Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma-inducing factor on the production of interferon-gamma by natural killer.

abstract：:Human peripheral blood mononuclear leukocytes (PBL) cocultured with WISH human amnion cells rapidly produced alpha-type interferon (IFN-alpha) and in an IFN-dependent manner protected the WISH cells against the cytopathic effects caused by vesicular stomatitis virus. When the number of PBL per WISH cell monolayer cult...

journal_title：European journal of immunology

authors： Rönnblom L,Alm GV

更新日期：1982-05-01 00:00:00

abstract：:An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic di...

journal_title：European journal of immunology

authors： Chen Y,Meng F,Wang B,He L,Liu Y,Liu Z

更新日期：2018-06-01 00:00:00

abstract：:R24 is a monoclonal antibody directed against the cell surface ganglioside GD3. It can detect GD3 on the surface of a subset of T lymphocytes and can stimulate proliferation and secretion of cytokines in vitro. In the present report, we examined the effects of the R24 antibody upon antigen-specific T cell response, em...

journal_title：European journal of immunology

authors： Boussiotis VA,Pardo NA,Collins H,Houghton A,Ritz J,Nadler LM,Soiffer RJ

更新日期：1996-09-01 00:00:00

abstract：:B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...

journal_title：European journal of immunology

authors： Hoehlig K,Shen P,Lampropoulou V,Roch T,Malissen B,O'Connor R,Ries S,Hilgenberg E,Anderton SM,Fillatreau S

更新日期：2012-05-01 00:00:00

abstract：:Granzyme A (TSP-1) is a serine esterase expressed in cytotoxic T and natural killer (NK) cell lines. Its presence in in vivo primed T cells is disputed at present. Here we show that normal rat NK cells contain granzyme A in vivo and that its expression is augmented by their short-term in vitro treatment with IL 2. Gra...

journal_title：European journal of immunology

authors： Velotti F,Palmieri G,Morrone S,Piccoli M,Frati L,Santoni A

更新日期：1989-03-01 00:00:00

abstract：:T-cell activation and the subsequent transformation of activated T cells into T-cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T-cell immunology has not been characterized. Here we studied the role of the cell-volume regulating osmolyte transporter Taut for T-cel...

journal_title：European journal of immunology

authors： Kaesler S,Sobiesiak M,Kneilling M,Volz T,Kempf WE,Lang PA,Lang KS,Wieder T,Heller-Stilb B,Warskulat U,Häussinger D,Lang F,Biedermann T

更新日期：2012-04-01 00:00:00

abstract：:An interferon (IFN)-gamma immunoreactive molecule, localized to small neurons in peripheral sensory ganglia (N-IFN-gamma), has been detected with two mouse monoclonal antibodies (DB1 and DB16) directed against different epitopes of rat IFN-gamma. To define N-IFN-gamma with regard to its protein characteristics and bio...

journal_title：European journal of immunology

authors： Olsson T,Kelic S,Edlund C,Bakhiet M,Höjeberg B,van der Meide PH,Ljungdahl A,Kristensson K

更新日期：1994-02-01 00:00:00

abstract：:A survey of KIR2DL4 polymorphism revealed seven common sequences in the Australian population. The seven sequences encode three different amino acid sequences of the immunoglobulin domains. Two of the sequences encoding different amino acid sequences in the immunoglobulin domains also occur on some chromosomes with a ...

journal_title：European journal of immunology

authors： Witt CS,Whiteway JM,Warren HS,Barden A,Rogers M,Martin A,Beilin L,Christiansen FT

更新日期：2002-01-01 00:00:00

abstract：:Influenza matrix peptide 58-66 is shown to be the optimal nonamer for binding to HLA-A2 and presentation to cytotoxic T lymphocytes (CTL). If titered out to 2 x 10(-10) - 4 x 10(-10) M in CTL-mediated lysis assays and to 3 x 10(-9) M in an HLA-A2 assembly-stabilization assay in cell lysates. The peptide was shown to m...

