p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.


:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation capacity of naïve T cells from wild type and p70(S6K1) knockout mice. Expression of many of the genes associated with Th17-cell differentiation, such as IL17a, IL17f, and IL-23R, were reduced in p70(S6K1) knockout mice. In contrast, the development of Th1, Th2, and Treg cells was unaffected in the absence of p70(S6K1) . Furthermore, expression of the major transcription factor in Th17-cell differentiation, retinoic acid receptor-related orphan receptor gamma T, remained unchanged. However, the acetylation of histone 3 at the promoters of IL17a and IL17f was reduced in the absence of p70(S6K1) . In accordance with the in vitro data, the kinetics, but not the development, of EAE was affected with the loss of p70(S6K1) expression. Collectively, our findings suggested that both in vitro and in vivo differentiation of Th17 cells were positively regulated by p70(S6K1) .


Eur J Immunol


Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P




Has Abstract


2016-01-01 00:00:00












  • Stress protein (hsp73)-mediated, TAP-independent processing of endogenous, truncated SV40 large T antigen for Db-restricted peptide presentation.

    abstract::Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schirmbeck R,Böhm W,Reimann J

    更新日期:1997-08-01 00:00:00

  • Studies on the mechanism of polyclonal B cell stimulation by TH2 cells.

    abstract::Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lohoff M,Dirks M,Rohwer P,Röllinghoff M

    更新日期:1989-01-01 00:00:00

  • The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells.

    abstract::We have proposed earlier that the poor capacity of the lipocalin allergen Bos d 2 to stimulate highly allergic subjects' peripheral blood mononuclear cells could be ascribed to endogenous lipocalins and could be related to the allergenic potential of the molecule. Here, we have characterized the proliferative and cyto...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kinnunen T,Buhot C,Närvänen A,Rytkönen-Nissinen M,Saarelainen S,Pouvelle-Moratille S,Rautiainen J,Taivainen A,Maillère B,Mäntyjärvi R,Virtanen T

    更新日期:2003-06-01 00:00:00

  • Role of adherent T cells and of B cells in the immune response to purified protein derivative of tuberculin.

    abstract::The role of monocytes, B cells, and adherent and nonadherent T cells in the response of purified protein derivative of tuberculin (PPD) as measured by [3H]thymidine uptake in vitro has been explored. The response to PPD was found to be highly dependent on monocytes, to approximately the same extent as previously found...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Arala-Chaves MP,Porto MT,Hope L,Fudenberg HH

    更新日期:1979-04-01 00:00:00

  • Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism.

    abstract::Transgenic CBA (H-2k haplotype) mice expressing the H-2 Kb major histocompatibility complex (MHC) class I gene under control of transcriptional promoter elements from a milk protein gene display high-level H-2 Kb transcription in lactating mammary glands and low-level transcription in skin and thymus of male and virgi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Husbands SD,Schönrich G,Arnold B,Chandler PR,Simpson E,Philpott KL,Tomlinson P,O'Reilly L,Cooke A,Mellor AL

    更新日期:1992-10-01 00:00:00

  • DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands.

    abstract::Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the mole...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: End C,Bikker F,Renner M,Bergmann G,Lyer S,Blaich S,Hudler M,Helmke B,Gassler N,Autschbach F,Ligtenberg AJ,Benner A,Holmskov U,Schirmacher P,Nieuw Amerongen AV,Rosenstiel P,Sina C,Franke A,Hafner M,Kioschis P,Schre

    更新日期:2009-03-01 00:00:00

  • Mutations of the gene FNIP1 associated with a syndromic autosomal recessive immunodeficiency with cardiomyopathy and pre-excitation syndrome.

    abstract::AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Folliculin (FLCN) and the FLCN-interacting proteins 1 and 2 (FNIP1, 2) modulate AMPK. FNIP1 deficiency patients have a AMPK-P gain of f...

    journal_title:European journal of immunology

    pub_type: 信件


    authors: Niehues T,Özgür TT,Bickes M,Waldmann R,Schöning J,Bräsen J,Hagel C,Ballmaier M,Klusmann JH,Niedermayer A,Pannicke U,Enders A,Dückers G,Siepermann K,Hempel J,Schwarz K,Viemann D

    更新日期:2020-07-01 00:00:00

  • All the small things: How virus-like particles and liposomes modulate allergic immune responses.

    abstract::Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Kratzer B,Hofer S,Zabel M,Pickl WF

