The selective localization of B lymphocytes in the spleen and the role of complement receptors.

abstract：:Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) molecule that is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at ...

journal_title：European journal of immunology

authors： Medesan C,Radu C,Kim JK,Ghetie V,Ward ES

更新日期：1996-10-01 00:00:00

abstract：:Anti-peroxidase antibody (Ab)-secreting hybrids have been produced by fusion of peroxidase (PO)-immunized mouse lymph node cells and immunoglobulin (Ig)-secreting P3-X63-Ag8 (X63) myeloma cells. Identification of Ab-secreting hybrids can be performed as early as day 5 after cell fusion by the hemolytic plaque assay. I...

journal_title：European journal of immunology

authors： Zagury D,Phalente L,Bernard J,Hollande E,Buttin G

更新日期：1979-01-01 00:00:00

abstract：:Using the patch-clamp technique in combination with fluorescence microscopy we have found an abnormality in voltage-gated K+ channel expression in T cells that represents the first molecular marker linking three disparate autoimmune diseases in mice. CD4-CD8-Thy-1.2+ (double-negative or DN) lymphocytes from every know...

journal_title：European journal of immunology

authors： Chandy KG,Cahalan MD,Grissmer S

更新日期：1990-04-01 00:00:00

abstract：:Although potentially autoreactive T cells are present even in healthy subjects, most individuals do not develop autoimmune disease. It has been well demonstrated that CD4+ CD25+ regulatory T cells play a significant role in controlling the expansion of autoreactive T cells in the periphery. However, some healthy indiv...

journal_title：European journal of immunology

authors： James EA,Kwok WW

更新日期：2007-01-01 00:00:00

abstract：:Tertiary lymphoid organs can form at sites of chronic inflammation. Their presence has been mainly associated with tissue destruction. In transplantation, there is a dynamic immune response as in chronic inflammation. Indeed, the presence of tertiary lymphoid organs has been associated with chronic rejection. In addit...

journal_title：European journal of immunology

authors： Brown K,Sacks SH,Wong W

更新日期：2011-01-01 00:00:00

abstract：:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...

journal_title：European journal of immunology

authors： Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman G

更新日期：1996-05-01 00:00:00

abstract：:Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to non-tuberculous environmental mycobacteria (Env) are suspected to underlie this phenomenon, but the mechanisms remain unclear. We postulated that it could be d...

journal_title：European journal of immunology

authors： Ho P,Zhang L,Wei X,Seah GT

更新日期：2009-07-01 00:00:00

abstract：:Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to...

journal_title：European journal of immunology

authors： Ferrero E,Fabbri M,Poggi A,Galati G,Bernasconi S,Zocchi MR

更新日期：1998-08-01 00:00:00

abstract：:We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presentin...

journal_title：European journal of immunology

authors： Darji A,Stockinger B,Wehland J,Chakraborty T,Weiss S

更新日期：1997-07-01 00:00:00

abstract：:AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Folliculin (FLCN) and the FLCN-interacting proteins 1 and 2 (FNIP1, 2) modulate AMPK. FNIP1 deficiency patients have a AMPK-P gain of f...

journal_title：European journal of immunology

authors： Niehues T,Özgür TT,Bickes M,Waldmann R,Schöning J,Bräsen J,Hagel C,Ballmaier M,Klusmann JH,Niedermayer A,Pannicke U,Enders A,Dückers G,Siepermann K,Hempel J,Schwarz K,Viemann D

更新日期：2020-07-01 00:00:00

abstract：:An association between T-cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T-cell lymphopenia affects B-cell responses to autoantigens. Human neonatal thymectomy (Tx) results in a decrease in T-cell numbers and we used this model to study the development of autoreactivit...

journal_title：European journal of immunology

authors： van den Broek T,Madi A,Delemarre EM,Schadenberg AWL,Tesselaar K,Borghans JAM,Nierkens S,Redegeld FA,Otten HG,Rossetti M,Albani S,Sorek R,Cohen IR,Jansen NJG,van Wijk F

更新日期：2017-11-01 00:00:00

abstract：:The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1/PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, while adoptive cell therapies...

journal_title：European journal of immunology

authors： Hope HC,Salmond RJ

更新日期：2019-08-01 00:00:00

abstract：:An anti-T cell receptor (TcR) monoclonal antibody (mAb), LC4, directed against a human leukemic T cell line, SUP-T13, caused DNA fragmentation ("apoptosis") and cell death upon binding to this cell line. Cross-linking of receptor molecules was necessary for this effect since F(ab')2, but not Fab', fragments of LC4 cou...

journal_title：European journal of immunology

authors： Takahashi S,Maecker HT,Levy R

更新日期：1989-10-01 00:00:00

abstract：:The present report describes functional characteristics of a monoclonal antibody (mAb), TA/211, which is reactive with a common determinant of the human CD45 molecules. When added to purified testing human T cells, TA/211, which is itself not mitogenic, leads to a strong proliferative response in combination with subm...

journal_title：European journal of immunology

authors： Schraven B,Roux M,Hutmacher B,Meuer SC

更新日期：1989-02-01 00:00:00

abstract：:It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from Th1 to Th17). We show here that ectopic ROR-γt expression can re...

