Epstein Barr virus infection and immune defense related to HLA-DR15: consequences for multiple sclerosis.

abstract：:Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation. The synthesis, activation, and release of IL-1β are crucial for MSU-induced inflammation. The current st...

journal_title：European journal of immunology

authors： Amaral FA,Bastos LF,Oliveira TH,Dias AC,Oliveira VL,Tavares LD,Costa VV,Galvão I,Soriani FM,Szymkowski DE,Ryffel B,Souza DG,Teixeira MM

更新日期：2016-01-01 00:00:00

abstract：:The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear Ags and a heightened inflammatory environment, which together result in end organ damage. Lyn-deficient mice, a model of systemic lupus erythematosus, lack an inhibitor of B-cell and myeloid cell activation. This resul...

journal_title：European journal of immunology

authors： Gutierrez T,Mayeux JM,Ortega SB,Karandikar NJ,Li QZ,Rakheja D,Zhou XJ,Satterthwaite AB

更新日期：2013-02-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:The importance of human herpesvirus 6 (HHV-6) species as human pathogens is increasingly appreciated. However, we do not understand how infection is controlled in healthy virus carriers, and why control fails in patients with disease. Other persistent viruses are under continuous surveillance by antigen-specific T cel...

journal_title：European journal of immunology

authors： Martin LK,Schub A,Dillinger S,Moosmann A

更新日期：2012-11-01 00:00:00

abstract：:Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further the role of this cytokine in resistance to infection and the differentiation of f...

journal_title：European journal of immunology

authors： Mattner F,Magram J,Ferrante J,Launois P,Di Padova K,Behin R,Gately MK,Louis JA,Alber G

更新日期：1996-07-01 00:00:00

abstract：:Macrophages can be stimulated to produce a relatively large amount of nitric oxide, which is an important component in macrophage-mediated defense mechanisms and regulation of T cell activities. It has been known that T helper (Th) cell activation requires intimate physical interaction between T helper cells and macro...

journal_title：European journal of immunology

authors： Tian L,Noelle RJ,Lawrence DA

更新日期：1995-01-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a membrane glycoprotein first identified on rat mucosal type mast cells (line RBL-2H3) and known to inhibit the Fc epsilon RI-mediated secretory response. In its extracellular domain, an amino acid stretch homologous to the carbohydrate binding domain of calcium-depe...

journal_title：European journal of immunology

authors： Binsack R,Pecht I

更新日期：1997-10-01 00:00:00

abstract：:Interleukin (IL)-7 and IL-2 are important lymphoproliferative cytokines which both use the gamma c chain as part of their respective receptors. To learn more of their signaling mechanisms a comparison was made of the patterns of intracellular tyrosine phosphorylated proteins induced by these cytokines in the murine T ...

journal_title：European journal of immunology

authors： Crawley JB,Willcocks J,Foxwell BM

更新日期：1996-11-01 00:00:00

abstract：:APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...

journal_title：European journal of immunology

authors： Mariani SM,Matiba B,Armandola EA,Krammer PH

更新日期：1994-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B-cell function and development, we created transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase ...

journal_title：European journal of immunology

authors： Ogura M,Inoue T,Yamaki J,Homma MK,Kurosaki T,Homma Y

更新日期：2017-02-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:Surfactant protein A (SP-A) and surfactant protein D (SP-D) are collectins, and both proteins were shown to interact with influenza A virus and alveolar macrophages. However, it is not known whether SP-A and SP-D can serve as opsonins for the phagocytosis of influenza A virus by alveolar macrophages. In the present st...

journal_title：European journal of immunology

authors： Benne CA,Benaissa-Trouw B,van Strijp JA,Kraaijeveld CA,van Iwaarden JF

更新日期：1997-04-01 00:00:00

abstract：:The monoclonal antibody OKT3 can induce T suppressor cells of the in vitro antibody response when used at concentrations as low as 10 ng/ml and in cultures containing as few as 4% OKT3-pretreated T cells. These suppressor cells are radioresistant, cyclosporin sensitive and belong to the T4 as well as the T8 subpopulat...

journal_title：European journal of immunology

authors： Delfraissy JF,Wallon C,Boué F,Vazquez A,Galanaud P

更新日期：1985-05-01 00:00:00

abstract：:Tuberculosis (TB) is one of the world's most pernicious diseases mainly due to immune evasion strategies displayed by its causative agent Mycobacterium tuberculosis (Mtb). Blood monocytes (Mos) represent an important source of DCs during chronic infections; consequently, the alteration of their differentiation constit...

journal_title：European journal of immunology

authors： Balboa L,Romero MM,Laborde E,Sabio Y García CA,Basile JI,Schierloh P,Yokobori N,Musella RM,Castagnino J,de la Barrera S,Sasiain MC,Alemán M

