Abstract：
:An expanding spectrum of acute and chronic non-infectious inflammatory diseases is uniquely responsive to IL-1β neutralization. IL-1β-mediated diseases are often called "auto-inflammatory" and the dominant finding is the release of the active form of IL-1β driven by endogenous molecules acting on the monocyte/macrophage. IL-1β activity is tightly controlled and requires the conversion of the primary transcript, the inactive IL-1β precursor, to the active cytokine by limited proteolysis. Limited proteolysis can take place extracellularly by serine proteases, released in particular by infiltrating neutrophils or intracellularly by the cysteine protease caspase-1. Therefore, blocking IL-1β resolves inflammation regardless of how the cytokine is released from the cell or how the precursor is cleaved. Endogenous stimulants such as oxidized fatty acids and lipoproteins, high glucose concentrations, uric acid crystals, activated complement, contents of necrotic cells, and cytokines, particularly IL-1 itself, induce the synthesis of the inactive IL-1β precursor, which awaits processing to the active form. Although bursts of IL-1β precipitate acute attacks of systemic or local inflammation, IL-1β also contributes to several chronic diseases. For example, ischemic injury, such as myocardial infarction or stroke, causes acute and extensive damage, and slowly progressive inflammatory processes take place in atherosclerosis, type 2 diabetes, osteoarthritis and smoldering myeloma. Evidence for the involvement of IL-1β and the clinical results of reducing IL-1β activity in this broad spectrum of inflammatory diseases are the focus of this review.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Dinarello CAdoi
10.1002/eji.201141550subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1203-17issue
5eissn
0014-2980issn
1521-4141journal_volume
41pub_type
杂志文章,评审abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200425669
更新日期：2005-02-01 00:00:00
abstract：:DNase II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. Macrophages in DNase II-deficient mice accumulate undigested DNA and constitutively produce IFN-beta as well as TNF-alpha. The IFN-beta causes severe anemia in the DNase II(-/-) embryos, which die...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200838559
更新日期：2008-11-01 00:00:00
abstract：:The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fl...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201646504
更新日期：2017-01-01 00:00:00
abstract：:By combining velocity and linear density fractionations as well as target cell rosetting techniques we have isolated and morphologically identified the human effector cell type responsible for spontaneous, trypsin-augmentable cytotoxicity against chicken red cells and human myeloma cell line targets. This cell is a la...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830071104
更新日期：1977-11-01 00:00:00
abstract：:Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a promiscuous 7-transmembrane-domain receptor expressed on lymphatic vessels which recognizes most inflammatory, but not homeostatic, CC chemokines. In vitro expe...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200526114
更新日期：2005-05-01 00:00:00
abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830181239
更新日期：1988-12-01 00:00:00
abstract：:Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830181112
更新日期：1988-11-01 00:00:00
abstract：:Adoptive lymphocyte transfers between Iga, Igb and Igd allotype-congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig-4b but not that of Ig-1 b. The apparent mediators of this Ig-1 b barr...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830080805
更新日期：1978-08-01 00:00:00
abstract：:NKR-P1 is a type II transmembrane protein which acts as an activation receptor on natural killer (NK) cells. The cytoplasmic domains of the CD4, CD8 and 4-1BB receptors contain the sequence Cys-X-Cys-Pro which is directly involved in coupling to another pair of cysteines in the N-terminal domain of the src family tyro...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830270111
更新日期：1997-01-01 00:00:00
abstract：:To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self-reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing V beta...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830210310
更新日期：1991-03-01 00:00:00
abstract：:IL-12 and IL-4, respectively, dominate Th1 versus Th2 polarization. Additionally IL-4 can inhibit IL-12 p40 production in DC. Here we show that macrophages respond to bacterial CpG-DNA with IL-12 p40 production in an IL-4-sensitive manner. Analysis of the molecular mechanism of this inhibition shows that IL-4 acts by ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/immu.200310017
更新日期：2003-02-01 00:00:00
