Persistence of autoreactive myelin oligodendrocyte glycoprotein (MOG)-specific T cell repertoires in MOG-expressing mice.

abstract：:The developmental stages and the role of protein tyrosine kinases (PTK) in the maturation of CD3+CD8 alpha alpha+ intraepithelial lymphocytes (IEL) have not been extensively characterized. However, comparisons of thymic and extrathymic T cell development indicate that these processes involve some distinct signaling an...

journal_title：European journal of immunology

authors： Page ST,van Oers NS,Perlmutter RM,Weiss A,Pullen AM

更新日期：1997-02-01 00:00:00

abstract：:Delayed hypersensitivity (DH) reaction to human Ig, corynebacterium parvum or allogeneic cells at the site of tumor cell injection, suppressed the fibrosarcoma (SCFS) growth in chickens. Spleen cells of SC chickens sensitized to human Ig or C. parvum suppressed SCFS growth when adoptively transferred with tumor cells,...

journal_title：European journal of immunology

authors： Palladino MA,Thorbecke GJ

更新日期：1978-04-01 00:00:00

abstract：:Cyclopentenone prostaglandins (CP-PG), such as prostaglandin A1 (PGA1) or 15-deoxy-Delta(12,14)-prostaglandin J2 (PGJ2), induce apoptosis in different cell types. PGJ2 is also a potent activator of the peroxisome proliferator-activated receptor-gamma (PPARgamma). We investigated whether PPARgamma regulates CP-PG-induc...

journal_title：European journal of immunology

authors： Erl W,Weber C,Zernecke A,Neuzil J,Vosseler CA,Kim HJ,Weber PC

更新日期：2004-01-01 00:00:00

abstract：:Multinucleated giant cells (MGC), which are a common feature of various pathologic states, were generated in vitro by cytokine-stimulation of human peripheral blood monocytes. As expected, conditioned medium, i.e. the supernatant of concanavalin A-stimulated peripheral blood mononuclear cells, readily caused generatio...

journal_title：European journal of immunology

authors： Möst J,Neumayer HP,Dierich MP

更新日期：1990-08-01 00:00:00

abstract：:Activated human monocytes are a source of numerous beta-chemokines. The present study was conducted to determine whether these cells produce the human beta-chemokine I-309 and to compare the induction requirements of I-309 to those of other beta-chemokines. We demonstrate that appropriately stimulated adherence-purifi...

journal_title：European journal of immunology

authors： Selvan RS,Zhou LJ,Krangel MS

更新日期：1997-03-01 00:00:00

abstract：:Lipid antigens are presented to T cells by the non-polymorphic MHC class I-related CD1 molecules. Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident chaperone that has been shown to lipidate the group 2 CD1 molecule CD1d and thus to regulate its function. We now report that MTP al...

journal_title：European journal of immunology

authors： Kaser A,Hava DL,Dougan SK,Chen Z,Zeissig S,Brenner MB,Blumberg RS

更新日期：2008-08-01 00:00:00

abstract：:The specificity and efficiency of endogenous peptides in the HLA class I binding have been investigated by the use of a simple procedure that is based on the serological detection of the folding of HLA class I alpha chains that is induced by the binding to specific peptides in the presence of beta 2 microglobulin. HLA...

journal_title：European journal of immunology

authors： Tanigaki N

更新日期：1992-08-01 00:00:00

abstract：:Human interdigitating dendritic cells (IDC) were isolated from tonsils based on their CD40+ lineage-negative expression in situ. Isolated IDC displayed a phenotypic profile similar to that of IDC in tonsils and spleen in situ, characterized by high-level expression of major histocompatibility complex class II, the co-...

journal_title：European journal of immunology

authors： Björck P,Flores-Romo L,Liu YJ

更新日期：1997-05-01 00:00:00

abstract：:The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...

journal_title：European journal of immunology

authors： Quin SJ,Seixas EM,Cross CA,Berg M,Lindo V,Stockinger B,Langhorne J

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-gamma enzyme-linked immunospot assays to evaluate CD8(+) T cell responses in antiret...

journal_title：European journal of immunology

authors： Gillespie GM,Pinheiro S,Sayeid-Al-Jamee M,Alabi A,Kaye S,Sabally S,Sarge-Njie R,Njai H,Joof K,Jaye A,Whittle H,Rowland-Jones S,Dorrell L

更新日期：2005-05-01 00:00:00

abstract：:The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engag...

journal_title：European journal of immunology

authors： Messal N,Mamessier E,Sylvain A,Celis-Gutierrez J,Thibult ML,Chetaille B,Firaguay G,Pastor S,Guillaume Y,Wang Q,Hirsch I,Nunès JA,Olive D

更新日期：2011-12-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a phospholipid mediator of anaphylaxis, released from basophils of several mammalian species, that aggregates platelets and releases their vasoactive amines. The ionophore A23 187 induced the release of PAF from rat and mouse peritoneal cells, a mixed cell population that was fracti...

journal_title：European journal of immunology

authors： Mencia-Huerta JM,Benveniste J

更新日期：1979-05-01 00:00:00

abstract：:The activating NK cell receptor NKG2D binds to numerous stress-induced cell surface glycoproteins with MHC class I-related ectodomains. In humans, NKG2D ligands (NKG2DL) are members of the MHC-encoded MIC and non-MHC-encoded ULBP families of proteins. The redundancy of NKG2DL raises questions about unique features ass...

