KLRG1 activity is regulated by association with the transferrin receptor.

Abstract:

:The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the transferrin receptor (TfR). Fluorescence microscopy additionally revealed substantial colocalization of KLRG1 and TfR in intracellular compartments and on the cell surface. TfR expression in resting lymphocytes is known to be low but it is strongly upregulated in proliferating cells. Intriguingly, our data further demonstrate that the inhibitory activity of KLRG1 is decreased in T cells expressing high levels of TfR, indicating that association of KLRG1 with TfR hinders KLRG1-mediated silencing. This implies that proliferating TfR(high) KLRG1(+) lymphocytes may respond strongly to activation signals even in the presence of KLRG1 ligands, whereas resting TfR(low) cells may be efficiently silenced via KLRG1.

journal_name

Eur J Immunol

authors

Schweier O,Hofmann M,Pircher H

doi

10.1002/eji.201344234

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

1851-6

issue

6

eissn

0014-2980

issn

1521-4141

journal_volume

44

pub_type

杂志文章
  • Cellular competition modulates survival and selection of CD8+ T cells.

    abstract::In this investigation we compare the repopulation of the CD8+ T cell compartments of bone marrow (BM) chimeras by either normal nontransgenic or T cell receptor (TcR) alpha beta-transgenic (TG) CD8+ T cells, the fate of TG and non-TG CD8+ T cells in different parabionts and the survival of TG and non-TG peripheral CD8...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830261115

    authors: Freitas AA,Agenes F,Coutinho GC

    更新日期:1996-11-01 00:00:00

  • Group 1 CD1-restricted T cells take center stage.

    abstract::The recognition of lipid antigens by T cells is a complex and fascinating phenomenon. The MHC-like molecules of the CD1 family have evolved to present a wide variety of both self and foreign lipids for recognition by T-cell receptors. While much progress has been made in our understanding of the NKT cells that recogni...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章

    doi:10.1002/eji.201141408

    authors: Young MH,Gapin L

    更新日期:2011-03-01 00:00:00

  • Major histocompatibility complex class I presentation of exogenously acquired minor alloantigens initiates skin allograft rejection.

    abstract::Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft reject...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830271251

    authors: Oukka M,Galou M,Belkaid Y,Tricotet V,Riche N,Reynes M,Kosmatopoulos K

    更新日期:1997-12-01 00:00:00

  • TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules.

    abstract::The migration of immunocytes within the extracellular matrix (ECM) is influenced by the activation state of the incoming cell and its responses to the presence of chemokines and cytokines. We studied the regulatory role of TGF-beta1 on T cell homing to secondary lymphatic organs, such as the spleen, and chemotaxis wit...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/1521-4141(200201)32:1<193::AID-IMMU193>3.0

    authors: Franitza S,Kollet O,Brill A,Vaday GG,Petit I,Lapidot T,Alon R,Lider O

    更新日期:2002-01-01 00:00:00

  • Epratuzumab modulates B-cell signaling without affecting B-cell numbers or B-cell functions in a mouse model with humanized CD22.

    abstract::Treatment of systemic lupus erythematosus patients with epratuzumab (Emab), a humanized monoclonal antibody targeting CD22, leads to moderately reduced B-cell numbers but does not completely deplete B cells. Emab appears to induce immunomodulation of B cells, but the exact mode of action has not been defined. In the p...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201646383

    authors: Özgör L,Brandl C,Shock A,Nitschke L

    更新日期:2016-09-01 00:00:00

  • A combination of stem cell factor and granulocyte colony-stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS-5.

    abstract::We have developed a long-term culture system using the murine bone marrow stromal cells MS-5 to support the growth of progenitor B cells with CD34-, CD10+, CD19+, and cytoplasmic mu chain (C mu)-negative surface phenotype from human CD34+ cells purified from umbilical cord blood (CB). When 10(3) CD34+ cells/well were ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199803)28:03<855::AID-IMMU

    authors: Nishihara M,Wada Y,Ogami K,Ebihara Y,Ishii T,Tsuji K,Ueno H,Asano S,Nakahata T,Maekawa T

    更新日期:1998-03-01 00:00:00

  • Treg suppress CTL responses upon immunization with HSP gp96.

    abstract::HSP gp96-based vaccines have been trialled in rodent models and, more recently, in humans. Better understanding of gp96's immunomodulatory role will help with the design of more effective strategies for treatment of cancer and infectious diseases. In this study, we monitored the activities of T cells and activation of...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200939593

    authors: Liu Z,Li X,Qiu L,Zhang X,Chen L,Cao S,Wang F,Meng S

    更新日期:2009-11-01 00:00:00

  • Immunologic induction of reticulum cell sarcoma: donor-type lymphomas in the graft-versus-host model.

    abstract::The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830050610

    authors: Gleichmann E,Peters K,Lattmann E,Gleichmann H

    更新日期:1976-06-01 00:00:00

  • Functional characteristics of murine macrophages responding to migration inhibitory factors.

    abstract::Mouse bone marrow cells differentiate in culture in the presence of L cell-conditioned medium to macrophages (M phi). Proliferation, release of plasminogen activator, expression of transglutaminase, random motility and response to a standard preparation of purified M phi migration inhibitory factor (MIF) was recorded ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830141008

    authors: Michels E,Stenzinger W,Sorg C

    更新日期:1984-10-01 00:00:00

  • Suppressor T cell induction by soluble OKT3 antibody does not require cross-linking of the T3 molecule.

