Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3.

abstract：:Leukosialin (CD43) is a major glycoprotein of T lymphocytes which has an extracellular domain of 45 nm in length that is heavily O-glycosylated. Monoclonal antibodies (mAb) to the extracellular domain of human leukosialin induce aggregation of T lymphocytes, monocytes and some cell lines that express leukosialin. The ...

journal_title：European journal of immunology

authors： Cyster JG,Williams AF

更新日期：1992-10-01 00:00:00

abstract：:HLA-A2.1-binding peptides (n = 38) were screened for immunogenicity with human peripheral blood mononuclear cells in cytotoxic T lymphocyte (CTL) induction experiments in vitro and with splenocytes from HLA-A2.1/Kb transgenic mice following immunization in vivo. These data were compiled and analyzed to determine the l...

journal_title：European journal of immunology

authors： Wentworth PA,Vitiello A,Sidney J,Keogh E,Chesnut RW,Grey H,Sette A

更新日期：1996-01-01 00:00:00

abstract：:B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 ce...

journal_title：European journal of immunology

authors： Ng LG,Ng CH,Woehl B,Sutherland AP,Huo J,Xu S,Mackay F,Lam KP

更新日期：2006-07-01 00:00:00

abstract：:A study was made of the ability of the superantigen staphylococcal enterotoxin B (SEB) to induce relapses of experimental allergic encephalomyelitis (EAE) in SJL mice that had partially or completely recovered from acute EAE. We find that a single injection of 0.05 mg SEB i.v. induces mild relapses in 50% of such mice...

journal_title：European journal of immunology

authors： Crisi GM,Santambrogio L,Hochwald GM,Smith SR,Carlino JA,Thorbecke GJ

更新日期：1995-11-01 00:00:00

abstract：:In previous studies, Saimiri sciureus boliviensis monkeys have been immunized with four recombinant proteins reproducing part of the circumsporozoite (CS) protein of Plasmodium vivax sporozoites (NS1(81) V20, rPvCS-1, rPvCS-2, rPv-CS-3), or with irradiated sporozoites of P. vivax Salvador I strain. To analyze the anti...

journal_title：European journal of immunology

authors： Millet P,Chizzolini C,Wirtz RA,Bathurst I,Broderson JR,Campbell GH,Collins WE

更新日期：1992-02-01 00:00:00

abstract：:In M54 mice transgenic for a completely rearranged mu(a) heavy chain there is a decrease in total B cells and the rearrangement of endogenous immunoglobulin genes is partially inhibited. Surprisingly, however, endogenous immunoglobulin gene rearrangement and significant heavy chain polypeptide production does occur. W...

journal_title：European journal of immunology

authors： Rabin E,Cong Y,Imanishi-Kari T,Wortis HH

更新日期：1992-09-01 00:00:00

abstract：:Alkaline phosphatases (APases, EC 3.1.3.1) are ecto-enzymes bound to cell membranes by a phosphatidyl-inositol anchor. We have previously shown that APase is present on activated murine B cells and its expression correlates with the process of B cell differentiation into immunoglobulin secretion. Recently, a monoclona...

journal_title：European journal of immunology

authors： Márquez C,De la Hera A,Leonardo E,Pezzi L,Strasser A,Martínez-A C

更新日期：1990-04-01 00:00:00

abstract：:Natural Killer (NK) cell-based immunotherapy is a promising approach to treat hepatocellular carcinoma (HCC). The mechanisms underlying the regulation of NK cell activity are not completely understood. In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 mem...

journal_title：European journal of immunology

authors： Liu S,Xu M,Zhu C,Zhao Q,Zhou F

更新日期：2018-12-01 00:00:00

abstract：:The glycosylphosphatidylinositol (GPI)-anchored CD59 protein (human protectin) protects cells against complement-induced lysis, binds to CD2 and also transduces activation signals within T cells. We have further examined the biochemical signals transduced by CD59 and addressed its role in regard to the CD3-mediated si...

journal_title：European journal of immunology

authors： Deckert M,Ticchioni M,Mari B,Mary D,Bernard A

更新日期：1995-07-01 00:00:00

abstract：:Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...

journal_title：European journal of immunology

authors： Kato A,Takaori-Kondo A,Minato N,Hamazaki Y

更新日期：2018-10-01 00:00:00

abstract：:We investigated here the potential role of Toll-like receptors (TLR) and the adaptor protein MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic encapsulated yeast. Peritoneal macrophages from MyD88(-/-) or TLR2(-/-) mice released significantly less TNF-alpha, compared with wild-type controls, ...

journal_title：European journal of immunology

authors： Biondo C,Midiri A,Messina L,Tomasello F,Garufi G,Catania MR,Bombaci M,Beninati C,Teti G,Mancuso G

更新日期：2005-03-01 00:00:00

abstract：:Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtain...

journal_title：European journal of immunology

authors： D'Orlando O,Zhao F,Kasper B,Orinska Z,Müller J,Hermans-Borgmeyer I,Griffiths GM,Zur Stadt U,Bulfone-Paus S

更新日期：2013-01-01 00:00:00

abstract：:We have studied the role of murine eosinophils as antigen-presenting cells (APC). Eosinophils have several characteristics that support the hypothesis of its function as potential APC: they have phagocytic capacity, express adhesion molecules and major histocompatibility complex (MHC) class II antigens and can produce...

journal_title：European journal of immunology

authors： Del Pozo V,De Andrés B,Martín E,Cárdaba B,Fernández JC,Gallardo S,Tramón P,Leyva-Cobian F,Palomino P,Lahoz C

