Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.

abstract：:The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...

journal_title：European journal of immunology

authors： Hayari Y,Kukulansky T,Globerson A

更新日期：1985-01-01 00:00:00

abstract：:IL-6-specific autoantibodies (aAb-IL-6) have been reported in diseased and healthy individuals. We recently established a model for aAb-IL-6 in different mouse strains, based on vaccination with immunogenic IL-6 analogues, in which titers of aAb-IL-6 above 1,000 resulted in an in vivo IL-6 deficiency. Here, we examine...

journal_title：European journal of immunology

authors： Galle P,Svenson M,Bendtzen K,Hansen MB

更新日期：2004-11-01 00:00:00

abstract：:CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

journal_title：European journal of immunology

authors： Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

更新日期：1997-12-01 00:00:00

abstract：:In the murine system, we tested in vivo the immunogenicity of different preparations of the yeast-derived surface antigen (S-antigen or S-protein) of hepatitis B virus (HBV). Native S-protein molecules self-assemble into stable 22-nm particles. BALB/c mice immunized with low doses of native S-particles without adjuvan...

journal_title：European journal of immunology

authors： Schirmbeck R,Melber K,Mertens T,Reimann J

更新日期：1994-05-01 00:00:00

abstract：:DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...

journal_title：European journal of immunology

authors： Remer KA,Apetrei C,Schwarz T,Linden C,Moll H

更新日期：2007-09-01 00:00:00

abstract：:We have previously reported the development of a two-step culture system in which soluble anti-mu monoclonal antibodies prime small resting murine B cells to secrete immunoglobulin (Ig) in response to restimulation with a mixture of interleukin-4 (IL-4) and IL-5. Here we have extended these studies to investigate the ...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1993-02-01 00:00:00

abstract：:Stromal elements are major components of lymphoid tissues contributing to both tissue architecture and function. In this study we report on the phenotype and function of fibroblast-like stromal cells obtained from human spleen. These cells express high levels of CD44 and ICAM-1 and moderate levels of VLA-4, VCAM, CD40...

journal_title：European journal of immunology

authors： Skibinski G,Skibinska A,Stewart GD,James K

更新日期：1998-12-01 00:00:00

abstract：:Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of MAPK-, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. This activation state is inherently unstable and often transitions into a state of 'tolerance' characte...

journal_title：European journal of immunology

authors： Ivashkiv LB

更新日期：2011-09-01 00:00:00

abstract：:Barrier surfaces of multicellular organisms are in constant contact with the environment and infractions to the integrity of epithelial surfaces is likely a frequent event. Interestingly, components of the immune system, that can be activated by environmental compounds such as the microbiota or nutrients, are interspe...

journal_title：European journal of immunology

authors： Hernandez P,Gronke K,Diefenbach A

更新日期：2018-01-01 00:00:00

abstract：:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...

journal_title：European journal of immunology

authors： Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman G

更新日期：1996-05-01 00:00:00

abstract：:Natural Killer (NK) cell-based immunotherapy is a promising approach to treat hepatocellular carcinoma (HCC). The mechanisms underlying the regulation of NK cell activity are not completely understood. In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 mem...

journal_title：European journal of immunology

authors： Liu S,Xu M,Zhu C,Zhao Q,Zhou F

更新日期：2018-12-01 00:00:00

abstract：:Because of their plasticity and central role in orchestrating immunity and tolerance, DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we show that pregnancy-specific glycoprotein (PSG1a), the major variant of PSG released into the circu...

journal_title：European journal of immunology

authors： Martínez FF,Knubel CP,Sánchez MC,Cervi L,Motrán CC

更新日期：2012-06-01 00:00:00

abstract：:Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern that effective vaccine adjuvants may similarly rely on widespread DC ...

journal_title：European journal of immunology

authors： Kamath AT,Valenti MP,Rochat AF,Agger EM,Lingnau K,von Gabain A,Andersen P,Lambert PH,Siegrist CA

更新日期：2008-05-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) recognize antigenic peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of target cells. Optimal induction of CD8+ CTL depends on the amount of relevant peptide/MHC-I complexes and the presence of co-stimulatory molecules on antigen-presenting c...

journal_title：European journal of immunology

authors： Bellone M,Iezzi G,Manfredi AA,Protti MP,Dellabona P,Casorati G,Rugarli C

更新日期：1994-11-01 00:00:00

abstract：:The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

journal_title：European journal of immunology

authors： Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

更新日期：2020-07-01 00:00:00

abstract：:T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...

journal_title：European journal of immunology

authors： Shields JG,Smith SH,Strobel S,Levinsky RJ,Defrance T,De Vries J,Banchereau J,Callard RE

