p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.


:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation capacity of naïve T cells from wild type and p70(S6K1) knockout mice. Expression of many of the genes associated with Th17-cell differentiation, such as IL17a, IL17f, and IL-23R, were reduced in p70(S6K1) knockout mice. In contrast, the development of Th1, Th2, and Treg cells was unaffected in the absence of p70(S6K1) . Furthermore, expression of the major transcription factor in Th17-cell differentiation, retinoic acid receptor-related orphan receptor gamma T, remained unchanged. However, the acetylation of histone 3 at the promoters of IL17a and IL17f was reduced in the absence of p70(S6K1) . In accordance with the in vitro data, the kinetics, but not the development, of EAE was affected with the loss of p70(S6K1) expression. Collectively, our findings suggested that both in vitro and in vivo differentiation of Th17 cells were positively regulated by p70(S6K1) .


Eur J Immunol


Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P




Has Abstract


2016-01-01 00:00:00












  • Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

    abstract::Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further the role of this cytokine in resistance to infection and the differentiation of f...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mattner F,Magram J,Ferrante J,Launois P,Di Padova K,Behin R,Gately MK,Louis JA,Alber G

    更新日期:1996-07-01 00:00:00

  • Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes.

    abstract::Human immunodeficiency virus binds to CD4 T lymphocytes by interaction between its envelope glycoprotein gp120 and the CD4 molecule. The latter is non-covalently associated with a src-related tyrosine kinase, p56lck. CD4 cross-linking increases the activity of p56lck, leading to phosphorylation of several cellular sub...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Hivroz C,Mazerolles F,Soula M,Fagard R,Graton S,Meloche S,Sekaly RP,Fischer A

    更新日期:1993-03-01 00:00:00

  • Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy.

    abstract::The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1/PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, while adoptive cell therapies...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Hope HC,Salmond RJ

    更新日期:2019-08-01 00:00:00

  • Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 produc

    abstract::To study the biological consequences of cytokine production and apoptosis by intraepithelial lymphocytes (IEL), we have studied these characteristics in both the high and low density CD3+ IEL populations. Stimulation of low- or high-density CD3+ IEL via the T cell receptor (TCR)-CD3 complex using monoclonal anti-CD3, ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Yamamoto M,Fujihashi K,Amano M,McGhee JR,Beagley KW,Kiyono H

    更新日期:1994-06-01 00:00:00

  • Influences on the lifespan of B cell subpopulations defined by different phenotypes.

    abstract::The turnover of mature and immature B cells defined by a range of cell surface markers was investigated by feeding normal or bcl-2-transgenic (bcl-2-Tg) mice 5'-bromo-2-deoxyuridine (BrdUrd) for up to 6 weeks. In peripheral lymphoid tissue, B cells accumulated BrdUrd with a 50% labeling time of 4.3 weeks and a pattern...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Fulcher DA,Basten A

    更新日期:1997-05-01 00:00:00

  • The gene expression profile of phosphoantigen-specific human γδ T lymphocytes is a blend of αβ T-cell and NK-cell signatures.

    abstract::Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

    更新日期:2012-01-01 00:00:00

  • The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen.

    abstract::Tissue distribution and expression on mitogen and virally stimulated lymphocytes render the ACT35 molecule a human lymphocyte activation antigen which as yet could not be clustered. Expression cloning of the ACT35 antigen from a pCDM8 library of the HUT-102 cell line revealed strong homology of the cDNA and its encode...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Latza U,Dürkop H,Schnittger S,Ringeling J,Eitelbach F,Hummel M,Fonatsch C,Stein H

    更新日期:1994-03-01 00:00:00

  • Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16.

    abstract::Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor. Here, we describe the effects of mutation of acidic extracellular CXCR6 residues on receptor function. Although most CXCR6 mutants examined were expressed at levels...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Petit SJ,Chayen NE,Pease JE

    更新日期:2008-08-01 00:00:00

  • Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.

    abstract::The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engag...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Messal N,Mamessier E,Sylvain A,Celis-Gutierrez J,Thibult ML,Chetaille B,Firaguay G,Pastor S,Guillaume Y,Wang Q,Hirsch I,Nunès JA,Olive D

    更新日期:2011-12-01 00:00:00

  • Interaction within clusters of dendritic cells and helper T cells during initial Th1/Th2 commitment.

