p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

abstract：:The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP compa...

journal_title：European journal of immunology

authors： Carrera AC,Rincón M,De Landázuri MO,López-Botet M

更新日期：1988-06-01 00:00:00

abstract：:Toll-like receptors (TLRs) are playing important roles in stimulating the innate immune response and intensifying adaptive immune response against invading pathogens. Appropriate regulation of TLR activation is important to maintain a balance between preventing tumor activation and inhibiting autoimmunity. Toll-like r...

journal_title：European journal of immunology

authors： Kim TW,Hong S,Talukder AH,Pascual V,Liu YJ

更新日期：2016-03-01 00:00:00

abstract：:The major role of cells of the dendritic family in immunity and tolerance has been amply documented. Since their discovery in 1973, these cells have gained increasing interest from immunologists, as they are able to detect infectious agents, migrate to secondary lymphoid tissue, and prime naive T lymphocytes, thereby ...

journal_title：European journal of immunology

authors： Hespel C,Moser M

更新日期：2012-10-01 00:00:00

abstract：:The extent of emigration of cells from the bursa of Fabricius to the periphery was estimated. Per anum application of fluorescein isothiocyanate to label bursal cells in situ was used. Migrant cells can be visualized on frozen sections or cell suspensions of peripheral organs by their fluorescence. The data show that ...

journal_title：European journal of immunology

authors： Lassila O

更新日期：1989-05-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of MAPK-, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. This activation state is inherently unstable and often transitions into a state of 'tolerance' characte...

journal_title：European journal of immunology

authors： Ivashkiv LB

更新日期：2011-09-01 00:00:00

abstract：:MRL/MP-lpr/lpr mice are homozygous for the lpr mutation that results in the accumulation of phenotypically abnormal cells (CD3+CD4+CD8-) in all lymphoid issues. Although no major abnormalities in the T cell receptor repertoire expressed by such lpr cells have been reported, the lpr mutation is a major disease-accelera...

journal_title：European journal of immunology

authors： De Alborán IM,Gutierrez JC,Gonzalo JA,Andreu JL,Marcos MA,Kroemer G,Martínez C

更新日期：1992-04-01 00:00:00

abstract：:Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play...

journal_title：European journal of immunology

authors： Nagy L

更新日期：2012-07-01 00:00:00

abstract：:The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII. Treatment of mouse antigen-presenting cells (APC) with the pharmacological Hsp90 inhibi...

journal_title：European journal of immunology

authors： Rajagopal D,Bal V,Mayor S,George A,Rath S

更新日期：2006-04-01 00:00:00

abstract：:The modulatory activity of dextran sulfate with a relative molecular mass of 8 and 500 kDa and pentosan polysulfate with a relative molecular mass of 6 kDa on human T cell surface molecules CD2, CD3, CD4, CD8 and HLA-DR was investigated by analytical flow cytometry. The 500-kDa dextran sulfate induces a complete disap...

journal_title：European journal of immunology

authors： Thiele B,Braig HR,Ehm I,Kunze R,Ruf B

更新日期：1989-06-01 00:00:00

abstract：:The pathways of human anti-pig T cell xenorecognition have been investigated. Freshly isolated porcine alveolar lavage (AL) cells induced primary proliferative responses by human peripheral and cord blood mononuclear cells which were inhibited by anti-HLA-DR antibody (indirect xenorecognition). Following over-night cu...

journal_title：European journal of immunology

authors： Dorling A,Lombardi G,Binns R,Lechler RI

更新日期：1996-06-01 00:00:00

abstract：:Production of indoleamine 2,3-dioxygenase (IDO) by tumor cells, leading to tryptophan depletion and production of immunosuppressive metabolites, may facilitate immune tolerance of cancer. IDO gene is also expressed in dendritic cells (DC) upon maturation induced by lipopolysaccarides or IFN. We investigated IDO gene e...

journal_title：European journal of immunology

authors： Weber WP,Feder-Mengus C,Chiarugi A,Rosenthal R,Reschner A,Schumacher R,Zajac P,Misteli H,Frey DM,Oertli D,Heberer M,Spagnoli GC

更新日期：2006-02-01 00:00:00

abstract：:Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...

journal_title：European journal of immunology

authors： Seyerl M,Blüml S,Kirchberger S,Bochkov VN,Oskolkova O,Majdic O,Stöckl J

更新日期：2008-03-01 00:00:00

abstract：:Pre-B cells which show a delayed development of responsiveness to the B cell mitogen lipopolysaccharide (LPS) are found in murine embryonic blood between day 10 and 14 of gestation. The highest frequency of pre-B cells in embryonic blood is found at day 12 of gestation. All pre-B cells of embryonic blood, isolated at ...

journal_title：European journal of immunology

authors： Melchers F,Abramczuk J

更新日期：1980-10-01 00:00:00

abstract：:Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

journal_title：European journal of immunology

authors： Sun D,Hu XZ,Coleclough C

更新日期：1995-01-01 00:00:00

abstract：:A conditionally immortalized dendritic cell line was established from bone marrow of mice transgenic for a thermolabile mutant of the SV40 large T antigen under the control of the class I Kb promoter. At the permissive temperature of 33 degrees-37 degrees C, the line divides in the absence of granulocyte/macrophage co...

journal_title：European journal of immunology

authors： Volkmann A,Neefjes J,Stockinger B

更新日期：1996-11-01 00:00:00

abstract：:Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here explore the functional and phenotypic heterogeneity of individual transcriptomes of 1167 murine BM mesenchymal stromal cells. These cells exhibit a tremendous heterog...

