IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression.

abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

journal_title：European journal of immunology

authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

更新日期：1994-05-01 00:00:00

abstract：:The human T cell leukemia virus type-1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). Since the HTLV-I-encoded transactivator Tax has been shown to activate many cellular genes including cytokine genes interleukin (IL-)1alpha, 2, 5, 6, 8, 10 and 15, we ask whether Tax also affects IL-4 expression. In ...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Chlichlia K,Khazaie K,Krammer PH

更新日期：2001-09-01 00:00:00

abstract：:The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

journal_title：European journal of immunology

authors： Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

更新日期：1996-01-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clone...

journal_title：European journal of immunology

authors： Ghio M,Contini P,Negrini S,Boero S,Musso A,Poggi A

更新日期：2009-12-01 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:The presentation of islet antigens in the pancreatic LNs (PLNs) of mice is a developmentally regulated process. It has been hypothesized that, during physiological tissue remodeling, a wave of neonatal β-cell apoptosis may initiate diabetes in autoimmune-prone strains of mice. If true, increasing or decreasing physiol...

journal_title：European journal of immunology

authors： Carrington EM,Kos C,Zhan Y,Krishnamurthy B,Allison J

更新日期：2011-08-01 00:00:00

abstract：:The use of fetal bovine serum (FBS) for the culture and expansion of mesenchymal stromal cells (MSCs) limits their possible clinical applications. Although some recent studies recommended substituting FBS with human platelet lysate (HPL) for the expansion of MSCs for clinical use, the functional capacity of the expand...

journal_title：European journal of immunology

authors： Abdelrazik H,Spaggiari GM,Chiossone L,Moretta L

更新日期：2011-11-01 00:00:00

abstract：:Cure of leishmaniasis requires a type 1 immune response characterized by IFN-gamma production. Leishmania major infection leads to a type 2 response suppressing cure of susceptible BALB/c mice, and L. major causes an exacerbated type 2 response in mouse strains with a gene knockout (KO) such that they lack IL-12p40 (I...

journal_title：European journal of immunology

authors： Wilson ME,Recker TJ,Rodriguez NE,Young BM,Burnell KK,Streit JA,Kline JN

更新日期：2002-12-01 00:00:00

abstract：:The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B c...

journal_title：European journal of immunology

authors： Dexter CM,Corley RB

更新日期：1987-06-01 00:00:00

abstract：:The encephalitogenic peptide pMOG 35-55 from the myelin oligodendrocyte glycoprotein was used to induce experimental autoimmune encephalomyelitis (EAE) in H-2b mice with the interleukin-6 (IL-6) gene intact or disrupted. The IL-6+/+ mice developed a chronic form of EAE ascending paralysis, whereas the IL-6-/- mice wer...

journal_title：European journal of immunology

authors： Mendel I,Katz A,Kozak N,Ben-Nun A,Revel M

更新日期：1998-05-01 00:00:00

abstract：:The extracellular domain of the lymphocyte surface antigen CD38 has been recently shown to share a high sequence homology with a nicotinamide adenine dinucleotide (NAD+)-specific hydrolyzing enzyme cloned from the ovotestis of the gastropod Aplysia (E. States, D.J., Walseth, T.F., Lee, H. C., Trends Biochem. Sci. 1992...

journal_title：European journal of immunology

authors： Gelman L,Deterre P,Gouy H,Boumsell L,Debré P,Bismuth G

更新日期：1993-12-01 00:00:00

abstract：:The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation. Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells. However, immedi...

journal_title：European journal of immunology

authors： Pimentel-Muiños FX,Mazana J,Fresno M

更新日期：1995-01-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the tra...

journal_title：European journal of immunology

authors： Schweier O,Hofmann M,Pircher H

更新日期：2014-06-01 00:00:00

abstract：:Vaccinia virus (VV)-encoded MHC class I Kd molecules which differ by a single amino acid change from glutamine (Kdw, wild type) to histidine (Kdm, mutant) at position 114 located in the floor of the peptide binding groove were compared in terms of peptide binding and cytotoxic T (Tc) cell recognition. Most anti-viral ...

journal_title：European journal of immunology

authors： Müllbacher A,Lobigs M,Yewdell JW,Bennink JR,Tha Hla R,Blanden RV

更新日期：1999-04-01 00:00:00

abstract：:Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...

journal_title：European journal of immunology

authors： Blankenstein T,Krawinkel U

更新日期：1987-09-01 00:00:00

abstract：:Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

journal_title：European journal of immunology

authors： Sun D,Hu XZ,Coleclough C

更新日期：1995-01-01 00:00:00

abstract：:Thymocytes of T cell receptor transgenic mice with nonselecting and RAG-2 -/- backgrounds were developmentally arrested at the CD4+CD8+ stage before positive selection. These thymocytes underwent lineage commitment upon transient stimulation with a combination of ionomycin, a calcium ionophore, and phorbol 12-myristat...

