An interaction between CD16 and CR3 enhances iC3b binding to CR3 but is lost during differentiation of monocytes into dendritic cells.

abstract：:FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a ric...

journal_title：European journal of immunology

authors： Aldridge A,O'Neill SM

更新日期：2016-05-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II-associated antigen presentation is mainly linked to processing of exogenous antigens upon cellular uptake by endocytosis, but has also been observed for endogenously synthesized antigens. We have studied the MHC class II-associated presentation of the endogenously synthe...

journal_title：European journal of immunology

authors： Oxenius A,Bachmann MF,Ashton-Rickardt PG,Tonegawa S,Zinkernagel RM,Hengartner H

更新日期：1995-12-01 00:00:00

abstract：:Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cytotoxic CD127+ CD94- , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127+ ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94+ I...

journal_title：European journal of immunology

authors： Krabbendam L,Heesters BA,Kradolfer CMA,Spits H,Bernink JH

更新日期：2020-12-09 00:00:00

abstract：:The nature of Ig receptors carried by lipopolysaccharide (LPS)-stimulated mouse spleen B cells was analyzed by surface iodination, direct antiserum precipitation and polyacrylamide gel electrophoresis. LPS activation led to a rapid decrease of surface IgD to 20 % and 80 % of the original level on days three and five o...

journal_title：European journal of immunology

authors： Bourgois A,Kitajima K,Hunter IR,Askonas BA

更新日期：1977-03-01 00:00:00

abstract：:In this study we examined the effect of interleukin 4 (IL 4) on T cell activation and proliferation via the alternative CD2 pathway. To this end highly purified human resting T cells were cultured with a stimulating pair of anti-CD2 monoclonal antibodies in the absence of accessory signals from monocytes. Addition of ...

journal_title：European journal of immunology

authors： Lorré K,Van Damme J,Ceuppens JL

更新日期：1990-07-01 00:00:00

abstract：:To delineate the extent of O-galactosyltransferase deficiency within the lymphoid lineage, monoclonal antibody specific for the Thomsen-Friedenreich (TF) antigen (Gal beta 1----3GalNAc alpha 1-O-Ser/Thr) and its precursor the Tn antigen (GalNAc alpha 1-O-Ser/Thr) were applied to the flow cytometric analysis of periphe...

journal_title：European journal of immunology

authors： Thurnher M,Clausen H,Fierz W,Lanzavecchia A,Berger EG

更新日期：1992-07-01 00:00:00

abstract：:The activity of granzyme B, a main effector molecule of cytotoxic T lymphocytes (CTL) and natural killer cells, is regulated by the human intracellular serpin proteinase inhibitor 9 (PI9). This inhibitor is particularly expressed by CTL and dendritic cells, in which it serves to protect these cells against endogenous ...

journal_title：European journal of immunology

authors： Bladergroen BA,Strik MC,Wolbink AM,Wouters D,Broekhuizen R,Kummer JA,Hack CE

更新日期：2005-04-01 00:00:00

abstract：:HSP gp96-based vaccines have been trialled in rodent models and, more recently, in humans. Better understanding of gp96's immunomodulatory role will help with the design of more effective strategies for treatment of cancer and infectious diseases. In this study, we monitored the activities of T cells and activation of...

journal_title：European journal of immunology

authors： Liu Z,Li X,Qiu L,Zhang X,Chen L,Cao S,Wang F,Meng S

更新日期：2009-11-01 00:00:00

abstract：:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogen...

journal_title：European journal of immunology

authors： Borras-Cuesta F,Petit-Camurdan A,Fedon Y

更新日期：1987-08-01 00:00:00

abstract：:Human interdigitating dendritic cells (IDC) were isolated from tonsils based on their CD40+ lineage-negative expression in situ. Isolated IDC displayed a phenotypic profile similar to that of IDC in tonsils and spleen in situ, characterized by high-level expression of major histocompatibility complex class II, the co-...

journal_title：European journal of immunology

authors： Björck P,Flores-Romo L,Liu YJ

更新日期：1997-05-01 00:00:00

abstract：:An immune response (Ir) gene is described which controls the ability of mice to respond to seven very closely related gallinaceous egg white lysozymes (GEL). This Ir-GEL gene locus is linked to the major histocompatibility locus of the mouse and operates at the level of the T cell. Responsiveness to the nonimmunogenic...

journal_title：European journal of immunology

authors： Hill SW,Sercarz EE

更新日期：1975-05-01 00:00:00

abstract：:IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coinciding with release of ...

journal_title：European journal of immunology

authors： Brennan FM,Green P,Amjadi P,Robertshaw HJ,Alvarez-Iglesias M,Takata M

更新日期：2008-04-01 00:00:00

abstract：:Single-positive thymocytes are the immediate precursors of peripheral recent thymic emigrants (RTE) which develop into mature peripheral T cells. The functional ability of RTE is unclear but their state of differentiation may be relevant to the development of tolerance to peripheral "self" antigens. Since RTE are diff...

journal_title：European journal of immunology

authors： Charlton B,Meltzer J,Fathman CG

更新日期：1994-07-01 00:00:00

abstract：:High BDCA3 expression is associated with a specific human IFN-λ-producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC subsets. Thus far, development and function of BDCA3 expression on DCs remains poorly understood. Human Langerhans cells (LCs) and interstitial DCs (intDCs) can be gen...

journal_title：European journal of immunology

authors： van der Aa E,van de Laar L,Janssen HL,van Montfoort N,Woltman AM

更新日期：2015-05-01 00:00:00

abstract：:Growing evidence suggests that some immune responses are mediated not only by conventional and distinct NK cells and CTL, but also by T cell subsets expressing NK receptors and NK cell-associated molecules. Consistent with our previously published finding that the mAb 1F8 identifies non-T/non-B cells in Xenopus that e...

