Abstract:
:The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed that this fragment is required for activation of the NF-kappaB pathway as a means of controlling B cell maturation. The opposing view holds that defects in the assembly of MHC class II molecules result in impaired B cell development. Here we demonstrate that a lack of Ii indeed causes defects in B cell development, with fewer mature B cells in the periphery as previously reported, but that in a compound-mutant from which both Ii and all MHC class II subunits are absent, B cell development is normal. We suggest that neither Ii itself, nor the MHC class II products are required for normal B cell development.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Maehr R,Kraus M,Ploegh HLdoi
10.1002/eji.200425246keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
2230-6issue
8eissn
0014-2980issn
1521-4141journal_volume
34pub_type
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