Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity.

abstract：:We have explored how IL-15 influences Th1 or Th2 type immune response in vivo. Intraperitoneal application of an IL-15-IgG2b fusion protein (FP) to mice did neither significantly affect the footpad swelling nor the production of hemagglutinizing antibodies in a delayed type hypersensitivity reaction to sheep red blood...

journal_title：European journal of immunology

authors： Rückert R,Herz U,Paus R,Ungureanu D,Pohl T,Renz H,Bulfone-Paus S

更新日期：1998-10-01 00:00:00

abstract：:Specific members of the Rho family of GTPases exert unique influences on thymocyte proliferation, differentiation and deletion. Dbs is a guanine nucleotide exchange factor which is expressed throughout thymocyte development and is able to activate the Rho family GTPases CDC42, RhoA and RhoG. Transgenic mice expressing...

journal_title：European journal of immunology

authors： Klinger MB,Guilbault B,Kay RJ

更新日期：2004-03-01 00:00:00

abstract：:The infiltration and activation of monocytes is a hallmark of chronic inflammation, including that associated with a variety of disease states such as rheumatoid arthritis, atherosclerosis, and various autoimmune conditions. Recently, a family of small molecular mass proteins has been described which appear to have in...

journal_title：European journal of immunology

authors： Schall TJ,Simpson NJ,Mak JY

更新日期：1992-06-01 00:00:00

abstract：:IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but here we analyze a second, antigen-nonspecific pathway capable of inducing full IFN-gamma transcription. IL-12 or IL-18 alone do not ind...

journal_title：European journal of immunology

authors： Yang J,Murphy TL,Ouyang W,Murphy KM

更新日期：1999-02-01 00:00:00

abstract：:IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural...

journal_title：European journal of immunology

authors： Zhai K,Shi XY,Yi FS,Huang ZY,Wu XZ,Dong SF,Wang W,Wu MT,Shi HZ

更新日期：2020-11-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:In the present study, we examined whether anti-CD40+IL-4-mediated B cell proliferation and immunoglobulin synthesis is affected by vitamin D (VD) and its low-hypercalcemic analogue EB1089 in Bcells from healthy donors. Analysis of vitamin D receptor (VDR) expression showed that only anti-CD40+IL-4-stimulated, but not ...

journal_title：European journal of immunology

authors： Heine G,Anton K,Henz BM,Worm M

更新日期：2002-12-01 00:00:00

abstract：:To determine whether antigen (Ag)-specific cytotoxic T lymphocytes are generated during experimental Candida albicans infection, purified L3T4+ and Ly-2+ lymphocytes from immunized mice were cultured in the presence of syngeneic accessory cells, C. albicans Ag, and interleukin 2. Yeast-infected bone marrow macrophages...

journal_title：European journal of immunology

authors： Romani L,Mocci S,Cenci E,Rossi R,Puccetti P,Bistoni F

更新日期：1991-06-01 00:00:00

abstract：:The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...

journal_title：European journal of immunology

authors： Claus C,Schlaak J,Dittmayer M,Meyer zum Büschenfelde K,Dippold W

更新日期：1994-05-01 00:00:00

abstract：:Dendritic cells (DC) play an essential role in the induction of primary immune responses; however, very little information is available on cytokine production by DC. Here we determined the cytokine gene expression profile of two immortalized DC clones, CB1 and D2SC/1, both generated from mouse spleen but differing in ...

journal_title：European journal of immunology

authors： Granucci F,Girolomoni G,Lutz MB,Foti M,Marconi G,Gnocchi P,Nolli L,Ricciardi-Castagnoli P

更新日期：1994-10-01 00:00:00

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a phospholipid mediator of anaphylaxis, released from basophils of several mammalian species, that aggregates platelets and releases their vasoactive amines. The ionophore A23 187 induced the release of PAF from rat and mouse peritoneal cells, a mixed cell population that was fracti...

journal_title：European journal of immunology

authors： Mencia-Huerta JM,Benveniste J

更新日期：1979-05-01 00:00:00

abstract：:The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)-alpha/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF-alpha synthesis and secretion were induced after incubation of purifie...

journal_title：European journal of immunology

authors： Santis AG,Campanero MR,Alonso JL,Sánchez-Madrid F

更新日期：1992-12-01 00:00:00

abstract：:The capacity of old (18-24 months) C57BL/6 mice to develop an immune reaction against MC-B6-1 fibrosarcoma cells was studied using in vivo adoptive transfer experiments (Winn assay) and in vitro T cell-mediated cytotoxicity test. Anti-tumor immunity was found to decline with age, as indicated by a decreased anti-tumor...

journal_title：European journal of immunology

authors： Bruley-Rosset M,Payelle B

更新日期：1987-03-01 00:00:00

abstract：:The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM antibody (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated with rabbit IgG or IgM antibody. It was found that while EA(IgG)-rosette-forming cells (RFC) were detected ...

journal_title：European journal of immunology

authors： Moretta L,Ferrarini M,Durante ML,Mingari MC

更新日期：1975-08-01 00:00:00

abstract：:Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to non-tuberculous environmental mycobacteria (Env) are suspected to underlie this phenomenon, but the mechanisms remain unclear. We postulated that it could be d...

journal_title：European journal of immunology

authors： Ho P,Zhang L,Wei X,Seah GT

更新日期：2009-07-01 00:00:00

abstract：:Autoantigenic epitope mapping represents a critical issue in autoimmune diseases. The islet tyrosine phosphatase-like protein IA-2/ICA512bdc is a major autoantigen in type 1 diabetes (IDDM), but the epitopes responsible for autoantibody binding have been only partially defined. The aim of our study was to identify ICA...

