p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.


:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation capacity of naïve T cells from wild type and p70(S6K1) knockout mice. Expression of many of the genes associated with Th17-cell differentiation, such as IL17a, IL17f, and IL-23R, were reduced in p70(S6K1) knockout mice. In contrast, the development of Th1, Th2, and Treg cells was unaffected in the absence of p70(S6K1) . Furthermore, expression of the major transcription factor in Th17-cell differentiation, retinoic acid receptor-related orphan receptor gamma T, remained unchanged. However, the acetylation of histone 3 at the promoters of IL17a and IL17f was reduced in the absence of p70(S6K1) . In accordance with the in vitro data, the kinetics, but not the development, of EAE was affected with the loss of p70(S6K1) expression. Collectively, our findings suggested that both in vitro and in vivo differentiation of Th17 cells were positively regulated by p70(S6K1) .


Eur J Immunol


Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P




Has Abstract


2016-01-01 00:00:00












  • Expression and function of the costimulatory molecule B7 on murine Langerhans cells: evidence for an alternative CTLA-4 ligand.

    abstract::We have previously shown, through transfection experiments, that the murine B7 (mB7) molecule, a ligand for the CD28 and CTLA-4 receptors, is a sufficient costimulatory signal for the antigen-specific and major histocompatibility complex (MHC)-restricted activation of murine CD4+ T lymphocytes. In addition to mB7, ano...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Razi-Wolf Z,Falo LD Jr,Reiser H

    更新日期:1994-04-01 00:00:00

  • NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules.

    abstract::Using a new mAb, 2F1, we characterize a mouse natural killer (NK) cell antigen termed 'killer cell lectin-like receptor G1' (KLRG1; formerly mouse MAFA or 2F1-Ag). KLRG1 is expressed on 30-60% of murine NK cells, and a small fraction of T cells, and is composed of a homodimer of glycosylated 30-38-kDa subunits. Striki...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Corral L,Hanke T,Vance RE,Cado D,Raulet DH

    更新日期:2000-03-01 00:00:00

  • Environmental and allele-specific influences on T cell receptor gene rearrangement: skewed alpha, delta, and gamma gene rearrangement patterns in chimeric mice.

    abstract::This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Larché M,Manzo AR,Hurwitz JL

    更新日期:1991-12-01 00:00:00

  • The 3' part of the immunoglobulin kappa locus of the mouse.

    abstract::A detailed restriction map of a 430-kb contig comprising the single Ckappa, the 5 Jkappa and the adjoining 22 Vkappa gene segments is presented. The first 12 Vkappa genes following the JkappaCkappa region belong to the Vkappa21 family, the subsequent ones to the closely related families Vkappa8 and Vkappal 9/ 28. Prev...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kirschbaum T,Pourrajabi S,Zocher I,Schwendinger J,Heim V,Röschenthaler F,Kirschbaum V,Zachau HG

    更新日期:1998-05-01 00:00:00

  • Suppression of polyclonal and antigen-specific murine IgG1 but not IgE responses by neutralizing interleukin-6 in vivo.

    abstract::The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: van Ommen R,Vredendaal AE,Savelkoul HF

    更新日期:1994-06-01 00:00:00

  • Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn.

    abstract::A major feature of the immature immune system in the newborn is its inability to produce significant levels of immunoglobulins other than IgM in response to antigens. It has recently been demonstrated that interaction of the CD40 molecule on B cells with the CD40 ligand (CD40L) on activated T cells is pivotal for immu...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Brugnoni D,Airò P,Graf D,Marconi M,Lebowitz M,Plebani A,Giliani S,Malacarne F,Cattaneo R,Ugazio AG

    更新日期:1994-08-01 00:00:00

  • HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway.

    abstract::HLA class II molecules are involved in the OKT3-induced T cell activation, since monoclonal antibodies (mAb) to monomorphic determinants of class II antigens are able to inhibit T cell proliferation. This effect involves several of the events leading to T cell activation and proliferation, i.e. interleukin (IL) 1, IL ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ruggiero G,Racioppi L,Manzo C,Pirozzi G,D'Oro U,Ferrone S,Zappacosta S,Fontana S

    更新日期:1991-01-01 00:00:00

  • Eosinophilia and reduced STAT3 signaling affect neutrophil cell death in autosomal-dominant Hyper-IgE syndrome.

    abstract::The autosomal-dominant hyper-IgE syndrome (HIES), caused by mutations in STAT3, is a rare primary immunodeficiency that predisposes to mucocutaneous candidiasis and staphylococcal skin and lung infections. This infection phenotype is suggestive of defects in neutrophils, but data on neutrophil functions in HIES are in...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Farmand S,Kremer B,Häffner M,Pütsep K,Bergman P,Sundin M,Ritterbusch H,Seidl M,Follo M,Henneke P,Henriques-Normark B

    更新日期:2018-12-01 00:00:00

  • Antigen-specific T cell receptor antagonism by antigen-presenting cells treated with the hemolysin of Listeria monocytogenes: a novel type of immune escape.

