Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection.

abstract：:Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception ...

journal_title：European journal of immunology

authors： Wellington D,Yin Z,Abdel-Haq A,Zhang L,Forbester J,Kite K,Rajapaksa U,Laurenson-Schafer H,Makvandi-Nejad S,Jin B,Bowes E,Manoharan K,Maldonado-Perez D,Verrill C,Humphreys IR,Dong T

更新日期：2020-10-30 00:00:00

abstract：:We report here the identification and characterization of murine CCX-CKR, a high affinity receptor for the murine beta-chemokines SLC/mCCL21, MIP-3beta/mCCL19 and TECK/mCCL25. Unlike most other chemokine receptors, CCX-CKR is unable to mediate Ca(2+) fluxes upon ligand binding when expressed in HEK293 cells. Murine CC...

journal_title：European journal of immunology

authors： Townson JR,Nibbs RJ

更新日期：2002-05-01 00:00:00

abstract：:Delivery of foreign antigens to mucosal surfaces, such as the pulmonary airways, has been shown to preferentially induce Th2-mediated responses in humans and in mice. What is not clear from these studies is whether this preferential skewing in responses is the result of the limited types of antigen being administered ...

journal_title：European journal of immunology

authors： Constant SL,Lee KS,Bottomly K

更新日期：2000-03-01 00:00:00

abstract：:The involvement of Lyt-2+ T cells in the immunological control of cutaneous leishmaniasis was assessed by studying the course of the disease in mice in which the number of these cells was reduced by treatment with anti-Lyt-2 monoclonal antibody (mAb). Administration of anti-Lyt-2 mAb exacerbated Leishmania major-induc...

journal_title：European journal of immunology

authors： Titus RG,Milon G,Marchal G,Vassalli P,Cerottini JC,Louis JA

更新日期：1987-10-01 00:00:00

abstract：:We have analyzed the T cell receptor (TcR) V alpha and TcR V beta regions in the spontaneous mouse model for insulin-dependent diabetes mellitus, the NOD mouse, and compared it to the regions in the two sister strains, the NON and CTS strains. Based on restriction fragment length polymorphism analysis the TcR V alpha ...

journal_title：European journal of immunology

authors： Lund T,Shaikh S,Hattori M,Makino S

更新日期：1992-03-01 00:00:00

abstract：:Indirect immunofluorescence performed with 2 polyclonal and 4 monoclonal antibodies directed against human beta 2-microglobulin (beta 2m) revealed the presence of a beta 2m-like determinant on the membrane of a subpopulation of earthworm leukocytes classified as weakly adherent acidophils. Two out of the 4 monoclonal ...

journal_title：European journal of immunology

authors： Roch P,Cooper EL,Eskinazi DP

更新日期：1983-12-01 00:00:00

abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

journal_title：European journal of immunology

authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

更新日期：2003-09-01 00:00:00

abstract：:F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion o...

journal_title：European journal of immunology

authors： Humphrey JH,Grennan D,Sundaram V

更新日期：1984-09-01 00:00:00

abstract：:Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which ar...

journal_title：European journal of immunology

authors： Jones ND,Brook MO,Carvalho-Gaspar M,Luo S,Wood KJ

更新日期：2010-11-01 00:00:00

abstract：:The role of B cells and antibody in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) remains controversial. We previously demonstrated that B cells are required for EAE to be induced by the 120-amino acid extracellular domain of myelin oligodendrocyte glycoprotein (MOG). In the present study, the ro...

journal_title：European journal of immunology

authors： Lyons JA,Ramsbottom MJ,Cross AH

更新日期：2002-07-01 00:00:00

abstract：:The NKG2D receptor is expressed by human NK, gammadelta T and alpha/beta T lymphocytes and its engagement results in the stimulation of effector cells. We evaluated the role of NKG2D receptor in anti-colorectal cancer (CRC) immune response. The cell surface expression of stress-inducible NKG2D ligands MICA/B (MHC clas...

journal_title：European journal of immunology

authors： Maccalli C,Pende D,Castelli C,Mingari MC,Robbins PF,Parmiani G

更新日期：2003-07-01 00:00:00

abstract：:A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

journal_title：European journal of immunology

authors： Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

更新日期：1992-02-01 00:00:00

abstract：:Langerhans cells (LC) are the principal dendritic cell (DC) population in the epidermis of the skin. Owing to their prominent position at the environmental barrier, LC have long been considered to be prototypic sentinel DC. More recently, the precise role of LC in the initiation and control of cutaneous immune respons...

journal_title：European journal of immunology

authors： Kaplan DH,Kissenpfennig A,Clausen BE

更新日期：2008-09-01 00:00:00

abstract：:IL-12 is a potent inducer of IFN-gamma production and drives the development of Th1 cells. Human polarized Th2 cells do not express the signaling beta2-subunit of the IL-12R and, therefore, do not signal in response to IL-12. The question was raised as to what extent the loss of the IL-12Rbeta2 chain in Th2 cells has ...

