Human neonatal thymectomy induces altered B-cell responses and autoreactivity.

abstract：:Nude mice given antigen before being given congenic T cells are specifically tolerant to that antigen and recovery of the ability to respond takes at least 2 weeks. If, after giving antigen, spleen cells are transferred to irradiated congenic recipients together with normal congenic thymocytes, the recipients usually ...

journal_title：European journal of immunology

authors： Kindred B

更新日期：1975-09-01 00:00:00

abstract：:Although alterations in CD3-associated signal-transducing molecules in tumor-infiltrating T cells of patients with advanced cancer have been previously described, the mechanism behind these changes is not known. We demonstrate that macrophages isolated from metastatic lymph nodes of patients with malignant melanoma do...

journal_title：European journal of immunology

authors： Kono K,Salazar-Onfray F,Petersson M,Hansson J,Masucci G,Wasserman K,Nakazawa T,Anderson P,Kiessling R

更新日期：1996-06-01 00:00:00

abstract：:We have previously reported the development of a two-step culture system in which soluble anti-mu monoclonal antibodies prime small resting murine B cells to secrete immunoglobulin (Ig) in response to restimulation with a mixture of interleukin-4 (IL-4) and IL-5. Here we have extended these studies to investigate the ...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1993-02-01 00:00:00

abstract：:Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts fo...

journal_title：European journal of immunology

authors： Anderson S,Shires VL,Wilson RA,Mountford AP

更新日期：1998-09-01 00:00:00

abstract：:T-cell homeostasis preserves the numbers, the diversity and functional competence of different T-cell subsets that are required for adaptive immunity. Naïve CD4(+) T (TN ) cells are maintained in the periphery via the common γ-chain family cytokine IL-7 and weak antigenic signals. However, it is not clear how memory C...

journal_title：European journal of immunology

authors： Yamaki S,Ine S,Kawabe T,Okuyama Y,Suzuki N,Soroosh P,Mousavi SF,Nagashima H,Sun SL,So T,Sasaki T,Harigae H,Sugamura K,Kudo H,Wada M,Nio M,Ishii N

更新日期：2014-10-01 00:00:00

abstract：:Many lymphocytes are produced in the intestinal mucosa, especially in the Peyer's patches. These newly formed lymphoid cells leave the gut wall, undergo further maturation and many reach the lamina propria of the intestinal mucosa where they function as effector and regulator cells of the intestinal immune response. H...

journal_title：European journal of immunology

authors： Rothkötter HJ,Hriesik C,Pabst R

更新日期：1995-03-01 00:00:00

abstract：:Leishmaniases are a major international public health problem, and macrophages are crucial for host resistance to this parasite. To determine if phosphatase and tensin homologue deleted on chromosome ten (Pten), a negative regulator of the PI3K pathway, plays a role in macrophage-mediated resistance to Leishmania, we ...

journal_title：European journal of immunology

authors： Kuroda S,Nishio M,Sasaki T,Horie Y,Kawahara K,Sasaki M,Natsui M,Matozaki T,Tezuka H,Ohteki T,Förster I,Mak TW,Nakano T,Suzuki A

更新日期：2008-05-01 00:00:00

abstract：:Cathelicidins are a family of host defence peptides that are known to selectively alter innate immunity in response to infection and other changes in immune status. A study in this issue of the European Journal of Immunology elucidates a new role for mouse cathelin-related antimicrobial peptide in the adaptive immune ...

journal_title：European journal of immunology

authors： Wuerth K,Hancock RE

更新日期：2011-10-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:In contrast to previous studies, we report that heterologous anti-delta antibodies can act as a powerful multi-class humoral immunosuppressant. Primary direct plaque-forming cell (IgM) responses of BALB/c mice injected from birth with a rabbit anti-delta antiserum were reduced to 3% of control levels against a T-depen...

journal_title：European journal of immunology

authors： Wathen PM,Manning DD

更新日期：1986-08-01 00:00:00

abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...

journal_title：European journal of immunology

authors： Esche C,Cai Q,Peron JM,Hunter O,Subbotin VM,Lotze MT,Shurin MR

更新日期：2000-09-01 00:00:00

abstract：:Among human peripheral blood B cells we localized the precursors of two interleukin-dependent B cell activation processes: the specific response to a particulate antigen, trinitrophenylated polyacrylamide beads (TNP-PAA) and the polyclonally induced response to pokeweed mitogen. In both cases the precursors belong to ...

journal_title：European journal of immunology

authors： Richard Y,Leprince C,Treton D,Galanaud P

更新日期：1986-10-01 00:00:00

abstract：:Dendritic cells (DC) play the dual task of initiating cellular immunity against potentially harmful foreign antigens (Ag), while maintaining immunological tolerance to self-Ag and environmental Ag. As an approach to induce Ag-specific suppression, we and others introduced CD95 ligand (L) cDNA into DC. The resulting "k...

journal_title：European journal of immunology

authors： Kusuhara M,Matsue K,Edelbaum D,Loftus J,Takashima A,Matsue H

更新日期：2002-04-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is one of the key primary response genes in the immune system that can be activated by a variety of stimuli. Previous analysis of chromatin accessibility to DNaseI demonstrated open chromatin conformation of the TNF proximal promoter in T cells. Here, using chromatin probing with restrictio...

journal_title：European journal of immunology

authors： Shebzukhov YV,Horn K,Brazhnik KI,Drutskaya MS,Kuchmiy AA,Kuprash DV,Nedospasov SA