    abstract::We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presentin...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Darji A,Stockinger B,Wehland J,Chakraborty T,Weiss S

    更新日期:1997-07-01 00:00:00

  • Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking.

    abstract::Chemokines are proinflammatory mediators that regulate leukocyte trafficking at different steps of the leukocyte recruitment cascade. Studies using new imaging approaches and new mouse models are giving new insights into the role of chemokines in neutrophil migration at sites of inflammation. Conventional rolling and ...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Sanz MJ,Kubes P

    更新日期:2012-02-01 00:00:00

  • c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.

    abstract::The transcription factor c-Maf is critical for IL-4 production and the development of Th2 cells, which promote humoral immunity and protect against extracellular parasites. Yet, little else is known of c-Maf function in CD4 cells. Here, we identify a novel role for c-Maf in regulating susceptibility to apoptosis. Over...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Peng S,Lalani S,Leavenworth JW,Ho IC,Pauza ME

    更新日期:2007-10-01 00:00:00

  • MicroRNA-142 controls thymocyte proliferation.

    abstract::T-cell development is a spatially and temporally regulated process, orchestrated by well-defined contributions of transcription factors and cytokines. Here, we identify the noncoding RNA miR-142 as an additional regulatory layer within murine thymocyte development and proliferation. MiR-142 deficiency impairs the expr...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mildner A,Chapnik E,Varol D,Aychek T,Lampl N,Rivkin N,Bringmann A,Paul F,Boura-Halfon S,Hayoun YS,Barnett-Itzhaki Z,Amit I,Hornstein E,Jung S

    更新日期:2017-07-01 00:00:00

  • Antigen receptor-initiated growth inhibition is blocked in CD45-loss variants of a mature B lymphoma, with limited effects on apoptosis.

    abstract::Role of CD45 in B cell antigen receptor (BcR)-mediated signaling events in mature B cells was examined using BAL-17 and its CD45-negative clones. In the CD45-negative clones, BcR stimulation induced tyrosine phosphorylation almost identical to the parental cells, with a few exceptions of reduced phosphorylation, espec...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ogimoto M,Katagiri T,Mashima K,Hasegawa K,Mizuno K,Yakura H

    更新日期:1995-08-01 00:00:00

  • CMV and natural killer cells: shaping the response to vaccination.

    abstract::Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Goodier MR,Jonjić S,Riley EM,Juranić Lisnić V

    更新日期:2018-01-01 00:00:00

  • Proliferative activation up-regulates expression of CD4 and HIV-1 co-receptors on NK cells and induces their infection with HIV-1.

    abstract::NK cells play important roles in immune surveillance against malignancy and virus-infected cells. NK cell functions are affected in patients infected with HIV-1; however, whether there is direct interaction between NK cells and HIV-1 remains controversial. In this study the expression of CD4, an important receptor for...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Harada H,Goto Y,Ohno T,Suzu S,Okada S

    更新日期:2007-08-01 00:00:00

  • The action of human C3 in soluble or cross-linked form with resting and activated murine B lymphocytes.

    abstract::The third component of complement C3 has been implied in the stimulation of B lymphocytes to proliferation and maturation for Ig secretion. We have reinvestigated the extent of this activation with either activated or resting murine splenic lymphocytes in serum-substituted cultures. Human C3 was used in either soluble...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Erdei A,Melchers F,Schulz T,Dierich M

    更新日期:1985-02-01 00:00:00

  • IL-10 promotes malignant pleural effusion by regulating TH 1 response via an miR-7116-5p/GPR55/ERK pathway in mice.

    abstract::IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Zhai K,Shi XY,Yi FS,Huang ZY,Wu XZ,Dong SF,Wang W,Wu MT,Shi HZ

    更新日期:2020-11-01 00:00:00

  • Th1 and Th2 CD4+ T cell clones specific for Plasmodium chabaudi but not for an unrelated antigen protect against blood stage P. chabaudi infection.

    abstract::The host protective immune response to blood stage malaria infection was studied using Plasmodium chabaudi chabaudi (P.chabaudi) in NIH mice. It has been shown previously that CD4+ cells are critically required for protection against erythrocytic infection. Mice lacking a functional CD4+ cell compartment suffer unremi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Taylor-Robinson AW,Phillips RS

    更新日期:1994-01-01 00:00:00

  • Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo.

    abstract::IL-7 is a major regulator of lymphocyte homeostasis; however, little is known about the mechanisms that regulate IL-7 production. To study Il7 gene regulation in vivo, we generated a novel IL-7-reporter mouse, which allows the non-invasive quantification of Il7 gene activity in live mice and, additionally, the simulta...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Shalapour S,Deiser K,Sercan O,Tuckermann J,Minnich K,Willimsky G,Blankenstein T,Hämmerling GJ,Arnold B,Schüler T

    更新日期:2010-09-01 00:00:00

  • The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis.

    abstract::Recent studies have suggested that T cell memory for recall antigens resides in clones of primed T cells with a short inter-mitotic half-life. In humans such cells express an isoform of the leukocyte common antigen termed CD45RO. Nevertheless, little is known of the fate of these primed T cells after initial activatio...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Salmon M,Pilling D,Borthwick NJ,Viner N,Janossy G,Bacon PA,Akbar AN

