Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation.

abstract：:TCR- but not CD2-triggered IL-2 production is p56(lck) dependent. To test the hypothesis that p59(fyn), a second src-family protein tyrosine kinase (PTK) expressed in T lymphocytes, might be an essential upstream component of the CD2 signaling pathway, we generated human (h) CD2 transgenic (tg) fyn(+/+) and fyn(-/-) m...

journal_title：European journal of immunology

authors： Fukai I,Hussey RE,Sunder-Plassmann R,Reinherz EL

更新日期：2000-12-01 00:00:00

abstract：:Spontaneous apoptosis in germinal center (GC) B cells can be arrested either by engaging cell surface immunoglobulin (Ig) with immobilized ligand or, more effectively, by treatment with soluble monoclonal antibody (mAb) directed against CD40. The present study examines the intracellular signal transduction pathways th...

journal_title：European journal of immunology

authors： Knox KA,Gordon J

更新日期：1993-10-01 00:00:00

abstract：:The physical association of CD5 and the T cell antigen receptor (TcR)/CD3 complex on the surface of intact human lymphocytes was investigated using co-capping experiments and fluorescence resonance energy transfer (FRET) analyses. Antibody-induced capping of CD5 or CD3 and double indirect immunofluorescence labeling r...

journal_title：European journal of immunology

authors： Osman N,Lazarovits AI,Crumpton MJ

更新日期：1993-05-01 00:00:00

abstract：:Human natural killer (NK) cells are divided into two subsets: CD56bright and CD56dim NK cells, which differ in maturation, function and distribution. Mechanisms regulating NK cell functions are not completely understood. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, that binds to a variet...

journal_title：European journal of immunology

authors： Moreno-Nieves UY,Mundy DC,Shin JH,Tam K,Sunwoo JB

更新日期：2018-05-01 00:00:00

abstract：:We have previously demonstrated that mycobacterial lipoproteins engage TLR2 on human CD4(+) T cells and upregulate TCR-triggered IFN-γ secretion and cell proliferation in vitro. Here we examined the role of CD4(+) T-cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T-cell priming and in protection ag...

journal_title：European journal of immunology

authors： Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE

更新日期：2014-05-01 00:00:00

abstract：:The 95-kDa antigen recognized by the anti-CD19 panel of monoclonal antibodies is found on the surface of most cells of the B cell lineage. Anti-CD19 antibodies inhibit B cell proliferation in response to anti-Ig plus interleukin 4 (IL4), but enhance the response to mitogenic concentrations of either phorbol 12-myrista...

journal_title：European journal of immunology

authors： Rigley KP,Callard RE

更新日期：1991-03-01 00:00:00

abstract：:The nonobese diabetic (NOD) mouse is a relevant model for studying human insulin-dependent diabetes mellitus (IDDM). The selective destruction of insulin-secreting cells in this model is subsequent to an autoimmune reaction directed towards the beta cells inside the islets of Langerhans of the pancreas. Given the key ...

journal_title：European journal of immunology

authors： Sempé P,Bédossa P,Richard MF,Villà MC,Bach JF,Boitard C

更新日期：1991-05-01 00:00:00

abstract：:C3 is the central component of the complement system. Upon activation, C3 sequentially generates various proteolytic fragments, C3a, C3b, iC3b, C3dg, each of them exposing novel surfaces, which are sites of interaction with other proteins. C3 and its fragments are therapeutic targets and markers of complement activati...

journal_title：European journal of immunology

authors： Subías Hidalgo M,Yébenes H,Rodríguez-Gallego C,Martín-Ambrosio A,Domínguez M,Tortajada A,Rodríguez de Córdoba S,Llorca O

更新日期：2017-03-01 00:00:00

abstract：:Analysis of proliferation and cytokine production at the single-cell level indicated that proliferation of pre-existing type 2 cytokine(+) human peripheral naive T cells (CD4(+) and CD8(+)) accounts for the accumulation of type 2 T cells in lymphocytes cultured with IL-2, with or without IL-4, and independently from T...

journal_title：European journal of immunology

authors： Loza MJ,Perussia B

更新日期：2003-04-01 00:00:00

abstract：:CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...

journal_title：European journal of immunology

authors： Armitage RJ,Tough TW,Macduff BM,Fanslow WC,Spriggs MK,Ramsdell F,Alderson MR

更新日期：1993-09-01 00:00:00

abstract：:The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...

journal_title：European journal of immunology

authors： de Waal LP,Melief CJ,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...

journal_title：European journal of immunology

authors： Kahn S,Kahn M,Eisen H

更新日期：1992-12-01 00:00:00

abstract：:Based upon the success of using polyclonal, Epstein-Barr virus (EBV)-specific CTL lines for the prophylaxis and treatment of patients with post-transplant lymphoproliferative disease (PTLPD), there is now considerable incentive to develop CTL directed against the sub-dominant EBV antigens EBNA1, LMP1 and LMP2, which a...

