当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > The introduction of one or two 3 beta-cholestanyl residues into benzylpenicilloyl-eicosa-L-lysines greatly potentiates their tolerogenicity for anti-benzylpenicillol IgE antibody formation.

The introduction of one or two 3 beta-cholestanyl residues into benzylpenicilloyl-eicosa-L-lysines greatly potentiates their tolerogenicity for anti-benzylpenicillol IgE antibody formation.

Abstract：

:BALB/c mice were repeatedly immunized with microgram doses of benzylpenicilloylated Ascaris protein(s) (BPO9Asc) in alum. At different stages of the immune response, BPO21 eicosa-L-lysine or two analogs containing one or two hydrophobic p-oxymethylbenzyl-3 beta-cholestanyl succinate (OSuco) groups were injected. When injected early in the immune response, the anti-BPO IgE antibody formation was much more strongly and permanently suppressed by the lipophilic conjugates than by the hydrophilic BPO21 eicosa-L-lysine. A similar, but less marked, suppressive effect was observed on the anti-BPO IgG1 response. By adoptive cell transfer experiments, it was found that the OSuco-containing derivatives induce and act via suppressor T lymphocytes, since this cell-mediated suppression was sensitive to cyclophosphamide or to treatment with anti-Lyt-2.2 antibody plus complement. When these compounds were injected into repeatedly immunized mice producing late ongoing antibody responses no differences in suppression between hydrophilic and hydrophobic derivatives were observed. In this case, the IgE response was suppressed by about 50%, while the IgG1 response was not affected. These results are compatible with the suggestion that early IgE responses are most sensitive to T cell-mediated suppression and that T suppressor cells are better induced by lipophilic than by hydrophilic antigens. The late ongoing IgE response, on the other hand, is less amenable to T cell-induced suppression and tolerogenic effects brought about by plurivalent BPO antigens operate directly on hapten-specific IgE-bearing B cells, regardless of their lipophilic character.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Lüscher IF,Weber E,de Weck AL

doi

10.1002/eji.1830140113

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

68-74

issue

1

eissn

0014-2980

issn

1521-4141

journal_volume

14

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor.

    abstract：:IL-15 induces proliferation, inhibits apoptosis and increases IL-4 production in murine mast cells. There is evidence that these activities are mediated via the uncharacterised receptor, IL-15R-X, rather than the classical three-chain IL-15 receptor. Effects of IL-15 on important aspects of mast cell biology, such as ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200526154

    authors： Jackson NE,Wang HW,Tedla N,McNeil HP,Geczy CL,Collins A,Grimm MC,Hampartzoumian T,Hunt JE

    更新日期：2005-08-01 00:00:00

  • A human-hybridoma system based on a fast-growing mutant of the ARH-77 plasma cell leukemia-derived line.

    abstract：:A rapidly-growing, HAT-sensitive cell line LICR-LON-HMy2 has been derived from the ARH-77 human plasma cell leukemia-derived line. It lacks the enzyme hypoxanthine phosphoribosyltransferase (EC 2.4.2.8). Hybrids have been reproducibly made for more than a year and in independent laboratories with lymphocytes from tons...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830120804

    authors： Edwards PA,Smith CM,Neville AM,O'Hare MJ

    更新日期：1982-08-01 00:00:00

  • Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment.

    abstract：:The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed th...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425246

    authors： Maehr R,Kraus M,Ploegh HL

    更新日期：2004-08-01 00:00:00

  • Classical transplantation tolerance in the adult: the interaction between myeloablation and immunosuppression.

