Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma.

abstract：:Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

journal_title：European journal of immunology

authors： Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

更新日期：2012-01-01 00:00:00

abstract：:Interferon-gamma inducing factor (IGIF) is a recently identified cytokine which stimulates the production of interferon-gamma (IFN-gamma) by T cells and enhances natural killer (NK) cell cytolytic activity. Protein fold recognition, structure prediction and comparative modeling have revealed that IGIF is a member of t...

journal_title：European journal of immunology

authors： Hunter CA,Timans J,Pisacane P,Menon S,Cai G,Walker W,Aste-Amezaga M,Chizzonite R,Bazan JF,Kastelein RA

更新日期：1997-11-01 00:00:00

abstract：:Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

journal_title：European journal of immunology

authors： Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

更新日期：1993-07-01 00:00:00

abstract：:Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

journal_title：European journal of immunology

authors： Picarella D,Serunian LA,Rosenberg N

更新日期：1991-01-01 00:00:00

abstract：:Cells present in the polyoma virus-induced murine ascites tumor SEYF-a showed the capacity to fix soluble immune complexes of ovalbumin anti-ovalbumin. The fixation could be inhibited by preincubating the cells with antisera directed against H-2 antigens and with syngeneic anti-tumor antibodies. The latter did not rea...

journal_title：European journal of immunology

authors： Braslawsky GR,Serban D,Witz IP

更新日期：1976-08-01 00:00:00

abstract：:Genetic control has been studied of the response to the encephalitogenic nonapeptide (NP) determinant of myelin basic protein (BP) in inbred guinea pigs of strains resistant or susceptible to induction of experimental autoimmune encephalomyelitis (EAE). By studying bone marrow-reconstituted animals, we found that susc...

journal_title：European journal of immunology

authors： Ben-Nun A,Otmy H,Cohen IR

更新日期：1981-04-01 00:00:00

abstract：:GITR (glucocorticoid-induced TNFR family related gene) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes. Because of a high homology in its cytoplasmic region with other known costimulatory members of the TNFRSF, we investigated whether GITR played a costim...

journal_title：European journal of immunology

authors： Ronchetti S,Zollo O,Bruscoli S,Agostini M,Bianchini R,Nocentini G,Ayroldi E,Riccardi C

更新日期：2004-03-01 00:00:00

abstract：:LIGHT is a recently identified member of the TNF superfamily that is up-regulated on activated T cells and can cooperate with CD40L to condition DC for the priming of CTL. In this report, we show that an intracellular pool of LIGHT is found selectively in some CD45RA-CD27+CD4+ "central" memory T cells and to a greater...

journal_title：European journal of immunology

authors： Morel Y,Truneh A,Costello RT,Olive D

更新日期：2003-11-01 00:00:00

abstract：:Dendritic cells (DC) are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses. Characterization of DC-specific genes may help to unravel the mechanism underlying their potent antigen presenting capacity. Here we describe the identification...

journal_title：European journal of immunology

authors： Hartgers FC,Vissers JL,Looman MW,van Zoelen C,Huffine C,Figdor CG,Adema GJ

更新日期：2000-12-01 00:00:00

abstract：:We have investigated the vaccine potential of two peptides derived from the 6-kDa early secretory antigenic target (ESAT)-6 antigen in the mouse model of tuberculosis. The peptides were both strongly immunogenic in B6CBAF1 (H-2b,k) mice and primed recall responses of the same intensity after immunization. However, bot...

journal_title：European journal of immunology

authors： Olsen AW,Hansen PR,Holm A,Andersen P

更新日期：2000-06-01 00:00:00

abstract：:To determine whether antigen (Ag)-specific cytotoxic T lymphocytes are generated during experimental Candida albicans infection, purified L3T4+ and Ly-2+ lymphocytes from immunized mice were cultured in the presence of syngeneic accessory cells, C. albicans Ag, and interleukin 2. Yeast-infected bone marrow macrophages...

journal_title：European journal of immunology

authors： Romani L,Mocci S,Cenci E,Rossi R,Puccetti P,Bistoni F

更新日期：1991-06-01 00:00:00

abstract：:Persistent polyclonal B cell lymphocytosis (PPBL) is a hematological disorder diagnosed predominantly in women, characterized by a polyclonal increase in the number of peripheral blood B lymphocytes. Abnormality of the B cell population was evidenced by the finding of multiple bcl-2/Ig gene rearrangements and an addit...

journal_title：European journal of immunology

authors： Loembé MM,Néron S,Delage R,Darveau A

更新日期：2002-12-01 00:00:00

abstract：:Central and peripheral tolerance mechanisms are expected to hamper the generation of effective immunity against tumors. To break self tolerance against malignant gliomas, we assessed the therapeutic potential of self/foreign antigen cross-reactivity in an immunocompetent rat glioma model. Immunotherapy of tumors using...

journal_title：European journal of immunology

authors： Sioud M,Sørensen D

更新日期：2003-01-01 00:00:00

abstract：:T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...

