Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide.

abstract：:To delineate the extent of O-galactosyltransferase deficiency within the lymphoid lineage, monoclonal antibody specific for the Thomsen-Friedenreich (TF) antigen (Gal beta 1----3GalNAc alpha 1-O-Ser/Thr) and its precursor the Tn antigen (GalNAc alpha 1-O-Ser/Thr) were applied to the flow cytometric analysis of periphe...

journal_title：European journal of immunology

authors： Thurnher M,Clausen H,Fierz W,Lanzavecchia A,Berger EG

更新日期：1992-07-01 00:00:00

abstract：:Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...

journal_title：European journal of immunology

authors： van den Ham HJ,de Waal L,Zaaraoui-Boutahar F,Bijl M,van Ijcken WF,Osterhaus AD,de Boer RJ,Andeweg AC

更新日期：2013-04-01 00:00:00

abstract：:IgG complexes bind to Fc receptor family members FcgammaRI (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16), activating cell MAPK and PI3K resulting in increased cytokine production from particular leukocytes. The signaling molecules involved in cytokine production after cross-linking CD16 have not been determined in ...

journal_title：European journal of immunology

authors： Kramer PR,Winger V,Reuben J

更新日期：2009-02-01 00:00:00

abstract：:In the murine system, we tested in vivo the immunogenicity of different preparations of the yeast-derived surface antigen (S-antigen or S-protein) of hepatitis B virus (HBV). Native S-protein molecules self-assemble into stable 22-nm particles. BALB/c mice immunized with low doses of native S-particles without adjuvan...

journal_title：European journal of immunology

authors： Schirmbeck R,Melber K,Mertens T,Reimann J

更新日期：1994-05-01 00:00:00

abstract：:Similar idiotopes are detected on anti-allotypic antibodies synthesized by all rabbits immunized against the b6 allotype. The expression of similar idiotypes on anti-b6 antibodies has been found in rabbits of all VHa allotypic types thus far studies. For their expression, these idiotypes require the interaction betwee...

journal_title：European journal of immunology

authors： Roland J,Cazenave PA

更新日期：1981-06-01 00:00:00

abstract：:Ig class switch recombination (CSR) is dependent upon the expression of activation-induced deaminase and targeted to specific isotypes by germ-line transcript expression and isotype-specific factors. NF-kappaB plays critical roles in multiple aspects of B cell biology and has been implicated in the mechanism of CSR by...

journal_title：European journal of immunology

authors： Wang L,Wuerffel R,Kenter AL

更新日期：2006-12-01 00:00:00

abstract：:Precursor CD4-CD8- (DN) thymocytes rearrange their TCR-beta genes, and only those which succeed in beta-selection subsequently expand and differentiate into immature CD4+CD8+ (DP) thymocytes. The cell subsets corresponding to the successive steps of this transition can be defined in terms of CD44 and CD25 expression. ...

journal_title：European journal of immunology

authors： Vasseur F,Le Campion A,Pénit C

更新日期：2001-10-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:T helper cell type 2 (Th2) cells when triggered by antibodies to CD3 acquire the capacity to stimulate the polyclonal proliferation of syngeneic, resting B cells. Here, we tested the ability of various monoclonal antibodies (mAb) to block the B cell proliferation-inducing potential of such activated Th2 cells. We demo...

journal_title：European journal of immunology

authors： Lohoff M,Koch A,Röllinghoff M

更新日期：1992-02-01 00:00:00

abstract：:Cholesterol- and sphingolipid-rich membrane microdomains termed lipid rafts appear to play a central role in B cell activation. In mature B cells, signaling through the B cell antigen receptor(BCR) is initiated from within rafts and leads to activation. In immature B cells, the BCR is excluded from rafts and signaling...

journal_title：European journal of immunology

authors： Malapati S,Pierce SK

更新日期：2001-12-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the tra...

journal_title：European journal of immunology

authors： Schweier O,Hofmann M,Pircher H

更新日期：2014-06-01 00:00:00

abstract：:Haemophilus influenzae type b capsular polysaccharide (PRP) conjugate vaccines, which are thought to induce T cell-dependent antibody production, induce protective responses after a single dose in individuals under 15 months of age. However, multiple doses of these vaccines are required to induce protective antibody r...

journal_title：European journal of immunology

authors： Pérez-Melgosa M,Ochs HD,Linsley PS,Laman JD,van Meurs M,Flavell RA,Ernst RK,Miller SI,Wilson CB

更新日期：2001-08-01 00:00:00

abstract：:In rheumatoid arthritis (RA), T cells in the inflamed joint are considered to play a crucial role in the pathogenesis. However, despite the fact that synovial T cells have an activated memory phenotype, they are functionally suppressed upon combined CD3 and CD28 stimulation. Here, we analyzed the contribution of both ...

journal_title：European journal of immunology

authors： Maurice MM,van der Voort EA,Leow A,Levarht N,Breedveld FC,Verweij CL

更新日期：1998-05-01 00:00:00

abstract：:The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X ...

journal_title：European journal of immunology

authors： Gleichmann E,Peters K,Lattmann E,Gleichmann H

更新日期：1976-06-01 00:00:00

abstract：:T cell clones of C57BL/6 origin which recognize porcine lactate dehydrogenase B (LDH-BP) together with the Ab molecule were characterized in terms of fine specificity for both LDH-B and self-major histocompatibility complex determinants. Using antigen-presenting cells from the Ab-mutant strain B6.C-H-2bm12 (bm12), thr...