journal_title：European journal of immunology

authors： Mazzoni A,Maggi L,Siracusa F,Ramazzotti M,Rossi MC,Santarlasci V,Montaini G,Capone M,Rossettini B,De Palma R,Kruglov A,Chang HD,Cimaz R,Maggi E,Romagnani S,Liotta F,Cosmi L,Annunziato F

更新日期：2019-01-01 00:00:00

abstract：:IL-12, IL-23, and IL-27, which are produced by APC, modulate innate and adaptive immunities. Human beta-defensin-2 (hBD-2) produced by epidermal keratinocytes promotes cutaneous antimicrobial defense and inflammation. We examined the in vitro effects of IL-12, IL-23, and IL-27 on hBD-2 production in human keratinocyte...

journal_title：European journal of immunology

authors： Kanda N,Watanabe S

更新日期：2008-05-01 00:00:00

abstract：:Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from t...

journal_title：European journal of immunology

authors： Nimmerjahn F,Milosevic S,Behrends U,Jaffee EM,Pardoll DM,Bornkamm GW,Mautner J

更新日期：2003-05-01 00:00:00

abstract：:Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses in intestinal infection models. Mice were held on iron-deficient, normal iron, or high iron di...

journal_title：European journal of immunology

authors： Kortman GA,Mulder ML,Richters TJ,Shanmugam NK,Trebicka E,Boekhorst J,Timmerman HM,Roelofs R,Wiegerinck ET,Laarakkers CM,Swinkels DW,Bolhuis A,Cherayil BJ,Tjalsma H

更新日期：2015-09-01 00:00:00

abstract：:Antigen-specific CD4(+) T cells are central to natural and vaccine-induced immunity. An ongoing antigen-specific T-cell response can, however, influence surrounding T cells with unrelated antigen specificities. We previously observed this bystander effect in healthy human subjects following recall vaccination with tet...

journal_title：European journal of immunology

authors： Di Genova G,Savelyeva N,Suchacki A,Thirdborough SM,Stevenson FK

更新日期：2010-04-01 00:00:00

abstract：:Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

journal_title：European journal of immunology

authors： Malissen B,Rebai N,Liabeuf A,Mawas C

更新日期：1982-09-01 00:00:00

abstract：:Lymphocyte function-associated-antigen-1 (LFA-1) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 (ICAM-1 and ICAM-3), suggesting that LFA-1 can exist in distinct ligand-specific binding states. In the case of ICAM-1, apart from ligand itself and the recently cloned molecule cytohesi...

journal_title：European journal of immunology

authors： Buckley CD,Ferguson ED,Littler AJ,Bossy D,Simmons DL

更新日期：1997-04-01 00:00:00

abstract：:Spleen cells from BALB/c mice primed with keyhole limpet hemocyanin (KLH), were stimulated with heat-killed vaccine of rough Pneumococcus pneumoniae R36A (Pn) and/or phosphorylcholine (PC)-coupled KLH to induce an anti-PC response in vitro. The response to PC-KLH was found to be T-dependent while it is T-independent t...

journal_title：European journal of immunology

authors： Quintáns J,Cosenza H

更新日期：1976-06-01 00:00:00

abstract：:The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...

journal_title：European journal of immunology

authors： Suzuki T,Kohyama K,Moriyama K,Ozaki M,Hasegawa S,Ueno T,Saitoe M,Morio T,Hayashi M,Sakuma H

更新日期：2020-02-01 00:00:00

abstract：:Toll-like receptors (TLRs) are innate immune receptors that respond to both exogenous and endogenous stimuli and are suggested to contribute to the perpetuation of chronic inflammation associated with rheumatoid arthritis (RA). In particular, the endosomal TLRs 3, 7, 8, and 9 have more recently been postulated to be o...

journal_title：European journal of immunology

authors： Sacre S,Lo A,Gregory B,Stephens M,Chamberlain G,Stott P,Brennan F

更新日期：2016-03-01 00:00:00

abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

journal_title：European journal of immunology

authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

更新日期：2005-01-01 00:00:00

abstract：:NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK ce...

journal_title：European journal of immunology

authors： Colonna M

更新日期：2008-11-01 00:00:00

abstract：:Murine Thy-1+, TcR V gamma 3/V delta 1+ dendritic epidermal T cells (DETC) differ from most other T cell subsets by the absence of CD4 and CD8 antigens as well as the lack of CD5 expression. To see whether negativity for those antigens is an intrinsic feature of a given T cell population or if such triple-negative T c...

journal_title：European journal of immunology

authors： Payer E,Kutil R,Stingl G

更新日期：1994-06-01 00:00:00

abstract：:T cells from human peripheral blood were enriched in T4+ cells by lysis of T8+ cells with the monoclonal antibody OKT8 plus complement. The T4+ subset was separated into 4 fractions differing in avidity for the lectin Helix pomatia A hemagglutinin (HP). The fractions were studied for their capacity to help autologous ...

journal_title：European journal of immunology

authors： Wikén M,Hellström U,Perlmann P

更新日期：1984-11-01 00:00:00

abstract：:Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 product...

journal_title：European journal of immunology

authors： Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

更新日期：1997-02-01 00:00:00

abstract：:The influence of muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1-mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5-mg dose administered on days 3, 2, 1 prior ...

journal_title：European journal of immunology

authors： Zídek Z,Capková J,Boubelík M,Masek K

更新日期：1983-10-01 00:00:00