Treg suppress CTL responses upon immunization with HSP gp96.

abstract：:CD72 has been reported to regulate BCR-mediated signals both positively and negatively. SHP-1 and Grb2 bind, respectively, to ITIM1 and ITIM2 of CD72. We generated transformed B cell lines with an immature phenotype following J2 virus infection of splenocytes from CD72(-/-) and wild-type (Wt) mice. The transformed lin...

journal_title：European journal of immunology

authors： Baba T,Fusaki N,Aoyama A,Li DH,Okamura RM,Parnes JR,Hozumi N

更新日期：2005-05-01 00:00:00

abstract：:We show that, in vitro, the response of thymocytes to certain stimuli, and their survival largely depend on the nature of the culture environment, i.e. whether thymocytes are stimulated within intact thymus lobes or in cell suspension. Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+iono...

journal_title：European journal of immunology

authors： Moore NC,Jenkinson EJ,Owen JJ

更新日期：1992-10-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:Anti-HLA alloantisera inhibit mixed lymphocyte responses in which normal lymphocytes are used as stimulator cells. These same antisera are unable to inhibit lymphocyte proliferative responses stimulated by lymphoblastoid cells from cultured lymphoid cell lines. They also fail to inhibit either the generation of cytoto...

journal_title：European journal of immunology

authors： Corley RB,Dawson JR,Amos DB

更新日期：1976-04-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:Paxillin is an adaptor protein associated with focal adhesion complex, and is activated by tyrosine phosphorylation through focal adhesion kinase (FAK) and Src kinase. Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellu...

journal_title：European journal of immunology

authors： Lee YC,Chang AY,Lin-Feng MH,Tsou WI,Chiang IH,Lai MZ

更新日期：2012-08-01 00:00:00

abstract：:A monoclonal antibody (mAb), 2D1(IgM), was identified for its anti-proliferative effect on human T leukemia cell line, SUP-T13. The cells bound with 2D1 showed DNA ladder patterns of oligonucleosomes, demonstrating apoptosis. Peripheral mononuclear cells activated by phytohemagglutinin or OKT3 induced expression of 2D...

journal_title：European journal of immunology

authors： Takahashi S,Sato N,Takayama S,Ichimiya S,Satoh M,Hyakumachi N,Kikuchi K

更新日期：1993-08-01 00:00:00

abstract：:Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*...

journal_title：European journal of immunology

authors： Lewis JW,Sewell A,Price D,Elliott T

更新日期：1998-10-01 00:00:00

abstract：:The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...

journal_title：European journal of immunology

authors： Rückert R,Brandt K,Bulanova E,Mirghomizadeh F,Paus R,Bulfone-Paus S

更新日期：2003-12-01 00:00:00

abstract：:Glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) is a synthetic adjuvant TLR4 agonist that promotes potent poly-functional T(H)1 responses. Different TLR4 agonists may preferentially signal via MyD88 or TIR-domain-containing adapter inducing IFN-beta (TRIF) to exert adjuvant effects; however, the contribution of...

journal_title：European journal of immunology

authors： Orr MT,Duthie MS,Windish HP,Lucas EA,Guderian JA,Hudson TE,Shaverdian N,O'Donnell J,Desbien AL,Reed SG,Coler RN

更新日期：2013-09-01 00:00:00

abstract：:The 95-kDa antigen recognized by the anti-CD19 panel of monoclonal antibodies is found on the surface of most cells of the B cell lineage. Anti-CD19 antibodies inhibit B cell proliferation in response to anti-Ig plus interleukin 4 (IL4), but enhance the response to mitogenic concentrations of either phorbol 12-myrista...

journal_title：European journal of immunology

authors： Rigley KP,Callard RE

更新日期：1991-03-01 00:00:00

abstract：:Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrop...

journal_title：European journal of immunology

authors： Boff D,Oliveira VLS,Queiroz Junior CM,Silva TA,Allegretti M,Verri WA Jr,Proost P,Teixeira MM,Amaral FA

