Granzyme A expression by normal rat natural killer (NK) cells in vivo and by interleukin 2-activated NK cells in vitro.

abstract：:Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

journal_title：European journal of immunology

authors： Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

更新日期：1988-07-01 00:00:00

abstract：:Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71. The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was s...

journal_title：European journal of immunology

authors： Brekelmans P,van Soest P,Leenen PJ,van Ewijk W

更新日期：1994-11-01 00:00:00

abstract：:CD22 is a B lymphocyte-specific membrane protein that functions as an adhesion molecule via its interactions with a subset of alpha 2-6-linked sialic acid-containing glycoproteins. Engagement of CD22 with a monoclonal antibody (HB22.23) that blocks the binding of CD22 to its ligands results in rapid CD22 tyrosine phos...

journal_title：European journal of immunology

authors： Tuscano JM,Engel P,Tedder TF,Agarwal A,Kehrl JH

更新日期：1996-06-01 00:00:00

abstract：:Continuous antigen stimulation of CD4(+)CD25(-) T cells leads to generation of adaptive CD4(+)CD25(+)FOXP3(+) regulatory T (T(R)) cells. Here, we show that highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) T cells can be generated in the same manner by continuous antigen stimulation in the presence of CD14(+) monocyte...

journal_title：European journal of immunology

authors： Mahic M,Henjum K,Yaqub S,Bjørnbeth BA,Torgersen KM,Taskén K,Aandahl EM

更新日期：2008-03-01 00:00:00

abstract：:Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

journal_title：European journal of immunology

authors： Malissen B,Rebai N,Liabeuf A,Mawas C

更新日期：1982-09-01 00:00:00

abstract：:We have developed a long-term culture system using the murine bone marrow stromal cells MS-5 to support the growth of progenitor B cells with CD34-, CD10+, CD19+, and cytoplasmic mu chain (C mu)-negative surface phenotype from human CD34+ cells purified from umbilical cord blood (CB). When 10(3) CD34+ cells/well were ...

journal_title：European journal of immunology

authors： Nishihara M,Wada Y,Ogami K,Ebihara Y,Ishii T,Tsuji K,Ueno H,Asano S,Nakahata T,Maekawa T

更新日期：1998-03-01 00:00:00

abstract：:Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*...

journal_title：European journal of immunology

authors： Lewis JW,Sewell A,Price D,Elliott T

更新日期：1998-10-01 00:00:00

abstract：:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...

journal_title：European journal of immunology

authors： Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

更新日期：2016-01-01 00:00:00

abstract：:Stimulation of T cells via the T cell receptor (TCR) leads to an increase intracellular in free Ca2+ levels ([Ca2+]i) and the activation of the MAP kinase signaling pathway. This study analyzes for the first time Ca2+ fluxes in naive cytotoxic T cells stimulated with full agonists, partial agonists, or antagonists. Fo...

journal_title：European journal of immunology

authors： Bachmann MF,Mariathasan S,Bouchard D,Speiser DE,Ohashi PS

更新日期：1997-12-01 00:00:00

abstract：:Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...

journal_title：European journal of immunology

authors： Bosco N,Engdahl C,Bénard A,Rolink J,Ceredig R,Rolink AG

更新日期：2008-12-01 00:00:00

abstract：:Mice carrying the lpr gene, SCG and MRL-lpr/lpr mice, were used to characterize the phenotype and lpr gene of abnormally proliferating T cells in these mice. A major population which expanded in these mice were T cells expressing intermediate (int) levels of T cell receptor (TCR) (and CD3) and the phenotype of interle...

journal_title：European journal of immunology

authors： Yamagiwa S,Kuwano Y,Hasegawa K,Sato K,Ohtsuka K,Iiai T,Tomiyama K,Watanabe H,Sugahara S,Seki S,Asakura H,Abo T

更新日期：1996-07-01 00:00:00

abstract：:Interleukin 2 (IL2)-dependent cytolytic hybrids usually loose IL2 dependence and cytolytic activity concomittantly. Here we describe an exceptional IL2-independent variant which lost IL2 receptor but retained cytolytic activity. When the IL2-independent cytolytic hybrid cells were fused with IL2-dependent cytolytic cl...

journal_title：European journal of immunology

authors： Haas W,Kisielow P

更新日期：1985-08-01 00:00:00

abstract：:Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor. Here, we describe the effects of mutation of acidic extracellular CXCR6 residues on receptor function. Although most CXCR6 mutants examined were expressed at levels...

journal_title：European journal of immunology

authors： Petit SJ,Chayen NE,Pease JE

更新日期：2008-08-01 00:00:00

abstract：:We analyzed the functional outcome of the interaction between tumor-associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian cancer patients displayed an alternatively activated functional phenotype (M2) characterized by a remarkably high frequency and surface density of membrane-bound...

journal_title：European journal of immunology

authors： Bellora F,Castriconi R,Dondero A,Pessino A,Nencioni A,Liggieri G,Moretta L,Mantovani A,Moretta A,Bottino C

更新日期：2014-06-01 00:00:00

abstract：:Human NK cells can be subdivided into CD56(dim) and CD56(bright) NK cells, which exhibit different phenotypical and functional characteristics. As murine NK cells lack CD56 or a distinct correlate, direct comparative studies of NK cells in mice and humans are limited. Although CD27 is currently proposed as a feasible ...

