BAFF costimulation of Toll-like receptor-activated B-1 cells.

abstract：:In the homeostasis of the immune system regulatory cells play a major role. Removal of one group of regulatory cells, the CD25(+)CD4(+) T cells, leads to autoimmune manifestations in experimental animal models, and reintroduction of this population prevents disease. This study addresses the role of such regulatory T c...

journal_title：European journal of immunology

authors： Cao D,Malmström V,Baecher-Allan C,Hafler D,Klareskog L,Trollmo C

更新日期：2003-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B-cell function and development, we created transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase ...

journal_title：European journal of immunology

authors： Ogura M,Inoue T,Yamaki J,Homma MK,Kurosaki T,Homma Y

更新日期：2017-02-01 00:00:00

abstract：:The autosomal-dominant hyper-IgE syndrome (HIES), caused by mutations in STAT3, is a rare primary immunodeficiency that predisposes to mucocutaneous candidiasis and staphylococcal skin and lung infections. This infection phenotype is suggestive of defects in neutrophils, but data on neutrophil functions in HIES are in...

journal_title：European journal of immunology

authors： Farmand S,Kremer B,Häffner M,Pütsep K,Bergman P,Sundin M,Ritterbusch H,Seidl M,Follo M,Henneke P,Henriques-Normark B

更新日期：2018-12-01 00:00:00

abstract：:The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...

journal_title：European journal of immunology

authors： Quin SJ,Seixas EM,Cross CA,Berg M,Lindo V,Stockinger B,Langhorne J

更新日期：2001-01-01 00:00:00

abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

journal_title：European journal of immunology

authors： Guo L,Tian J,Marinova E,Zheng B,Han S

更新日期：2010-01-01 00:00:00

abstract：:A mouse T cell hybrid specific for pigeon cytochrome c in the context of I-Ek responds by secreting interleukin 2 when co-cultured with the native antigen and the B cell lymphoma, LK-35.2, or naive splenic B cells as antigen-presenting cells (APC). Cytochromes c and their corresponding C-terminal fragments which are n...

journal_title：European journal of immunology

authors： Lakey EK,Margoliash E,Flouret G,Pierce SK

更新日期：1986-07-01 00:00:00

abstract：:Activated human T cells via the CD2 or the CD3 pathways exhibited a higher capacity than resting T lymphocytes to incorporate and metabolize [3H]pafacether (paf) at 37 degrees C. Resting T lymphocytes lacked specific binding capacity for paf, yet high-affinity paf receptors (paf-R) were induced on CD3- or CD2-dependen...

journal_title：European journal of immunology

authors： Calabresse C,Nguer MC,Pellegrini O,Benveniste J,Richard Y,Thomas Y

更新日期：1992-06-01 00:00:00

abstract：:Stimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of ...

journal_title：European journal of immunology

authors： Gullberg M,Larsson EL

更新日期：1982-12-01 00:00:00

abstract：:Normal immunosuppressive protein, prepared from human plasma by DEAE-cellulose chromatography, inhibits DNA synthesis in human cell lines of lymphocytes of both T and B origin. It also inhibits [3H]thymidine incorporation in mouse cell lines. Normal immunosuppressive protein was able to inhibit the proliferation of th...

journal_title：European journal of immunology

authors： Nelken D,Ovadia H,Hanna N

更新日期：1979-02-01 00:00:00

abstract：:Using immunoglobulin (Ig)-recognizing T helper clones the expression of Ig peptide/major histocompatibility complex class II complexes derived by the processing of endogeneous Ig molecules in the thymus was demonstrated. It was found that thymic B cells but not "classic" thymic antigen-presenting cells and macrophages...

journal_title：European journal of immunology

authors： Rudensky AY,Mazel SM,Yurin VL

更新日期：1990-10-01 00:00:00

abstract：:Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral blood (PB) FOXP3(+) cells present in CD25(high), CD25(low) and even CD25(-) subsets of CD4(+) cells expressed high levels of TNFR2. Consequently, TNFR2-expressi...

journal_title：European journal of immunology

authors： Chen X,Subleski JJ,Hamano R,Howard OM,Wiltrout RH,Oppenheim JJ

更新日期：2010-04-01 00:00:00

abstract：:Human tonsils contain B cells capable of spontaneous and high-rate immunoglobulin (Ig) secretion in vitro. These cells are in vivo induced mature B cells, and, as such, they provide and adequate model for studying tonsil B cell differentiation. The present report analyzes the effect of a variety of factors on purified...

journal_title：European journal of immunology

authors： Rodríguez C,Roldán E,Navas G,Brieva JA

更新日期：1993-05-01 00:00:00

abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

journal_title：European journal of immunology

authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

更新日期：2005-01-01 00:00:00

abstract：:Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a promiscuous 7-transmembrane-domain receptor expressed on lymphatic vessels which recognizes most inflammatory, but not homeostatic, CC chemokines. In vitro expe...

journal_title：European journal of immunology

authors： Martinez de la Torre Y,Locati M,Buracchi C,Dupor J,Cook DN,Bonecchi R,Nebuloni M,Rukavina D,Vago L,Vecchi A,Lira SA,Mantovani A

更新日期：2005-05-01 00:00:00

abstract：:Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

journal_title：European journal of immunology

authors： Picarella D,Serunian LA,Rosenberg N

更新日期：1991-01-01 00:00:00

abstract：:In vivo, T cells expressing low-affinity TCR predominate in primary, but not in secondary responses, a process referred to as T cell affinity maturation. Using CD4 dependence as a measure of the avidity of the interaction between the allospecific TCR and the alloantigen, we show that a similar process occurs in mixed ...

