Defective T-cell receptor-induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53(-/-) mice.

abstract：:MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...

journal_title：European journal of immunology

authors： Marquet J,Lasoudris F,Cousin C,Puiffe ML,Martin-Garcia N,Baud V,Chereau F,Farcet JP,Molinier-Frenkel V,Castellano F

更新日期：2010-09-01 00:00:00

abstract：:The specificity of the IgM receptor expressed by human T cells cultured in IgM-free media has been investigated. IgM receptors have been detected using a rosette system with ox erythrocytes coated with rabbit antibody (EA(IgM)), and the inhibitory capacity of different IgM fragments in the rosette system has been test...

journal_title：European journal of immunology

authors： Ferrarini M,Moretta L,Mingari MC,Tonda P,Pernis B

更新日期：1976-07-01 00:00:00

abstract：:The immune mechanisms underlying immunization-induced protection of mice from lethal central nervous system (CNS) listeriosis were evaluated by immunohistochemistry, flow cytometry of leukocytes isolated from the brain, reverse transcription-polymerase chain reaction analysis of intracerebral (i.c.) tumor-necrosis fac...

journal_title：European journal of immunology

authors： Schlüter D,Oprisiu SB,Chahoud S,Weiner D,Wiestler OD,Hof H,Deckert-Schlüter M

更新日期：1995-08-01 00:00:00

abstract：:Antigen-presenting cells (APC), including dendritic cells and macrophages, produce a large amount of interferon (IFN)-gamma, a crucial cytokine for the control of infectious diseases. To elucidate the role of IFN-gamma from APC in vivo, we employed cytokine receptor common gamma subunit (gamma c) and recombination-act...

journal_title：European journal of immunology

authors： Suzue K,Asai T,Takeuchi T,Koyasu S

更新日期：2003-10-01 00:00:00

abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

journal_title：European journal of immunology

authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

更新日期：2011-03-01 00:00:00

abstract：:MHC class II tetramers are attractive tools to study antigen-specific CD4(+) T cell responses in various clinical situations in humans. HLA-DRA1*0101/DRB1*0401 MHC class II heterodimers were produced as empty molecules using the Drosophila melanogaster expression system. Peptide binding experiments revealed that these...

journal_title：European journal of immunology

authors： Lemaître F,Viguier M,Cho MS,Fourneau JM,Maillère B,Kourilsky P,Van Endert PM,Ferradini L

更新日期：2004-10-01 00:00:00

abstract：:In experimental autoimmune encephalomyelitis (EAE), intravenous transfer of activated CD4(+) myelin-specific T cells is sufficient to induce disease. Transferred T cells access the CNS parenchyma by trafficking across the blood brain barrier (BBB) vascular endothelium into the perivascular space, and then across the g...

journal_title：European journal of immunology

authors： Archambault AS,Sim J,Gimenez MA,Russell JH

更新日期：2005-04-01 00:00:00

abstract：:The present study demonstrates that the C3b receptor CR1 (CD35) and the C3dg/Epstein-Barr virus receptor CR2 (CD21) are expressed by 25% and 70% of normal human thymocytes, respectively. The expression of CR2 extends to both CD1+ and CD1- cells in the thymus. Two subsets of CR2+ thymocytes were defined expressing low ...

journal_title：European journal of immunology

authors： Delibrias CC,Mouhoub A,Fischer E,Kazatchkine MD

更新日期：1994-11-01 00:00:00

abstract：:Naturally occurring CD4+CD25(high) regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despit...

journal_title：European journal of immunology

authors： Battaglia M,Roncarolo MG

更新日期：2009-12-01 00:00:00

abstract：:Pathogens have developed a plethora of strategies to undermine host immune defenses in order to guarantee their survival. For large DNA viruses, these immune evasion mechanisms frequently rely on the expression of genes acquired from host genomes. Horizontally transferred genes include members of the immunoglobulin su...

journal_title：European journal of immunology

authors： Farré D,Martínez-Vicente P,Engel P,Angulo A

更新日期：2017-05-01 00:00:00

abstract：:The induction of B cell tolerance to 2,4-dinitrophenyl conjugates of polysaccharide antigens (levan or dextran) was studied in mice primed with keyhole limpet hemocyanin (KLH) or 2,4,6-trinitrophenylated KLH. The relationship of the epitope density of the tolerogen with avidity of B cell receptors (as judged indirectl...

