Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system.

abstract：:Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

journal_title：European journal of immunology

authors： Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

更新日期：1988-07-01 00:00:00

abstract：:Recurrent respiratory tract infections (RRTIs) are the first leading cause of community- and nosocomial-acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore, the development of new alternative approaches to prevent and treat RRTIs is hi...

journal_title：European journal of immunology

authors： Cirauqui C,Benito-Villalvilla C,Sánchez-Ramón S,Sirvent S,Diez-Rivero CM,Conejero L,Brandi P,Hernández-Cillero L,Ochoa JL,Pérez-Villamil B,Sancho D,Subiza JL,Palomares O

更新日期：2018-01-01 00:00:00

abstract：:The transition from fully developed CD4+CD8- single-positive (SP) thymocytes into fully mature recirculating peripheral T cells is both poorly understood with regard to the expression of restricted isoforms (CD45R) of the leukocyte common antigen and in terms of T cell function. The present investigation monitored the...

journal_title：European journal of immunology

authors： Yang CP,Bell EB

更新日期：1992-09-01 00:00:00

abstract：:Production of indoleamine 2,3-dioxygenase (IDO) by tumor cells, leading to tryptophan depletion and production of immunosuppressive metabolites, may facilitate immune tolerance of cancer. IDO gene is also expressed in dendritic cells (DC) upon maturation induced by lipopolysaccarides or IFN. We investigated IDO gene e...

journal_title：European journal of immunology

authors： Weber WP,Feder-Mengus C,Chiarugi A,Rosenthal R,Reschner A,Schumacher R,Zajac P,Misteli H,Frey DM,Oertli D,Heberer M,Spagnoli GC

更新日期：2006-02-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent inducer of interleukin 1 (IL 1) synthesis and release, and of tumor necrosis factor (TNF) secretion. Many signals can enhance the LPS-induced production of these cytokines. We have previously observed that addition of low amounts of normal human serum to the culture medium enhances...

journal_title：European journal of immunology

authors： Cavaillon JM,Fitting C,Haeffner-Cavaillon N

更新日期：1990-02-01 00:00:00

abstract：:Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral blood (PB) FOXP3(+) cells present in CD25(high), CD25(low) and even CD25(-) subsets of CD4(+) cells expressed high levels of TNFR2. Consequently, TNFR2-expressi...

journal_title：European journal of immunology

authors： Chen X,Subleski JJ,Hamano R,Howard OM,Wiltrout RH,Oppenheim JJ

更新日期：2010-04-01 00:00:00

abstract：:Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific ...

journal_title：European journal of immunology

authors： Schneider-Schaulies J,Hünig T,Schimpl A,Wecker E

更新日期：1986-03-01 00:00:00

abstract：:Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...

journal_title：European journal of immunology

authors： Davis FM,denDekker A,Joshi AD,Wolf SJ,Audu C,Melvin WJ,Mangum K,Riordan MO,Kunkel SL,Gallagher KA

更新日期：2020-12-01 00:00:00

abstract：:Interleukin-5 (IL-5) plays a critical role in the pathogenesis of eosinophil-associated allergic disorders, such as asthma. IL-5 may also play a major role in the development of eosinophilia-associated lymphoproliferative disorders caused by human T lymphotropic virus type I (HTLV-I). In this study, we have investigat...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Krammer PH

更新日期：2001-12-01 00:00:00

abstract：:Autoimmune diseases including multiple sclerosis (MS) are the result of an imbalanced immune tolerance network. Dendritic cells (DCs) are key players in both initiating immunity (immunogenic DCs) and regulating immune responses (tolerogenic DCs = tolDCs) and are potential targets for the treatment of MS. While the imm...

journal_title：European journal of immunology

authors： Gross CC,Jonuleit H,Wiendl H

更新日期：2012-03-01 00:00:00

abstract：:Terminal differentiation of B cells into antibody-secreting cells is the foundation of humoral immune response. B-1 cells, which are different from B-2 cells, preferentially differentiate into plasma cells. CMTM7 is a MARVEL-domain-containing membrane protein predominantly expressed in B cells that plays an important ...

journal_title：European journal of immunology

authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

更新日期：2020-06-01 00:00:00

abstract：:Splenic T cells were primed, after removal of alloreactive cells, to beef insulin on allogeneic antigen-presenting cells (APC). The fine specificity of in vitro secondary response was tested in combinations H-2b (responder) T cell-H-2k (nonresponder) APC, and vice versa, using separated chains of beef and pork insulin...

journal_title：European journal of immunology

authors： Ishii N,Klein J,Nagy ZA

更新日期：1983-08-01 00:00:00

abstract：:Tetanus toxin has been a valuable model antigen to study the MHC class II-restricted antigen processing pathway and is also frequently used to provide T helper determinants in vaccine formulations. To date most basic studies on the processing of this antigen have utilized human T and B cell clones. As a first step tow...

journal_title：European journal of immunology

authors： Antoniou AN,Watts C

更新日期：2002-02-01 00:00:00

abstract：:T-cell death is a fundamental process that is intricately regulated at multiple phases during T-cell differentiation, tolerance induction and the decline of the immune response. Caspase 3 is a crucial molecule regulating both mitochondrial and death receptor apoptotic pathways and therefore we were interested in exami...