    abstract::Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schuhbauer DM,Mitchison NA,Mueller B

    更新日期:2000-05-01 00:00:00

  • A human-hybridoma system based on a fast-growing mutant of the ARH-77 plasma cell leukemia-derived line.

    abstract::A rapidly-growing, HAT-sensitive cell line LICR-LON-HMy2 has been derived from the ARH-77 human plasma cell leukemia-derived line. It lacks the enzyme hypoxanthine phosphoribosyltransferase (EC Hybrids have been reproducibly made for more than a year and in independent laboratories with lymphocytes from tons...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Edwards PA,Smith CM,Neville AM,O'Hare MJ

    更新日期:1982-08-01 00:00:00

  • A monoclonal antibody against a new differentiation antigen of thymocytes.

    abstract::B14-2-14 is a monoclonal cytotoxic IgM antibody which reacts with thymocytes of all mouse strains tested. The fraction of positive cells (by visual immunofluorescence) varies between strains from about 25-45% in A.CA to 65-85% in C57BL/6, and high levels are dominant in F1 hybrids. In the periphery, the antigen is fou...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Sidman CL,Forni L,Köhler G,Langhorne J,Lindahl KF

    更新日期:1983-06-01 00:00:00

  • Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor.

    abstract::Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

    更新日期:2008-06-01 00:00:00

  • Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

    abstract::C3 is the central component of the complement system. Upon activation, C3 sequentially generates various proteolytic fragments, C3a, C3b, iC3b, C3dg, each of them exposing novel surfaces, which are sites of interaction with other proteins. C3 and its fragments are therapeutic targets and markers of complement activati...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Subías Hidalgo M,Yébenes H,Rodríguez-Gallego C,Martín-Ambrosio A,Domínguez M,Tortajada A,Rodríguez de Córdoba S,Llorca O

    更新日期:2017-03-01 00:00:00

  • The in vitro immune response to a T-independent antigen. I. The effect of macrophages and 2-mercaptoethanol.

    abstract::The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Nordin AA

    更新日期:1978-11-01 00:00:00

  • Oxidized phospholipids induce anergy in human peripheral blood T cells.

    abstract::Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Seyerl M,Blüml S,Kirchberger S,Bochkov VN,Oskolkova O,Majdic O,Stöckl J

    更新日期:2008-03-01 00:00:00

  • A bidirectional regulatory network involving IL 2 and IL 4 in the alternative CD2 pathway of T cell activation.

    abstract::In this study we examined the effect of interleukin 4 (IL 4) on T cell activation and proliferation via the alternative CD2 pathway. To this end highly purified human resting T cells were cultured with a stimulating pair of anti-CD2 monoclonal antibodies in the absence of accessory signals from monocytes. Addition of ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lorré K,Van Damme J,Ceuppens JL

    更新日期:1990-07-01 00:00:00

  • Induction of murine cytotoxic T lymphocytes against Plasmodium falciparum sporozoite surface protein 2.

    abstract::Sporozoite surface protein 2 has been identified as a target of malaria vaccines designed to produce protective CD8+ cytotoxic T lymphocytes (CTL) because mice immunized with mastocytoma cells expressing a fragment of Plasmodium yoelii sporozoite surface protein 2 (PySSP2) are protected against malaria by an immune re...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Wizel B,Rogers WO,Houghten RA,Lanar DE,Tine JA,Hoffman SL

    更新日期:1994-07-01 00:00:00

  • Human eosinophils express a receptor for secretory component. Role in secretory IgA-dependent activation.

    abstract::The existence of a functional receptor for secretory component (SC) on the eosinophil membrane might explain the preferential degranulation induced by secretory IgA (sIgA) when compared to serum IgA. Indeed, flow cytometry analysis revealed that purified human SC could bind to a subpopulation (4-59%) of blood eosinoph...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lamkhioued B,Gounni AS,Gruart V,Pierce A,Capron A,Capron M

    更新日期:1995-01-01 00:00:00

  • Most anti-human CD3 monoclonal antibodies are directed to the CD3 epsilon subunit.

    abstract::The T cell receptor is a molecular complex compriSed of a clonally-restricted heterodimer (Ti) responsible for specific antigen recognition and a set of invariant CD3 peptides termed gamma, delta, epsilon, zeta and eta. The latter are believed to be involved in transmembrane signaling events given that monoclonal anti...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Transy C,Moingeon PE,Marshall B,Stebbins C,Reinherz EL

