Abstract:
:Human adherent monocytes were incubated with interferon (IFN) preparations, then washed and stimulated with endotoxins. The interleukin (IL1) activity in the supernatants of IFN-treated monocyte cultures was found to be increased as compared to control (not pretreated) cultures. This phenomenon was observed whether alpha or beta IFN was used, and was completely abolished by antiserum to the relevant IFN. IL1 secretion of IFN-treated monocyte cultures could be triggered by suboptimal dosage of endotoxins, unable to induce any IL1 activity in control medium-treated cultures. IFN was highly efficient in this system, since very low concentrations (of the order of 2 units) were effective. Since IFN alone, without endotoxin stimulation, was unable to induce IL1 secretion, the results indicate that IFN is able to activate monocytes, by inducing a potential secretory capable rather than an ongoing IL1 secretion function. The ability of IFN to enhance the IL1 secretory potential of human monocytes may be relevant to the known immunoenhancing effects of IFN preparations and to the pyrogenic effects of IFN administration in patients.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Arenzana-Seisdedos F,Virelizier JLdoi
10.1002/eji.1830130602subject
Has Abstractpub_date
1983-06-01 00:00:00pages
437-40issue
6eissn
0014-2980issn
1521-4141journal_volume
13pub_type
杂志文章abstract::The CD4 T cell surface molecule binds MHC class II determinants expressed on antigen-presenting cells. CD4 is thought to enhance T cell activation by serving as an adhesion molecule as well as possibly by transducing an independent intracellular signal during the process of antigen stimulation. The recent observation ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200628
更新日期:1990-06-01 00:00:00
abstract::Cofilin, an actin-depolymerizing protein, is essential for the functional dynamics of the actin cytoskeleton and for cell viability. In unstimulated human peripheral blood T lymphocytes cofilin is phosphorylated and localized in the cytoplasm. Following co-stimulation through accessory receptors (e.g. CD2 or CD28) - h...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(2000012)30:12<3422::AID-IMMU3422
更新日期:2000-12-01 00:00:00
abstract::The immunosuppressive drugs FK506 and rapamycin bind to a family of intracellular proteins termed FK506-binding proteins (FKBP). FK506 and rapamycin inhibit lymphocyte-activation pathways by forming complexes with an FKBP; subsequently, the drug/FKBP complexes interact with target molecules involved in signal transduc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250239
更新日期:1995-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160106
更新日期:1986-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242620
更新日期:2013-04-01 00:00:00
abstract::A cDNA encoding the human beta Fc gamma receptor II (FcRII) was isolated from a placental cDNA library. Analysis of the predicted amino acid sequence indicates that this receptor is synthesized with a 42-amino acid leader sequence. The mature protein consists of 249 amino acids. The leader sequence and the cytoplasmic...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200624
更新日期:1990-06-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160314
更新日期:1986-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142192
更新日期:2012-08-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/1521-4141(200002)30:2<541::AID-IMMU541>3.0
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abstract::BALB/c and anti-IL-12-treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB/c mice, C3H mice treated transiently with an anti-IL-12 monoclonal antibody switch from a Th2 to a Th1 response and resolve their lesions once treatment is terminated. We report here that the...
journal_title:European journal of immunology
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doi:10.1002/1521-4141(200007)30:7<2007::AID-IMMU2007>3
更新日期:2000-07-01 00:00:00
abstract::An intracellular staining procedure for the cytoskeletal marker, glial fibrillary acidic protein of astrocytes, has been developed which allows flow cytometric phenotyping of astrocytes within complex mixtures of glial cells. Employing this technique, we show here that measles virus infection of rat mixed glial cell c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220126
更新日期:1992-01-01 00:00:00
abstract::Adult, male Lewis rats received a single injection of 5-bromo-2'-deoxyuridine (BrdUrd) i.v. to label proliferating cells in the S phase of the cell cycle. After 1 and 24 h the thymus, bone marrow, blood, spleen, peripheral, cervical and mesenteric lymph nodes as well as Peyer's patches were removed. In cell suspension...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190619
更新日期:1989-06-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201848013
更新日期:2020-02-01 00:00:00
abstract::DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636780
更新日期:2007-09-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636569
更新日期:2007-04-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142207
更新日期:2012-06-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160518
更新日期:1986-05-01 00:00:00
abstract::Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clone...
journal_title:European journal of immunology
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更新日期:2009-12-01 00:00:00
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journal_title:European journal of immunology
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更新日期:2003-10-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142238
更新日期:2012-07-01 00:00:00
abstract::The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210518
更新日期:1991-05-01 00:00:00
abstract::Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in inflammatory scenarios. Fungal pathogens cause a large burden of morbi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201848081
更新日期:2019-11-01 00:00:00
abstract::Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevance of other periphe...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040909
更新日期:2011-04-01 00:00:00
abstract::Recent experimental studies have greatly clarified the function of cell surface molecules in the induction and modulation of T cell responses by antigen-presenting cells (APC). However, the differences in ability to stimulate T cells evident for different types and subpopulations of the same APC, such as dendritic cel...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199801)28:01<1::AID-IMMU1>
更新日期:1998-01-01 00:00:00
abstract::Majority of HIV-2-infected individuals meet the criteria of long-term non-progressors. This has been linked to superior qualitative HIV-2-specific cellular immune responses that correlate with viral control. However, it is unknown whether this is due to frequent targeting of immunodominant Gag epitopes in HIV-2 than H...
journal_title:European journal of immunology
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abstract::The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancing the average affinity of the antibodies produced. The molecular mechanism underlying these B cell hypermutations remains ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251210
更新日期:1995-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830161109
更新日期:1986-11-01 00:00:00
abstract::In recent years, factors potentially involved in pathogenesis of rheumatoid arthritis have mostly been identified by studying well-defined patient cohorts. Characterization of antibodies from sera of affected patients, family-based heritability studies, genome-wide association scans, the analysis of environmental fact...
journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00