p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

abstract：:MHC class II molecules present peptides, derived largely from exogenous antigens, to CD4+ T cells. Complex-generation occurs mainly in the specialized late endosomal MHC class II-rich compartment (MIIC) vesicles of antigen-presenting cells (APC). Dendritic cells (DC) have been reported to store intact antigen in MIIC ...

journal_title：European journal of immunology

authors： Colledge L,Bennett CL,Reay PA,Blackburn CC

更新日期：2002-11-01 00:00:00

abstract：:The cytotoxic response of cell sorter-purified small Lyt-2+ splenic cytotoxic lymphocyte precursors from 10 individual C57BL/6 mice to mutant class I H-2Kbm1 or H-2Dbm14 allodeterminants was analyzed under limiting dilution conditions. The cytotoxic activity of anti-bm1-specific or anti-bm14-specific cytotoxic T lymph...

journal_title：European journal of immunology

authors： Reimann J,Bellan A

更新日期：1986-12-01 00:00:00

abstract：:T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage(-) Sca1(+)c-kit(+) BM hematopoietic progenitors very efficiently differ...

journal_title：European journal of immunology

authors： Gehre N,Nusser A,von Muenchow L,Tussiwand R,Engdahl C,Capoferri G,Bosco N,Ceredig R,Rolink AG

更新日期：2015-03-01 00:00:00

abstract：:The interaction of KB-V1, a multidrug resistant (MDR) variant of the KB-3-1 human oral carcinoma, with human complement was investigated. KB-V1 cells were found to be more sensitive than KB-3-1 cells to complement-mediated lysis. Detailed analysis of the capacity of KB cells to activate human complement demonstrated t...

journal_title：European journal of immunology

authors： Bomstein Y,Fishelson Z

更新日期：1997-09-01 00:00:00

abstract：:The relationship between immunogenicity of Shigella paradysenteriae, the branched synthetic polypeptide poly-L (Tyr, Glu)-polylpro-polyllys [(T, G)-Pro--L] and human albumin (HSA) interacting with macrophages and kinetics of antigen degradation and degree of binding to the cell surface was studied. Following thioglyco...

journal_title：European journal of immunology

authors： Gallily R,Bar-Eli M

更新日期：1976-11-01 00:00:00

abstract：:Stem cell antigen-1 (Sca1, Ly-6A/E) is a well-established marker of murine hematopoietic stem cells, and also is expressed on memory T cells. It has been suggested that the functional maintenance of T-cell memory requires the expression of Sca1 on a specialized population of memory T cells termed "memory stem cells". ...

journal_title：European journal of immunology

authors： Whitmire JK,Eam B,Whitton JL

更新日期：2009-06-01 00:00:00

abstract：:The progression of experimental allergic encephalomyelitis (EAE) in certain mouse strains has been reported to involve a broadening of the response to myelin antigens, apparently resulting from priming to endogenous determinants of the myelin sheath. The phenomenon has been termed determinant spread. Interest in this ...

journal_title：European journal of immunology

authors： Takács K,Chandler P,Altmann DM

更新日期：1997-11-01 00:00:00

abstract：:The objective of the present investigation was to culture helper or suppressor/cytotoxic T cell subsets after extensive purification in interleukin 2-containing medium to determine whether phenotype changes for OKT4/91d6- or OKT8/Leu-2a-defined antigens do occur with prolonged culture. Repeated and sequential analysis...

journal_title：European journal of immunology

authors： Gramatzki M,Baum W,Burmester GR,Kalden JR

更新日期：1984-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma ), a member of the nuclear receptor superfamily, has recently been described as a modulator of macrophage functions and as an inhibitor of T cell proliferation. Here, we investigated the role of PPARgamma in dendritic cells (DC), the most potent antigen-prese...

journal_title：European journal of immunology

authors： Gosset P,Charbonnier AS,Delerive P,Fontaine J,Staels B,Pestel J,Tonnel AB,Trottein F

更新日期：2001-10-01 00:00:00

abstract：:Act1 is a negative regulator of B-cell activation factor of the TNF family (BAFF) and CD40L-induced signaling. BALB/C mice lacking Act1 develop systemic autoimmunity resembling systemic lupus erythematosus (SLE) and Sjögren's syndrome (SjS). SLE and SjS are characterized by anti-nuclear IgG autoantibody (ANA-IgG) prod...

journal_title：European journal of immunology

authors： Johnson AC,Davison LM,Giltiay NV,Vareechon C,Li X,Jørgensen TN

更新日期：2012-07-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:The immunoglobulin lambda light chain system displays a limited diversity in inbred mice. Indeed, the lambda locus is organized in two recombination units: V lambda 2-V lambda x-J lambda 2-C lambda 2-psi J lambda 4-psi C lambda 4, which can produce either lambda 2(V2) or lambda 2(Vx) chains; and V lambda 1-J lambda 3-...

journal_title：European journal of immunology

authors： Boudinot P,Drapier AM,Cazenave PA,Sanchez P

更新日期：1994-09-01 00:00:00

abstract：:The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)-alpha/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF-alpha synthesis and secretion were induced after incubation of purifie...