    更新日期:1994-04-01 00:00:00

  • p49, a putative HLA class I-specific inhibitory NK receptor belonging to the immunoglobulin superfamily.

    abstract::NK cells display several killer inhibitory receptors (KIR) specific for different alleles of MHC class I molecules. A family of KIR are represented by type I transmembrane proteins belonging to the immunoglobulin superfamily (Ig-SF). Besides cDNA encoding for these KIR, additional cDNA have been identified which encod...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Cantoni C,Verdiani S,Falco M,Pessino A,Cilli M,Conte R,Pende D,Ponte M,Mikaelsson MS,Moretta L,Biassoni R

    更新日期:1998-06-01 00:00:00

  • Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.

    abstract::Lipid antigens are presented to T cells by the non-polymorphic MHC class I-related CD1 molecules. Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident chaperone that has been shown to lipidate the group 2 CD1 molecule CD1d and thus to regulate its function. We now report that MTP al...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kaser A,Hava DL,Dougan SK,Chen Z,Zeissig S,Brenner MB,Blumberg RS

    更新日期:2008-08-01 00:00:00

  • A role for lymphotoxin beta receptor in host defense against Mycobacterium bovis BCG infection.

    abstract::To investigate the role of membrane lymphotoxin (LT)alpha1 / beta2 and its LTbeta receptor (LTbetaR) in the protective immune response to Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, we have used a soluble fusion molecule (LTbetaR-IgG1). LTbetaR-Ig treatment interferes with granuloma formation mainly ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lucas R,Tacchini-Cottier F,Guler R,Vesin D,Jemelin S,Olleros ML,Marchal G,Browning JL,Vassalli P,Garcia I

    更新日期:1999-12-01 00:00:00

  • Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type.

    abstract::Natural killer T (NKT) lymphocytes rapidly produce several cytokines, including IL-4 and IFN-gamma, upon activation, and act as regulatory cells at an early interphase of innate and adaptive immune responses. They have been implicated as important elements in diverse immune responses including the regulation of autoim...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Stenström M,Sköld M,Ericsson A,Beaudoin L,Sidobre S,Kronenberg M,Lehuen A,Cardell S

    更新日期:2004-01-01 00:00:00

  • Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16.

    abstract::Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor. Here, we describe the effects of mutation of acidic extracellular CXCR6 residues on receptor function. Although most CXCR6 mutants examined were expressed at levels...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Petit SJ,Chayen NE,Pease JE

    更新日期:2008-08-01 00:00:00

  • Epitope specificity of the T cell proliferative response to lysozyme: proliferative T cells react predominantly to different determinants from those recognized by B cells.

    abstract::The fine specificity of murine B 10.A/SgSn (B 10.A) T cells reactive with hen egg-white lysozyme (HEL) has been studied through the use of reduced, carboxymethylated HEL, a set of peptides encompassing the entire molecule, and a set of variant lysozymes from other species. Cells were taken from the lymph nodes drainin...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Maizels RM,Clarke JA,Harvey MA,Miller A,Sercarz EE

    更新日期:1980-07-01 00:00:00

  • HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression.

    abstract::Co-infection of HCV with HIV has been associated with more rapid progression of HCV-related disease. HCV-specific T-cell immune responses, which are essential for disease control, are attenuated in co-infection with HIV. T-cell exhaustion has recently been implicated in the deficient control of chronic viral infection...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Vali B,Jones RB,Sakhdari A,Sheth PM,Clayton K,Yue FY,Gyenes G,Wong D,Klein MB,Saeed S,Benko E,Kovacs C,Kaul R,Ostrowski MA

    更新日期:2010-09-01 00:00:00

  • Phenotypical and functional characterization of Fc gamma receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity.

    abstract::Fc gamma receptor I-positive (CD64+) and Fc gamma receptor I-negative (CD64-) monocytes were prepared from highly purified (elutriation-derived) human monocytes by cytofluorograph cell sorting, and a phenotypical and functional dissociation of the isolated CD64+ and CD64- monocyte subsets is demonstrated. Surface anal...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Grage-Griebenow E,Lorenzen D,Fetting R,Flad HD,Ernst M

    更新日期:1993-12-01 00:00:00

  • IL-13 and TNF-alpha inhibit dual-tropic HIV-1 in primary macrophages by reduction of surface expression of CD4, chemokine receptors CCR5, CXCR4 and post-entry viral gene expression.

    abstract::We show that IL-13 in the presence of TNF-alpha effected an equal or greater antiviral activity against a dual-tropic HIV-1 (R5X4) in macrophages. A temporary or continued exposure of macrophages to both cytokines significantly decreased the infection and replication of R5X4 HIV-1(89.6) (median, 128-fold, n = 9, p = 0...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Bailer RT,Lee B,Montaner LJ

    更新日期:2000-05-01 00:00:00

  • Effects of interferon-alpha on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells.

    abstract::A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

    更新日期:1996-03-01 00:00:00