journal_title：European journal of immunology

authors： Morrison J,Elvin J,Latron F,Gotch F,Moots R,Strominger JL,McMichael A

更新日期：1992-04-01 00:00:00

abstract：:The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

journal_title：European journal of immunology

authors： Kimoto M,Kishimoto S

更新日期：1986-07-01 00:00:00

abstract：:Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a promiscuous 7-transmembrane-domain receptor expressed on lymphatic vessels which recognizes most inflammatory, but not homeostatic, CC chemokines. In vitro expe...

journal_title：European journal of immunology

authors： Martinez de la Torre Y,Locati M,Buracchi C,Dupor J,Cook DN,Bonecchi R,Nebuloni M,Rukavina D,Vago L,Vecchi A,Lira SA,Mantovani A

更新日期：2005-05-01 00:00:00

abstract：:CD4+ CD25+ Foxp3+ regulatory T cells (Treg) are natural suppressors of autoimmunity but they can also dampen the effective clearance of infectious organisms. These cells have the potential to be exploited to prevent transplant rejection and to treat autoimmune disease. A paper in this issue of the European Journal of ...

journal_title：European journal of immunology

authors： Graça L,Silva-Santos B,Coutinho A

更新日期：2006-04-01 00:00:00

abstract：:Signaling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer. Many IL-2Rgamma-sharing (gammaC) cytokines decrease CD127 expression on CD4+ and C...

journal_title：European journal of immunology

authors： Crawley AM,Vranjkovic A,Young C,Angel JB

更新日期：2010-05-01 00:00:00

abstract：:Dendritic cells (DC) are the main orchestrators of specific immune responses. Depending on microbial information they encounter in peripheral tissues, they promote the development of Th1, Th2 or unpolarized Th cell responses. In this study we have investigated the immunomodulatory effect of non-pathogenic intestinal G...

journal_title：European journal of immunology

authors： Smits HH,van Beelen AJ,Hessle C,Westland R,de Jong E,Soeteman E,Wold A,Wierenga EA,Kapsenberg ML

更新日期：2004-05-01 00:00:00

abstract：:Viruses encode immune evasion mechanisms to survive in the immunocompetent host. Chemokines mediate the migration of immune cells and their critical role in immunity is emphasized by the numerous virus-encoded strategies to modulate their activity. Evidence published in this issue of the European Journal of Immunology...

journal_title：European journal of immunology

authors： Alcami A

更新日期：2007-04-01 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) is an immunologically privileged retinal antigen that can elicit experimental autoimmune uveitis (EAU). The nature and extent of tolerance to immunologically privileged self antigens is poorly understood. To investigate whether transgenic expression of IRBP extraocula...

journal_title：European journal of immunology

authors： Xu H,Wawrousek EF,Redmond TM,Nickerson JM,Wiggert B,Chan CC,Caspi RR

更新日期：2000-01-01 00:00:00

abstract：:We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...

journal_title：European journal of immunology

authors： Kobayashi K,Tomonaga S,Teshima K,Kajii T

更新日期：1985-09-01 00:00:00

abstract：:Adaptive immune responses have long been considered the "territory" of antigenic proteins, whereas carbohydrates are characterized as T-cell-independent antigens that are not typically recognized by the complete adaptive machinery. The current modus operandi when searching for dominant epitopes is the use of synthetic...

journal_title：European journal of immunology

authors： Cobb BA,Kasper DL

更新日期：2005-02-01 00:00:00

abstract：:TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory responses by C5aR, suggesting crosstalk between TLRs and C5aR. However,...

journal_title：European journal of immunology

authors： Raby AC,Holst B,Davies J,Colmont C,Laumonnier Y,Coles B,Shah S,Hall J,Topley N,Köhl J,Morgan BP,Labéta MO

更新日期：2011-09-01 00:00:00

abstract：:Priming mice with a chicken gamma globulin (CGG) carrier protein significantly accelerated the onset of somatic mutation in the V chi Ox1 gene when the mice were subsequently immunized with 2-phenyl-5-oxazolone (phOx) coupled to CGG. The first mutations were already detected 7 days after immunization, while in the tru...

