The influence of CD40 on the association of the B cell antigen receptor with lipid rafts in mature and immature cells.

abstract：:Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...

journal_title：European journal of immunology

authors： Kato A,Takaori-Kondo A,Minato N,Hamazaki Y

更新日期：2018-10-01 00:00:00

abstract：:The thymus is the primary organ for T-cell differentiation and maturation. Unlike other major organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost complete atrophy followed by rapid restoration. The process of thymic atrophy, or involution, results in decreased thymopoiesis and emigrat...

journal_title：European journal of immunology

authors： Dooley J,Liston A

更新日期：2012-05-01 00:00:00

abstract：:Strains CBA (M523) (= M523) and CBA differ by a mutation which has been mapped genetically into the K region of the H-2 complex. Similarly, strains B 10.D2 (M504 (= M504) and b 10.D2 differ in a mutation which occurred in the D region. The data presented in this study show that mixed lymphocyte culture in M523 anti-CB...

journal_title：European journal of immunology

authors： Geib RW,Klein J

更新日期：1979-02-01 00:00:00

abstract：:We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixture of APC from bot...

journal_title：European journal of immunology

authors： Chai JG,Tsang JY,Lechler R,Simpson E,Dyson J,Scott D

更新日期：2002-08-01 00:00:00

abstract：:ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significa...

journal_title：European journal of immunology

authors： Klein C,Wüstefeld T,Heinrich PC,Streetz KL,Manns MP,Trautwein C

更新日期：2003-08-01 00:00:00

abstract：:We have studied the role of murine eosinophils as antigen-presenting cells (APC). Eosinophils have several characteristics that support the hypothesis of its function as potential APC: they have phagocytic capacity, express adhesion molecules and major histocompatibility complex (MHC) class II antigens and can produce...

journal_title：European journal of immunology

authors： Del Pozo V,De Andrés B,Martín E,Cárdaba B,Fernández JC,Gallardo S,Tramón P,Leyva-Cobian F,Palomino P,Lahoz C

更新日期：1992-07-01 00:00:00

abstract：:The inheritance of responsiveness to lipopolysaccharide (LPS), and of a marker recognized in LPS-reactive cells by a heterologous antiserum, was studied in crosses between C3H/HeJ (nonresponder) and C3H/Tif (high responder) mice. F1 hybrid mice show codominant expression of these traits: (a) LPS-reactive cells are onl...

journal_title：European journal of immunology

authors： Coutinho A,Forni L,Watanabe T

更新日期：1978-01-01 00:00:00

abstract：:The elevated interleukin (IL)-4 and IgE production in Schistosoma mansoni infection seems to be induced essentially by the egg stage of the parasite. The underlying mechanism, however, is not known. Since basophils from human peripheral blood can produce IL-4, we asked, whether soluble S. mansoni egg antigens (SEA) wo...

journal_title：European journal of immunology

authors： Falcone FH,Dahinden CA,Gibbs BF,Noll T,Amon U,Hebestreit H,Abrahamsen O,Klaucke J,Schlaak M,Haas H

更新日期：1996-05-01 00:00:00

abstract：:By combining velocity and linear density fractionations as well as target cell rosetting techniques we have isolated and morphologically identified the human effector cell type responsible for spontaneous, trypsin-augmentable cytotoxicity against chicken red cells and human myeloma cell line targets. This cell is a la...

journal_title：European journal of immunology

authors： Saksela E,Häyry P,Andersson LC

更新日期：1977-11-01 00:00:00

abstract：:The spleen is anatomically and functionally divided into two compartments: the red pulp, where particles are effectively removed from the blood, and the white pulp, where specific immune responses are generated. Here the isolation of white pulp from red pulp is described, allowing a detailed analysis of the cellular c...

journal_title：European journal of immunology

authors： Nolte MA,Hoen EN,van Stijn A,Kraal G,Mebius RE

更新日期：2000-02-01 00:00:00

abstract：:Human CD8(+) T cells are functionally heterogeneous and can be divided into phenotypically and functionally distinct subsets according to CCR7 and CD45RA expression levels. Among these, CCR7(low) CD45RA(low) effector memory CD8(+) T cells (Tem) and CCR7(low) CD45RA(high) CD8(+) T cells, which are designated as Temra a...