journal_title：European journal of immunology

authors： Wittenbrink M,Spreu J,Steinle A

更新日期：2009-06-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:Induction of optimal HIV-1-specific T-cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and presentation processes occurring in DCs. Opsonization can influence the routing of antigen processing and pathways used for presentation. We studied antigen proteolysis a...

journal_title：European journal of immunology

authors： Tjomsland V,Ellegård R,Burgener A,Mogk K,Che KF,Westmacott G,Hinkula J,Lifson JD,Larsson M

更新日期：2013-06-01 00:00:00

abstract：:Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...

journal_title：European journal of immunology

authors： Lohoff M,Dirks M,Rohwer P,Röllinghoff M

更新日期：1989-01-01 00:00:00

abstract：:The germ-line V gene segments encoding the subgroups A and G of the BALB/c V kappa 21 family were cloned and assigned to the previously described 30-kb cluster of the V kappa 21 family. Sequence comparison revealed close homology between the two gene segments at the DNA and the predicted amino acid sequence level, ind...

journal_title：European journal of immunology

authors： Alanen A,Weiss S

更新日期：1989-10-01 00:00:00

abstract：:An effective immune response against the intracellular pathogen Mycobacterium tuberculosis is strictly dependent on T cell activation. Although this protective response mainly depends on local release of pro-inflammatory cytokines by Th1 CD4(+) T cells, contribution of Vgamma9 / Vdelta2 T lymphocytes to immune protect...

journal_title：European journal of immunology

authors： Dieli F,Troye-Blomberg M,Ivanyi J,Fournié JJ,Bonneville M,Peyrat MA,Sireci G,Salerno A

更新日期：2000-05-01 00:00:00

abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

journal_title：European journal of immunology

authors： Brandstadter JD,Huang X,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:Hematopoietic development is a delicate balance of cell fate decisions in multipotent cells between self-renewal and differentiation. In multiple developmental systems, the Notch receptors are important factors regulating these processes. Hematopoietic progenitor cells have been shown to express Notch1, and studies wi...

journal_title：European journal of immunology

authors： Jönsson JI,Xiang Z,Pettersson M,Lardelli M,Nilsson G

更新日期：2001-11-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a member of the immunoglobulin gene superfamily (IgSF) which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. Herein, we report on the isolation and characterization of cDNA clones encoding mous...

journal_title：European journal of immunology

authors： Bowen MA,Bajorath J,D'Egidio M,Whitney GS,Palmer D,Kobarg J,Starling GC,Siadak AW,Aruffo A

更新日期：1997-06-01 00:00:00

abstract：:The antigen receptor of the T lymphocytes is one of the most complex eukaryotic membrane structures studied to date. The T cell receptor (TcR) consists of two disulfide-linked glycoprotein chains (alpha/beta or gamma/delta) and is noncovalently associated with a group of small and invariable CD 3 proteins. Four CD 3 c...

journal_title：European journal of immunology

authors： Clevers H,Dunlap S,Terhorst C

更新日期：1988-05-01 00:00:00

abstract：:The human type I interferon (IFN) receptor was characterized by ligand blotting. In this method, plasmalemma proteins or detergent-lysed whole-cell extracts from human Burkitt lymphoma cell lines were separated on polyacrylamide gels and subsequently transferred onto nitrocellulose sheets. Probing the blots with 3 x 1...

journal_title：European journal of immunology

authors： Schwabe M,Princler GL,Faltynek CR

更新日期：1988-12-01 00:00:00

abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

journal_title：European journal of immunology

authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

更新日期：1993-10-01 00:00:00

abstract：:The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

journal_title：European journal of immunology

authors： Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

更新日期：2019-06-01 00:00:00

abstract：:Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. ...

journal_title：European journal of immunology

authors： Zhang MX,Zheng HY,Jiang J,Song JH,Chen M,Xiao Y,Lian XD,Song TZ,Tian RR,Pang W,Zheng YT

更新日期：2018-02-01 00:00:00

abstract：:Using limiting dilution analysis, we investigated proliferative responses of UCHL1+ and UCHL1- T cell populations to compare the precursor cell frequencies following recall and alloantigen stimulation, and the complexity of cellular interactions within UCHL1+ and UCHL1- populations. We find high frequencies of recall ...

journal_title：European journal of immunology

authors： Merkenschlager M,Terry L,Edwards R,Beverley PC

更新日期：1988-11-01 00:00:00

abstract：:F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

journal_title：European journal of immunology

authors： Robertson K,Simon K,Schneider S,Timms E,Mitchison A

更新日期：1992-01-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. Transcripts of most cytokines contain adenylate-uridylate (A/U)-rich e...

journal_title：European journal of immunology

authors： Herdy B,Karonitsch T,Vladimer GI,Tan CS,Stukalov A,Trefzer C,Bigenzahn JW,Theil T,Holinka J,Kiener HP,Colinge J,Bennett KL,Superti-Furga G

更新日期：2015-05-01 00:00:00