更新日期：1992-07-01 00:00:00

abstract：:The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...

journal_title：European journal of immunology

authors： Masci AM,Paz FL,Borriello A,Cassano S,Della Pietra V,Stoiber H,Matarese G,Della Ragione F,Zappacosta S,Racioppi L

更新日期：1999-06-01 00:00:00

abstract：:T lymphocyte subsets expressing either T cell receptor alpha/beta or gamma/delta were selected from human peripheral blood T cells and proliferative responses to molecular mass-fractionated mycobacterial lysates were determined. alpha/beta T cells primarily responded to fractions greater than 30 kDa whereas gamma/delt...

journal_title：European journal of immunology

authors： Pfeffer K,Schoel B,Gulle H,Kaufmann SH,Wagner H

更新日期：1990-05-01 00:00:00

abstract：:Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was show...

journal_title：European journal of immunology

authors： Amagai T,Cinader B

更新日期：1981-11-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) plays an important role in the immune response by modulating the complex interactions between leukocytes and tissue cells under inflammatory conditions. PGE(2) may possibly influence pro-inflammatory effects of chemokines and chemokine receptors that are among the main regulators of directi...

journal_title：European journal of immunology

authors： Panzer U,Uguccioni M

更新日期：2004-12-01 00:00:00

abstract：:Cross-linking induced interactions between the membrane form of immunoglobulin (mIg) and the cytoskeletal matrix have been described by several groups. To date, the function of mIgM association with the cytoskeleton is not yet understood. Delineation of the molecular basis of these interactions will be instrumental in...

journal_title：European journal of immunology

authors： Park JY,Jongstra-Bilen J

更新日期：1997-11-01 00:00:00

abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

journal_title：European journal of immunology

authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

更新日期：1993-11-01 00:00:00

abstract：:By means of a novel technique for identification and isolation of MHC class II-restricted antigen-specific T cells, we describe here in non-transgenic BALB / c mice physiological positive selection of an oligoclonal population of T cells which recognizes both a self MHC-derived peptide (Ialpha52) and a bacterial homol...

journal_title：European journal of immunology

authors： Bonnin D,Prakken B,Samodal R,La Cava A,Carson DA,Albani S

更新日期：1999-12-01 00:00:00

abstract：:The extent of emigration of cells from the bursa of Fabricius to the periphery was estimated. Per anum application of fluorescein isothiocyanate to label bursal cells in situ was used. Migrant cells can be visualized on frozen sections or cell suspensions of peripheral organs by their fluorescence. The data show that ...

journal_title：European journal of immunology

authors： Lassila O

更新日期：1989-05-01 00:00:00

abstract：:Gene targeting in hybridoma cells provides a tool for generating chimeric antibodies with great ease and at high yield. We present an evaluation of integration vectors for the chimerization of the immunoglobulin heavy chain locus which are universally applicable to hybridomas of different isotypes and mouse strains. T...

journal_title：European journal of immunology

authors： Kardinal C,Hooijberg E,Lang P,Zeidler R,Mocikat R

更新日期：1995-03-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a membrane glycoprotein first identified on rat mucosal type mast cells (line RBL-2H3) and known to inhibit the Fc epsilon RI-mediated secretory response. In its extracellular domain, an amino acid stretch homologous to the carbohydrate binding domain of calcium-depe...

journal_title：European journal of immunology

authors： Binsack R,Pecht I

更新日期：1997-10-01 00:00:00

abstract：:Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity...

journal_title：European journal of immunology

authors： Haigwood NL

更新日期：2009-08-01 00:00:00

abstract：:Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts fo...

journal_title：European journal of immunology

authors： Anderson S,Shires VL,Wilson RA,Mountford AP

更新日期：1998-09-01 00:00:00

abstract：:Interleukin (IL)-5 is produced by variety of cell types and contributes to both lymphocyte development an eosinophil terminal differentiation in vitro. The coincidence of worm expulsion and eosinophilia in sheep infected with the gastrointestinal nematode Trichostrongylus colubriformis suggest that eosinophils may be ...

journal_title：European journal of immunology

authors： Bao S,McClure SJ,Emery DL,Husband AJ

更新日期：1996-03-01 00:00:00

abstract：:MS and EAE are T cell-driven autoimmune diseases of the CNS where IL-17-producing Th17 cells promote damage and are pathogenic. Conversely, tolerogenic DCs induce Treg cells and suppress Th17 cells. Chloroquine (CQ) suppresses EAE through the modulation of DCs by unknown mechanisms. Here, we show that STAT 1 is necess...

journal_title：European journal of immunology

authors： Thome R,Bonfanti AP,Rasouli J,Mari ER,Zhang GX,Rostami A,Verinaud L

更新日期：2018-07-01 00:00:00

abstract：:Upon treatment with lipopolysaccharide (LPS), primary B cells proliferate and differentiate into plasma cells with concomitant up-regulation of immunoglobulin (Ig) gene expression. Here we examine the role of the Igkappa 3' enhancer in this process using a kappa3'-enhancer-driven beta-globin reporter gene in transgeni...

journal_title：European journal of immunology

authors： Meyer KB

更新日期：1999-03-01 00:00:00

abstract：:We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...

journal_title：European journal of immunology

authors： Kobayashi K,Tomonaga S,Teshima K,Kajii T

更新日期：1985-09-01 00:00:00

abstract：:Using a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)-reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activate...

journal_title：European journal of immunology

authors： Hooper DC,Taylor RB

更新日期：1987-06-01 00:00:00