Abstract:
:Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during stimulation of the B cells by activated T cells, can be mediated by a mechanism other than cognate interaction. This conclusion is derived from experiments in which highly purified, small B cells of high density were polyclonally stimulated by L1/1 T cells triggered by an anti-T3 monoclonal antibody in the absence of antigen. The triggering process was independent of the presence of the Fc part of the antibody and occurred in cultures devoid of macrophages. Thus, the well-established cognate recognition does not appear to be the only mechanism of B cell induction by T helper cells.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Lohoff M,Dirks M,Rohwer P,Röllinghoff Mdoi
10.1002/eji.1830190113subject
Has Abstractpub_date
1989-01-01 00:00:00pages
77-81issue
1eissn
0014-2980issn
1521-4141journal_volume
19pub_type
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