    更新日期:2020-01-01 00:00:00

  • Type-I Interferon assessment in 45 minutes using the FilmArray® PCR platform in SARS-CoV-2 and other viral infections.

    abstract::Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

    更新日期:2020-12-12 00:00:00

  • Subclasses of T cells with different sensitivities to cytotoxic antibody in the presence of anesthetics.

    abstract::When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lee SK,Singh J,Taylor RB

    更新日期:1975-04-01 00:00:00

  • Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid.

    abstract::A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65-kDa heat-shock protein (hsp) as a putative causal agent. The 65-kDa hsp has over 40% sequence homology with the human hsp 60, and elevated synovial T cell resp...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Quayle AJ,Wilson KB,Li SG,Kjeldsen-Kragh J,Oftung F,Shinnick T,Sioud M,Førre O,Capra JD,Natvig JB

    更新日期:1992-05-01 00:00:00

  • Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.

    abstract::Tissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R

    更新日期:2016-02-01 00:00:00

  • Abundance of H-2 promiscuous T cells specific for mycobacterial determinants in H-2b/d F1 hybrid mice.

    abstract::A majority of immunodominant epitopes of mycobacterial antigens are known to be recognized by murine T cells in the context of several H-2 haplotypes. In this study, we established the frequency of T cells able to recognize these peptides promiscuously, i.e. in the context of allogeneic antigen-presenting cells, using...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Vordermeier HM,Arya A,Harris DP,Moreno C,Ivanyi J

    更新日期:1995-10-01 00:00:00

  • A Leishmania protein that modulates interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production and expression of B7-1 in human monocyte-derived antigen-presenting cells.

    abstract::LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Probst P,Skeiky YA,Steeves M,Gervassi A,Grabstein KH,Reed SG

    更新日期:1997-10-01 00:00:00

  • Defined antigens secreted by the larvae of schistosomes protect against schistosomiasis: induction of cytotoxic antibodies in the rat and the monkey.

    abstract::The study of the immunology of schistosomiasis has allowed a clear understanding of the basic mechanisms of resistance, emphasizing the important role played by cellular and humoral factors. Whereas the production of polyclonal or monoclonal antibodies and the precise inventory of immune effector mechanisms in the rat...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Auriault C,Damonneville M,Joseph M,Capron M,Verwaerde C,Billaut P,Capron A

    更新日期:1985-12-01 00:00:00

  • Maintenance of memory CD8 T cells: Divided over division.

    abstract::Once generated during an infection, memory CD8+ T cells can provide long-lasting protection against reinfection with an intracellular pathogen, but the longevity of this defense depends on the ability of these pathogen-specific memory cells to be maintained. It is generally believed that the bone marrow plays an impor...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Nolte MA,Goedhart M,Geginat J

    更新日期:2017-11-01 00:00:00

  • Tolerance of self induced in thymus organ culture.

    abstract::F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Robertson K,Simon K,Schneider S,Timms E,Mitchison A

    更新日期:1992-01-01 00:00:00

  • ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cells.

    abstract::Several sets of data indicate that ICOS regulates cytokine production in activated T cells, but is less effective on naïve T cells. This work evaluates ICOS function in human naïve CD4+ T cells through an assessment of the effect of soluble forms of the ICOS and CD28 physiological ligands on activation driven by anti-...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mesturini R,Nicola S,Chiocchetti A,Bernardone IS,Castelli L,Bensi T,Ferretti M,Comi C,Dong C,Rojo JM,Yagi J,Dianzani U

    更新日期:2006-10-01 00:00:00

  • The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis.

    abstract::The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

    更新日期:2019-06-01 00:00:00

  • Induction of high-affinity paf receptor expression during T cell activation.

    abstract::Activated human T cells via the CD2 or the CD3 pathways exhibited a higher capacity than resting T lymphocytes to incorporate and metabolize [3H]pafacether (paf) at 37 degrees C. Resting T lymphocytes lacked specific binding capacity for paf, yet high-affinity paf receptors (paf-R) were induced on CD3- or CD2-dependen...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Calabresse C,Nguer MC,Pellegrini O,Benveniste J,Richard Y,Thomas Y

    更新日期:1992-06-01 00:00:00

  • The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes.

