Abstract:
:Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Czarneski J,Berguer P,Bekinschtein P,Kim DC,Hakimpour P,Wagner N,Nepomnaschy I,Piazzon I,Ross SRdoi
10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
945-56issue
4eissn
0014-2980issn
1521-4141journal_volume
32pub_type
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