Abstract:
:We have analyzed the T cell receptor (TcR) V alpha and TcR V beta regions in the spontaneous mouse model for insulin-dependent diabetes mellitus, the NOD mouse, and compared it to the regions in the two sister strains, the NON and CTS strains. Based on restriction fragment length polymorphism analysis the TcR V alpha region in the NOD mouse is essentially identical to that of the SJL/J strain. In contrast both the NON and CTS strains have a unique TcR V alpha haplotype. Whereas the NOD and NON strains apparently contains all the TcR V beta genes, the CTS mouse has three deletions in the V beta region. Our analysis does not give any indications for the diabetic phenotype of the NOD mouse.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Lund T,Shaikh S,Hattori M,Makino Sdoi
10.1002/eji.1830220337keywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
871-4issue
3eissn
0014-2980issn
1521-4141journal_volume
22pub_type
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journal_title:European journal of immunology
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