Differences in outcome of the interaction between Cryptococcus neoformans glucuronoxylomannan and human monocytes and neutrophils.

abstract：:A human IgE-producing myeloma has been cultivated in vitro as a continuous cell line (U-266) since 1968. Analysis of immunoglobulin production during early passages of the cell line demonstrated a high synthesis rate of monoclonal IgE. Analysis of late passages, cultivated after 1980, revealed a 3-6-fold lower rate of...

journal_title：European journal of immunology

authors： Hellman L,Josephson S,Jernberg H,Nilsson K,Pettersson U

更新日期：1988-06-01 00:00:00

abstract：:CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...

journal_title：European journal of immunology

authors： Suzuki H,Onishi H,Wada J,Yamasaki A,Tanaka H,Nakano K,Morisaki T,Katano M

更新日期：2010-01-01 00:00:00

abstract：:Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

journal_title：European journal of immunology

authors： Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

更新日期：1988-07-01 00:00:00

abstract：:Hypersensitivity to nickel (Ni) represents the most common manifestation of contact allergy in humans. The role of metal-specific T cells in this disease is well established, but the molecular interactions involved in their activation are poorly understood. We examined the T cell receptor (TCR) repertoire in T cells a...

journal_title：European journal of immunology

authors： Vollmer J,Fritz M,Dormoy A,Weltzien HU,Moulon C

更新日期：1997-08-01 00:00:00

abstract：:Previous studies from our laboratory have shown that prolonged exposure of mouse macrophages to IFN-beta interferes with their subsequent ability to become activated for tumor cell killing. Data reported here show that such inhibition is due to reduced production of NO, resulting from decreased transcription of the ge...

journal_title：European journal of immunology

authors： Gao JJ,Filla MB,Lorsbach RB,Pace JL,Crespo A,Russell SW,Murphy WJ

更新日期：2000-06-01 00:00:00

abstract：:Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the immune response of the majority of these patients is not sufficient to prevent the growth and spread of their tumors. That tumor cells can be killed in vitro by tumor-reactive cytotoxic T cells is testimony to the fact tha...

journal_title：European journal of immunology

authors： Legler DF,Johnson-Léger C,Wiedle G,Bron C,Imhof BA

更新日期：2004-06-01 00:00:00

abstract：:Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

journal_title：European journal of immunology

authors： Webb LM,Walmsley MJ,Feldmann M

更新日期：1996-10-01 00:00:00

abstract：:Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...

journal_title：European journal of immunology

authors： Hoppstädter J,Diesel B,Eifler LK,Schmid T,Brüne B,Kiemer AK

更新日期：2012-05-01 00:00:00

abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...

journal_title：European journal of immunology

authors： Esche C,Cai Q,Peron JM,Hunter O,Subbotin VM,Lotze MT,Shurin MR

更新日期：2000-09-01 00:00:00

abstract：:Interleukin-HP1 (HP1) is a murine T cell-derived lymphokine, originally described as a growth factor for B cell hybridomas and plasmacytomas, that was recently shown to stimulate growth and differentiation of normal B and T lymphocytes. Here, we describe a cDNA for HP1 that was isolated from a library prepared using m...

journal_title：European journal of immunology

authors： Van Snick J,Cayphas S,Szikora JP,Renauld JC,Van Roost E,Boon T,Simpson RJ

更新日期：1988-02-01 00:00:00

abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

journal_title：European journal of immunology

authors： Ashman RF

更新日期：1976-06-01 00:00:00

abstract：:MHC-peptide-specific Fab antibodies binding to HLA-A*0201 complexes presenting the wild-type EAAGIGILTV (EAA) or analogue Melan-A 10-mer ELAGIGILTV (ELA) peptide were generated to study efficacy of peptide processing and presentation. None of the selected Fab antibodies detected the naturally processed EAA/HLA-A*0201 ...

journal_title：European journal of immunology

authors： Held G,Wadle A,Dauth N,Stewart-Jones G,Sturm C,Thiel M,Zwick C,Dieckmann D,Schuler G,Hoogenboom HR,Lévy F,Cerundolo V,Pfreundschuh M,Renner C

更新日期：2007-07-01 00:00:00

abstract：:To define activation-specific sequences in human T lymphocytes, a cDNA library was constructed by subtractive hybridization using resting and stimulated peripheral blood lymphocyte pairs. Stimulation of peripheral blood lymphocytes was achieved by triggering with mitogenic anti-CD2 (T11) monoclonal antibodies. Differe...

journal_title：European journal of immunology

authors： Chang HC,Reinherz EL

更新日期：1989-06-01 00:00:00

abstract：:The receptor for the iC3b fragment of complement, CR3, is involved in monocytes/macrophages and neutrophils phagocytosis. CR3 is known to interact with the low affinity receptor for Ig (CD16) and previous studies have suggested that this cooperation modulates CR3 functions. Herein we have studied the effect of CD16 on...

journal_title：European journal of immunology

authors： Preynat-Seauve O,Villiers CL,Jourdan G,Richard MJ,Plumas J,Favier A,Marche PN,Favrot MC

更新日期：2004-01-01 00:00:00

abstract：:The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...