journal_title：European journal of immunology

authors： Setoguchi R,Matsui Y,Mouri K

更新日期：2015-03-01 00:00:00

abstract：:MHC class I molecules are important components of immune surveillance. There are no available methods to directly visualize and determine the quantity and distribution of MHC/peptide complexes on individual cells or to detect such complexes on antigen-presenting cells in tissues. MHC-restricted recombinant antibodies ...

journal_title：European journal of immunology

authors： Epel M,Carmi I,Soueid-Baumgarten S,Oh S,Bera T,Pastan I,Berzofsky J,Reiter Y

更新日期：2008-06-01 00:00:00

abstract：:The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancing the average affinity of the antibodies produced. The molecular mechanism underlying these B cell hypermutations remains ...

journal_title：European journal of immunology

authors： Wu H,Pelkonen E,Knuutila S,Kaartinen M

更新日期：1995-12-01 00:00:00

abstract：:Aggregation of the human high-affinity receptor for immunoglobulin G, FcgammaRI, results in initiation of intracellular signaling cascades. However, as the receptor contains no known signaling motif, it is required to recruit an accessory molecule. The gamma chain has been proposed to fulfil this role. Here, we show t...

journal_title：European journal of immunology

authors： Cameron AJ,Harnett MM,Allen JM

更新日期：2001-09-01 00:00:00

abstract：:The effector function of activated CD4(+) T cells and secretion of cytokines are important in the establishment of productive immune responses and tolerance. We identified expression by CD4(+) T cells of Notch receptors and ligands and enhanced Notch signaling upon activation. Notch1 expression was up regulated and co...

journal_title：European journal of immunology

authors： Benson RA,Adamson K,Corsin-Jimenez M,Marley JV,Wahl KA,Lamb JR,Howie SE

更新日期：2005-03-01 00:00:00

abstract：:Disseminated infections by the opportunistic yeast Cryptococcus neoformans are characterized by accumulation in tissues of glucuronoxylomannan (GXM), the major component of the capsular polysaccharide. We investigated binding, uptake, and disposal of GXM by peripheral blood neutrophils and monocytes, and the effect of...

journal_title：European journal of immunology

authors： Monari C,Retini C,Casadevall A,Netski D,Bistoni F,Kozel TR,Vecchiarelli A

更新日期：2003-04-01 00:00:00

abstract：:GITR (glucocorticoid-induced TNFR family related gene) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes. Because of a high homology in its cytoplasmic region with other known costimulatory members of the TNFRSF, we investigated whether GITR played a costim...

journal_title：European journal of immunology

authors： Ronchetti S,Zollo O,Bruscoli S,Agostini M,Bianchini R,Nocentini G,Ayroldi E,Riccardi C

更新日期：2004-03-01 00:00:00

abstract：:A number of applications of antibodies in diagnosis and therapy require multivalent reagents either because of the polymeric nature of the antigens or because biological activity depends on an effect on the formation of homodimeric species. Here, we report a procedure for mass screening of phage-derived monomeric anti...

journal_title：European journal of immunology

authors： Zaccolo M,Griffiths AP,Prospero TD,Winter G,Gherardi E

更新日期：1997-03-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) recognize antigenic peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of target cells. Optimal induction of CD8+ CTL depends on the amount of relevant peptide/MHC-I complexes and the presence of co-stimulatory molecules on antigen-presenting c...

journal_title：European journal of immunology

authors： Bellone M,Iezzi G,Manfredi AA,Protti MP,Dellabona P,Casorati G,Rugarli C

更新日期：1994-11-01 00:00:00

abstract：:Dendritic cells (DC) are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses. Characterization of DC-specific genes may help to unravel the mechanism underlying their potent antigen presenting capacity. Here we describe the identification...

journal_title：European journal of immunology

authors： Hartgers FC,Vissers JL,Looman MW,van Zoelen C,Huffine C,Figdor CG,Adema GJ

