Abstract:
:CD4+ CD25+ Foxp3+ regulatory T cells (Treg) are natural suppressors of autoimmunity but they can also dampen the effective clearance of infectious organisms. These cells have the potential to be exploited to prevent transplant rejection and to treat autoimmune disease. A paper in this issue of the European Journal of Immunology details a method to selectively expand antigen-specific Treg from a polyclonal Treg population, by using a specific dendritic cell (DC) subset. Furthermore, the authors show that such Treg can be used to prevent experimental type I diabetes; however, as Treg are positively selected by thymic epithelial cells (TEC) on the basis of self-reactivity, they would systematically suppress protective immune responses unless their repertoire is devoid of recognition towards peripheral antigen-presenting cells. This may be achieved by negative selection of developing Treg on thymic DC, thus creating a 'blind-spot' corresponding to DC-self-antigens in the mature Treg repertoire. Therefore, therapeutic use of DC subsets for the expansion of rare Treg populations should take into account this blind-spot, as peptides that are not accessible to thymic DC may be significantly more effective for the expansion of Treg.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Graça L,Silva-Santos B,Coutinho Adoi
10.1002/eji.200635967keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
802-5issue
4eissn
0014-2980issn
1521-4141journal_volume
36pub_type
评论,杂志文章,评审abstract::This study was conducted to further characterize the effector cells of experimental allergic encephalomyelitis (EAE) which are activated in vitro when spleen cells from Lewis rats previously immunized with myelin basic protein and adjuvant are cultured with antigen prior to transfer to syngeneic recipients. The effect...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120519
更新日期:1982-05-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis, an experimental murine model for multiple sclerosis, is induced by stimulation of myelin-specific T lymphocytes. Myelin oligodendrocyte glycoprotein (MOG), a minor component of myelin proteins, is a potent autoantigen which contributes extensively to the anti-myelin response....
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200535021
更新日期:2006-03-01 00:00:00
abstract::MHC class II molecules present peptides, derived largely from exogenous antigens, to CD4+ T cells. Complex-generation occurs mainly in the specialized late endosomal MHC class II-rich compartment (MIIC) vesicles of antigen-presenting cells (APC). Dendritic cells (DC) have been reported to store intact antigen in MIIC ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200211)32:11<3246::AID-IMMU3246>
更新日期:2002-11-01 00:00:00
abstract::Indirect immunofluorescence performed with 2 polyclonal and 4 monoclonal antibodies directed against human beta 2-microglobulin (beta 2m) revealed the presence of a beta 2m-like determinant on the membrane of a subpopulation of earthworm leukocytes classified as weakly adherent acidophils. Two out of the 4 monoclonal ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830131216
更新日期:1983-12-01 00:00:00
abstract::To investigate the role of interferon-gamma (IFN-gamma) in experimental autoimmune thyroidits (EAT), H-2k mice with a disrupted IFN-gamma receptor (IFN-gamma R) gene were immunized with porcine thyroglobulin (pTg). We observed that EAT occurred on day 19 and remitted on day 35 in IFN-gamma R-deficient (IFN-gamma R(0/0...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199801)28:01<201::AID-IMMU
更新日期:1998-01-01 00:00:00
abstract::A recombinant Plasmodium vivax circumsporozoite (CS) protein (rPvCS-1) has been investigated as a possible malaria sporozoite vaccine candidate. Experiments were carried out to determine whether sporozoite-specific memory cells develop in Swiss Webster mice immunized with rPvCS-1. Challenge of rPvCS-1-immunized mice w...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171213
更新日期:1987-12-01 00:00:00
abstract::We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251019
更新日期:1995-10-01 00:00:00
abstract::Delayed hypersensitivity (DH) reaction to human Ig, corynebacterium parvum or allogeneic cells at the site of tumor cell injection, suppressed the fibrosarcoma (SCFS) growth in chickens. Spleen cells of SC chickens sensitized to human Ig or C. parvum suppressed SCFS growth when adoptively transferred with tumor cells,...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830080408
更新日期:1978-04-01 00:00:00
abstract::Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200535806
更新日期:2006-07-01 00:00:00
abstract::Leptin, a protein produced by adipocytes, exerts several functions, including modulation of the immune response. A report in this issue of the European Journal of Immunology describes for the first time the effect of either leptin receptor deficiency or blockade on murine dendritic cell (DC) maturation, survival and f...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.200636770
更新日期:2006-12-01 00:00:00
abstract::To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearra...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180126
更新日期:1988-01-01 00:00:00
abstract::This study reports on the earliest stages of mononuclear phagocyte differentiation. A crucial question in this developmental process is whether mature macrophage (M phi) heterogeneity is already appointed at the precursor cell level. For this purpose, we produced clonal populations of mononuclear phagocytes from bone ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200104