journal_title：European journal of immunology

authors： Nagy ZA,Servis C,Walden P,Klein J,Goldberg E

更新日期：1985-08-01 00:00:00

abstract：:Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays an important role in regulating the local inflammatory immune response, but regulatory mechanisms of this cytokine have not been fully elucidated. Here, we demonstrate that IL-10 deficiency renders LPS treatment ineffective in regulating the expression...

journal_title：European journal of immunology

authors： Zhou F,Ciric B,Li H,Yan Y,Li K,Cullimore M,Lauretti E,Gonnella P,Zhang GX,Rostami A

更新日期：2012-06-01 00:00:00

abstract：:TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory responses by C5aR, suggesting crosstalk between TLRs and C5aR. However,...

journal_title：European journal of immunology

authors： Raby AC,Holst B,Davies J,Colmont C,Laumonnier Y,Coles B,Shah S,Hall J,Topley N,Köhl J,Morgan BP,Labéta MO

更新日期：2011-09-01 00:00:00

abstract：:Expression of activation markers and proliferative status were measured in peripheral CD4+ and CD8+ T cells of various T cell receptor (TCR)-transgenic mice either before or after intentional antigenic stimulation. In the absence of intentional immunization, CD4+ T cells persisted as resting or partially activated and...

journal_title：European journal of immunology

authors： Bruno L,von Boehmer H,Kirberg J

更新日期：1996-12-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD4...

journal_title：European journal of immunology

authors： Gabriel H,Schmitt B,Kindermann W

更新日期：1993-10-01 00:00:00

abstract：:Terminal differentiation of B cells into antibody-secreting cells is the foundation of humoral immune response. B-1 cells, which are different from B-2 cells, preferentially differentiate into plasma cells. CMTM7 is a MARVEL-domain-containing membrane protein predominantly expressed in B cells that plays an important ...

journal_title：European journal of immunology

authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

更新日期：2020-06-01 00:00:00

abstract：:Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...

journal_title：European journal of immunology

authors： Tschopp J,Villiger W,Lustig A,Jaton JC,Engel J

更新日期：1980-07-01 00:00:00

abstract：:The desire to induce HIV-1-specific responses soon after birth to prevent breast milk transmission of HIV-1 led us to propose a vaccine regimen which primes HIV-1-specific T cells using a recombinant Mycobacterium bovis bacillus Calmette-Guérin (rBCG) vaccine. Because attenuated live bacterial vaccines are typically n...

journal_title：European journal of immunology

authors： Hopkins R,Bridgeman A,Bourne C,Mbewe-Mvula A,Sadoff JC,Both GW,Joseph J,Fulkerson J,Hanke T

更新日期：2011-12-01 00:00:00

abstract：:We previously showed that topical flagellin induces profound mucosal innate protection in the cornea against microbial infection, a response involving multiple genes and cell types. In this study, we used a Candida albicans (CA)-C57BL/6 mouse keratitis model to delineate the contribution of CXCL10- and CXCR3-expressin...

journal_title：European journal of immunology

authors： Liu X,Gao N,Dong C,Zhou L,Mi QS,Standiford TJ,Yu FS

更新日期：2014-09-01 00:00:00

abstract：:Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...

journal_title：European journal of immunology

authors： Blankenstein T,Krawinkel U

更新日期：1987-09-01 00:00:00

abstract：:The murine T cell response to heterologous insulins provides a good model system for studying the mechanism of immune response (Ir)-gene function, since insulin is a small, chemically well-defined molecule. H-2b mice respond predominantly to A chain loop determinants of beef insulin, presented by the I-A epitope Ia. W...

journal_title：European journal of immunology

authors： Huber BT,Hochman PS

更新日期：1984-12-01 00:00:00

abstract：:5'-Nucleotidase/CD73 is a key enzyme in the regulation of purinergic signaling, hydrolyzing extracellular AMP to produce adenosine, which is critical in the blood vascular system and in immunosuppression. CD73 is expressed by both blood endothelial cells and lymphatic endothelial cells. Although the role of CD73 on bl...

journal_title：European journal of immunology

authors： Sidibé A,Imhof BA

更新日期：2015-02-01 00:00:00

abstract：:Human Vgamma9Vdelta2 T cells contribute to immunity against intracellular pathogens and recognize nonpeptidic antigens, such as the mycobacterial phosphoantigen TUBAg. HIV infection is associated with a polyclonal decrease of peripheral Vgamma9Vdelta2 T cells and we previously reported that the remaining cells show a ...

journal_title：European journal of immunology

authors： Boullier S,Poquet Y,Debord T,Fournie JJ,Gougeon ML

更新日期：1999-01-01 00:00:00

abstract：:Previous studies have demonstrated that immunization of BALB/c mice with alpha(1----3) dextran (Dex) is accompanied by a reduction in the subsequent immune response to the acetylcholine receptor (AChR), depending on the timing of the Dex administration relative to AChR challenge. Here, we report that suppression of th...

journal_title：European journal of immunology

authors： Tong Z,Dwyer DS

更新日期：1990-08-01 00:00:00

abstract：:Dopamine by itself has not up to now been reported to activate T cell function. We show here that dopamine interacts directly with dopaminergic receptors on normal human T cells and triggers beta1 integrin-mediated T cell adhesion to a major extracellular matrix component, fibronectin (FN). Such adhesion is a characte...

journal_title：European journal of immunology

authors： Levite M,Chowers Y,Ganor Y,Besser M,Hershkovits R,Cahalon L

更新日期：2001-12-01 00:00:00