journal_title：European journal of immunology

authors： Iwata M,Kuwata T,Mukai M,Tozawa Y,Yokoyama M

更新日期：1996-09-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:Leukosialin (CD43) is a major glycoprotein of T lymphocytes which has an extracellular domain of 45 nm in length that is heavily O-glycosylated. Monoclonal antibodies (mAb) to the extracellular domain of human leukosialin induce aggregation of T lymphocytes, monocytes and some cell lines that express leukosialin. The ...

journal_title：European journal of immunology

authors： Cyster JG,Williams AF

更新日期：1992-10-01 00:00:00

abstract：:Immunologic control of C3 gene expression by tissue macrophages can be accomplished by treatment of spleen fragments with anti-C3 antibody. We now demonstrate that suppression of C3 requires participation of T lymphocytes of both the CD4+ and CD8+ phenotypes. Pretreatment of splenic tissue with anti-Thy-1.2 monoclonal...

journal_title：European journal of immunology

authors： Goldman MB,Knovich MA,Goldman JN

更新日期：1992-12-01 00:00:00

abstract：:Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

journal_title：European journal of immunology

authors： Richter E,Wick G,Schauenstein K

更新日期：1975-08-01 00:00:00

abstract：:The F1 progeny of autoimmune NZB and normal SWR mice uniformly develop severe and accelerated lupus nephritis. The (SWR x NZB)F1 mice produce an oligoclonally expanded population of nephritogenic anti-DNA autoantibodies that share a recurrent cross-reactive idiotype (Id564), use highly homologous VH genes and surprisi...

journal_title：European journal of immunology

authors： O'Keefe TL,Datta SK,Imanishi-Kari T

更新日期：1992-03-01 00:00:00

abstract：:Langerhans cells (LC) are the principal dendritic cell (DC) population in the epidermis of the skin. Owing to their prominent position at the environmental barrier, LC have long been considered to be prototypic sentinel DC. More recently, the precise role of LC in the initiation and control of cutaneous immune respons...

journal_title：European journal of immunology

authors： Kaplan DH,Kissenpfennig A,Clausen BE

更新日期：2008-09-01 00:00:00

abstract：:Our understanding of the biology of human natural killer (NK) cells has significantly advanced in recent years upon identification of a family of NK cell-expressed genes that encode killer cell inhibitory receptors (KIR). Individual KIR can selectively bind various HLA class I allotypes and consequently transduce inhi...

journal_title：European journal of immunology

authors： Campbell KS,Cella M,Carretero M,López-Botet M,Colonna M

更新日期：1998-02-01 00:00:00

abstract：:CTLA-4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA-4 isoform (sC...

journal_title：European journal of immunology

authors： Ward FJ,Dahal LN,Wijesekera SK,Abdul-Jawad SK,Kaewarpai T,Xu H,Vickers MA,Barker RN

更新日期：2013-05-01 00:00:00

abstract：:Tumor-specific helper T cell activity was detected in the spleens of tumor-bearing mice using a sensitive, simple and reproducible in vitro assay based on those previously described for soluble hapten-carrier antigens. Helper activity disappears when the tumor is large. This is coincident with the appearance of two di...

journal_title：European journal of immunology

authors： Howie S,McBride WH

更新日期：1982-08-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the...

journal_title：European journal of immunology

authors： Matsumoto Y,Kawai K,Fujiwara M

更新日期：1990-09-01 00:00:00

abstract：:Rodents are significantly less sensitive to enterotoxin-induced shock, and are thus not valid human disease models. Here, we describe a mouse strain carrying the human CD4 and human major histocompatibility complex (MHC) class II (DQ6) transgenes in an endogenous CD4- and CD8-deficient background. T lymphocytes from t...

journal_title：European journal of immunology

authors： Yeung RS,Penninger JM,Kündig T,Khoo W,Ohashi PS,Kroemer G,Mak TW

更新日期：1996-05-01 00:00:00

abstract：:Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell responses against six new high-affinity HLA-A*0201-binding CTL epitopes, en...

journal_title：European journal of immunology

authors： Charo J,Geluk A,Sundbäck M,Mirzai B,Diehl AD,Malmberg KJ,Achour A,Huriguchi S,van Meijgaarden KE,Drijfhout JW,Beekman N,van Veelen P,Ossendorp F,Ottenhoff TH,Kiessling R

更新日期：2001-12-01 00:00:00