High levels of neutralizing IL-6 autoantibodies in 0.1% of apparently healthy blood donors.

abstract：:The influence of Th2 cytokines in tuberculosis has been a matter of dispute. Here we report that IL-4 has a profound regulatory effect on the infection of BALB/c mice with Mycobacterium tuberculosis. Depletion of IL-4 with a neutralizing mAb caused only evanescent reduction of lung infection, but when combined with i....

journal_title：European journal of immunology

authors： Buccheri S,Reljic R,Caccamo N,Ivanyi J,Singh M,Salerno A,Dieli F

更新日期：2007-03-01 00:00:00

abstract：:Macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19 are members of the CC chemokine subfamily which exert their effects through specific receptors, CCR6 and CCR7, respectively. Previously, we have reported that human neutrophils have the capacity to produce a number of chemokines, including I...

journal_title：European journal of immunology

authors： Scapini P,Laudanna C,Pinardi C,Allavena P,Mantovani A,Sozzani S,Cassatella MA

更新日期：2001-07-01 00:00:00

abstract：:Ligation of interleukin 2 (IL2) is known to regulate both protein tyrosine and serine/threonine phosphorylation. A family of leukocyte transmembrane proteins whose cytoplasmic domain exhibits intrinsic protein tyrosine phosphatase activity is collectively called CD45 and is identified by a set of common cell surface e...

journal_title：European journal of immunology

authors： Valentine MA,Widmer MB,Ledbetter JA,Pinault F,Voice R,Clark EA,Gallis B,Brautigan DL

更新日期：1991-04-01 00:00:00

abstract：:Helicobacter pylori is a Gram-negative bacterium that causes a variety of gastrointestinal diseases, such as duodenal ulcer and gastric carcinoma. The T cell response against H. pylori is thought to contribute to the pathogenesis of these diseases. Here, we show that mouse-adapted H. pylori is able to polyclonally act...

journal_title：European journal of immunology

authors： Rosenplänter C,Sommer F,Kleemann P,Belkovets A,Schmidt A,Lohoff M

更新日期：2007-07-01 00:00:00

abstract：:Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the com...

journal_title：European journal of immunology

authors： Mahnke YD,Brodie TM,Sallusto F,Roederer M,Lugli E

更新日期：2013-11-01 00:00:00

abstract：:Mononuclear phagocytes and lymphocytes can both synthesize cytotoxins which kill certain tumor cell lines and recent evidence suggests that these cytotoxins may be identical. In this study, human monocyte cytotoxin and lymphoblastoid lymphotoxin have been critically compared in terms of specificity, physicochemical ch...

journal_title：European journal of immunology

authors： Matthews N

更新日期：1985-03-01 00:00:00

abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

journal_title：European journal of immunology

authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

更新日期：2016-08-01 00:00:00

abstract：:IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene exp...

journal_title：European journal of immunology

authors： Wolk K,Witte E,Wallace E,Döcke WD,Kunz S,Asadullah K,Volk HD,Sterry W,Sabat R

更新日期：2006-05-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:Stimulation of T cells via the T cell receptor (TCR) leads to an increase intracellular in free Ca2+ levels ([Ca2+]i) and the activation of the MAP kinase signaling pathway. This study analyzes for the first time Ca2+ fluxes in naive cytotoxic T cells stimulated with full agonists, partial agonists, or antagonists. Fo...

journal_title：European journal of immunology

authors： Bachmann MF,Mariathasan S,Bouchard D,Speiser DE,Ohashi PS

更新日期：1997-12-01 00:00:00

abstract：:To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a ...

journal_title：European journal of immunology

authors： Bikoff EK

更新日期：1991-06-01 00:00:00

abstract：:IL-12 is a potent inducer of IFN-gamma production and drives the development of Th1 cells. Human polarized Th2 cells do not express the signaling beta2-subunit of the IL-12R and, therefore, do not signal in response to IL-12. The question was raised as to what extent the loss of the IL-12Rbeta2 chain in Th2 cells has ...

journal_title：European journal of immunology

authors： Smits HH,van Rietschoten JG,Hilkens CM,Sayilir R,Stiekema F,Kapsenberg ML,Wierenga EA

更新日期：2001-04-01 00:00:00

abstract：:T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

journal_title：European journal of immunology

authors： Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

更新日期：1986-10-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the tra...

journal_title：European journal of immunology

authors： Schweier O,Hofmann M,Pircher H

更新日期：2014-06-01 00:00:00

abstract：:Interferon (IFN) was detected upon co-culture of cloned Sendai virus (SV)-specific T lymphocyte with SV-presenting syngeneic stimulator cells. The antiviral activity was defined as IFN-alpha, beta. The T cell clones, upon contact with antigen-presenting stimulator cells, stimulated adherent cells present in the stimul...

