Accumulation of type 2 cytokine+ T cells: differentiation-independent proliferation of pre-existing type 2 T cells.

abstract：:Chronic hepatitis C virus (HCV) infection frequently develops into liver disease and is accompanied by extra-hepatic autoimmune manifestations. The tetraspanin CD81 is a putative HCV receptor as it binds the E2 envelope glycoprotein of HCV and bona fide HCV particles. Here we show that HCV E2 binding to CD81 on human ...

journal_title：European journal of immunology

authors： Wack A,Soldaini E,Tseng C,Nuti S,Klimpel G,Abrignani S

更新日期：2001-01-01 00:00:00

abstract：:In contrast to previous studies, we report that heterologous anti-delta antibodies can act as a powerful multi-class humoral immunosuppressant. Primary direct plaque-forming cell (IgM) responses of BALB/c mice injected from birth with a rabbit anti-delta antiserum were reduced to 3% of control levels against a T-depen...

journal_title：European journal of immunology

authors： Wathen PM,Manning DD

更新日期：1986-08-01 00:00:00

abstract：:Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to...

journal_title：European journal of immunology

authors： Washington EA,Kimpton WG,Holder JE,Cahill RN

更新日期：1995-03-01 00:00:00

abstract：:A mouse lymphocyte surface molecule which is selectively expressed by mucosal T cells and detected with the monoclonal antibody (mAb) M290 has provisionally been identified as a beta 7 integrin. Identification was based on close homology of its beta subunit at the N terminus with the recently reported, highly distinct...

journal_title：European journal of immunology

authors： Kilshaw PJ,Murant SJ

更新日期：1991-10-01 00:00:00

abstract：:High BDCA3 expression is associated with a specific human IFN-λ-producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC subsets. Thus far, development and function of BDCA3 expression on DCs remains poorly understood. Human Langerhans cells (LCs) and interstitial DCs (intDCs) can be gen...

journal_title：European journal of immunology

authors： van der Aa E,van de Laar L,Janssen HL,van Montfoort N,Woltman AM

更新日期：2015-05-01 00:00:00

abstract：:Dendritic cells (DC) are known to support the activation of natural killer (NK) cells. However, little is known about the role for DC in NK-cell homeostasis. In order to investigate this question, a novel bacterial artificial chromosome transgenic mouse model was generated in which the diphtheria toxin receptor is exp...

journal_title：European journal of immunology

authors： Hochweller K,Striegler J,Hämmerling GJ,Garbi N

更新日期：2008-10-01 00:00:00

abstract：:This report describes the study of the expression of an idiotype in the human population which is associated with antibodies to N-acetyl-D-glucosamine (GlcNAc) present in most human sera presumably due to streptococcal infections. The idiotype is identified with antisera and monoclonal antibodies prepared against the ...

journal_title：European journal of immunology

authors： Emmrich F,Greger B,Eichmann K

更新日期：1983-04-01 00:00:00

abstract：:Caspases are essential mediators of cytokine release and apoptosis. Additionally, caspase activity is required for the proliferation of naive T lymphocytes. It remained unclear how proliferating cells are able to cope with the pro-apoptotic activity especially of effector caspases-3 and -7. Possible reasons might incl...

journal_title：European journal of immunology

authors： Paulsen M,Ussat S,Jakob M,Scherer G,Lepenies I,Schütze S,Kabelitz D,Adam-Klages S

更新日期：2008-07-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...

journal_title：European journal of immunology

authors： Hoppstädter J,Diesel B,Eifler LK,Schmid T,Brüne B,Kiemer AK

更新日期：2012-05-01 00:00:00

abstract：:Changes in the migration pattern of lymphocytes represent a key event in the evolution of an immune response since they enable lymphocytes to gain access to infected tissues. We studied the location of virus-specific CD8 T cells in various splenic compartments in response to infection with lymphocytic choriomeningitis...

journal_title：European journal of immunology

authors： Potsch C,Vöhringer D,Pircher H

更新日期：1999-11-01 00:00:00

abstract：:Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...

journal_title：European journal of immunology

authors： Redpath SA,Heieis GA,Reynolds LA,Fonseca NM,Kim SS,Perona-Wright G

更新日期：2018-01-01 00:00:00

abstract：:The immunosuppressor sanglifehrin A (SfA) is a member of a family of immunophilin cyclophilin A-binding molecules and does not inhibit calcineurin activity. Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability. This immunosuppre...

journal_title：European journal of immunology

authors： Sànchez-Tilló E,Wojciechowska M,Comalada M,Farrera C,Lloberas J,Celada A

更新日期：2006-09-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:Mercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were pe...

