre...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040943

    authors： Bianchini R,Bistoni O,Alunno A,Petrillo MG,Ronchetti S,Sportoletti P,Bocci EB,Nocentini G,Gerli R,Riccardi C

    更新日期：2011-08-01 00:00:00

  • Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: protein context influences the degree of TAP-independent presentation.

    abstract：:Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830261135

    authors： Wick MJ,Pfeifer JD

    更新日期：1996-11-01 00:00:00

  • A quantitative assay of peptide-dependent class I assembly.

    abstract：:We have developed a quantitative assay for the measurement of class I assembly induced by peptide. We have applied this assay to H-2Db, Kb and HLA-A2.1 with a panel of 49 overlapping peptides derived from HIV-1 gag protein. We find that the effects of peptide on assembly form a continuous distribution. By defining pos...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210909

    authors： Elvin J,Cerundolo V,Elliott T,Townsend A

    更新日期：1991-09-01 00:00:00

  • Differential T cell receptor-mediated signaling in naive and memory CD4 T cells.

    abstract：:Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270838

    authors： Farber DL,Acuto O,Bottomly K

    更新日期：1997-08-01 00:00:00

  • Activation of CD4⁺ Foxp3⁺ regulatory T cells proceeds normally in the absence of B cells during EAE.

    abstract：:B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201142242

    authors： Hoehlig K,Shen P,Lampropoulou V,Roch T,Malissen B,O'Connor R,Ries S,Hilgenberg E,Anderton SM,Fillatreau S

    更新日期：2012-05-01 00:00:00

  • The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice.

    abstract：:The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases. However, the relative contributions of these molecules to the development and progression of disease is not known. In the present study...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250647

    authors： Probert L,Plows D,Kontogeorgos G,Kollias G

    更新日期：1995-06-01 00:00:00

  • Suppression of polyclonal and antigen-specific murine IgG1 but not IgE responses by neutralizing interleukin-6 in vivo.

    abstract：:The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240624

    authors： van Ommen R,Vredendaal AE,Savelkoul HF

    更新日期：1994-06-01 00:00:00

  • Murine macrophage precursor characterization. I. Production, phenotype and differentiation of macrophage precursor hybrids.

    abstract：:This study reports on the earliest stages of mononuclear phagocyte differentiation. A crucial question in this developmental process is whether mature macrophage (M phi) heterogeneity is already appointed at the precursor cell level. For this purpose, we produced clonal populations of mononuclear phagocytes from bone ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200104

    authors： Leenen PJ,Slieker WA,Melis M,Van Ewijk W

    更新日期：1990-01-01 00:00:00

  • Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I-restricted cytotoxic T cells and the rejection of a cognate antigen-expressing model tumor.

    abstract：:We previously demonstrated that cholera toxin (CT) is highly efficient as a combined carrier and adjuvant for dendritic cell (DC) vaccination, inducing strong Th1-dominated B cell and CD4(+) T cell responses. In this study we show that vaccination with DC pre-pulsed ex vivo with CT-conjugated OVA (OVA-CT) gives rise t...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200324368

    authors： Eriksson K,Sun JB,Nordström I,Fredriksson M,Lindblad M,Li BL,Holmgren J

    更新日期：2004-05-01 00:00:00

  • Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.

    abstract：:Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognat...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0

    authors： Czarneski J,Berguer P,Bekinschtein P,Kim DC,Hakimpour P,Wagner N,Nepomnaschy I,Piazzon I,Ross SR

    更新日期：2002-04-01 00:00:00