journal_title：European journal of immunology

authors： Ertl HC,Brown EG,Finberg RW

更新日期：1982-12-01 00:00:00

abstract：:The magnitude of the IgE antibody response against the phosphorylcholine (PC) hapten and the rate of age-related change of IgE formation is polymorphic in the three long-lived and six relatively short-lived strains of mice studied. Long-lived mice showed an early increase, followed by a decline in the levels of anti-P...

journal_title：European journal of immunology

authors： Gerber V,Ponnappan U,Heusser CH,Blaser K,Cinader B

更新日期：1986-06-01 00:00:00

abstract：:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...

journal_title：European journal of immunology

authors： Conway de Macario E,Heumann AM,Macario AJ,Biozzi G

更新日期：1979-03-01 00:00:00

abstract：:Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71. The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was s...

journal_title：European journal of immunology

authors： Brekelmans P,van Soest P,Leenen PJ,van Ewijk W

更新日期：1994-11-01 00:00:00

abstract：:The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presen...

journal_title：European journal of immunology

authors： Denkberg G,Stronge VS,Zahavi E,Pittoni P,Oren R,Shepherd D,Salio M,McCarthy C,Illarionov PA,van der Merwe A,Besra GS,Dellabona P,Casorati G,Cerundolo V,Reiter Y

更新日期：2008-03-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection frequently develops into liver disease and is accompanied by extra-hepatic autoimmune manifestations. The tetraspanin CD81 is a putative HCV receptor as it binds the E2 envelope glycoprotein of HCV and bona fide HCV particles. Here we show that HCV E2 binding to CD81 on human ...

journal_title：European journal of immunology

authors： Wack A,Soldaini E,Tseng C,Nuti S,Klimpel G,Abrignani S

更新日期：2001-01-01 00:00:00

abstract：:High BDCA3 expression is associated with a specific human IFN-λ-producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC subsets. Thus far, development and function of BDCA3 expression on DCs remains poorly understood. Human Langerhans cells (LCs) and interstitial DCs (intDCs) can be gen...

journal_title：European journal of immunology

authors： van der Aa E,van de Laar L,Janssen HL,van Montfoort N,Woltman AM

更新日期：2015-05-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:Previous studies have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration. ...

journal_title：European journal of immunology

authors： Kasic T,Colombo P,Soldani C,Wang CM,Miranda E,Roncalli M,Bronte V,Viola A

更新日期：2011-07-01 00:00:00

abstract：:Mice carrying the H-2b and H-2s haplotypes are genetically nonresponsive to hen egg-white lysozyme (HEL). Analysis of the anti-HEL response patterns of F1, F2 and backcross progeny showed that responsiveness was dominant and H-2 linked. From plaque-forming cell and serum assays in intra-H-2 recombinant mice, it was es...

journal_title：European journal of immunology

authors： Hill SW,Kipp DE,Melchers I,Frelinger JA,Sercarz EE

更新日期：1980-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after i...

journal_title：European journal of immunology

authors： Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE

更新日期：2013-08-01 00:00:00

abstract：:The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...

journal_title：European journal of immunology

authors： Texier C,Pouvelle-Moratille S,Busson M,Charron D,Ménez A,Maillère B

更新日期：2001-06-01 00:00:00

abstract：:This study shows that both recombinant human interleukin (rhIL)3 and rhIL4 induced proliferation in bone marrow (BM) cells of myelogenous leukemia patients in a manner similar to that reported using normal BM cells. However, we additionally found that these cytokines also influenced expression of other cytokines. Name...

journal_title：European journal of immunology

authors： Brantschen S,Gauchat JF,De Weck AL,Stadler BM

更新日期：1989-11-01 00:00:00

abstract：:Role of CD45 in B cell antigen receptor (BcR)-mediated signaling events in mature B cells was examined using BAL-17 and its CD45-negative clones. In the CD45-negative clones, BcR stimulation induced tyrosine phosphorylation almost identical to the parental cells, with a few exceptions of reduced phosphorylation, espec...

journal_title：European journal of immunology

authors： Ogimoto M,Katagiri T,Mashima K,Hasegawa K,Mizuno K,Yakura H

更新日期：1995-08-01 00:00:00

abstract：:NK cells play important roles in immune surveillance against malignancy and virus-infected cells. NK cell functions are affected in patients infected with HIV-1; however, whether there is direct interaction between NK cells and HIV-1 remains controversial. In this study the expression of CD4, an important receptor for...

journal_title：European journal of immunology

authors： Harada H,Goto Y,Ohno T,Suzu S,Okada S

更新日期：2007-08-01 00:00:00

abstract：:Aggregation of the human high-affinity receptor for immunoglobulin G, FcgammaRI, results in initiation of intracellular signaling cascades. However, as the receptor contains no known signaling motif, it is required to recruit an accessory molecule. The gamma chain has been proposed to fulfil this role. Here, we show t...

journal_title：European journal of immunology

authors： Cameron AJ,Harnett MM,Allen JM

更新日期：2001-09-01 00:00:00