更新日期：2013-02-01 00:00:00

abstract：:T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

journal_title：European journal of immunology

authors： Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

更新日期：1986-10-01 00:00:00

abstract：:Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

journal_title：European journal of immunology

authors： Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

更新日期：2019-05-01 00:00:00

abstract：:Responding B cells in specific immune responses diversify their immunoglobulin genes and are selected on their variant antigen receptors in the microenvironment of the germinal center. The patterns of mutations previously reported for immunglobulin (Ig) genes have supported mechanistic hypotheses of either error-prone...

journal_title：European journal of immunology

authors： Ford JE,McHeyzer-Williams MG,Lieber MR

更新日期：1994-08-01 00:00:00

abstract：:The capacity of old (18-24 months) C57BL/6 mice to develop an immune reaction against MC-B6-1 fibrosarcoma cells was studied using in vivo adoptive transfer experiments (Winn assay) and in vitro T cell-mediated cytotoxicity test. Anti-tumor immunity was found to decline with age, as indicated by a decreased anti-tumor...

journal_title：European journal of immunology

authors： Bruley-Rosset M,Payelle B

更新日期：1987-03-01 00:00:00

abstract：:Bispecific antibodies binding to the TCR/CD3 complex and to a tumor-associated surface molecule can be used to target cytotoxic T lymphocytes against tumor cells. We reasoned that high-affinity binding to CD3 may reduce the efficiency of T cell stimulation and target the bispecific reagent to T cells rather than to tu...

journal_title：European journal of immunology

authors： Bortoletto N,Scotet E,Myamoto Y,D'Oro U,Lanzavecchia A

更新日期：2002-11-01 00:00:00

abstract：:Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...

journal_title：European journal of immunology

authors： Ruedl C,Jung S

更新日期：2018-07-01 00:00:00

abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

journal_title：European journal of immunology

authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

更新日期：1999-07-01 00:00:00

abstract：:We have previously shown, through transfection experiments, that the murine B7 (mB7) molecule, a ligand for the CD28 and CTLA-4 receptors, is a sufficient costimulatory signal for the antigen-specific and major histocompatibility complex (MHC)-restricted activation of murine CD4+ T lymphocytes. In addition to mB7, ano...

journal_title：European journal of immunology

authors： Razi-Wolf Z,Falo LD Jr,Reiser H

更新日期：1994-04-01 00:00:00

abstract：:We provide a robust four-color fluorescence-based flow cytometry protocol that distinguishes viable dividing plasmablasts from nondividing plasma cells and, based on CD19 surface abundance, identifies two mature plasma cell populations in the spleen and the bone marrow of mice. ...

journal_title：European journal of immunology

authors： Pracht K,Meinzinger J,Daum P,Schulz SR,Reimer D,Hauke M,Roth E,Mielenz D,Berek C,Côrte-Real J,Jäck HM,Schuh W

更新日期：2017-08-01 00:00:00

abstract：:Innate immunity directs the adaptive immune response by identifying antigens that are associated with infectious agents. Although some microbial antigens can be recognized by innate immune receptors, most cannot, and these require identification by some other means. The introduction of aldehydes into antigens by glyco...

journal_title：European journal of immunology

authors： Allison ME,Fearon DT

更新日期：2000-10-01 00:00:00

abstract：:This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...

journal_title：European journal of immunology

authors： Larché M,Manzo AR,Hurwitz JL

更新日期：1991-12-01 00:00:00

abstract：:We investigated here the potential role of Toll-like receptors (TLR) and the adaptor protein MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic encapsulated yeast. Peritoneal macrophages from MyD88(-/-) or TLR2(-/-) mice released significantly less TNF-alpha, compared with wild-type controls, ...

journal_title：European journal of immunology

authors： Biondo C,Midiri A,Messina L,Tomasello F,Garufi G,Catania MR,Bombaci M,Beninati C,Teti G,Mancuso G

更新日期：2005-03-01 00:00:00

abstract：:We have investigated the role of TNF-alpha in mast cell-mediated late airway hyperresponsiveness (AHR) using mast cell-deficient WBB6F1-W/W(v) (W/W(v)) mice in a murine model of asthma, which exhibits a biphasic increase in AHR. TNF-alpha levels in the airway and magnitude of late AHR in response to airway allergen ch...

journal_title：European journal of immunology

authors： Kim YS,Ko HM,Kang NI,Song CH,Zhang X,Chung WC,Kim JH,Choi IH,Park YM,Kim GY,Im SY,Lee HK

更新日期：2007-04-01 00:00:00

abstract：:Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...

journal_title：European journal of immunology

authors： Smith LJ,Sogh JA,Kindt TJ,Mandy WJ

更新日期：1979-01-01 00:00:00

abstract：:Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restric...

journal_title：European journal of immunology

authors： Webb TJ,Litavecz RA,Khan MA,Du W,Gervay-Hague J,Renukaradhya GJ,Brutkiewicz RR

更新日期：2006-10-01 00:00:00