journal_title：European journal of immunology

authors： Marquardt N,Wilk E,Pokoyski C,Schmidt RE,Jacobs R

更新日期：2010-05-01 00:00:00

abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

journal_title：European journal of immunology

authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

更新日期：2016-08-01 00:00:00

abstract：:Type I IFN are cytokines which play a central role in host resistance to viral or microbial infections and are important components linking innate and adaptive immunity. We and others have previously demonstrated that the production of IFN-beta by DC following bacterial infections or TLR triggering influences, in an a...

journal_title：European journal of immunology

authors： Remoli ME,Gafa V,Giacomini E,Severa M,Lande R,Coccia EM

更新日期：2007-12-01 00:00:00

abstract：:Precursor CD4-CD8- (DN) thymocytes rearrange their TCR-beta genes, and only those which succeed in beta-selection subsequently expand and differentiate into immature CD4+CD8+ (DP) thymocytes. The cell subsets corresponding to the successive steps of this transition can be defined in terms of CD44 and CD25 expression. ...

journal_title：European journal of immunology

authors： Vasseur F,Le Campion A,Pénit C

更新日期：2001-10-01 00:00:00

abstract：:B cell abnormalities are a prominent feature of the immunologic derangement in NZB and NZB / W mice. We recently demonstrated that these mice have an increased proportion of splenic B cells expressing B7.1 and elevated levels of B7.2 and ICAM-1 that possess the characteristics of marginal zone B cells (CD23(low / -) C...

journal_title：European journal of immunology

authors： Wither JE,Paterson AD,Vukusic B

更新日期：2000-02-01 00:00:00

abstract：:BALB/c mice were repeatedly immunized with microgram doses of benzylpenicilloylated Ascaris protein(s) (BPO9Asc) in alum. At different stages of the immune response, BPO21 eicosa-L-lysine or two analogs containing one or two hydrophobic p-oxymethylbenzyl-3 beta-cholestanyl succinate (OSuco) groups were injected. When ...

journal_title：European journal of immunology

authors： Lüscher IF,Weber E,de Weck AL

更新日期：1984-01-01 00:00:00

abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

journal_title：European journal of immunology

authors： Brandstadter JD,Huang X,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:The antibody response to the synthetic polypeptide, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), [(T,G)-A--L], injected entrapped in liposomes which served as adjuvant has been analyzed. The liposomes used were composed of phosphatidylcholine, cholesterol, dicetylphosphate and DL alpha-tocopherol (molar ratios as 4:3:0.1...

journal_title：European journal of immunology

authors： Lifshitz R,Gitler C,Mozes E

更新日期：1981-05-01 00:00:00

abstract：:C3 is the central component of the complement system. Upon activation, C3 sequentially generates various proteolytic fragments, C3a, C3b, iC3b, C3dg, each of them exposing novel surfaces, which are sites of interaction with other proteins. C3 and its fragments are therapeutic targets and markers of complement activati...

journal_title：European journal of immunology

authors： Subías Hidalgo M,Yébenes H,Rodríguez-Gallego C,Martín-Ambrosio A,Domínguez M,Tortajada A,Rodríguez de Córdoba S,Llorca O

更新日期：2017-03-01 00:00:00

abstract：:The approximately 20-kDa heat-labile toxin produced by enterotoxigenic Bacteroides fragilis is known to be associated with the development of enteritis. However, the molecular mechanism involved is not yet fully understood. In this study, we assessed whether B. fragilis enterotoxin (BFT)-induced enteritis is related t...

journal_title：European journal of immunology

authors： Kim JM,Jung HY,Lee JY,Youn J,Lee CH,Kim KH

更新日期：2005-09-01 00:00:00

abstract：:Since signals via CD40 and the B cell receptor are known to synergize to induce B cell activation, we have analyzed the pocket protein/E2F complexes in mouse B lymphocytes following stimulation by anti-IgM, anti-CD40, alone or together. We find that E2F4 and DP1 form the predominant E2F heterodimers in the G0 and G1 p...

journal_title：European journal of immunology

authors： Lam EW,Glassford J,van der Sman J,Banerji L,Pizzey AR,Shaun N,Thomas B,Klaus GG

更新日期：1999-10-01 00:00:00

abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

journal_title：European journal of immunology

authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

更新日期：1993-11-01 00:00:00

abstract：:A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

journal_title：European journal of immunology

authors： Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

更新日期：1996-03-01 00:00:00

abstract：:IL-6-specific autoantibodies (aAb-IL-6) have been reported in diseased and healthy individuals. We recently established a model for aAb-IL-6 in different mouse strains, based on vaccination with immunogenic IL-6 analogues, in which titers of aAb-IL-6 above 1,000 resulted in an in vivo IL-6 deficiency. Here, we examine...

journal_title：European journal of immunology

authors： Galle P,Svenson M,Bendtzen K,Hansen MB

更新日期：2004-11-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

journal_title：European journal of immunology

authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

更新日期：2006-03-01 00:00:00

abstract：:Sporozoite surface protein 2 has been identified as a target of malaria vaccines designed to produce protective CD8+ cytotoxic T lymphocytes (CTL) because mice immunized with mastocytoma cells expressing a fragment of Plasmodium yoelii sporozoite surface protein 2 (PySSP2) are protected against malaria by an immune re...

journal_title：European journal of immunology

authors： Wizel B,Rogers WO,Houghten RA,Lanar DE,Tine JA,Hoffman SL

更新日期：1994-07-01 00:00:00