    abstract：:Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830221111

    authors： Leong LY,Qin S,Cobbold SP,Waldmann H

    更新日期：1992-11-01 00:00:00

  • Guinea pig immunoglobulin light chain isotypes. II. The preferential expression of lambda chain-bearing anti-phenyltrimethylammonium antibodies is associated with restricted variable region expression, but not with any alteration in the proportion of lamb

    abstract：:The inbred strain 13 guinea pig expresses at least three isotypes of immunoglobulin (Ig) lambda chain. The proportion of these isotypes in normal Ig can be estimated by isolating a constant (C) region cyanogen bromide peptide from lambda chains and quantitatively analyzing its component tryptic peptides. Anti-phenyltr...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830081212

    authors： Brunhouse RF,Cebra JJ

    更新日期：1978-12-01 00:00:00

  • Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo.

    abstract：:The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250506

    authors： Kelso A,Groves P,Troutt AB,Francis K

    更新日期：1995-05-01 00:00:00

  • Identification and characterization of Xenopus CD8+ T cells expressing an NK cell-associated molecule.

    abstract：:Growing evidence suggests that some immune responses are mediated not only by conventional and distinct NK cells and CTL, but also by T cell subsets expressing NK receptors and NK cell-associated molecules. Consistent with our previously published finding that the mAb 1F8 identifies non-T/non-B cells in Xenopus that e...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200206)32:6<1574::AID-IMMU1574>3

    authors： Rau L,Gantress J,Bell A,Stewart R,Horton T,Cohen N,Horton J,Robert J

    更新日期：2002-06-01 00:00:00

  • Antigen presentation by human monocytes: effects of modifying major histocompatibility complex class II antigen expression and interleukin 1 production by using recombinant interferons and corticosteroids.

    abstract：:Lymphocyte proliferation in response to monocytes pulsed with an antigenic extract of Candida albicans was measured in vitro and the effects of modifying major histocompatibility complex (MHC) class II antigen expression at the surface of the antigen-presenting cells was investigated. The study shows that no simple co...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160410

    authors： Rhodes J,Ivanyi J,Cozens P

    更新日期：1986-04-01 00:00:00

  • On the significance of CD8 alpha alpha expression for T cell memory.

    abstract：:Longitudinal studies on the kinetics of viral antigen specific CD8 T cell responses have led to a model whereby a relatively small subset of the primary effector CD8 T cells expanding after the first week of acute viral infection initiate a program of cell survival and differentiation into long lived memory T cells. T...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.200535516

    authors： Romero P,Cerottini JC,Luescher I

    更新日期：2005-11-01 00:00:00

  • CD3+ T cells in severe combined immune deficiency (scid) mice. I. Transferred purified CD4+ T cells, but not CD8+ T cells are engrafted in the spleen of congenic scid mice.

    abstract：:Young (less than 3 months of age) and old (greater than 1 year of age) C.B-17 scid/scid mice were tested for the presence of immunoglobulin in serum and CD3+ T cells in spleen and peritoneal cavity. In all old severe combined immune deficiency (scid) mice tested we found detectable, but very variable levels of serum i...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210240

    authors： Rudolphi A,Spiess S,Conradt P,Claësson MH,Reimann J

    更新日期：1991-02-01 00:00:00

  • T cell factor (interleukin 2) allows in vivo induction of T helper cells against heterologous erythrocytes in athymic (nu/nu) mice.

    abstract：:Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice to have lymphocytes which can be activated in vivo by heterologous erythrocytes and a Lyt-1 T cell-derived factor (interleukin 2) to generate T helper cells. ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830100912

    authors： Stötter H,Rüde E,Wagner H

    更新日期：1980-09-01 00:00:00

  • Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells.

    abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201545835

    authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

    更新日期：2016-04-01 00:00:00

  • The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells.

    abstract：:The activity of granzyme B, a main effector molecule of cytotoxic T lymphocytes (CTL) and natural killer cells, is regulated by the human intracellular serpin proteinase inhibitor 9 (PI9). This inhibitor is particularly expressed by CTL and dendritic cells, in which it serves to protect these cells against endogenous ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425949

    authors： Bladergroen BA,Strik MC,Wolbink AM,Wouters D,Broekhuizen R,Kummer JA,Hack CE

