Update on animal models for HIV research.

Abstract:

:Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.

journal_name

Eur J Immunol

authors

Haigwood NL

doi

10.1002/eji.200939576

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

1994-9

issue

8

eissn

0014-2980

issn

1521-4141

journal_volume

39

pub_type

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