journal_title：European journal of immunology

authors： Smits HH,van Rietschoten JG,Hilkens CM,Sayilir R,Stiekema F,Kapsenberg ML,Wierenga EA

更新日期：2001-04-01 00:00:00

abstract：:Ly49Q, a type II C-type lectin expressed on mouse plasmacytoid DC (pDC), contains a single carbohydrate recognition domain in its extracellular region and an ITIM in its cytoplasmic domain. We have identified the MHC class I molecule H-2K(b) as a Ly49Q ligand, confirming prior reports. Although H-2K(b) is expressed on...

journal_title：European journal of immunology

authors： Toma-Hirano M,Namiki S,Shibata Y,Ishida K,Arase H,Miyatake S,Arai K,Kamogawa-Schifter Y

更新日期：2009-05-01 00:00:00

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:TGF-beta1 was examined for the ability to regulate Ag-presentation by B cells, using A20-HL B lymphoma cells bearing TNP-specific IgM receptors. Treatment of A20-HL cells with TGF-beta1 at 1 ng/ml, a concentration that inhibited proliferation, enhanced presentation of Ag internalized via surface IgM (sIgM), but not vi...

journal_title：European journal of immunology

authors： Arai C,Ichijo T,Tanaka Y,Okada Y,Umeda M,Uchida T,Kiniwa M,Kakiuchi T

更新日期：2003-07-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:A simple and efficient procedure for the construction of bifunctional molecules is described and their use in a variety of applications documented. This procedure is based on our observation that mouse IgG1 monoclonal antibodies, when mixed with equimolar amounts of a high-affinity rat monoclonal antibody specific for...

journal_title：European journal of immunology

authors： Lansdorp PM,Aalberse RC,Bos R,Schutter WG,Van Bruggen EF

更新日期：1986-06-01 00:00:00

abstract：:In the lymphoid tissues, adaptive immune responses are initiated by the interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans cells (mLC), migrating from human epidermis, as the correlate of IDC ex vivo to evaluate the different effects ...

journal_title：European journal of immunology

authors： Ludewig B,Graf D,Gelderblom HR,Becker Y,Kroczek RA,Pauli G

更新日期：1995-07-01 00:00:00

abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

journal_title：European journal of immunology

authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

更新日期：1998-08-01 00:00:00

abstract：:B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 ce...

journal_title：European journal of immunology

authors： Ng LG,Ng CH,Woehl B,Sutherland AP,Huo J,Xu S,Mackay F,Lam KP

更新日期：2006-07-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

journal_title：European journal of immunology

authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

更新日期：2006-03-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have revolutionized the search for genetic influences on complex disorders, such as primary biliary cirrhosis (PBC). Recent GWAS have identified many disease-associated genetic variants. These, overall, highlighted the remarkable contribution of key immunological pathways in PBC ...

journal_title：European journal of immunology

authors： Carbone M,Lleo A,Sandford RN,Invernizzi P

更新日期：2014-04-01 00:00:00

abstract：:As we approach the centenary of Elie Metchnikoff's Nobel Prize (1908), it is opportune to reflect upon the history of macrophage immunobiology, take stock of current knowledge and anticipate questions for the future. Starting from his appreciation of phagocytosis as an important determinant of host defence against inf...

journal_title：European journal of immunology

authors： Gordon S

更新日期：2007-11-01 00:00:00

abstract：:The contribution of direct and indirect alloresponses by CD4(+) Th1 and Th2 cells in acute and chronic rejection of allogeneic transplants remains unclear. In the present study, we addressed this question using a transplant model in a single MHC class I-disparate donor-recipient mouse combination. BALB/c-dm2 (dm2) mut...

journal_title：European journal of immunology

authors： Illigens BM,Yamada A,Anosova N,Dong VM,Sayegh MH,Benichou G

更新日期：2009-11-01 00:00:00

abstract：:T-cell destiny during thymic selection depends on the affinity of the TCR for autologous peptide ligands presented in the context of MHC molecules. This is a delicately balanced process; robust binding leads to negative selection, yet some affinity for the antigen complex is required for positive selection. All TCRs o...

journal_title：European journal of immunology

authors： Aleksic M,Liddy N,Molloy PE,Pumphrey N,Vuidepot A,Chang KM,Jakobsen BK

更新日期：2012-12-01 00:00:00

abstract：:Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...

journal_title：European journal of immunology

authors： O'Brien KL,Assmann N,O'Connor E,Keane C,Walls J,Choi C,Oefner PJ,Gardiner CM,Dettmer K,Finlay DK

更新日期：2020-09-18 00:00:00

abstract：:Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from t...

journal_title：European journal of immunology

authors： Nimmerjahn F,Milosevic S,Behrends U,Jaffee EM,Pardoll DM,Bornkamm GW,Mautner J

更新日期：2003-05-01 00:00:00

abstract：:We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of ...

journal_title：European journal of immunology

authors： Kirberg J,Bruno L,von Boehmer H

更新日期：1993-08-01 00:00:00