abstract：:The human monocyte line, U-937, derived from an individual with histiocytic lymphoma was studied for the expression of surface C3 receptors, after cultivation in the presence of phorbol myristate acetate (PMA) or T lymphocyte-conditioned medium. Receptors were detected by using EAC4b, EAC3b, EC3b, EAC3bi and EAC3d int...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830151005
更新日期：1985-10-01 00:00:00
abstract：:In this study we examined the effect of interleukin 4 (IL 4) on T cell activation and proliferation via the alternative CD2 pathway. To this end highly purified human resting T cells were cultured with a stimulating pair of anti-CD2 monoclonal antibodies in the absence of accessory signals from monocytes. Addition of ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830200724
更新日期：1990-07-01 00:00:00
abstract：:NK cells play important roles in immune surveillance against malignancy and virus-infected cells. NK cell functions are affected in patients infected with HIV-1; however, whether there is direct interaction between NK cells and HIV-1 remains controversial. In this study the expression of CD4, an important receptor for...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200737217
更新日期：2007-08-01 00:00:00
abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830070807
更新日期：1977-08-01 00:00:00
abstract：:The transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the ser...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830250212
更新日期：1995-02-01 00:00:00
abstract：:Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.202048784
更新日期：2020-09-18 00:00:00
abstract：:The migration of immunocytes within the extracellular matrix (ECM) is influenced by the activation state of the incoming cell and its responses to the presence of chemokines and cytokines. We studied the regulatory role of TGF-beta1 on T cell homing to secondary lymphatic organs, such as the spleen, and chemotaxis wit...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/1521-4141(200201)32:1<193::AID-IMMU193>3.0
更新日期：2002-01-01 00:00:00
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journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830060910
更新日期：1976-09-01 00:00:00
abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...
journal_title：European journal of immunology
pub_type： 杂志文章
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journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830220526
更新日期：1992-05-01 00:00:00
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journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830170216
更新日期：1987-02-01 00:00:00
abstract：:The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM antibody (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated with rabbit IgG or IgM antibody. It was found that while EA(IgG)-rosette-forming cells (RFC) were detected ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830050812
更新日期：1975-08-01 00:00:00
abstract：:Natural Killer (NK) cell-based immunotherapy is a promising approach to treat hepatocellular carcinoma (HCC). The mechanisms underlying the regulation of NK cell activity are not completely understood. In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 mem...
journal_title：European journal of immunology
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
abstract：:A recombinant Plasmodium vivax circumsporozoite (CS) protein (rPvCS-1) has been investigated as a possible malaria sporozoite vaccine candidate. Experiments were carried out to determine whether sporozoite-specific memory cells develop in Swiss Webster mice immunized with rPvCS-1. Challenge of rPvCS-1-immunized mice w...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830171213
更新日期：1987-12-01 00:00:00
abstract：:Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200838668
更新日期：2008-12-01 00:00:00
abstract：:The use of fetal bovine serum (FBS) for the culture and expansion of mesenchymal stromal cells (MSCs) limits their possible clinical applications. Although some recent studies recommended substituting FBS with human platelet lysate (HPL) for the expansion of MSCs for clinical use, the functional capacity of the expand...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201141542
更新日期：2011-11-01 00:00:00
abstract：:Mercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were pe...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830200114
更新日期：1990-01-01 00:00:00
abstract：:The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...
journal_title：European journal of immunology
pub_type： 杂志文章,评审
doi：10.1002/eji.201847895
更新日期：2019-07-01 00:00:00
abstract：:Human adherent monocytes were incubated with interferon (IFN) preparations, then washed and stimulated with endotoxins. The interleukin (IL1) activity in the supernatants of IFN-treated monocyte cultures was found to be increased as compared to control (not pretreated) cultures. This phenomenon was observed whether al...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830130602
更新日期：1983-06-01 00:00:00