journal_title：European journal of immunology

authors： Su Z,Peluso MV,Raffegerst SH,Schendel DJ,Roskrow MA

更新日期：2001-03-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein which is one of the ligands for the leukocyte function-associated antigen (LFA-1). It is involved in leukocyte adhesion to endothelial cells as well as in immune functions requiring cell-cell contact. The quantitative expression of ICAM-1 in various cell types can be either induce...

journal_title：European journal of immunology

authors： Geissler D,Gaggl S,Möst J,Greil R,Herold M,Dietrich M

更新日期：1990-12-01 00:00:00

abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

journal_title：European journal of immunology

authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

更新日期：1993-11-01 00:00:00

abstract：:Dendritic cells (DC) are known to support the activation of natural killer (NK) cells. However, little is known about the role for DC in NK-cell homeostasis. In order to investigate this question, a novel bacterial artificial chromosome transgenic mouse model was generated in which the diphtheria toxin receptor is exp...

journal_title：European journal of immunology

authors： Hochweller K,Striegler J,Hämmerling GJ,Garbi N

更新日期：2008-10-01 00:00:00

abstract：:High BDCA3 expression is associated with a specific human IFN-λ-producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC subsets. Thus far, development and function of BDCA3 expression on DCs remains poorly understood. Human Langerhans cells (LCs) and interstitial DCs (intDCs) can be gen...

journal_title：European journal of immunology

authors： van der Aa E,van de Laar L,Janssen HL,van Montfoort N,Woltman AM

更新日期：2015-05-01 00:00:00

abstract：:In viral meningitis the inflammatory response involves activated T cells and monocytes which are recruited into the subarachnoid space. To identify the chemotactic signals attracting the cells to the site of infection in the meninges, we measured the levels of two CXC chemokines, interferon-gamma (IFN-gamma) inducible...

journal_title：European journal of immunology

authors： Lahrtz F,Piali L,Nadal D,Pfister HW,Spanaus KS,Baggiolini M,Fontana A

更新日期：1997-10-01 00:00:00

abstract：:The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...

journal_title：European journal of immunology

authors： Rückert R,Brandt K,Bulanova E,Mirghomizadeh F,Paus R,Bulfone-Paus S

更新日期：2003-12-01 00:00:00

abstract：:The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and d...

journal_title：European journal of immunology

authors： Behrens EM,Gadue P,Gong SY,Garrett S,Stein PL,Cohen PL

更新日期：2003-08-01 00:00:00

abstract：:The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell resp...

journal_title：European journal of immunology

authors： Frick R,Gunnarsen KS,Dahal-Koirala S,Risnes LF,Sollid LM,Sandlie I,Høydahl LS,Løset GÅ

更新日期：2020-01-01 00:00:00

abstract：:Expression of the complement-regulatory proteins (CRP) CD46, CD55 and CD59 represents a strategy used by tumor cells to evade complement-dependent cell cytoxicity stimulated by monoclonal antibodies. We have isolated two single-chain variable fragments (scFv) to CD55 and CD59 from a human phage-display library and fro...

journal_title：European journal of immunology

authors： Ziller F,Macor P,Bulla R,Sblattero D,Marzari R,Tedesco F

更新日期：2005-07-01 00:00:00

abstract：:We here report the cDNA sequences of 11 new rat Ly49 genes with full and three with incomplete open reading frames. Although obtained from different inbred rat strains, these as well as six previously published cDNA represent non-allelic genes matching different loci in the Brown Norway (BN) rat genome, which is predi...

journal_title：European journal of immunology

authors： Nylenna O,Naper C,Vaage JT,Woon PY,Gauguier D,Dissen E,Ryan JC,Fossum S

更新日期：2005-01-01 00:00:00

abstract：:Membrane-bound IgG was found only on old populations of platelets from normal individuals. This IgG could be dissociated from senescent cells by repeatedly heating the cells. Heat-eluted IgG (He-IgG) prepared from senescent red blood cells was capable of binding to either heat-treated old platelets or Vibrio cholerae ...

journal_title：European journal of immunology

authors： Khansari N,Fudenberg HH

更新日期：1983-12-01 00:00:00

abstract：:The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC), presented in the ...

journal_title：European journal of immunology

authors： Boulter JM,Schmitz N,Sewell AK,Godkin AJ,Bachmann MF,Gallimore AM

更新日期：2007-03-01 00:00:00

abstract：:Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...

journal_title：European journal of immunology

authors： Skak K,Guerder S,Picarella DE,Brenden N,Flavell RA,Michelsen BK

更新日期：2003-05-01 00:00:00

abstract：:The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

journal_title：European journal of immunology

authors： Kiely PD,Gillespie KM,Oliveira DB

更新日期：1995-10-01 00:00:00

abstract：:A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

journal_title：European journal of immunology

authors： Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

更新日期：1992-02-01 00:00:00

abstract：:The migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells integrate the messages provided by different chemokines that are conc...

journal_title：European journal of immunology

authors： Kuscher K,Danelon G,Paoletti S,Stefano L,Schiraldi M,Petkovic V,Locati M,Gerber BO,Uguccioni M

更新日期：2009-04-01 00:00:00

abstract：:NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are ...

journal_title：European journal of immunology

authors： Held W

更新日期：2008-11-01 00:00:00