    更新日期:1989-05-01 00:00:00

  • Impaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient mice.

    abstract::The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. We demonstrate that the IL-7 receptor becomes progressively more important with age. B lymphopoiesis takes place...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Erlandsson L,Licence S,Gaspal F,Bell S,Lane P,Corcoran AE,Mårtensson IL

    更新日期:2004-12-01 00:00:00

  • The Tregs' world according to GARP.

    abstract::Naturally occurring CD4+CD25(high) regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despit...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Battaglia M,Roncarolo MG

    更新日期:2009-12-01 00:00:00

  • TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells.

    abstract::We analyzed the functional outcome of the interaction between tumor-associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian cancer patients displayed an alternatively activated functional phenotype (M2) characterized by a remarkably high frequency and surface density of membrane-bound...

    journal_title:European journal of immunology

    pub_type: 临床试验,杂志文章


    authors: Bellora F,Castriconi R,Dondero A,Pessino A,Nencioni A,Liggieri G,Moretta L,Mantovani A,Moretta A,Bottino C

    更新日期:2014-06-01 00:00:00

  • Atopic dermatitis: A tale of two distinct pathomechanisms that make you itch.

    abstract::Atopic dermatitis (AD) or eczema is the most common chronic inflammatory skin disease. It is a multifactorial disease with local and systemic immune changes. Current therapies focus on restoring the local skin barrier or inhibiting immune responses. In this issue of the European Journal of Immunology, Sehra et al. [Eu...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Knol EF,Hijnen D

    更新日期:2016-11-01 00:00:00

  • Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells.

    abstract::Foxp3-expressing Tregs play a non-redundant role in protecting against immune pathologies. Foxp3(+) Tregs can arise intra- and extra-thymically, however, the signals directing their differentiation and maintenance in the periphery are not well understood. We show that stimulation of mouse naïve CD4(+) T cells in vitro...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Gabryšová L,Christensen JR,Wu X,Kissenpfennig A,Malissen B,O'Garra A

    更新日期:2011-05-01 00:00:00

  • Fine specificity of the H-2 linked immune response gene for the gallinaceous lysozymes.

    abstract::An immune response (Ir) gene is described which controls the ability of mice to respond to seven very closely related gallinaceous egg white lysozymes (GEL). This Ir-GEL gene locus is linked to the major histocompatibility locus of the mouse and operates at the level of the T cell. Responsiveness to the nonimmunogenic...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Hill SW,Sercarz EE

    更新日期:1975-05-01 00:00:00

  • Class II-restricted IgG2ab-specific T cells recognize a signal-minus form of the V-CH3b antigen.

    abstract::To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Bikoff EK

    更新日期:1991-06-01 00:00:00

  • Complement alternative pathway activation and control on membranes of human lymphoid B cell lines.

    abstract::Membrane regulatory molecules normally prevent complement activation by autologous cells, therefore we compared the membrane control system of human lymphoid cell lines which activate or not human complement through the alternative pathway (AP). Membrane expression of decay-accelerating factor (DAF), membrane cofactor...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Caudwell V,Porteu F,Calender A,Pangburn MK,Halbwachs-Mecarelli L

    更新日期:1990-12-01 00:00:00

  • Specific binding of poly(I)-poly(C) to the membrane of murine B lymphocyte subsets.

    abstract::Indirect immunofluorescence revealed that 13% of BALB/c and 33% of CBA spleen cells of B type carry specific binding sites at their surface for double-stranded poly(I).poly(C). Pretreatment of BALB/c spleen cells with anti-mouse immunoglobulin serum increased the number of B cells capable of binding poly(I).poly(C) in...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Diamantstein T,Bittstein-Willinger E

    更新日期:1978-12-01 00:00:00

  • Autophagy plays a protective role as an anti-oxidant system in human T cells and represents a novel strategy for induction of T-cell apoptosis.

    abstract::Autophagy is an intracellular degradation system that plays an important role in T-cell survival. However, the precise mechanism linking autophagy and cell death in primary human T cells is unclear because methods for monitoring autophagy in small numbers of primary human cells remain controversial. We established a n...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Watanabe R,Fujii H,Shirai T,Saito S,Ishii T,Harigae H

    更新日期:2014-08-01 00:00:00