    abstract::Human peripheral blood T lymphocytes are stimulated to grow and divide by lectins such as concanavalin A (Con A) and Phaseolus vulgaris phytohemagglutinin (PHA), as well as a few anti-T cell monoclonal antibodies. The latter antibodies recognize the T3 antigen. It has been suggested previously that PHA and Con A media...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kanellopoulos JM,De Petris S,Leca G,Crumpton MJ

    更新日期:1985-05-01 00:00:00

  • Serologic distinction between the rabbit kappa L chain allotype b4 and an allele b4.

    abstract::Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Smith LJ,Sogh JA,Kindt TJ,Mandy WJ

    更新日期:1979-01-01 00:00:00

  • Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states.

    abstract::Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of MAPK-, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. This activation state is inherently unstable and often transitions into a state of 'tolerance' characte...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Ivashkiv LB

    更新日期:2011-09-01 00:00:00

  • Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4.

    abstract::CD40 ligand (CD40L) and IL-4 are sufficient to induce resting murine B cells to divide and switch isotypes from IgM and IgD to IgG1 and IgE. Tracking of cell division following (5- and 6) carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling revealed that B cells expressed IgG1 after three cell divisions, an...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Hasbold J,Lyons AB,Kehry MR,Hodgkin PD

    更新日期:1998-03-01 00:00:00

  • Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

    abstract::Immunity to tumor differentiation antigens, such as melanoma antigen recognized by T cells 1 (MART-1), has been comprehensively studied. Intriguingly, CD8(+) T cells specific for the MART-1(26(27)-35) epitope in the context of HLA-A0201 are about 100 times more abundant compared with T cells specific for other tumor-a...

    journal_title:European journal of immunology

    pub_type: 临床试验,杂志文章


    authors: Pinto S,Sommermeyer D,Michel C,Wilde S,Schendel D,Uckert W,Blankenstein T,Kyewski B

    更新日期:2014-09-01 00:00:00

  • In vivo induction of gamma/delta T cells with highly potent and selective anti-tumor cytotoxicity.

    abstract::High frequencies of CD5+TcR alpha/beta- T cells were induced in the peritoneal cavity of rats immunized with syngeneic W439 lymphoma cells. These TcR alpha/beta- cells expressed TcR delta mRNA as analyzed by the polymerase chain reaction technique. The delta + (TcR gamma/delta +) T cells were of the CD2+, CD3+, CD4-, ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ericsson PO,Hansson J,Widegren B,Dohlsten M,Sjögren HO,Hedlund G

    更新日期:1991-11-01 00:00:00

  • Double-negative thymocyte subsets in CD3 zeta chain-deficient mice: absence of HSA+CD44-CD25- cells.

    abstract::Double-negative (DN) thymocyte subsets were examined in mice deficient in the CD3 zeta chain (zeta-/-). The HSA+CD44-CD25- subset was found to be missing, and DN thymocytes seemed to differentiate directly from HSA+CD25+CD44- cells to double-positive (DP) cells. When fetal thymic ontogeny was examined, we found a mark...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Crompton T,Moore M,MacDonald HR,Malissen B

    更新日期:1994-08-01 00:00:00

  • Dendritic cells erase bad memory.

    abstract::DC not only activate CD4 T (Th) cell and cytotoxic CD8 T cell (CTL) responses against pathogens, but they also tolerize autoreactive T cells in order to avoid autoimmunity. Previous studies have demonstrated that steady-state DC can tolerize naïve CTL, naïve Th cells and memory CTL. A study in this issue of the Europe...

    journal_title:European journal of immunology



    authors: Kurts C

    更新日期:2010-07-01 00:00:00

  • Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.

    abstract::To define activation-specific sequences in human T lymphocytes, a cDNA library was constructed by subtractive hybridization using resting and stimulated peripheral blood lymphocyte pairs. Stimulation of peripheral blood lymphocytes was achieved by triggering with mitogenic anti-CD2 (T11) monoclonal antibodies. Differe...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Chang HC,Reinherz EL

    更新日期:1989-06-01 00:00:00

  • MLR blast cells generated in mutant-standard strain combinations bind H-2K and H-2D antigens.

    abstract::Strains CBA (M523) (= M523) and CBA differ by a mutation which has been mapped genetically into the K region of the H-2 complex. Similarly, strains B 10.D2 (M504 (= M504) and b 10.D2 differ in a mutation which occurred in the D region. The data presented in this study show that mixed lymphocyte culture in M523 anti-CB...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Geib RW,Klein J

    更新日期:1979-02-01 00:00:00