Human monocyte cell line (U937) releases suppressive IgG-binding factor(s).

abstract：:The desire to induce HIV-1-specific responses soon after birth to prevent breast milk transmission of HIV-1 led us to propose a vaccine regimen which primes HIV-1-specific T cells using a recombinant Mycobacterium bovis bacillus Calmette-Guérin (rBCG) vaccine. Because attenuated live bacterial vaccines are typically n...

journal_title：European journal of immunology

authors： Hopkins R,Bridgeman A,Bourne C,Mbewe-Mvula A,Sadoff JC,Both GW,Joseph J,Fulkerson J,Hanke T

更新日期：2011-12-01 00:00:00

abstract：:This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non-lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in ...

journal_title：European journal of immunology

authors： Steinman RM

更新日期：2010-08-01 00:00:00

abstract：:The 4-1BB is a costimulatory molecule similar to the receptor activator of NF-kappaB ligand (RANKL), both of which are key factors for the differentiation of osteoclasts and are expressed mainly by activated T cells. The 4-1BB shares common signaling pathways with RANK, suggesting a potential role in osteoclastogenesi...

journal_title：European journal of immunology

authors： Yang J,Park OJ,Lee YJ,Jung HM,Woo KM,Choi Y

更新日期：2008-06-01 00:00:00

abstract：:T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage(-) Sca1(+)c-kit(+) BM hematopoietic progenitors very efficiently differ...

journal_title：European journal of immunology

authors： Gehre N,Nusser A,von Muenchow L,Tussiwand R,Engdahl C,Capoferri G,Bosco N,Ceredig R,Rolink AG

更新日期：2015-03-01 00:00:00

abstract：:Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multip...

journal_title：European journal of immunology

authors： Jones R,Cosway EJ,Willis C,White AJ,Jenkinson WE,Fehling HJ,Anderson G,Withers DR

更新日期：2018-09-01 00:00:00

abstract：:We analyzed the stimulating capacities of malignant B cells from non-Hodgkin's lymphomas (NHL) to induce an allogeneic response in primary mixed lymphocyte reaction (MLR). T cells purified from a single healthy donor (KS) were used to compare the responses induced by either malignant or hyperplastic cells. Malignant B...

journal_title：European journal of immunology

authors： Plumas J,Chaperot L,Jacob MC,Molens JP,Giroux C,Sotto JJ,Bensa JC

更新日期：1995-12-01 00:00:00

abstract：:The CD4 T cell surface molecule binds MHC class II determinants expressed on antigen-presenting cells. CD4 is thought to enhance T cell activation by serving as an adhesion molecule as well as possibly by transducing an independent intracellular signal during the process of antigen stimulation. The recent observation ...

journal_title：European journal of immunology

authors： Veillette A,Sleckman BP,Ratnofsky S,Bolen JB,Burakoff SJ

更新日期：1990-06-01 00:00:00

abstract：:Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity...

journal_title：European journal of immunology

authors： Haigwood NL

更新日期：2009-08-01 00:00:00

abstract：:Central and peripheral tolerance mechanisms are expected to hamper the generation of effective immunity against tumors. To break self tolerance against malignant gliomas, we assessed the therapeutic potential of self/foreign antigen cross-reactivity in an immunocompetent rat glioma model. Immunotherapy of tumors using...

journal_title：European journal of immunology

authors： Sioud M,Sørensen D

更新日期：2003-01-01 00:00:00

abstract：:Antigen-presenting macrophages (M phi) were derived from day 7 cultures of bone marrow stem cells using L cell conditioned medium. The adherent bone marrow-derived macrophages (BMM phi) were 100% esterase-positive, 95% positive for C3 receptors, 93% positive for Fc receptors, and 95% actively phagocytic. Indirect immu...

journal_title：European journal of immunology

authors： Schook LB,Bingham EL,Gutmann DH,Niederhuber JE

更新日期：1982-12-01 00:00:00

abstract：:Antigen-presenting cells (APC), including dendritic cells and macrophages, produce a large amount of interferon (IFN)-gamma, a crucial cytokine for the control of infectious diseases. To elucidate the role of IFN-gamma from APC in vivo, we employed cytokine receptor common gamma subunit (gamma c) and recombination-act...

journal_title：European journal of immunology

authors： Suzue K,Asai T,Takeuchi T,Koyasu S

更新日期：2003-10-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the tra...

journal_title：European journal of immunology

authors： Schweier O,Hofmann M,Pircher H

更新日期：2014-06-01 00:00:00

abstract：:Inhibition of leukocyte trafficking via alpha4-integrin antibody blockade has recently become a validated therapeutic approach for several inflammatory diseases, including multiple sclerosis, ulcerative colitis and Crohn's disease. In the midst of this recent success, 3 patients receiving chronic treatment with the an...

journal_title：European journal of immunology

authors： Engelhardt B,Briskin MJ

更新日期：2005-08-01 00:00:00

abstract：:Specific monoclonal antibodies (mAb) directed against the CD23 antigen were used to study human interleukin 4 (hIL4)-induced IgE production by blood and tonsillar mononuclear cells. Both peripheral blood and tonsillar mononuclear cells stimulated by hIL4 expressed membrane CD23 as detected by the binding of all anti-C...

journal_title：European journal of immunology

authors： Bonnefoy JY,Shields J,Mermod JJ

更新日期：1990-01-01 00:00:00

abstract：:Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

journal_title：European journal of immunology

authors： Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

更新日期：2008-06-01 00:00:00

abstract：:IgG complexes bind to Fc receptor family members FcgammaRI (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16), activating cell MAPK and PI3K resulting in increased cytokine production from particular leukocytes. The signaling molecules involved in cytokine production after cross-linking CD16 have not been determined in ...