journal_title：European journal of immunology

authors： Shields JG,Smith SH,Strobel S,Levinsky RJ,Defrance T,De Vries J,Banchereau J,Callard RE

更新日期：1988-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) employs multiple mechanisms to evade the immune system and succeeds to persist lifelong in the host. Human dendritic cells (DC) are the main antigen-presenting cells and play the key role in inducing and maintaining immune responses. Here, we studied the interaction of HCMV with DC. We fou...

journal_title：European journal of immunology

authors： Beck K,Meyer-König U,Weidmann M,Nern C,Hufert FT

更新日期：2003-06-01 00:00:00

abstract：:The magnitude of the output of lymphocytes from Peyer's patches (PP), the morphology of the lymphocytes and their route of exit from PP has been examined in sheep. An extracorporeal perfusion system was used to selectively label a 3-4 m length of the terminal ileum of lambs at 6-10 weeks of age (the mesenteric lymph n...

journal_title：European journal of immunology

authors： Reynolds JD,Pabst R

更新日期：1984-01-01 00:00:00

abstract：:GTPase immune-associated proteins (Gimap) genes encode evolutionarily conserved GTP-binding proteins that are preferentially expressed in immune cells. Specific members have been shown to be involved in lymphocyte development, or are associated with inflammatory and autoimmune diseases. However, the function of these ...

journal_title：European journal of immunology

authors： Ciucci T,Bosselut R

更新日期：2014-02-01 00:00:00

abstract：:To study the biological consequences of cytokine production and apoptosis by intraepithelial lymphocytes (IEL), we have studied these characteristics in both the high and low density CD3+ IEL populations. Stimulation of low- or high-density CD3+ IEL via the T cell receptor (TCR)-CD3 complex using monoclonal anti-CD3, ...

journal_title：European journal of immunology

authors： Yamamoto M,Fujihashi K,Amano M,McGhee JR,Beagley KW,Kiyono H

更新日期：1994-06-01 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:The MRC OX-22 monoclonal antibody recognizes a restricted determinant of the rat leukocyte-common antigen (L-CA, CD45), which is expressed on most peripheral T cells and all B cells. In contrast only 2%-3% of thymocytes are OX-22+ and these are now shown to be mostly of the immature CD4-CD8- (double-negative, DN), phe...

journal_title：European journal of immunology

authors： Law DA,Spruyt LL,Paterson DJ,Williams AF

更新日期：1989-12-01 00:00:00

abstract：:1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Here, we analyze the effect of 1,25-(OH)2D3 on IF...

journal_title：European journal of immunology

authors： Cippitelli M,Santoni A

更新日期：1998-10-01 00:00:00

abstract：:The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...

journal_title：European journal of immunology

authors： Ko HJ,Kinkel SA,Hubert FX,Nasa Z,Chan J,Siatskas C,Hirubalan P,Toh BH,Scott HS,Alderuccio F

更新日期：2010-12-01 00:00:00

abstract：:Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play...

journal_title：European journal of immunology

authors： Nagy L

更新日期：2012-07-01 00:00:00

abstract：:Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

journal_title：European journal of immunology

authors： Schuhbauer DM,Mitchison NA,Mueller B

更新日期：2000-05-01 00:00:00

abstract：:Transgenic CBA (H-2k haplotype) mice expressing the H-2 Kb major histocompatibility complex (MHC) class I gene under control of transcriptional promoter elements from a milk protein gene display high-level H-2 Kb transcription in lactating mammary glands and low-level transcription in skin and thymus of male and virgi...

journal_title：European journal of immunology

authors： Husbands SD,Schönrich G,Arnold B,Chandler PR,Simpson E,Philpott KL,Tomlinson P,O'Reilly L,Cooke A,Mellor AL

更新日期：1992-10-01 00:00:00

abstract：:Although most cells of the T cell receptor (TcR) gamma/delta lineage are CD4-CD8-, some gamma/delta cells express CD8. We show here that mouse thymic gamma/delta cells express CD8 following in vitro activation by concanavalin A. Staining with monoclonal and polyclonal antibodies to the CD8 alpha (Ly-2) and CD8 beta (L...

journal_title：European journal of immunology

authors： MacDonald HR,Schreyer M,Howe RC,Bron C

更新日期：1990-04-01 00:00:00

abstract：:In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...

journal_title：European journal of immunology

authors： Viguier M,Lotteau V,Charron D,Debré P

更新日期：1987-11-01 00:00:00

abstract：:The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...

journal_title：European journal of immunology

authors： Siegrist CA,Barrios C,Martinez X,Brandt C,Berney M,Córdova M,Kovarik J,Lambert PH

更新日期：1998-12-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages. We have isolated full-length cDNA clones from a lambda gt 10 library, prepared from phorbol 12-myristate 13-acetate-dif...

journal_title：European journal of immunology

authors： Bellón T,Corbí A,Lastres P,Calés C,Cebrián M,Vera S,Cheifetz S,Massague J,Letarte M,Bernabéu C

更新日期：1993-09-01 00:00:00