journal_title：European journal of immunology

authors： van Bergen J,Kooy Y,Koning F

更新日期：2001-02-01 00:00:00

abstract：:Anti-HLA donor-specific antibodies are deleterious for organ transplant survival. Class I HLA donor-specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti-denatured HLA antibodies (anti-dHLAs). Anti-dHLAs are thought to be unable to recognize native HLA (nHLA...

journal_title：European journal of immunology

authors： Visentin J,Guidicelli G,Moreau JF,Lee JH,Taupin JL

更新日期：2015-07-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) generally recognize peptides derived from endogenously expressed proteins in association with nascent major histocompatibility complex (MHC) class I molecules. In contrast, peptides derived from exogenous proteins associate with MHC class II following endocytosis to an endosomal compartme...

journal_title：European journal of immunology

authors： Ulmer JB,Donnelly JJ,Liu MA

更新日期：1994-07-01 00:00:00

abstract：:This study describes a CD5+ B cell that differs from the majority of the CD5+ B cells from human tonsils. This cell, isolated from in vivo activated B cells, expressed activation markers and featured a CD23-, IgMhigh, IgDlow surface phenotype, responded to T cell-independent type-2 antigens in vitro, and was detected ...

journal_title：European journal of immunology

authors： Dono M,Burgio VL,Colombo M,Sciacchitano S,Reverberi D,Tarantino V,Cutrona G,Chiorazzi N,Ferrarini M

更新日期：2007-08-01 00:00:00

abstract：:LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...

journal_title：European journal of immunology

authors： Probst P,Skeiky YA,Steeves M,Gervassi A,Grabstein KH,Reed SG

更新日期：1997-10-01 00:00:00

abstract：:An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

journal_title：European journal of immunology

authors： Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

更新日期：1994-11-01 00:00:00

abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

journal_title：European journal of immunology

authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

更新日期：2010-06-01 00:00:00

abstract：:The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...

journal_title：European journal of immunology

authors： Nobrega A,Grandien A,Haury M,Hecker L,Malanchère E,Coutinho A

更新日期：1998-04-01 00:00:00

abstract：:A single T cell clone can be activated by many different peptides in the context of a particular HLA molecule. To quantify the number of peptides that can be recognized by a CD4(+) T cell clone, we screened a one-bead-one-peptide synthetic peptide library and a protein database for peptides that stimulate an HLA-DR3-r...

journal_title：European journal of immunology

authors： Hiemstra HS,van Veelen PA,Willemen SJ,Benckhuijsen WE,Geluk A,de Vries RR,Roep BO,Drijfhout JW

更新日期：1999-08-01 00:00:00

abstract：:MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...

journal_title：European journal of immunology

authors： Marquet J,Lasoudris F,Cousin C,Puiffe ML,Martin-Garcia N,Baud V,Chereau F,Farcet JP,Molinier-Frenkel V,Castellano F

更新日期：2010-09-01 00:00:00

abstract：:A diabetes-associated peptide in the glutamic acid decarboxylase 65 (GAD65) molecule, p524-543, activates two distinct populations of T cells, which apparently play opposite roles in the development of diabetes in NOD mice. By comparing the fine specificity of these two T cell repertoires using a nested set of truncat...

journal_title：European journal of immunology

authors： Dai YD,Jensen KP,Marrero I,Li N,Quinn A,Sercarz EE

更新日期：2008-04-01 00:00:00

abstract：:LL-37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL-37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down-regulated by LL-37. LL-37 functions similarly to CXCR2-specific chemokines CXCL1 and CXCL7 in terms of recept...

journal_title：European journal of immunology

authors： Zhang Z,Cherryholmes G,Chang F,Rose DM,Schraufstatter I,Shively JE

更新日期：2009-11-01 00:00:00

abstract：:NK cells display several killer inhibitory receptors (KIR) specific for different alleles of MHC class I molecules. A family of KIR are represented by type I transmembrane proteins belonging to the immunoglobulin superfamily (Ig-SF). Besides cDNA encoding for these KIR, additional cDNA have been identified which encod...

journal_title：European journal of immunology

authors： Cantoni C,Verdiani S,Falco M,Pessino A,Cilli M,Conte R,Pende D,Ponte M,Mikaelsson MS,Moretta L,Biassoni R

更新日期：1998-06-01 00:00:00

abstract：:On the premise that an individual with an intact immune system has the capability to develop both cellular and antibody immune responses supported by the balance between the lymphokines secreted by T helper (Th) cells, we studied the interaction between different types of Th cell clones in vivo and the parameters that...

journal_title：European journal of immunology

authors： Rizzo LV,DeKruyff RH,Umetsu DT,Caspi RR

更新日期：1995-03-01 00:00:00

abstract：:Recurrent respiratory tract infections (RRTIs) are the first leading cause of community- and nosocomial-acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore, the development of new alternative approaches to prevent and treat RRTIs is hi...

journal_title：European journal of immunology

authors： Cirauqui C,Benito-Villalvilla C,Sánchez-Ramón S,Sirvent S,Diez-Rivero CM,Conejero L,Brandi P,Hernández-Cillero L,Ochoa JL,Pérez-Villamil B,Sancho D,Subiza JL,Palomares O

更新日期：2018-01-01 00:00:00