更新日期：2000-12-01 00:00:00

abstract：:Spontaneous apoptosis in germinal center (GC) B cells can be arrested either by engaging cell surface immunoglobulin (Ig) with immobilized ligand or, more effectively, by treatment with soluble monoclonal antibody (mAb) directed against CD40. The present study examines the intracellular signal transduction pathways th...

journal_title：European journal of immunology

authors： Knox KA,Gordon J

更新日期：1993-10-01 00:00:00

abstract：:In M54 mice transgenic for a completely rearranged mu(a) heavy chain there is a decrease in total B cells and the rearrangement of endogenous immunoglobulin genes is partially inhibited. Surprisingly, however, endogenous immunoglobulin gene rearrangement and significant heavy chain polypeptide production does occur. W...

journal_title：European journal of immunology

authors： Rabin E,Cong Y,Imanishi-Kari T,Wortis HH

更新日期：1992-09-01 00:00:00

abstract：:Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...

journal_title：European journal of immunology

authors： Schlunck T,Schraut W,Riethmüller G,Ziegler-Heitbrock HW

更新日期：1990-09-01 00:00:00

abstract：:Rodents are significantly less sensitive to enterotoxin-induced shock, and are thus not valid human disease models. Here, we describe a mouse strain carrying the human CD4 and human major histocompatibility complex (MHC) class II (DQ6) transgenes in an endogenous CD4- and CD8-deficient background. T lymphocytes from t...

journal_title：European journal of immunology

authors： Yeung RS,Penninger JM,Kündig T,Khoo W,Ohashi PS,Kroemer G,Mak TW

更新日期：1996-05-01 00:00:00

abstract：:The pathogenesis of immune-mediated drug-induced liver injury (DILI) following halogenated anesthetics, carbamazepine or alcohol has not been fully elucidated. Detecting cytochrome P450 2E1 (CYP2E1) IgG4 auto-antibodies in anesthetic DILI patients suggests a role for IL-4 in this hapten-mediated process. We investigat...

journal_title：European journal of immunology

authors： Njoku DB,Li Z,Washington ND,Mellerson JL,Talor MV,Sharma R,Rose NR

更新日期：2009-06-01 00:00:00

abstract：:Naturally activated T lymphocytes present in normal mouse spleen were studied for direct reactivity to interleukin 2 (IL 2) and for binding of anti-IL 2 receptor (IL 2R) antibodies or radiolabeled IL 2. The majority of large-sized splenic T lymphocytes are IL 2R-; thus, at the most one third of large L3T4+ T cells and...

journal_title：European journal of immunology

authors： Bandeira A,Larsson EL,Forni L,Pereira P,Coutinho A

更新日期：1987-07-01 00:00:00

abstract：:The CD38 antigen displays restricted functional associations with surface molecules involved in immune system and complement. Capping of the CD38 molecule in normal or neoplastic T cells is followed by rapid and specific co-modulation of the CD3-T cell receptor (TcR) complex. In normal and tumor cells of B lineage, CD...

journal_title：European journal of immunology

authors： Funaro A,De Monte LB,Dianzani U,Forni M,Malavasi F

更新日期：1993-10-01 00:00:00

abstract：:In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...

journal_title：European journal of immunology

authors： Horvat B,Loukides JA,Anandan L,Brewer E,Flood PM

更新日期：1991-08-01 00:00:00

abstract：:The capacity of bone marrow-derived surface immunoglobulin-positive (sIg+) human and mouse immature B cells, generated either in vitro or in vivo, to change their light (L) chain expression, has been assayed by the number of cells which change in vitro from one type of L chain to the other type, or to no sIg at all. I...

journal_title：European journal of immunology

authors： Ghia P,Gratwohl A,Signer E,Winkler TH,Melchers F,Rolink AG

更新日期：1995-11-01 00:00:00

abstract：:The influence of muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1-mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5-mg dose administered on days 3, 2, 1 prior ...

journal_title：European journal of immunology

authors： Zídek Z,Capková J,Boubelík M,Masek K

更新日期：1983-10-01 00:00:00