journal_title：European journal of immunology

authors： Santis AG,Campanero MR,Alonso JL,Sánchez-Madrid F

更新日期：1992-12-01 00:00:00

abstract：:A panel of closely and distantly related lysozymes and lysozyme-peptide fragments were utilized in assessing the specificity repertoire of murine anti-hen egg white lysozyme hybridomas. The 44 monoclonal antibodies could be divided into a minimum of 18 fine specificity groups in tests using the lysozyme panel. Two hyb...

journal_title：European journal of immunology

authors： Metzger DW,Ch'ng LK,Miller A,Sercarz EE

更新日期：1984-01-01 00:00:00

abstract：:Inhibition of growth or eradication of experimentally induced tumors has been shown to be accompanied by infiltration of eosinophils and macrophages into the tumor mass. Since macrophages are important mediators of host antitumor activity, the possibility arises that a collaboration may exist between these two cell ty...

journal_title：European journal of immunology

authors： Spessotto P,Dri P,Bulla R,Zabucchi G,Patriarca P

更新日期：1995-05-01 00:00:00

abstract：:Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody-mediated immunity. To what extent the same is true for T-cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4(+) T-cell responses, ...

journal_title：European journal of immunology

authors： Marks E,Helgeby A,Andersson JO,Schön K,Lycke NY

更新日期：2011-09-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognat...

journal_title：European journal of immunology

authors： Czarneski J,Berguer P,Bekinschtein P,Kim DC,Hakimpour P,Wagner N,Nepomnaschy I,Piazzon I,Ross SR

更新日期：2002-04-01 00:00:00

abstract：:The DC-derived chemokine CCL17, a ligand of CCR4, has been shown to promote various inflammatory diseases such as atopic dermatitis, atherosclerosis, and inflammatory bowel disease. Under steady-state conditions, and even after systemic stimulation with LPS, CCL17 is not expressed in resident splenic DCs as opposed to...

journal_title：European journal of immunology

authors： Globisch T,Steiner N,Fülle L,Lukacs-Kornek V,Degrandi D,Dresing P,Alferink J,Lang R,Pfeffer K,Beyer M,Weighardt H,Kurts C,Ulas T,Schultze JL,Förster I

更新日期：2014-02-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the...

journal_title：European journal of immunology

authors： Matsumoto Y,Kawai K,Fujiwara M

更新日期：1990-09-01 00:00:00

abstract：:The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

journal_title：European journal of immunology

authors： Becker D,Reske-Kunz AB,Knop J,Reske K

更新日期：1991-05-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:The receptor for the inflammatory peptide C3a has scarcely been examined on human cells. This work demonstrates that human tumor-derived basophilic granulocytes express C3a receptors, and presents parts of the hitherto unknown C3a-signal transduction. When incubated with IL-3, these cells specifically liberated histam...

journal_title：European journal of immunology

authors： Kretzschmar T,Jeromin A,Gietz C,Bautsch W,Klos A,Köhl J,Rechkemmer G,Bitter-Suermann D

更新日期：1993-02-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...

journal_title：European journal of immunology

authors： Conway de Macario E,Heumann AM,Macario AJ,Biozzi G

更新日期：1979-03-01 00:00:00

abstract：:Regulation of the development of thymocytes into mature T cells within the thymus is now known to involve antigen-induced deletion, by apoptosis, of potentially autoreactive thymocytes, and it can be mimicked either by stimulating the T cell receptor (TcR) complex by monoclonal antibody (mAb) or by ionophore-induced e...

journal_title：European journal of immunology

authors： Conroy LA,Jenkinson EJ,Owen JJ,Michell RH

更新日期：1995-07-01 00:00:00

abstract：:Protein antigens with both allergenic and immunoprotective properties represent appropriate molecules to study IgE and IgG regulation. We have established a panel of T cell clones specific to bee venom phospholipase A2 (PLA) from human individuals allergic, hyposensitized or immune (protected) to bee sting. All clones...

journal_title：European journal of immunology

authors： Carballido JM,Carballido-Perrig N,Terres G,Heusser CH,Blaser K

更新日期：1992-06-01 00:00:00

abstract：:A major contributing factor to the final magnitude and breadth of CD8(+) T-cell responses to complex antigens is immunodomination, where CD8(+) T cells recognizing their cognate ligand inhibit the proliferation of other CD8(+) T cells engaged with the same APC. In this study, we examined how the half-life of cell s...

journal_title：European journal of immunology

authors： Galea I,Stasakova J,Dunscombe MS,Ottensmeier CH,Elliott T,Thirdborough SM

更新日期：2012-01-01 00:00:00

abstract：:The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...

journal_title：European journal of immunology

authors： Peng X,Kasran A,Warmerdam PA,de Boer M,Ceuppens JL

更新日期：1996-07-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:Oxidant stress can initiate or enhance inflammatory responses during tissue injury, possibly through activation of redox-sensitive chemokines. Because the transcription factor Nrf2 (NF-E2-related factor 2) is responsive to oxidative stress, and induces expression of cytoprotective and antioxidant genes that attenuate ...

journal_title：European journal of immunology

authors： Zhang X,Chen X,Song H,Chen HZ,Rovin BH

更新日期：2005-11-01 00:00:00