journal_title：European journal of immunology

authors： Kramer PR,Winger V,Reuben J

更新日期：2009-02-01 00:00:00

abstract：:Cytokines elicited by superantigens have been suggested to play a central role in severe systemic clinical manifestations of gram-positive sepsis. Here we provide evidence for a potent inflammatory cytokine response in acute invasive group A streptococcal infections, and show a direct correlation between the magnitude...

journal_title：European journal of immunology

authors： Norrby-Teglund A,Chatellier S,Low DE,McGeer A,Green K,Kotb M

更新日期：2000-11-01 00:00:00

abstract：:Pre-B cells which show a delayed development of responsiveness to the B cell mitogen lipopolysaccharide (LPS) are found in murine embryonic blood between day 10 and 14 of gestation. The highest frequency of pre-B cells in embryonic blood is found at day 12 of gestation. All pre-B cells of embryonic blood, isolated at ...

journal_title：European journal of immunology

authors： Melchers F,Abramczuk J

更新日期：1980-10-01 00:00:00

abstract：:Human papillomavirus (HPV) infections account for more than 50% of infection-linked cancers in women worldwide. The immune system controls, at least partially, viral infection and around 90% of HPV-infected women clear the virus within two years. However, it remains unclear which immune cells are implicated in this pr...

journal_title：European journal of immunology

authors： Renoux VM,Bisig B,Langers I,Dortu E,Clémenceau B,Thiry M,Deroanne C,Colige A,Boniver J,Delvenne P,Jacobs N

更新日期：2011-11-01 00:00:00

abstract：:To elucidate the rapid destruction of allogeneic bone marrow (BM) grafts in nonsensitized rats we have assessed: (a) the 21-h tissue localization of 51Cr-labeled allogeneic vs. syngeneic BM cells, (b) the ability of allogeneic BM cells to proliferate in the BM or irradiated recipients, (c) the survival of allogeneic v...

journal_title：European journal of immunology

authors： Rolstad B,Benestad HB

更新日期：1984-09-01 00:00:00

abstract：:B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...

journal_title：European journal of immunology

authors： Lehtonen L,Vainio O,Veromaa T,Toivanen P

更新日期：1989-03-01 00:00:00

abstract：:TCR- but not CD2-triggered IL-2 production is p56(lck) dependent. To test the hypothesis that p59(fyn), a second src-family protein tyrosine kinase (PTK) expressed in T lymphocytes, might be an essential upstream component of the CD2 signaling pathway, we generated human (h) CD2 transgenic (tg) fyn(+/+) and fyn(-/-) m...

journal_title：European journal of immunology

authors： Fukai I,Hussey RE,Sunder-Plassmann R,Reinherz EL

更新日期：2000-12-01 00:00:00

abstract：:Signaling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer. Many IL-2Rgamma-sharing (gammaC) cytokines decrease CD127 expression on CD4+ and C...

journal_title：European journal of immunology

authors： Crawley AM,Vranjkovic A,Young C,Angel JB

更新日期：2010-05-01 00:00:00

abstract：:Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of huma...

journal_title：European journal of immunology

authors： Sanderson JP,Waldburger-Hauri K,Garzón D,Matulis G,Mansour S,Pumphrey NJ,Lissin N,Villiger PM,Jakobsen B,Faraldo-Gómez JD,Gadola SD

更新日期：2012-01-01 00:00:00

abstract：:In mice infected with the non-lethal malaria parasite Plasmodium chabaudi chabaudi AS, a prominent switch from a Th1 to a Th2 type of response occurs in CD4+ T cells at the time of peak parasitemia or shortly thereafter (9-15 days after infection). This is accompanied by a major increase in IL-4, and a similar decreas...

journal_title：European journal of immunology

authors： Poorafshar M,Helmby H,Troye-Blomberg M,Hellman L

更新日期：2000-09-01 00:00:00

abstract：:Pathogens have developed a plethora of strategies to undermine host immune defenses in order to guarantee their survival. For large DNA viruses, these immune evasion mechanisms frequently rely on the expression of genes acquired from host genomes. Horizontally transferred genes include members of the immunoglobulin su...

journal_title：European journal of immunology

authors： Farré D,Martínez-Vicente P,Engel P,Angulo A

更新日期：2017-05-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portio...

journal_title：European journal of immunology

authors： Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

更新日期：1998-08-01 00:00:00

abstract：:The interaction between TCR and peptide-MHC is well described in terms of the recognition of the peptide, but the recognition of the MHC is less well understood. At issue is whether particular V gene products may have higher affinity for some MHC over others and to what extent the bound peptide influences V gene selec...

journal_title：European journal of immunology

authors： Battaglia M,Gorski J

更新日期：2002-08-01 00:00:00

abstract：:In this study, we examined which cell population contributes to IL-5 production by Peyer's patch (PP) cells. Thy1.2(-) fraction of PP cells, but not those of splenocytes, secreted IL-5 in response to IL-2. We found that CD3epsilon(-)IL-2Ralpha(+) cells purified from the Thy1.2(-)B220(-) fraction of PP cells secreted I...

journal_title：European journal of immunology

authors： Kuraoka M,Hashiguchi M,Hachimura S,Kaminogawa S

更新日期：2004-07-01 00:00:00