journal_title：European journal of immunology

authors： Källberg E,Gray D,Leanderson T

更新日期：1995-08-01 00:00:00

abstract：:Previous studies from our laboratory have shown that prolonged exposure of mouse macrophages to IFN-beta interferes with their subsequent ability to become activated for tumor cell killing. Data reported here show that such inhibition is due to reduced production of NO, resulting from decreased transcription of the ge...

journal_title：European journal of immunology

authors： Gao JJ,Filla MB,Lorsbach RB,Pace JL,Crespo A,Russell SW,Murphy WJ

更新日期：2000-06-01 00:00:00

abstract：:Sand fly saliva contains maxadilan, a peptide that causes vasodilation and modifies the secretion of pro-inflammatory cytokines by macrophages. We show that 1 to 10 microg maxadilan protected BALB/c mice against a lethal dose of LPS. Maxadilan reduced serum levels of TNF-alpha by approximately tenfold, while it caused...

journal_title：European journal of immunology

authors： Bozza M,Soares MB,Bozza PT,Satoskar AR,Diacovo TG,Brombacher F,Titus RG,Shoemaker CB,David JR

更新日期：1998-10-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a phospholipid mediator of anaphylaxis, released from basophils of several mammalian species, that aggregates platelets and releases their vasoactive amines. The ionophore A23 187 induced the release of PAF from rat and mouse peritoneal cells, a mixed cell population that was fracti...

journal_title：European journal of immunology

authors： Mencia-Huerta JM,Benveniste J

更新日期：1979-05-01 00:00:00

abstract：:Similarities between the physical structures of avian and mammalian major histocompatibility complex (MHC) class I glycoproteins have been proposed based on comparative alignment of their amino acid sequences. To investigate the physical structure of the chicken class I glycoprotein, we cloned the cDNA representing th...

journal_title：European journal of immunology

authors： Fulton JE,Thacker EL,Bacon LD,Hunt HD

更新日期：1995-07-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein which is one of the ligands for the leukocyte function-associated antigen (LFA-1). It is involved in leukocyte adhesion to endothelial cells as well as in immune functions requiring cell-cell contact. The quantitative expression of ICAM-1 in various cell types can be either induce...

journal_title：European journal of immunology

authors： Geissler D,Gaggl S,Möst J,Greil R,Herold M,Dietrich M

更新日期：1990-12-01 00:00:00

abstract：:The structure of two T-immunogenic peptides, one from the gag p24 protein of the human immunodeficiency virus, the other from the 11.1 gene product of Plasmodium falciparum, was studied by circular dichroism spectroscopy in various pH and solvent conditions. Although both sequences are predicted to adopt an alpha-heli...

journal_title：European journal of immunology

authors： Abergel C,Loret E,Claverie JM

更新日期：1989-10-01 00:00:00

abstract：:The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...

journal_title：European journal of immunology

authors： Ko HJ,Kinkel SA,Hubert FX,Nasa Z,Chan J,Siatskas C,Hirubalan P,Toh BH,Scott HS,Alderuccio F

更新日期：2010-12-01 00:00:00

abstract：:Soluble anti-immunoglobulin (Ig) antibodies have been generally found to inhibit Ig secretion in B cells, via largely unknown mechanisms. To investigate this phenomenon further a two-step culture system was used in which B cells are primed for 24-72 h with various soluble monoclonal or polyclonal anti-Ig antibodies: a...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1992-06-01 00:00:00

abstract：:Listeria monocytogenes (LM) is a foodborne Gram-positive intracellular pathogen that can cause listeriosis in humans and animals. Although phagocytes are known to be involved in the response to this infection, the role of neutrophils is not entirely clear. Here, we have demonstrated that soon after LM infection, a lar...

journal_title：European journal of immunology

authors： Wang G,Lin A,Han Q,Zhao H,Tian Z,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:Dendritic cells (DCs) are the key APCs not only for the priming of naïve T cells, but also for the induction and maintenance of peripheral T-cell tolerance. We have recently shown that cognate interactions between Foxp3(+) Tregs and steady-state DCs are crucial to maintain the tolerogenic potential of DCs. Using DIETE...

journal_title：European journal of immunology

authors： Muth S,Schütze K,Hain T,Yagita H,Schild H,Probst HC

更新日期：2014-04-01 00:00:00