The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes.

abstract：:The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

journal_title：European journal of immunology

authors： Becker D,Reske-Kunz AB,Knop J,Reske K

更新日期：1991-05-01 00:00:00

abstract：:We have developed a quantitative assay for the measurement of class I assembly induced by peptide. We have applied this assay to H-2Db, Kb and HLA-A2.1 with a panel of 49 overlapping peptides derived from HIV-1 gag protein. We find that the effects of peptide on assembly form a continuous distribution. By defining pos...

journal_title：European journal of immunology

authors： Elvin J,Cerundolo V,Elliott T,Townsend A

更新日期：1991-09-01 00:00:00

abstract：:Japanese encephalitis, caused by infection with the neurotropic flavivirus, Japanese encephalitis virus (JEV), is among the most important viral encephalitides in Asia. While previous studies established an essential role of Ab and type I IFN, it is still unclear if the cell-mediated immune responses, through their di...

journal_title：European journal of immunology

authors： Larena M,Regner M,Lobigs M

更新日期：2013-07-01 00:00:00

abstract：:Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...

journal_title：European journal of immunology

authors： Kato A,Takaori-Kondo A,Minato N,Hamazaki Y

更新日期：2018-10-01 00:00:00

abstract：:Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host response to Mycoba...

journal_title：European journal of immunology

authors： Lachmandas E,Beigier-Bompadre M,Cheng SC,Kumar V,van Laarhoven A,Wang X,Ammerdorffer A,Boutens L,de Jong D,Kanneganti TD,Gresnigt MS,Ottenhoff TH,Joosten LA,Stienstra R,Wijmenga C,Kaufmann SH,van Crevel R,Netea MG

更新日期：2016-11-01 00:00:00

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00

abstract：:The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...

journal_title：European journal of immunology

authors： de Waal LP,Melief CJ,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:Human CD8(+) T cells are functionally heterogeneous and can be divided into phenotypically and functionally distinct subsets according to CCR7 and CD45RA expression levels. Among these, CCR7(low) CD45RA(low) effector memory CD8(+) T cells (Tem) and CCR7(low) CD45RA(high) CD8(+) T cells, which are designated as Temra a...

journal_title：European journal of immunology

authors： Setoguchi R,Matsui Y,Mouri K

更新日期：2015-03-01 00:00:00

abstract：:The extent of emigration of cells from the bursa of Fabricius to the periphery was estimated. Per anum application of fluorescein isothiocyanate to label bursal cells in situ was used. Migrant cells can be visualized on frozen sections or cell suspensions of peripheral organs by their fluorescence. The data show that ...

journal_title：European journal of immunology

authors： Lassila O

更新日期：1989-05-01 00:00:00

abstract：:A cell surface lectin found on activated human lymphoid cells has been identified and characterized using membrane glycoprotein micelles as probes. These micelles, which are large, water-soluble aggregates, are composed of glycoproteins isolated from detergent-solubilized membranes of human B lymphoblastoid cell lines...

journal_title：European journal of immunology

authors： Apgar JR,Cresswell P

更新日期：1982-07-01 00:00:00

abstract：:Natural interferon-producing cells (NIPC), also called plasmacytoid dendritic cells, are the most potent producers of IFN-alpha in response to viral and bacterial components, serving an important function in innate immune defences. The present work demonstrates that NIPC responsiveness can be primed by immunisation, i...

journal_title：European journal of immunology

authors： Balmelli C,Vincent IE,Rau H,Guzylack-Piriou L,McCullough K,Summerfield A

更新日期：2005-08-01 00:00:00

abstract：:Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four ...

journal_title：European journal of immunology

authors： Wang X,Wei Y,Xiao H,Liu X,Zhang Y,Han G,Chen G,Hou C,Ma N,Shen B,Li Y,Egwuagu CE,Wang R

更新日期：2016-06-01 00:00:00

abstract：:We recently reported that differentiation of CD8(+) T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism. Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. To determine a more glob...

journal_title：European journal of immunology

authors： Cham CM,Driessens G,O'Keefe JP,Gajewski TF

更新日期：2008-09-01 00:00:00

abstract：:Vitamin A deficiency is known to be accompanied with immune deficiency and susceptibility to a wide range of infectious diseases. Experimental evidence suggests that the active metabolites of vitamin A that mediate its effects on the immune system are the retinoic acids (RA), which are ligands for the nuclear RA recep...

journal_title：European journal of immunology

authors： Kiss I,Rühl R,Szegezdi E,Fritzsche B,Tóth B,Pongrácz J,Perlmann T,Fésüs L,Szondy Z

更新日期：2008-01-01 00:00:00

abstract：:An expanding spectrum of acute and chronic non-infectious inflammatory diseases is uniquely responsive to IL-1β neutralization. IL-1β-mediated diseases are often called "auto-inflammatory" and the dominant finding is the release of the active form of IL-1β driven by endogenous molecules acting on the monocyte/macropha...