journal_title：European journal of immunology

authors： Murakami K,Liadis N,Sarmiento J,Elford AR,Woo M,Nguyen LT,Mak TW,Ohashi PS

更新日期：2010-12-01 00:00:00

abstract：:We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph ...

journal_title：European journal of immunology

authors： Maloy KJ,Donachie AM,Mowat AM

更新日期：1995-10-01 00:00:00

abstract：:Ia. W39 is a B cell differentiation antigen whose membrane expression is controlled by the xid gene. In this report we show that, analogous to its B cell expression, Ia. W39 is also present on a subset of Ia+ macrophages, indicating heterogeneity within that cell population. The Ir gene(s) for the antigenic determinan...

journal_title：European journal of immunology

authors： Huber BT,Rosenwasser LJ

更新日期：1982-01-01 00:00:00

abstract：:Adaptive immune responses have long been considered the "territory" of antigenic proteins, whereas carbohydrates are characterized as T-cell-independent antigens that are not typically recognized by the complete adaptive machinery. The current modus operandi when searching for dominant epitopes is the use of synthetic...

journal_title：European journal of immunology

authors： Cobb BA,Kasper DL

更新日期：2005-02-01 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...

journal_title：European journal of immunology

authors： Dimanche-Boitrel MT,Guyot A,De Saint-Basile G,Fischer A,Griscelli C,Lisowska-Grospierre B

更新日期：1988-10-01 00:00:00

abstract：:The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1/PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, while adoptive cell therapies...

journal_title：European journal of immunology

authors： Hope HC,Salmond RJ

更新日期：2019-08-01 00:00:00

abstract：:In mouse Peyer's patches (PP), dendritic cells (DC) are localized in T cell areas as NLDC145+ CD11c+ cells, and in the dome and corona region of the follicle as NLDC145- CD11c+ cells, respectively, suggesting the presence of two different DC populations with distinct roles in antigen uptake, processing, and presentati...

journal_title：European journal of immunology

authors： Ruedl C,Hubele S

更新日期：1997-06-01 00:00:00

abstract：:T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...

journal_title：European journal of immunology

authors： Shields JG,Smith SH,Strobel S,Levinsky RJ,Defrance T,De Vries J,Banchereau J,Callard RE

更新日期：1988-02-01 00:00:00

abstract：:The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function have been identified. E+/UCHT1+ cell...

journal_title：European journal of immunology

authors： Beverley PC,Callard RE

更新日期：1981-04-01 00:00:00

abstract：:Granzyme A (TSP-1) is a serine esterase expressed in cytotoxic T and natural killer (NK) cell lines. Its presence in in vivo primed T cells is disputed at present. Here we show that normal rat NK cells contain granzyme A in vivo and that its expression is augmented by their short-term in vitro treatment with IL 2. Gra...

journal_title：European journal of immunology

authors： Velotti F,Palmieri G,Morrone S,Piccoli M,Frati L,Santoni A

更新日期：1989-03-01 00:00:00

abstract：:In M54 mice transgenic for a completely rearranged mu(a) heavy chain there is a decrease in total B cells and the rearrangement of endogenous immunoglobulin genes is partially inhibited. Surprisingly, however, endogenous immunoglobulin gene rearrangement and significant heavy chain polypeptide production does occur. W...

journal_title：European journal of immunology

authors： Rabin E,Cong Y,Imanishi-Kari T,Wortis HH

更新日期：1992-09-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:Incorporation of an 11 amino acid region of the HIV TAT protein transduction domain (TAT PTD) into proteins facilitates rapid, efficient entry into cells. We previously showed that rTAT-PTD-OVA-transduced dendritic cells (DC) stimulated antigen (Ag)-specific CTL and Th cells, and vaccinated against OVA-expressing tumo...

journal_title：European journal of immunology

authors： Shibagaki N,Udey MC

更新日期：2003-04-01 00:00:00

abstract：:The inbred strain 13 guinea pig expresses at least three isotypes of immunoglobulin (Ig) lambda chain. The proportion of these isotypes in normal Ig can be estimated by isolating a constant (C) region cyanogen bromide peptide from lambda chains and quantitatively analyzing its component tryptic peptides. Anti-phenyltr...

journal_title：European journal of immunology

authors： Brunhouse RF,Cebra JJ

更新日期：1978-12-01 00:00:00

abstract：:The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC), presented in the ...

journal_title：European journal of immunology

authors： Boulter JM,Schmitz N,Sewell AK,Godkin AJ,Bachmann MF,Gallimore AM

更新日期：2007-03-01 00:00:00

abstract：:Macrophages can be stimulated to produce a relatively large amount of nitric oxide, which is an important component in macrophage-mediated defense mechanisms and regulation of T cell activities. It has been known that T helper (Th) cell activation requires intimate physical interaction between T helper cells and macro...

journal_title：European journal of immunology

authors： Tian L,Noelle RJ,Lawrence DA

更新日期：1995-01-01 00:00:00

abstract：:Hematopoietic development is a delicate balance of cell fate decisions in multipotent cells between self-renewal and differentiation. In multiple developmental systems, the Notch receptors are important factors regulating these processes. Hematopoietic progenitor cells have been shown to express Notch1, and studies wi...

journal_title：European journal of immunology

authors： Jönsson JI,Xiang Z,Pettersson M,Lardelli M,Nilsson G

更新日期：2001-11-01 00:00:00