journal_title：European journal of immunology

authors： Farilla L,Tiberti C,Luzzago A,Yu L,Eisenbarth GS,Cortese R,Dotta F,Di Mario U

更新日期：2002-05-01 00:00:00

abstract：:Antisera were prepared in rabbits against the idiotypic (Id) determinants of antiallergen antibodies. These antibodies were isolated from the plasma of 10 unrelated patients by immunoabsorption. Three major allergens isolated from the house dust mite, Dermatophagoides pteronyssinus (DPT), were used. The anti-Id antise...

journal_title：European journal of immunology

authors： Saint-Remy JM,Lebrun PM,Lebecque SJ,Masson PL

更新日期：1986-05-01 00:00:00

abstract：:MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...

journal_title：European journal of immunology

authors： Olsson T

更新日期：2020-12-22 00:00:00

abstract：:Priming mice with a chicken gamma globulin (CGG) carrier protein significantly accelerated the onset of somatic mutation in the V chi Ox1 gene when the mice were subsequently immunized with 2-phenyl-5-oxazolone (phOx) coupled to CGG. The first mutations were already detected 7 days after immunization, while in the tru...

journal_title：European journal of immunology

authors： Källberg E,Gray D,Leanderson T

更新日期：1995-08-01 00:00:00

abstract：:gp140 is the Epstein-Barr virus receptor and the C3d receptor (EBVR/C3dR) of human B lymphocytes. Recently, we have shown that cross-linking of EBVR/C3dR on cell surface by polyclonal anti-gp140 induced B cell activation, in presence of T cell factors. Immunoregulatory abnormalities of EBV-induced B cell activation ha...

journal_title：European journal of immunology

authors： Barel M,Kahan A,Charriaut-Marlangue C,Kahan A,Frade R

更新日期：1986-11-01 00:00:00

abstract：:Stimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of ...

journal_title：European journal of immunology

authors： Gullberg M,Larsson EL

更新日期：1982-12-01 00:00:00

abstract：:The MHC-related 1 (MR1) protein is a monomorphic, evolutionarily conserved MHC class I-like molecule, which is necessary for the development and functions of mucosal-associated invariant T (MAIT) cells, a new subset of innate-like lymphocytes. Multiple isoforms of the MR1 gene are naturally transcribed, but only the f...

journal_title：European journal of immunology

authors： Lion J,Debuysscher V,Wlodarczyk A,Hodroge A,Serriari NE,Choteau L,Ouled-haddou H,Plistat M,Lassoued K,Lantz O,Treiner E

更新日期：2013-05-01 00:00:00

abstract：:To further define DNA immunization as a model for anti-DNA production, we investigated the cellular requirements for this response in mice immunized with single-stranded DNA from E. coli. The anti-DNA responses of genetically immune-deficient mice and congenic controls were measured by ELISA after immunization with E....

journal_title：European journal of immunology

authors： Gilkeson GS,Pritchard AJ,Pisetsky DS

更新日期：1990-08-01 00:00:00

abstract：:A detailed restriction map of a 430-kb contig comprising the single Ckappa, the 5 Jkappa and the adjoining 22 Vkappa gene segments is presented. The first 12 Vkappa genes following the JkappaCkappa region belong to the Vkappa21 family, the subsequent ones to the closely related families Vkappa8 and Vkappal 9/ 28. Prev...

journal_title：European journal of immunology

authors： Kirschbaum T,Pourrajabi S,Zocher I,Schwendinger J,Heim V,Röschenthaler F,Kirschbaum V,Zachau HG

更新日期：1998-05-01 00:00:00

abstract：:The magnitude and quality of T cell responses generated when Ag is targeted to receptors on DC is influenced by both the specific receptor targeted and its distribution among DC subsets. Here we examine the targeting of the model Ag OVA to potential DC targets, including CD11c, CD205, MHC class II, CD40, TLR2 and Fcga...

journal_title：European journal of immunology

authors： Castro FV,Tutt AL,White AL,Teeling JL,James S,French RR,Glennie MJ

更新日期：2008-08-01 00:00:00

abstract：:Barrier surfaces of multicellular organisms are in constant contact with the environment and infractions to the integrity of epithelial surfaces is likely a frequent event. Interestingly, components of the immune system, that can be activated by environmental compounds such as the microbiota or nutrients, are interspe...

journal_title：European journal of immunology

authors： Hernandez P,Gronke K,Diefenbach A

更新日期：2018-01-01 00:00:00

abstract：:Type B T cells recognize peptide-MHC class II (pMHCII) isoforms that are structurally distinct from those recognized by conventional type A T cells. These alternative type B conformers result from peptide loading in the absence of HLA-DM. Type A conformers are more stable than type B pMHCII conformers but bind the sam...

journal_title：European journal of immunology

authors： Jackson N,Compton E,Trowsdale J,Kelly AP

更新日期：2014-04-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are specialized in massive production of type I interferons (IFN) upon viral infections. Activation of IFN regulatory factor (IRF)-7 is critically required for the synthesis of type I IFN in pDC. IRF-7 is highly expressed by resting pDC and translocates into the nucleus to initiate t...

journal_title：European journal of immunology

authors： Danis B,George TC,Goriely S,Dutta B,Renneson J,Gatto L,Fitzgerald-Bocarsly P,Marchant A,Goldman M,Willems F,De Wit D

更新日期：2008-02-01 00:00:00

abstract：:The major role of cells of the dendritic family in immunity and tolerance has been amply documented. Since their discovery in 1973, these cells have gained increasing interest from immunologists, as they are able to detect infectious agents, migrate to secondary lymphoid tissue, and prime naive T lymphocytes, thereby ...

journal_title：European journal of immunology

authors： Hespel C,Moser M

更新日期：2012-10-01 00:00:00