Abstract:
:The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have infected B7-1/B7-2-deficient mice on the BALB/c and 129 background with L. major and subsequently examined different parameters of infection and cytokine responses upon restimulation of lymph node cells in vitro. BALB/c B7-2-deficient and B7-1/B7-2-double deficient mice are resistant to L. major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Brown JA,Greenwald RJ,Scott S,Schweitzer AN,Satoskar AR,Chung C,Schopf LR,van der Woude D,Sypek JP,Sharpe AHdoi
10.1002/1521-4141(200206)32:6<1764::AID-IMMU1764>3keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
1764-72issue
6eissn
0014-2980issn
1521-4141journal_volume
32pub_type
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