更新日期：1988-02-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:We have studied the role of murine eosinophils as antigen-presenting cells (APC). Eosinophils have several characteristics that support the hypothesis of its function as potential APC: they have phagocytic capacity, express adhesion molecules and major histocompatibility complex (MHC) class II antigens and can produce...

journal_title：European journal of immunology

authors： Del Pozo V,De Andrés B,Martín E,Cárdaba B,Fernández JC,Gallardo S,Tramón P,Leyva-Cobian F,Palomino P,Lahoz C

更新日期：1992-07-01 00:00:00

abstract：:The nonobese diabetic (NOD) mouse is a relevant model for studying human insulin-dependent diabetes mellitus (IDDM). The selective destruction of insulin-secreting cells in this model is subsequent to an autoimmune reaction directed towards the beta cells inside the islets of Langerhans of the pancreas. Given the key ...

journal_title：European journal of immunology

authors： Sempé P,Bédossa P,Richard MF,Villà MC,Bach JF,Boitard C

更新日期：1991-05-01 00:00:00

abstract：:Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...

journal_title：European journal of immunology

authors： Kratzer B,Hofer S,Zabel M,Pickl WF

更新日期：2020-01-01 00:00:00

abstract：:Invariant NKT cells were stimulated with cholesteryl O-acyl α-glycosides in the context of CD1d. The activated NKT cells have potential to sustain the homeostasis in the body exposed to excess in either Th1- or Th2-immunity. ...

journal_title：European journal of immunology

authors： Shimamura M,Kamijo SI,Illarionov P

更新日期：2019-02-01 00:00:00

abstract：:The adoptive transfer of CD4(+)CD25(+) natural regulatory T cells (Treg) is a promising strategy for the treatment of autoimmune diseases and the prevention of alloresponses after transplantation. Clinical trials exploring this strategy require efficient in vitro expansion of this rare cell population. Protocols devel...

journal_title：European journal of immunology

authors： Hoffmann P,Boeld TJ,Eder R,Huehn J,Floess S,Wieczorek G,Olek S,Dietmaier W,Andreesen R,Edinger M

更新日期：2009-04-01 00:00:00

abstract：:Age-associated thymic involution results in a diminished capacity to regenerate T cell populations, although the magnitude of this effect is unknown. In this report, thymic function was studied in aged vs. young adult mice after lethal irradiation and administration of T cell-depleted bone marrow (BM) from young mice....

journal_title：European journal of immunology

authors： Mackall CL,Punt JA,Morgan P,Farr AG,Gress RE

更新日期：1998-06-01 00:00:00

abstract：:On the premise that an individual with an intact immune system has the capability to develop both cellular and antibody immune responses supported by the balance between the lymphokines secreted by T helper (Th) cells, we studied the interaction between different types of Th cell clones in vivo and the parameters that...

journal_title：European journal of immunology

authors： Rizzo LV,DeKruyff RH,Umetsu DT,Caspi RR

更新日期：1995-03-01 00:00:00

abstract：:The pathways leading to activation of mucosal lamina propria (LP) T cells differ from those of peripheral T cells. LP T cells exhibit enhanced IFN-gamma secretion when activated through the CD2 pathway. This study demonstrates CD2 signaling is followed by activation of STAT proteins in both peripheral blood mononuclea...

journal_title：European journal of immunology

authors： Gonsky R,Deem RL,Young HA,Targan SR

更新日期：2003-05-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...

journal_title：European journal of immunology

authors： Skak K,Guerder S,Picarella DE,Brenden N,Flavell RA,Michelsen BK

更新日期：2003-05-01 00:00:00

abstract：:The MOPC460 idiotype is expressed in mice with the IghCa allotypic haplotype after anti-2,4-dinitrophenyl (DNP) immunization. We have previously shown that two monoclonal syngeneic anti-idiotypic antibodies (IDM 92-13 and IDM 41-27) define two distinct idiotopes (the 460.92 and the 460.41) on the M460 idiotype. The cu...

journal_title：European journal of immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1983-12-01 00:00:00

abstract：:To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self-reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing V beta...

journal_title：European journal of immunology

authors： Iwasaki A,Yoshikai Y,Yuuki H,Takimoto H,Nomoto K

更新日期：1991-03-01 00:00:00

abstract：:We investigated whether percutaneous sensitization with different allergens through barrier-disrupted skin regulates the balance of Th1/Th2 cytokine expression. When mice were sensitized with the typical hapten picryl chloride (PiCl) by a single topical application to intact skin, there was an up-regulation in the lym...

journal_title：European journal of immunology

authors： Kondo H,Ichikawa Y,Imokawa G

更新日期：1998-03-01 00:00:00