    更新日期：2005-04-01 00:00:00

  • High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones.

    abstract：:The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but onl...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160107

    authors： Ceredig R,Corradin G

    更新日期：1986-01-01 00:00:00

  • Dendritic cells transduced with TAT protein transduction domain-containing tyrosinase-related protein 2 vaccinate against murine melanoma.

    abstract：:Incorporation of an 11 amino acid region of the HIV TAT protein transduction domain (TAT PTD) into proteins facilitates rapid, efficient entry into cells. We previously showed that rTAT-PTD-OVA-transduced dendritic cells (DC) stimulated antigen (Ag)-specific CTL and Th cells, and vaccinated against OVA-expressing tumo...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323709

    authors： Shibagaki N,Udey MC

    更新日期：2003-04-01 00:00:00

  • The in vitro immune response to a T-independent antigen. I. The effect of macrophages and 2-mercaptoethanol.

    abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830081105

    authors： Nordin AA

    更新日期：1978-11-01 00:00:00

  • Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells.

    abstract：:The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210518

    authors： Becker D,Reske-Kunz AB,Knop J,Reske K

    更新日期：1991-05-01 00:00:00

  • Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model.

    abstract：:CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200839004

    authors： Polte T,Fuchs L,Behrendt AK,Hansen G

    更新日期：2009-07-01 00:00:00

  • Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gamma.

    abstract：:Cyclopentenone prostaglandins (CP-PG), such as prostaglandin A1 (PGA1) or 15-deoxy-Delta(12,14)-prostaglandin J2 (PGJ2), induce apoptosis in different cell types. PGJ2 is also a potent activator of the peroxisome proliferator-activated receptor-gamma (PPARgamma). We investigated whether PPARgamma regulates CP-PG-induc...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200324053

    authors： Erl W,Weber C,Zernecke A,Neuzil J,Vosseler CA,Kim HJ,Weber PC

    更新日期：2004-01-01 00:00:00

  • B lineage-restricted rearrangement of a human Ig kappa transgene.

    abstract：:To study the control of immunoglobulin kappa light chain gene rearrangement, we generated transgenic mice carrying a germ-line human kappa minilocus (HK) containing the J kappa-proximal V gene, V kappa IV, the V-J intergenic region, the five J kappa segments and the C kappa gene. This construct includes the intronic, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：

    authors： Cavelier P,Nato F,Coquilleau I,Rolink A,Rougeon F,Goodhardt M

    更新日期：1997-07-01 00:00:00

  • Antibody-independent activation of complement by human peripheral B lymphocytes.

    abstract：:Normal human peripheral blood lymphocytes were shown to activate complement in normal human serum (NHS). This activation led to C3 fixation on the cell membrane, which in turn was visualized by fluorescence. The reaction occurred in the absence of detectable amounts of antibodies, since an agammaglobulinemic patient's...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830090115

    authors： Gutiérrez C,Vega J,Kreisler M

    更新日期：1979-01-01 00:00:00

  • Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family.

    abstract：:The causative agents of Lyme disease, Borrelia burgdorferi s.s., B. garinii, and B. afzelii, differ in their susceptibility to complement-mediated lysis. This phenomenon apparently depends on the expression of proteins termed complement regulator-acquiring surface proteins (CRASP) and their binding to the inhibitory p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323571

    authors： Kraiczy P,Hellwage J,Skerka C,Kirschfink M,Brade V,Zipfel PF,Wallich R

    更新日期：2003-03-01 00:00:00

  • Somatic hypermutation and mismatch repair in non-B cells.

    abstract：:Mismatch repair contributes to hypermutation in B lymphocytes, both by increasing the frequency of mutations and by changing the mutational patterns. In this paper, we investigated whether or not mismatch repair influences activation-induced cytidine deaminase (AID)-mediated hypermutation in a non-B lymphocyte line. W...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200526221

    authors： Klasen M,Spillmann FJ,Marra G,Cejka P,Wabl M

    更新日期：2005-07-01 00:00:00

  • Surfactant protein A, but not surfactant protein D, is an opsonin for influenza A virus phagocytosis by rat alveolar macrophages.