journal_title：European journal of immunology

authors： Desaymard C,Pearce B,Feldmann M

更新日期：1976-09-01 00:00:00

abstract：:Several groups have described that a low percentage of in vitro cultured T cell receptor (TcR) gamma/delta cells express CD8. Contrary to TcR alpha/beta cells, however, CD8 on these TcR gamma/delta cells was shown to be a CD8 alpha homodimer. We describe here that addition of interleukin-7 (IL-7) to a short-term in vi...

journal_title：European journal of immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1992-09-01 00:00:00

abstract：:Activation of T cells was shown to up-regulate the Fas ligand (FasL) which binds to the CD95 (APO-1/Fas) antigen and mediates activation-induced cell death (AICD) of activated T cells and T lymphoma cells. A recent report showed that mouse B cells express the FasL upon activation with lipopolysaccharide (LPS). We ther...

journal_title：European journal of immunology

authors： Daniel PT,Oettinger U,Mapara MY,Bommert K,Bargou R,Dörken B

更新日期：1997-04-01 00:00:00

abstract：:Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (Th2) or Th1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant Th2 response, sub-threshold levels of...

journal_title：European journal of immunology

authors： Bancroft AJ,Else KJ,Grencis RK

更新日期：1994-12-01 00:00:00

abstract：:A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-...

journal_title：European journal of immunology

authors： Sorobetea D,Holm JB,Henningsson H,Kristiansen K,Svensson-Frej M

更新日期：2017-02-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) caused by donor T cells attacking recipient tissues is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (alloSCT). Studies have shown that effector memory T (T(EM) ) cells do not cause GVHD but are capable of immune functions post-tr...

journal_title：European journal of immunology

authors： Anderson BE,Tang AL,Wang Y,Froicu M,Rothstein D,McNiff JM,Jain D,Demetris AJ,Farber DL,Shlomchik WD,Shlomchik MJ

更新日期：2011-09-01 00:00:00

abstract：:We have demonstrated that analogues of alpha-mannosyl ceramide (alpha-ManCer) consisting of a series of immunosuppressive 2-aminoalcohol derivatives in place of sphingosine promote a greater immune response from mouse invariant Valpha19-Jalpha26 (AV19-AJ33) TCR-bearing NKT (Valpha19 NKT) cells than alpha-ManCer itself...

journal_title：European journal of immunology

authors： Shimamura M,Huang YY,Okamoto N,Suzuki N,Yasuoka J,Morita K,Nishiyama A,Amano Y,Mishina T

更新日期：2007-07-01 00:00:00

abstract：:The thymus provides the microenvironment in which thymocytes develop into mature T cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T cells is a basic requirement for mature T-cell functions, and those thymocytes that do...

journal_title：European journal of immunology

authors： Szondy Z,Garabuczi É,Tóth K,Kiss B,Köröskényi K

更新日期：2012-07-01 00:00:00

abstract：:Paxillin is an adaptor protein associated with focal adhesion complex, and is activated by tyrosine phosphorylation through focal adhesion kinase (FAK) and Src kinase. Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellu...

journal_title：European journal of immunology

authors： Lee YC,Chang AY,Lin-Feng MH,Tsou WI,Chiang IH,Lai MZ

更新日期：2012-08-01 00:00:00

abstract：:Inhibitory anti-antibodies induced in patients by xenogeneic or even by humanized anti-T cell antibodies remain an unresolved problem. Mice also produce anti-antibodies following injection of xeno- or allogeneic anti-T cell antibodies. Here we report a principle based on sequentially applied anti-T cell antibodies gen...

journal_title：European journal of immunology

authors： Mysliwietz J,Thierfelder S,Mocikat R,Kremmer E

更新日期：1994-10-01 00:00:00

abstract：:Adoptive T-cell therapy (ATCT) can result in tumor rejection, yet the behavior and fate of the introduced T cells remain unclear. We developed a novel bioluminescence mouse model, which enabled highly sensitive detection of T-cell signals at the single-cell level. Transferred T cells preferentially accumulated within ...