journal_title：European journal of immunology

authors： Dinarello CA

更新日期：2011-05-01 00:00:00

abstract：:Dendritic cells (DC) are known to support the activation of natural killer (NK) cells. However, little is known about the role for DC in NK-cell homeostasis. In order to investigate this question, a novel bacterial artificial chromosome transgenic mouse model was generated in which the diphtheria toxin receptor is exp...

journal_title：European journal of immunology

authors： Hochweller K,Striegler J,Hämmerling GJ,Garbi N

更新日期：2008-10-01 00:00:00

abstract：:The TNF member LIGHT also known as TL4 or TNFSF14) can play a major role in cancer control via its two receptors; it induces tumor cell death through lymphotoxin-beta receptor (LT-betaR) and ligation to the herpes virus entry mediator (HVEM) amplifies the immune response. By studying the effect of LIGHT in the transcr...

journal_title：European journal of immunology

authors： Pasero C,Barbarat B,Just-Landi S,Bernard A,Aurran-Schleinitz T,Rey J,Eldering E,Truneh A,Costello RT,Olive D

更新日期：2009-09-01 00:00:00

abstract：:IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell ...

journal_title：European journal of immunology

authors： Mensah-Brown EP,Shahin A,Al-Shamisi M,Wei X,Lukic ML

更新日期：2006-01-01 00:00:00

abstract：:The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination. To formally test this hypothesis, C57BL/6-lpr and -gld mice, which due to gene mutation express Fas and FasL in an inactive form, were immunized with myelin oligodendro...

journal_title：European journal of immunology

authors： Malipiero U,Frei K,Spanaus KS,Agresti C,Lassmann H,Hahne M,Tschopp J,Eugster HP,Fontana A

更新日期：1997-12-01 00:00:00

abstract：:Unexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC-205+ dendritic cells (DCs) and NK1.1+ invariant natural killer T (iNKT) cells are recruited into t...

journal_title：European journal of immunology

authors： Negishi Y,Ichikawa T,Takeshita T,Takahashi H

更新日期：2018-06-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine which, among other properties, is a principle mediator of inflammation and septic shock. It acts upon target cells by binding to specific cell surface receptors. A10G10 is a murine monoclonal antibody which recognizes human TNF and neutralizes its activity. A rabbit polyclonal...

journal_title：European journal of immunology

authors： Galloway CJ,Madanat MS,Sarr T,Espevik T,Dumas ML,Mitra G,Ranges GE

更新日期：1992-11-01 00:00:00

abstract：:Riboflavin, also known as vitamin B2 , is converted by riboflavin kinase (RFK) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential cofactors of dehydrogenases, reductases, and oxidases including the phagocytic NADPH oxidase 2 (Nox2). Riboflavin deficiency is common in young adul...

journal_title：European journal of immunology

authors： Schramm M,Wiegmann K,Schramm S,Gluschko A,Herb M,Utermöhlen O,Krönke M

更新日期：2014-03-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reacti...

journal_title：European journal of immunology

authors： Mantovani A,Germano G,Marchesi F,Locatelli M,Biswas SK

更新日期：2011-09-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:In humans infected with lymphatic filariasis, microfilaraemia [the presence of microfilariae (Mf) in the blood] is generally associated with both poor antigen (Ag)-specific proliferative responses and with protection from severe disease. Clonal deletion has been suggested as one possible mechanism by which parasite-re...

journal_title：European journal of immunology

authors： Jenson JS,O'Connor R,Osborne J,Devaney E

更新日期：2002-03-01 00:00:00

abstract：:There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into its modulation is of significance in the context of many physiological and pathologica...

journal_title：European journal of immunology

authors： Siednienko J,Halle A,Nagpal K,Golenbock DT,Miggin SM

更新日期：2010-11-01 00:00:00

abstract：:We have previously identified a molecule on the T cell surface, which, in addition to CD2 is involved in the rosette phenomenon. This is a 32-kDa single polypeptide chain which we have termed E2. The studies reported here show striking patterns on the glycosylation status of E2. It is a heavily sialylated and glycosyl...

journal_title：European journal of immunology

authors： Aubrit F,Gelin C,Pham D,Raynal B,Bernard A

更新日期：1989-08-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein which is one of the ligands for the leukocyte function-associated antigen (LFA-1). It is involved in leukocyte adhesion to endothelial cells as well as in immune functions requiring cell-cell contact. The quantitative expression of ICAM-1 in various cell types can be either induce...

journal_title：European journal of immunology

authors： Geissler D,Gaggl S,Möst J,Greil R,Herold M,Dietrich M

更新日期：1990-12-01 00:00:00

abstract：:F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

journal_title：European journal of immunology

authors： Robertson K,Simon K,Schneider S,Timms E,Mitchison A

更新日期：1992-01-01 00:00:00