Abstract:
:To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearranged fragments, four of which occurred only once, were found among 80 rearranged chromosomes. Furthermore, in the leukemic population as a whole, the frequency distribution of the most common types of rearranged V gamma gene-containing fragments appeared to be nonrandom (p less than 0.01). Of interest is the clear preference for functional vs. nonfunctional V gamma genes (nonfunctional genes being those which carry frameshifts or nonsense mutations but which presumably can still rearrange due to their conserved signal sequences). We discuss the possibilities that this preference may result either from selection of the TRG gamma product at some stage during T cell development or, alternatively, from an intrinsic, antigen-independent polarity in V gamma gene activation.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Migone N,Casorati G,Di Celle PF,Lusso P,Foa R,Lefranc MPdoi
10.1002/eji.1830180126subject
Has Abstractpub_date
1988-01-01 00:00:00pages
173-8issue
1eissn
0014-2980issn
1521-4141journal_volume
18pub_type
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