journal_title：European journal of immunology

authors： Charo J,Perez C,Buschow C,Jukica A,Czeh M,Blankenstein T

更新日期：2011-11-01 00:00:00

abstract：:The magnitude of the IgE antibody response against the phosphorylcholine (PC) hapten and the rate of age-related change of IgE formation is polymorphic in the three long-lived and six relatively short-lived strains of mice studied. Long-lived mice showed an early increase, followed by a decline in the levels of anti-P...

journal_title：European journal of immunology

authors： Gerber V,Ponnappan U,Heusser CH,Blaser K,Cinader B

更新日期：1986-06-01 00:00:00

abstract：:From several years, the anticancer effects of Vγ9 T lymphocytes make these cells good candidates for cancer immunotherapies. However, the proved efficacy of γδ Τ cell-based cancer immunotherapies in some clinical trials was minimized due to the inherent toxicity of IL-2, which is essential for the combination therapy ...

journal_title：European journal of immunology

authors： Duault C,Betous D,Bezombes C,Roga S,Cayrol C,Girard JP,Fournié JJ,Poupot M

更新日期：2017-12-01 00:00:00

abstract：:Soluble TRAIL (sTRAIL) can be produced by myeloid-derived cells to kill cancer cells. Whether this mechanism is used by T cells, and if so, how sTRAIL production is regulated, remains unclear. Our previous studies showed that ex vivo expanded human γδ T cells express TRAIL and NK receptor group 2 (R2), member D (NKG2D...

journal_title：European journal of immunology

authors： Dokouhaki P,Schuh NW,Joe B,Allen CA,Der SD,Tsao MS,Zhang L

更新日期：2013-12-01 00:00:00

abstract：:GTPase immune-associated proteins (Gimap) genes encode evolutionarily conserved GTP-binding proteins that are preferentially expressed in immune cells. Specific members have been shown to be involved in lymphocyte development, or are associated with inflammatory and autoimmune diseases. However, the function of these ...

journal_title：European journal of immunology

authors： Ciucci T,Bosselut R

更新日期：2014-02-01 00:00:00

abstract：:We have explored how IL-15 influences Th1 or Th2 type immune response in vivo. Intraperitoneal application of an IL-15-IgG2b fusion protein (FP) to mice did neither significantly affect the footpad swelling nor the production of hemagglutinizing antibodies in a delayed type hypersensitivity reaction to sheep red blood...

journal_title：European journal of immunology

authors： Rückert R,Herz U,Paus R,Ungureanu D,Pohl T,Renz H,Bulfone-Paus S

更新日期：1998-10-01 00:00:00

abstract：:The thymus is the primary organ for T-cell differentiation and maturation. Unlike other major organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost complete atrophy followed by rapid restoration. The process of thymic atrophy, or involution, results in decreased thymopoiesis and emigrat...

journal_title：European journal of immunology

authors： Dooley J,Liston A

更新日期：2012-05-01 00:00:00

abstract：:The proliferative state of functionally defined populations of size-separated pre-B cells was investigated. The results presented here support the hypothesis that pre-B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlik...

journal_title：European journal of immunology

authors： Deslauriers-Boisvert N,Mercier G,Lafleur L

更新日期：1982-04-01 00:00:00

abstract：:T lymphocytes derived from peripheral blood of a patient with adenosine deaminase (ADA) deficiency were expanded in vitro. The human ADA (hADA) gene was introduced into these replicating ADA- T cells with the use of an amphotropic recombinant retrovirus carrying the hADA gene. Subsequently, infected T cells were selec...

journal_title：European journal of immunology

authors： Braakman E,Van Beusechem VW,Van Krimpen BA,Fischer A,Bolhuis RL,Valerio D

更新日期：1992-01-01 00:00:00

abstract：:Influenza matrix peptide 58-66 is shown to be the optimal nonamer for binding to HLA-A2 and presentation to cytotoxic T lymphocytes (CTL). If titered out to 2 x 10(-10) - 4 x 10(-10) M in CTL-mediated lysis assays and to 3 x 10(-9) M in an HLA-A2 assembly-stabilization assay in cell lysates. The peptide was shown to m...

journal_title：European journal of immunology

authors： Morrison J,Elvin J,Latron F,Gotch F,Moots R,Strominger JL,McMichael A

更新日期：1992-04-01 00:00:00