journal_title：European journal of immunology

authors： Guéry JC,Druet E,Glotz D,Hirsch F,Mandet C,De Heer E,Druet P

更新日期：1990-01-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:The human T cell leukemia virus type-1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). Since the HTLV-I-encoded transactivator Tax has been shown to activate many cellular genes including cytokine genes interleukin (IL-)1alpha, 2, 5, 6, 8, 10 and 15, we ask whether Tax also affects IL-4 expression. In ...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Chlichlia K,Khazaie K,Krammer PH

更新日期：2001-09-01 00:00:00

abstract：:Previously we have reported on the production of two sets of human monoclonal antibodies reacting with mouse mammary tumor virus (MMTV) and human mammary tumor virus (HuMTV) cross-reacting antigens. B11 is a monoclonal IgG generated by the human-human hybridoma technique using axillary lymph node of breast cancer pati...

journal_title：European journal of immunology

authors： Smorodinsky NI,Ghendler Y,Bakimer R,Chaitchuk S,Keydar I,Shoenfeld Y

更新日期：1988-11-01 00:00:00

abstract：:An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parental cell line. However, ...

journal_title：European journal of immunology

authors： Reno TA,Ley S,Sugiyama E,Cantagrel A,Blumberg R,Bonventre J,Terhorst C,Yeh ET

更新日期：1990-07-01 00:00:00

abstract：:The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...

journal_title：European journal of immunology

authors： Ko HJ,Kinkel SA,Hubert FX,Nasa Z,Chan J,Siatskas C,Hirubalan P,Toh BH,Scott HS,Alderuccio F

更新日期：2010-12-01 00:00:00

abstract：:Many lymphocytes are produced in the intestinal mucosa, especially in the Peyer's patches. These newly formed lymphoid cells leave the gut wall, undergo further maturation and many reach the lamina propria of the intestinal mucosa where they function as effector and regulator cells of the intestinal immune response. H...

journal_title：European journal of immunology

authors： Rothkötter HJ,Hriesik C,Pabst R

更新日期：1995-03-01 00:00:00

abstract：:The presentation of islet antigens in the pancreatic LNs (PLNs) of mice is a developmentally regulated process. It has been hypothesized that, during physiological tissue remodeling, a wave of neonatal β-cell apoptosis may initiate diabetes in autoimmune-prone strains of mice. If true, increasing or decreasing physiol...

journal_title：European journal of immunology

authors： Carrington EM,Kos C,Zhan Y,Krishnamurthy B,Allison J

更新日期：2011-08-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:CD22 is a B lymphocyte-specific membrane protein that functions as an adhesion molecule via its interactions with a subset of alpha 2-6-linked sialic acid-containing glycoproteins. Engagement of CD22 with a monoclonal antibody (HB22.23) that blocks the binding of CD22 to its ligands results in rapid CD22 tyrosine phos...

journal_title：European journal of immunology

authors： Tuscano JM,Engel P,Tedder TF,Agarwal A,Kehrl JH

更新日期：1996-06-01 00:00:00

abstract：:Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to...

journal_title：European journal of immunology

authors： Ferrero E,Fabbri M,Poggi A,Galati G,Bernasconi S,Zocchi MR

更新日期：1998-08-01 00:00:00

abstract：:E-selectin is a cytokine-inducible membrane glycoprotein capable of mediating adhesion of leukocytes to endothelial cells. It is highly glycosylated, containing 11 sites for N-linked glycosylation. N-Glycosylation of E-selectin was analyzed by endoglycosidase treatment. Analysis of immunoprecipitated E-selectin from h...

journal_title：European journal of immunology

authors： Påhlsson P,Strindhall J,Srinivas U,Lundblad A

更新日期：1995-09-01 00:00:00

abstract：:Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3+ Treg, have been shown to play a central role in the esta...

journal_title：European journal of immunology

authors： Belkaid Y

更新日期：2008-04-01 00:00:00

abstract：:The CBA/N mouse carries the X-linked immunodeficiency xid, resulting in defective B cell development. B cells from these animals cannot mount antibody responses to type 2 T-independent antigens, and do not synthesize DNA when stimulated with anti-immunoglobulin (Ig) antibodies which are mitogenic for normal B cells. T...

journal_title：European journal of immunology

authors： Hasbold J,Klaus GG

更新日期：1994-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft reject...

journal_title：European journal of immunology

authors： Oukka M,Galou M,Belkaid Y,Tricotet V,Riche N,Reynes M,Kosmatopoulos K

更新日期：1997-12-01 00:00:00

abstract：:The capacity of bone marrow-derived surface immunoglobulin-positive (sIg+) human and mouse immature B cells, generated either in vitro or in vivo, to change their light (L) chain expression, has been assayed by the number of cells which change in vitro from one type of L chain to the other type, or to no sIg at all. I...

journal_title：European journal of immunology

authors： Ghia P,Gratwohl A,Signer E,Winkler TH,Melchers F,Rolink AG

更新日期：1995-11-01 00:00:00