更新日期：2014-01-01 00:00:00

abstract：:Dendritic cells isolated from sheep afferent lymph were examined for their ability to bind soluble protein and peptide antigens labeled with fluorescein both in in vitro assays and following intradermal injection of antigen in vivo. Analysis of dendritic cells by flow cytometry revealed weak direct binding of proteins...

journal_title：European journal of immunology

authors： Harkiss GD,Hopkins J,McConnell I

更新日期：1990-11-01 00:00:00

abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

journal_title：European journal of immunology

authors： Nordin AA

更新日期：1978-11-01 00:00:00

abstract：:Interleukin (IL)-6 transsignaling plays a pivotal role in the shift from neutrophil to monocyte recruitment at the inflammatory site. Release of neutrophil IL-6 receptor-alpha (IL-6Ralpha, CD126) in its soluble form is a key step of IL-6 transsignaling, however, its physiological inducers are poorly known. Here, we ob...

journal_title：European journal of immunology

authors： Marin V,Montero-Julian F,Grès S,Bongrand P,Farnarier C,Kaplanski G

更新日期：2002-10-01 00:00:00

abstract：:In humans infected with lymphatic filariasis, microfilaraemia [the presence of microfilariae (Mf) in the blood] is generally associated with both poor antigen (Ag)-specific proliferative responses and with protection from severe disease. Clonal deletion has been suggested as one possible mechanism by which parasite-re...

journal_title：European journal of immunology

authors： Jenson JS,O'Connor R,Osborne J,Devaney E

更新日期：2002-03-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixture of APC from bot...

journal_title：European journal of immunology

authors： Chai JG,Tsang JY,Lechler R,Simpson E,Dyson J,Scott D

更新日期：2002-08-01 00:00:00

abstract：:Aging is accompanied by altered immunity, resulting in a variable state of poorly understood immunodeficiency. While both the numbers and the functionality of naïve T cells are decreased by aging, the impact of these changes upon immune defense against bacterial pathogens in vivo remains understudied. Using a model of...

journal_title：European journal of immunology

authors： Smithey MJ,Renkema KR,Rudd BD,Nikolich-Žugich J

更新日期：2011-05-01 00:00:00

abstract：:Immunoglobulin (Ig) production by lipopolysaccharide (LPS)-stimulated cells in the presence of various combinations of interleukin (IL)2, IL4 and IL5 was examined. IgG1, IgM and IgE secretion was studied using a 3T3-fibroblast filler cell-supported B cell culture system, either at low cell density to support maximal I...

journal_title：European journal of immunology

authors： McHeyzer-Williams MG

更新日期：1989-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) recognize antigenic peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of target cells. Optimal induction of CD8+ CTL depends on the amount of relevant peptide/MHC-I complexes and the presence of co-stimulatory molecules on antigen-presenting c...

journal_title：European journal of immunology

authors： Bellone M,Iezzi G,Manfredi AA,Protti MP,Dellabona P,Casorati G,Rugarli C

更新日期：1994-11-01 00:00:00

abstract：:CD4 T cells play a central role as helper cells in adaptive immunity. Presentation of exogenous antigens in MHC class II by professional antigen-presenting cells is a crucial step in induction of specific CD4 T cells in adaptive immune responses. For efficient induction of immunity against intracellular threats such a...

journal_title：European journal of immunology

authors： Kremer AN,Zonneveld MI,Kremer AE,van der Meijden ED,Falkenburg JHF,Wauben MHM,Nolte-'t Hoen ENM,Griffioen M

更新日期：2018-10-01 00:00:00

abstract：:We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the V chi 4 gene family in both CD5+ and CD5- populations. The majority of cDNA from both CD5+ and CD5- B cells population...

journal_title：European journal of immunology

authors： Ebeling SB,Schutte ME,Logtenberg T

更新日期：1993-06-01 00:00:00

abstract：:DNase II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. Macrophages in DNase II-deficient mice accumulate undigested DNA and constitutively produce IFN-beta as well as TNF-alpha. The IFN-beta causes severe anemia in the DNase II(-/-) embryos, which die...

journal_title：European journal of immunology

authors： Okabe Y,Kawane K,Nagata S

更新日期：2008-11-01 00:00:00

abstract：:Antigens in the form of immune complexes are retained on the membranes of follicular dendritic cells (FDC) for long periods of time. To examine how immune complexes reach germinal centers, where FDC are located, we injected mice with anti-2,4-dinitrophenyl (DNP) antibodies complexed to DNP-myoglobin-coated gold partic...

journal_title：European journal of immunology

authors： Heinen E,Braun M,Coulie PG,Van Snick J,Moeremans M,Cormann N,Kinet-Denoël C,Simar LJ

更新日期：1986-02-01 00:00:00

abstract：:Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

journal_title：European journal of immunology

authors： Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

更新日期：2008-06-01 00:00:00

abstract：:Genetic and environmental factors both influence autoimmune disease occurrence, but the identity and mechanism of action of environmental factors are poorly understood. Here we show that pinworm-infected neonatal but not adult mice, injected with an ovarian self peptide of the zona pellucida protein 3 (pZP3) in water ...

journal_title：European journal of immunology

authors： Agersborg SS,Garza KM,Tung KS

更新日期：2001-03-01 00:00:00

abstract：:The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell resp...

journal_title：European journal of immunology

authors： Frick R,Gunnarsen KS,Dahal-Koirala S,Risnes LF,Sollid LM,Sandlie I,Høydahl LS,Løset GÅ

更新日期：2020-01-01 00:00:00