    abstract：:Surfactant protein A (SP-A) and surfactant protein D (SP-D) are collectins, and both proteins were shown to interact with influenza A virus and alveolar macrophages. However, it is not known whether SP-A and SP-D can serve as opsonins for the phagocytosis of influenza A virus by alveolar macrophages. In the present st...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270413

    authors： Benne CA,Benaissa-Trouw B,van Strijp JA,Kraaijeveld CA,van Iwaarden JF

    更新日期：1997-04-01 00:00:00

  • Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice.

    abstract：:Mucosal boosting of BCG-immunised individuals with a subunit tuberculosis (TB) vaccine would be highly desirable, considering that the lungs are the principal port of entry for Mycobacterium tuberculosis (MTB) and the site of the primary infection and reactivation. However, the main roadblock for subunit TB vaccine de...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201343887

    authors： Stylianou E,Diogo GR,Pepponi I,van Dolleweerd C,Arias MA,Locht C,Rider CC,Sibley L,Cutting SM,Loxley A,Ma JK,Reljic R

    更新日期：2014-02-01 00:00:00

  • Natural variations at position 93 of the invariant Vα24-Jα18 α chain of human iNKT-cell TCRs strongly impact on CD1d binding.

    abstract：:Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of huma...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201141956

    authors： Sanderson JP,Waldburger-Hauri K,Garzón D,Matulis G,Mansour S,Pumphrey NJ,Lissin N,Villiger PM,Jakobsen B,Faraldo-Gómez JD,Gadola SD

    更新日期：2012-01-01 00:00:00

  • Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice.

    abstract：:To detect possible differences in immunogenicity between tumors induced in T cell-deficient mice and phenotypically normal congenic mice, 16 sarcomas, 8 having developed in nude BALB/c mice and 8 having developed in congenic normal (nu/+) mice, were transplanted to normal BALB/c recipients and the rates of rejection o...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260827

    authors： Svane IM,Engel AM,Nielsen MB,Ljunggren HG,Rygaard J,Werdelin O

    更新日期：1996-08-01 00:00:00

  • Treatment and management of primary antibody deficiency: German interdisciplinary evidence-based consensus guideline.

    abstract：:This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.202048713

    authors： Hanitsch L,Baumann U,Boztug K,Burkhard-Meier U,Fasshauer M,Habermehl P,Hauck F,Klock G,Liese J,Meyer O,Müller R,Pachlopnik-Schmid J,Pfeiffer-Kascha D,Warnatz K,Wehr C,Wittke K,Niehues T,von Bernuth H

    更新日期：2020-10-01 00:00:00

  • Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

    abstract：:Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC...

    journal_title：European journal of immunology

    pub_type： 临床试验,杂志文章

    doi：10.1002/eji.201445344

    authors： Zheng J,van de Veerdonk FL,Crossland KL,Smeekens SP,Chan CM,Al Shehri T,Abinun M,Gennery AR,Mann J,Lendrem DW,Netea MG,Rowan AD,Lilic D

    更新日期：2015-10-01 00:00:00

  • Degeneracy of T cell receptor recognition of an influenza virus hemagglutinin epitope restricted by HLA-DQ and -DR class II molecules.

    abstract：:DT9301-0229737 the TcR are believed to provide the peptide fragments bound to major histocompatibility (MHC) molecules. TcR have an immunoglobulin (Ig)-like structure and, in an analogous manner to antigen recognition by Ig, the third complementarity determining regions (CDR3) of the TcR are believed to provide the pr...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240519

    authors： Jones CM,Lake RA,Lamb JR,Faith A

    更新日期：1994-05-01 00:00:00