Abstract:
:The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but only partially in DBA mice and had no effect in SJL mice. Clones derived from DBA mice showed a differential capacity to be inhibited by high antigen dose. On the other hand, interleukin 2 production by these clones was not impaired regardless of the antigen concentrations used.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Ceredig R,Corradin Gdoi
10.1002/eji.1830160107subject
Has Abstractpub_date
1986-01-01 00:00:00pages
30-4issue
1eissn
0014-2980issn
1521-4141journal_volume
16pub_type
杂志文章abstract::1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Here, we analyze the effect of 1,25-(OH)2D3 on IF...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199810)28:10<3017::AID-IMM
更新日期:1998-10-01 00:00:00
abstract::Paxillin is an adaptor protein associated with focal adhesion complex, and is activated by tyrosine phosphorylation through focal adhesion kinase (FAK) and Src kinase. Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellu...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142192
更新日期:2012-08-01 00:00:00
abstract::NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201848016
更新日期:2019-07-01 00:00:00
abstract::Naturally activated T lymphocytes present in normal mouse spleen were studied for direct reactivity to interleukin 2 (IL 2) and for binding of anti-IL 2 receptor (IL 2R) antibodies or radiolabeled IL 2. The majority of large-sized splenic T lymphocytes are IL 2R-; thus, at the most one third of large L3T4+ T cells and...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830170702
更新日期:1987-07-01 00:00:00
abstract::Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is d...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220526
更新日期:1992-05-01 00:00:00
abstract::Human T cells expressing Vgamma9Ndelta2-encoded TCR recognize several nonpeptide phosphoantigens in the absence of major histocompatibility complex restriction. As these cells respond differentially to increasing concentrations of structurally related phosphoantigens, such ligands constitute agonists of different stre...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200105)31:5<1628::AID-IMMU1628>3
更新日期:2001-05-01 00:00:00
abstract::Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft reject...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271251
更新日期:1997-12-01 00:00:00
abstract::We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150916
更新日期:1985-09-01 00:00:00
abstract::Spleen cells from BALB/c mice primed with keyhole limpet hemocyanin (KLH), were stimulated with heat-killed vaccine of rough Pneumococcus pneumoniae R36A (Pn) and/or phosphorylcholine (PC)-coupled KLH to induce an anti-PC response in vitro. The response to PC-KLH was found to be T-dependent while it is T-independent t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060605
更新日期:1976-06-01 00:00:00
abstract::Alum has been the only adjuvant licensed for human vaccines for decades and is still widely used, but its mechanism of action remains obscure. Recently, the NLRP3 inflammasome has been linked to the immunostimulatory properties of alum and other particulate adjuvants, although it is disputed to what degree NLRP3 is ge...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.200940039
更新日期:2010-03-01 00:00:00
abstract::CD16 is an IgG Fc receptor that is predominantly expressed on human natural killer (NK) cells and granulocytes. The CD16 antigen expressed on neutrophils is a 50 to 70-kDa glycoprotein attached to the plasma membrane by a phosphatidylinositol-glycan linkage that is susceptible to cleavage by phosphatidylinositol-speci...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190431
更新日期:1989-04-01 00:00:00
abstract::The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425246
更新日期:2004-08-01 00:00:00
abstract::MHC class II tetramers are attractive tools to study antigen-specific CD4(+) T cell responses in various clinical situations in humans. HLA-DRA1*0101/DRB1*0401 MHC class II heterodimers were produced as empty molecules using the Drosophila melanogaster expression system. Peptide binding experiments revealed that these...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425281
更新日期:2004-10-01 00:00:00
abstract::Immunoglobulin (Ig) production by lipopolysaccharide (LPS)-stimulated cells in the presence of various combinations of interleukin (IL)2, IL4 and IL5 was examined. IgG1, IgM and IgE secretion was studied using a 3T3-fibroblast filler cell-supported B cell culture system, either at low cell density to support maximal I...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191109
更新日期:1989-11-01 00:00:00
abstract::We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230835