journal_title：European journal of immunology

authors： Quin SJ,Seixas EM,Cross CA,Berg M,Lindo V,Stockinger B,Langhorne J

更新日期：2001-01-01 00:00:00

abstract：:The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short-term homing experiments in cobra venom factor (CoF)-treated animals. The localization ratio of B and T cells in the spleen of CoF-treated mice decreased significantly compared to control recipients. No c...

journal_title：European journal of immunology

authors： Kraal G,Van Hoogstraten I,Klerx JP,Van Dijk H

更新日期：1985-07-01 00:00:00

abstract：:We have investigated the complexity of the human gamma delta T cell repertoire by means of a VJ heteroduplex analysis method. cDNA obtained from peripheral blood mononuclear cells was amplified with V delta 1-C delta or V delta 2-C delta primers. The product was denatured and renatured to allow random reannealing of t...

journal_title：European journal of immunology

authors： Giachino C,Granziero L,Modena V,Maiocco V,Lomater C,Fantini F,Lanzavecchia A,Migone N

更新日期：1994-08-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

journal_title：European journal of immunology

authors： Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

更新日期：1993-07-01 00:00:00

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:Adaptive immune responses have long been considered the "territory" of antigenic proteins, whereas carbohydrates are characterized as T-cell-independent antigens that are not typically recognized by the complete adaptive machinery. The current modus operandi when searching for dominant epitopes is the use of synthetic...

journal_title：European journal of immunology

authors： Cobb BA,Kasper DL

更新日期：2005-02-01 00:00:00

abstract：:The regulation of neutrophil half-life by members of the coagulation cascade is critical for the resolution of the inflammatory response. We have demonstrated that soluble fibrinogen (sFbg) delays human neutrophil (PMN) apoptosis through a mechanism that involves CD11b interactions, and phosphorylation of focal adhesi...

journal_title：European journal of immunology

authors： Rubel C,Gómez S,Fernández GC,Isturiz MA,Caamaño J,Palermo MS

更新日期：2003-05-01 00:00:00

abstract：:The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancing the average affinity of the antibodies produced. The molecular mechanism underlying these B cell hypermutations remains ...

journal_title：European journal of immunology

authors： Wu H,Pelkonen E,Knuutila S,Kaartinen M

更新日期：1995-12-01 00:00:00

abstract：:The MOPC460 idiotype is expressed in mice with the IghCa allotypic haplotype after anti-2,4-dinitrophenyl (DNP) immunization. We have previously shown that two monoclonal syngeneic anti-idiotypic antibodies (IDM 92-13 and IDM 41-27) define two distinct idiotopes (the 460.92 and the 460.41) on the M460 idiotype. The cu...

journal_title：European journal of immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1983-12-01 00:00:00

abstract：:Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...

journal_title：European journal of immunology

authors： Schirmbeck R,Böhm W,Reimann J

更新日期：1997-08-01 00:00:00

abstract：:Regulatory T (Treg) cells are critically important for the maintenance of immunological tolerance. Both centrally arising natural nTreg cells and those emerging in the periphery in response to TGF-β, iTreg cells, play a role in the control of unwanted immune responses. Treg cells adopt multiple mechanisms to inhibit e...

journal_title：European journal of immunology

authors： Chen Y,Adams E,Regateiro FS,Vaux DJ,Betz AG,Andersen KG,Waldmann H,Howie D

更新日期：2012-06-01 00:00:00

abstract：:The effect of fractionated total lymphoid irradiation (TLI) on the maturation of B cells was examined in mice. At various times after irradiation of the mice, their spleen cells were tested for the mitogenic responses to dextran sulfate and lipopolysaccharide. In parallel the cells were stained with fluorescent anti-T...

journal_title：European journal of immunology

authors： Zan-Bar I

更新日期：1983-01-01 00:00:00

abstract：:The importance of human herpesvirus 6 (HHV-6) species as human pathogens is increasingly appreciated. However, we do not understand how infection is controlled in healthy virus carriers, and why control fails in patients with disease. Other persistent viruses are under continuous surveillance by antigen-specific T cel...

journal_title：European journal of immunology

authors： Martin LK,Schub A,Dillinger S,Moosmann A

更新日期：2012-11-01 00:00:00

abstract：:We have proposed earlier that the poor capacity of the lipocalin allergen Bos d 2 to stimulate highly allergic subjects' peripheral blood mononuclear cells could be ascribed to endogenous lipocalins and could be related to the allergenic potential of the molecule. Here, we have characterized the proliferative and cyto...

journal_title：European journal of immunology

authors： Kinnunen T,Buhot C,Närvänen A,Rytkönen-Nissinen M,Saarelainen S,Pouvelle-Moratille S,Rautiainen J,Taivainen A,Maillère B,Mäntyjärvi R,Virtanen T

更新日期：2003-06-01 00:00:00

abstract：:Several groups have described that a low percentage of in vitro cultured T cell receptor (TcR) gamma/delta cells express CD8. Contrary to TcR alpha/beta cells, however, CD8 on these TcR gamma/delta cells was shown to be a CD8 alpha homodimer. We describe here that addition of interleukin-7 (IL-7) to a short-term in vi...

journal_title：European journal of immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1992-09-01 00:00:00