journal_title：European journal of immunology

authors： Rau L,Gantress J,Bell A,Stewart R,Horton T,Cohen N,Horton J,Robert J

更新日期：2002-06-01 00:00:00

abstract：:Osteopontin (OPN) and CD44 have been implicated in the development of autoimmune diseases, including arthritis and multiple sclerosis, as well as chronic inflammatory diseases, such as atherosclerosis and colitis. To investigate their roles in autoimmune myocarditis induced by immunization with heart alpha-myosin (MyH...

journal_title：European journal of immunology

authors： Abel B,Kurrer M,Shamshiev A,Marty RR,Eriksson U,Günthert U,Kopf M

更新日期：2006-02-01 00:00:00

abstract：:The monoclonal antibody HC1/6 generated against phorbol 12-myristate 13-acetate-treated U-937 cells recognizes a new cell surface antigen with a broad relative molecular mass ranging from 100 to 150 kDa. This antigen is also present on monocytes, platelets and endothelial cells and is weakly expressed by granulocytes....

journal_title：European journal of immunology

authors： Cabañas C,Sanchez-Madrid F,Bellon T,Figdor CG,Te Velde AA,Fernandez JM,Acevedo A,Bernabeu C

更新日期：1989-08-01 00:00:00

abstract：:Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surfact of activating substances. Using sulfated polyanions as model substances, an efficient fluid-phase activation of complement is d...

journal_title：European journal of immunology

authors： Bitter-Suermann D,Burger R,Hadding U

更新日期：1981-04-01 00:00:00

abstract：:The capacity of bone marrow-derived surface immunoglobulin-positive (sIg+) human and mouse immature B cells, generated either in vitro or in vivo, to change their light (L) chain expression, has been assayed by the number of cells which change in vitro from one type of L chain to the other type, or to no sIg at all. I...

journal_title：European journal of immunology

authors： Ghia P,Gratwohl A,Signer E,Winkler TH,Melchers F,Rolink AG

更新日期：1995-11-01 00:00:00

abstract：:While c-myc often contributes to the generation of B cell transformation, its transgenic overexpression alone does not lead to full transformation of B-lineage cells. Synergistically acting second genes must cooperate. Here, we constructed doxycycline-inducible cDNA-libraries from pre-B cell mRNA. These libraries were...

journal_title：European journal of immunology

authors： Wolf I,Bouquet C,Melchers F

更新日期：2016-11-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can downregulate antigen-specific B-cell responses. Accordingly, FcγRIIB deficiencies have been associated with B-cell hyperactivity in patients with systemic lupus erythematosus and mouse models of lupus. However, we have previously sho...

journal_title：European journal of immunology

authors： Avalos AM,Uccellini MB,Lenert P,Viglianti GA,Marshak-Rothstein A

更新日期：2010-10-01 00:00:00

abstract：:Previous studies have demonstrated that immunization of BALB/c mice with alpha(1----3) dextran (Dex) is accompanied by a reduction in the subsequent immune response to the acetylcholine receptor (AChR), depending on the timing of the Dex administration relative to AChR challenge. Here, we report that suppression of th...

journal_title：European journal of immunology

authors： Tong Z,Dwyer DS

更新日期：1990-08-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:NK cells and cytotoxic T lymphocytes can induce apoptosis in virus-infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A (GrA) and B (GrB) h...

journal_title：European journal of immunology

authors： Bratke K,Kuepper M,Bade B,Virchow JC Jr,Luttmann W

更新日期：2005-09-01 00:00:00

abstract：:The functional role of the T8 antigen of human T cells was studied by inhibition with anti-T8 monoclonal antibodies (mAb) of the cytotoxic action of T8+ cytotoxic T lymphocyte clones (CTL). All clones were allospecific and directed against HLA-B7. The ability of seven different anti-T8 mAb to inhibit the cytotoxicity ...

journal_title：European journal of immunology

authors： Van Seventer GA,Van Lier RA,Spits H,Ivanyi P,Melief CJ

更新日期：1986-11-01 00:00:00

abstract：:Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented, its effect on hematopoietic progenitor cells is less well characterized. Here we have used recombinant retroviruses to transduce and express a cDNA clone encoding the p55 component of the human IL 2 receptor (h-p55), in a mur...

journal_title：European journal of immunology

authors： Collins MK,Malde P,Miyajima A,Arai K,Smith KA,Mulligan RC

更新日期：1990-03-01 00:00:00

abstract：:The immunocytochemical characteristics of large granular lymphocytes (LGL), isolated from the liver sinusoids of euthymic and athymic (nude) rats, were investigated in electron microscopy by the immunoperoxidase technique. The LGL were found positive for MRC OX-8 (natural killer cells and cytotoxic/suppressor T cells)...

journal_title：European journal of immunology

authors： Bouwens L,Wisse E

更新日期：1987-10-01 00:00:00

abstract：:Recognition of foreign DNA by cytosolic innate immune receptors triggers the production of IFN-beta. However, it is unclear whether different types of DNA ligands are recognized by similar receptors and whether the resulting response is distinct from the endosomal TLR response. To address these questions, we compared ...

journal_title：European journal of immunology

authors： Karayel E,Bürckstümmer T,Bilban M,Dürnberger G,Weitzer S,Martinez J,Superti-Furga G

更新日期：2009-07-01 00:00:00

abstract：:Two out of 25 monoclonal anti-DNA autoantibodies that were produced by human-human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4 degrees C) as well as at warm (37 degrees C) temperatures. The lymphocytotoxic activity of the monoclonal anti-DNA ...

journal_title：European journal of immunology

authors： Shoenfeld Y,Zamir R,Joshua H,Lavie G,Pinkhas J

更新日期：1985-10-01 00:00:00