更新日期：2018-03-01 00:00:00

abstract：:Interleukin (IL)-5 is produced by variety of cell types and contributes to both lymphocyte development an eosinophil terminal differentiation in vitro. The coincidence of worm expulsion and eosinophilia in sheep infected with the gastrointestinal nematode Trichostrongylus colubriformis suggest that eosinophils may be ...

journal_title：European journal of immunology

authors： Bao S,McClure SJ,Emery DL,Husband AJ

更新日期：1996-03-01 00:00:00

abstract：:The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

journal_title：European journal of immunology

authors： Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

更新日期：2005-11-01 00:00:00

abstract：:CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...

journal_title：European journal of immunology

authors： Polte T,Fuchs L,Behrendt AK,Hansen G

更新日期：2009-07-01 00:00:00

abstract：:Among human peripheral blood B cells we localized the precursors of two interleukin-dependent B cell activation processes: the specific response to a particulate antigen, trinitrophenylated polyacrylamide beads (TNP-PAA) and the polyclonally induced response to pokeweed mitogen. In both cases the precursors belong to ...

journal_title：European journal of immunology

authors： Richard Y,Leprince C,Treton D,Galanaud P

更新日期：1986-10-01 00:00:00

abstract：:We have analyzed the T cell receptor (TcR) V alpha and TcR V beta regions in the spontaneous mouse model for insulin-dependent diabetes mellitus, the NOD mouse, and compared it to the regions in the two sister strains, the NON and CTS strains. Based on restriction fragment length polymorphism analysis the TcR V alpha ...

journal_title：European journal of immunology

authors： Lund T,Shaikh S,Hattori M,Makino S

更新日期：1992-03-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...

journal_title：European journal of immunology

authors： Hoppstädter J,Diesel B,Eifler LK,Schmid T,Brüne B,Kiemer AK

更新日期：2012-05-01 00:00:00

abstract：:We recently reported that differentiation of CD8(+) T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism. Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. To determine a more glob...

journal_title：European journal of immunology

authors： Cham CM,Driessens G,O'Keefe JP,Gajewski TF

更新日期：2008-09-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection frequently develops into liver disease and is accompanied by extra-hepatic autoimmune manifestations. The tetraspanin CD81 is a putative HCV receptor as it binds the E2 envelope glycoprotein of HCV and bona fide HCV particles. Here we show that HCV E2 binding to CD81 on human ...

journal_title：European journal of immunology

authors： Wack A,Soldaini E,Tseng C,Nuti S,Klimpel G,Abrignani S

更新日期：2001-01-01 00:00:00

abstract：:Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated...

journal_title：European journal of immunology

authors： Wick MJ,Pfeifer JD

更新日期：1996-11-01 00:00:00

abstract：:The capacity of bone marrow-derived surface immunoglobulin-positive (sIg+) human and mouse immature B cells, generated either in vitro or in vivo, to change their light (L) chain expression, has been assayed by the number of cells which change in vitro from one type of L chain to the other type, or to no sIg at all. I...

journal_title：European journal of immunology

authors： Ghia P,Gratwohl A,Signer E,Winkler TH,Melchers F,Rolink AG

更新日期：1995-11-01 00:00:00

abstract：:Lymphoid follicles of the ileal Peyer's patch (PP) of young sheep function as the major source of B cells and a site of immunoglobulin (Ig) receptor diversification. However, extensive cell death in culture has restricted investigations of ileal PP follicular (iPf)B cell biology. We investigated the possibility that s...

journal_title：European journal of immunology

authors： Griebel PJ,Ferrari G

更新日期：1994-02-01 00:00:00

abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

journal_title：European journal of immunology

authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

更新日期：2005-01-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are innate effectors playing an important role in the defense against helminthic infections and in the pathogenesis of allergic inflammation. Cytokines have been identified as the major stimuli driving ILC2 activation and expansion. Conversely, it is unclear whether costimulatory ...

journal_title：European journal of immunology

authors： Paclik D,Stehle C,Lahmann A,Hutloff A,Romagnani C

更新日期：2015-10-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00