更新日期:1990-01-01 00:00:00
abstract::Regulation of the development of thymocytes into mature T cells within the thymus is now known to involve antigen-induced deletion, by apoptosis, of potentially autoreactive thymocytes, and it can be mimicked either by stimulating the T cell receptor (TcR) complex by monoclonal antibody (mAb) or by ionophore-induced e...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250706
更新日期:1995-07-01 00:00:00
abstract::In this study two newly developed monoclonal antibodies, ED5 and ED6, are described, which specifically recognize nonlymphoid cells in B cell follicles of spleen and lymph nodes. Enzyme and immunocytochemical techniques demonstrated that ED5 and ED6 stain two different types of reticulum cells. The staining patterns w...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160518
更新日期:1986-05-01 00:00:00
abstract::The expression of interleukin (IL)-1 beta, IL-6 and their respective receptors has been studied in the rat brain before and up to 24 h after injury. Messenger RNA transcripts of these four genes were detected by in situ hybridization (ISH) in different structures of the intact brain. The distribution was very similar ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221131
更新日期:1992-11-01 00:00:00
abstract::The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a publ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830110912
更新日期:1981-09-01 00:00:00
abstract::The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD4...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231049
更新日期:1993-10-01 00:00:00
abstract::Rodents are significantly less sensitive to enterotoxin-induced shock, and are thus not valid human disease models. Here, we describe a mouse strain carrying the human CD4 and human major histocompatibility complex (MHC) class II (DQ6) transgenes in an endogenous CD4- and CD8-deficient background. T lymphocytes from t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260518
更新日期:1996-05-01 00:00:00
abstract::Antigen-specific immunotherapy is an attractive strategy for cancer control. In the context of antiviral vaccines, adenoviral vectors have emerged as a favorable means for immunization. Therefore, we chose a strategy combining use of these vectors with another successful approach, namely linkage of the vaccine antigen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939543
更新日期:2009-10-01 00:00:00
abstract::Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA-DR*0401 and *0402, using mice expressing HLA-DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200203)32:3<662::AID-IMMU662>3.0
更新日期:2002-03-01 00:00:00
abstract::Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130611
更新日期:1983-06-01 00:00:00
abstract::Thymic nurse cells, cortical epithelial cells enclosing 20-200 lymphocytes, were prepared from mouse thymus by enzyme digestion and repetitive sedimentation. Individual nurse cells were then isolated free of any exogenous thymocytes by micromanipulation, and the endogeneous thymocytes released from inside the nurse ce...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830151016
更新日期:1985-10-01 00:00:00
abstract::We have analyzed the relationship between the signaling pathways coupled to surface immunoglobulin and interleukin (IL)-4 receptors in human B cells from the patterns of expression of a panel of phorbol ester-inducible early response genes (ERG) activated by anti-IgM and IL-4 stimulation in vitro. Anti-IgM stimulation...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231122
更新日期:1993-11-01 00:00:00
abstract::A novel surface molecule, Tp90, is described which appears to be involved in an antigen-independent pathway of human T lymphocyte activation. The Tp90 molecule was identified by a monoclonal antibody (mAb), MX20, obtained from a fusion using spleen cells of a mouse immunized with cells from two T cell leukemia lines, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830170616
更新日期:1987-06-01 00:00:00
abstract::Spleen cells from BALB/c mice primed with keyhole limpet hemocyanin (KLH), were stimulated with heat-killed vaccine of rough Pneumococcus pneumoniae R36A (Pn) and/or phosphorylcholine (PC)-coupled KLH to induce an anti-PC response in vitro. The response to PC-KLH was found to be T-dependent while it is T-independent t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060605
更新日期:1976-06-01 00:00:00
abstract::The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150109
更新日期:1985-01-01 00:00:00
abstract::A fraction of activated CD8+ T cells expresses CD40 ligand (CD40L), a molecule that plays a key role in T cell-dependent B cell stimulation. CD8+ T cell clones were examined for CD40L expression and for their capacity to allow the growth and differentiation of B cells, upon activation with immobilized anti-CD3. Accord...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251039
更新日期:1995-10-01 00:00:00
abstract::The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201847895
更新日期:2019-07-01 00:00:00
abstract::B cell development is dependent on both direct interactions with stromal cells and their secreted cytokines. The precise mechanisms by which these interactions regulate B cell differentiation are currently unknown. We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the ac...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260103
更新日期:1996-01-01 00:00:00
abstract::NK cells and cytotoxic T lymphocytes can induce apoptosis in virus-infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A (GrA) and B (GrB) h...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200526122
更新日期:2005-09-01 00:00:00