journal_title：European journal of immunology

authors： Addo RK,Heinrich F,Heinz GA,Schulz D,Sercan-Alp Ö,Lehmann K,Tran CL,Bardua M,Matz M,Löhning M,Hauser AE,Kruglov A,Chang HD,Durek P,Radbruch A,Mashreghi MF

更新日期：2019-09-01 00:00:00

abstract：:Even if omalizumab is broadly used in the treatment of severe, allergic asthma, the immunological effects in long-term treated patients have not been fully elucidated. To this aim, a cohort of 15 allergic asthmatic patients treated with omalizumab for at least three years was compared with 12 allergic asthma patients ...

journal_title：European journal of immunology

authors： Maggi L,Rossettini B,Montaini G,Matucci A,Vultaggio A,Mazzoni A,Palterer B,Parronchi P,Maggi E,Liotta F,Annunziato F,Cosmi L

更新日期：2018-12-01 00:00:00

abstract：:The proliferative state of functionally defined populations of size-separated pre-B cells was investigated. The results presented here support the hypothesis that pre-B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlik...

journal_title：European journal of immunology

authors： Deslauriers-Boisvert N,Mercier G,Lafleur L

更新日期：1982-04-01 00:00:00

abstract：:Cognate interactions between major histocompatibility complex class II antigen (Ag)-reactive CD4+ T helper (Th) and Ag-presenting B cells induce first the activation of B cells and their subsequent differentiation into Ig-secreting cells (IgSC). The Th cell-associated homodimeric glycoprotein CD28 has been implicated ...

journal_title：European journal of immunology

authors： Damle NK,Linsley PS,Ledbetter JA

更新日期：1991-05-01 00:00:00

abstract：:Treg subsets play a role in sustaining peripheral tolerance, are characterized by markers such as forkhead winged-helix transcription factor (FOXP3) and CD25, and produce suppressive cytokines, such as IL-10 and TGF-β. Glucocorticoid-induced TNF receptor family-related (GITR) protein has been suggested to regulate Tre...

journal_title：European journal of immunology

authors： Bianchini R,Bistoni O,Alunno A,Petrillo MG,Ronchetti S,Sportoletti P,Bocci EB,Nocentini G,Gerli R,Riccardi C

更新日期：2011-08-01 00:00:00

abstract：:IL-12 is an important immunomodulatory cytokine that induces tyrosine phosphorylation and activation of the signal transducer and activator of transcription (STAT)4. IL-12 induces sustained activation and nuclear translocation of STAT4 and this regulatory process is coupled to both tyrosine and serine phosphorylation ...

journal_title：European journal of immunology

authors： Athié-M V,Flotow H,Hilyard KL,Cantrell DA

更新日期：2000-05-01 00:00:00

abstract：:1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Here, we analyze the effect of 1,25-(OH)2D3 on IF...

journal_title：European journal of immunology

authors： Cippitelli M,Santoni A

更新日期：1998-10-01 00:00:00

abstract：:Ikaros is a transcriptional regulator whose function is essential for B cell development. It is expressed in the hematopoietic stem cell (HSC) through the mature B cell stage. Using genetically engineered mice in which the endogenous Ikaros gene is disrupted, it has been shown that a lack of Ikaros leads to a block in...

journal_title：European journal of immunology

authors： Wojcik H,Griffiths E,Staggs S,Hagman J,Winandy S

更新日期：2007-04-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...

journal_title：European journal of immunology

authors： Tschopp J,Villiger W,Lustig A,Jaton JC,Engel J

更新日期：1980-07-01 00:00:00

abstract：:Limited studies have addressed the ability of gammadelta T cells to become memory populations. We previously demonstrated that WC1.1(+) gammadelta T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN-gamma in recall responses. Here we show that this response is dependent ...

journal_title：European journal of immunology

authors： Blumerman SL,Herzig CT,Baldwin CL

更新日期：2007-05-01 00:00:00

abstract：:Ptak and Askenase showed that both alphabeta and gammadelta cells are required for transfer of contact sensitivity (CS). This study confirms that day 4 immune cells depleted of gammadelta cells fail to transfer CS to trinitrochlorobenzene (TNP-Cl) systemically and demonstrates that administration of anti-gammadelta mo...

journal_title：European journal of immunology

authors： Dieli F,Asherson GL,Sireci G,Dominici R,Gervasi F,Vendetti S,Colizzi V,Salerno A

更新日期：1997-01-01 00:00:00

abstract：:Alpha-galactosylceramide (alpha-GalCer) activates invariant (i)NKT cells, which in turn stimulate immunocompetent cells. Although activation of iNKT cells appears critical for regulation of immune responses, it remains elusive whether protection against intracellular bacteria can be induced by alpha-GalCer. Here, we s...

journal_title：European journal of immunology

authors： Emoto M,Emoto Y,Yoshizawa I,Kita E,Shimizu T,Hurwitz R,Brinkmann V,Kaufmann SH

更新日期：2010-05-01 00:00:00

abstract：:Histological techniques were used to identify antigen-presenting cells (APC) in adoptively transferred diabetes in NOD mice and Ins-HA transgenic mice, and in spontaneously diabetic NOD mice. In adoptively transferred disease, CD4+ T cells and F4/80+ macrophages dominated early infiltrates. By contrast, in spontaneous...

journal_title：European journal of immunology

authors： Lo D,Reilly CR,Scott B,Liblau R,McDevitt HO,Burkly LC

更新日期：1993-07-01 00:00:00