更新日期:1993-08-01 00:00:00
abstract::Once generated during an infection, memory CD8+ T cells can provide long-lasting protection against reinfection with an intracellular pathogen, but the longevity of this defense depends on the ability of these pathogen-specific memory cells to be maintained. It is generally believed that the bone marrow plays an impor...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201747249
更新日期:2017-11-01 00:00:00
abstract::Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270635
更新日期:1997-06-01 00:00:00
abstract::Biopsy specimens were obtained from the bronchial or the nasal mucosa of three patients with grass pollen-induced bronchial asthma or rhinitis 48 h after positive bronchial or nasal provocation test with grass pollen extract. T cell clones (TCC), derived from these and control specimens, were then assessed for their p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230707
更新日期:1993-07-01 00:00:00
abstract::Treatment of human peripheral blood lymphocytes with cloned N alpha-desacetylthymosin alpha 1 induced interferon production. The kinetics is similar to that of mitogen-induced interferon induction. N alpha-desacetylthymosin alpha 1, in combination with mitogen, augments the amount of interferon produced. This interfer...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120314
更新日期:1982-03-01 00:00:00
abstract::Macrophages can be stimulated to produce a relatively large amount of nitric oxide, which is an important component in macrophage-mediated defense mechanisms and regulation of T cell activities. It has been known that T helper (Th) cell activation requires intimate physical interaction between T helper cells and macro...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250152
更新日期:1995-01-01 00:00:00
abstract::In chickens, the pre-B cell development takes place in a specialized organ, the bursa of Fabricius. In this study, we show that fibronectin can be detected in the bursa at least from the day 15 of embryonic incubation up to 10 weeks of age after which the bursa starts to involute. During the embryonic incubation, fibr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230323
更新日期:1993-03-01 00:00:00
abstract::In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210813
更新日期:1991-08-01 00:00:00
abstract::The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250506
更新日期:1995-05-01 00:00:00
abstract::Mice lacking the tumor suppressor gene p53 spontaneously develop T-cell lymphomas at a high rate, suggesting that in these mice lymphomas arise due to defective apoptosis mechanisms in T cells mediated by p53. However, a role of p53 in regulation of T-cell responses or apoptosis has been poorly defined. TCR-mediated s...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939736
更新日期:2010-02-01 00:00:00
abstract::Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324668
更新日期:2004-02-01 00:00:00
abstract::We provide a robust four-color fluorescence-based flow cytometry protocol that distinguishes viable dividing plasmablasts from nondividing plasma cells and, based on CD19 surface abundance, identifies two mature plasma cell populations in the spleen and the bone marrow of mice. ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747019
更新日期:2017-08-01 00:00:00
abstract::Human peripheral blood T lymphocytes are stimulated to grow and divide by lectins such as concanavalin A (Con A) and Phaseolus vulgaris phytohemagglutinin (PHA), as well as a few anti-T cell monoclonal antibodies. The latter antibodies recognize the T3 antigen. It has been suggested previously that PHA and Con A media...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150512
更新日期:1985-05-01 00:00:00
abstract::Physical exercise, mental stress, or infusion of beta-adrenergic agonists result in an increase in the number of natural killer (NK) cells in the peripheral circulation. In view of the specific migration pattern of NK cells in vivo, it has been suggested that these cells may be released from the marginating pool in bl...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231230
更新日期:1993-12-01 00:00:00
abstract::Activated human T cells via the CD2 or the CD3 pathways exhibited a higher capacity than resting T lymphocytes to incorporate and metabolize [3H]pafacether (paf) at 37 degrees C. Resting T lymphocytes lacked specific binding capacity for paf, yet high-affinity paf receptors (paf-R) were induced on CD3- or CD2-dependen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220604
更新日期:1992-06-01 00:00:00
abstract::Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtain...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142343
更新日期:2013-01-01 00:00:00