    abstract::The monoclonal antibody OKT3 can induce T suppressor cells of the in vitro antibody response when used at concentrations as low as 10 ng/ml and in cultures containing as few as 4% OKT3-pretreated T cells. These suppressor cells are radioresistant, cyclosporin sensitive and belong to the T4 as well as the T8 subpopulat...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830150504

    authors: Delfraissy JF,Wallon C,Boué F,Vazquez A,Galanaud P

    更新日期:1985-05-01 00:00:00

  • Cytolytic effector pathways and IFN-γ help protect against Japanese encephalitis.

    abstract::Japanese encephalitis, caused by infection with the neurotropic flavivirus, Japanese encephalitis virus (JEV), is among the most important viral encephalitides in Asia. While previous studies established an essential role of Ab and type I IFN, it is still unclear if the cell-mediated immune responses, through their di...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201243152

    authors: Larena M,Regner M,Lobigs M

    更新日期:2013-07-01 00:00:00

  • IL-17-producing γδ T cells and innate lymphoid cells.

    abstract::The inflammatory cytokine IL-17 plays a critical role in immunity to infection and is involved in the inflammatory pathology associated with certain autoimmune diseases, such as psoriasis and rheumatoid arthritis. While CD4(+) and CD8(+) T cells are important sources of this cytokine, recent evidence has suggested tha...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.201242569

    authors: Sutton CE,Mielke LA,Mills KH

    更新日期:2012-09-01 00:00:00

  • Novel therapeutic targets along the Th17 pathway.

    abstract::The recent discovery of IL-17-producing CD4(+) Th subset significantly revised the Th1/Th2 dichotomy model proposed by Mosmann and Coffman almost two decades ago. Th17 cells are involved in the pathogenesis of many human autoimmune diseases. Th17 cells, their developmental pathways and their effector functions, theref...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200839105

    authors: Ouyang W,Filvaroff E,Hu Y,Grogan J

    更新日期:2009-03-01 00:00:00

  • Platelet-activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes.

    abstract::Platelet-activating factor (PAF) is a phospholipid mediator of anaphylaxis, released from basophils of several mammalian species, that aggregates platelets and releases their vasoactive amines. The ionophore A23 187 induced the release of PAF from rat and mouse peritoneal cells, a mixed cell population that was fracti...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830090512

    authors: Mencia-Huerta JM,Benveniste J

    更新日期:1979-05-01 00:00:00

  • Interactions between membrane IgM and the cytoskeleton involve the cytoplasmic domain of the immunoglobulin receptor.

    abstract::Cross-linking induced interactions between the membrane form of immunoglobulin (mIg) and the cytoskeletal matrix have been described by several groups. To date, the function of mIgM association with the cytoskeleton is not yet understood. Delineation of the molecular basis of these interactions will be instrumental in...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830271137

    authors: Park JY,Jongstra-Bilen J

    更新日期:1997-11-01 00:00:00

  • Combinations of interleukins 2, 4 and 5 regulate the secretion of murine immunoglobulin isotypes.

    abstract::Immunoglobulin (Ig) production by lipopolysaccharide (LPS)-stimulated cells in the presence of various combinations of interleukin (IL)2, IL4 and IL5 was examined. IgG1, IgM and IgE secretion was studied using a 3T3-fibroblast filler cell-supported B cell culture system, either at low cell density to support maximal I...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830191109

    authors: McHeyzer-Williams MG

    更新日期:1989-11-01 00:00:00

  • A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis.

    abstract::Autoantibodies in the form of immune complexes are known to be crucial mediators in initiating inflammation in a variety of autoimmune diseases. This has been well documented in the anti-collagen II antibody-induced arthritis animal model for a long time now. Recently, in the K/B x N mouse model (the F1 of the TCR-tra...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200526167

    authors: Solomon S,Rajasekaran N,Jeisy-Walder E,Snapper SB,Illges H

    更新日期:2005-10-01 00:00:00

  • Involvement of the CD4 molecule in a post-activation event on T cell proliferation.

    abstract::A monoclonal antibody (mAb) directed to a human leukocyte 55-kDa cell surface molecule with identical cellular distribution and biochemical properties to the CD4 was able to inhibit T cell proliferation induced either in a mixed lymphocyte culture or by activation with mAb anti-CD3, anti-CD2 or phytohemagglutinin. The...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830170205

    authors: Carrera AC,Sanchez-Madrid F,Lopez-Botet M,Bernabeu C,De Landazuri MO

    更新日期:1987-02-01 00:00:00

  • Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system.

    abstract::A mouse lymphocyte surface molecule which is selectively expressed by mucosal T cells and detected with the monoclonal antibody (mAb) M290 has provisionally been identified as a beta 7 integrin. Identification was based on close homology of its beta subunit at the N terminus with the recently reported, highly distinct...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830211041

    authors: Kilshaw PJ,Murant SJ

    更新日期:1991-10-01 00:00:00

  • Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism.

    abstract::Transgenic CBA (H-2k haplotype) mice expressing the H-2 Kb major histocompatibility complex (MHC) class I gene under control of transcriptional promoter elements from a milk protein gene display high-level H-2 Kb transcription in lactating mammary glands and low-level transcription in skin and thymus of male and virgi...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830221027

    authors: Husbands SD,Schönrich G,Arnold B,Chandler PR,Simpson E,Philpott KL,Tomlinson P,O'Reilly L,Cooke A,Mellor AL

    更新日期:1992-10-01 00:00:00

  • T cell clones with normal or defective O-galactosylation from a patient with permanent mixed-field polyagglutinability.

    abstract::To delineate the extent of O-galactosyltransferase deficiency within the lymphoid lineage, monoclonal antibody specific for the Thomsen-Friedenreich (TF) antigen (Gal beta 1----3GalNAc alpha 1-O-Ser/Thr) and its precursor the Tn antigen (GalNAc alpha 1-O-Ser/Thr) were applied to the flow cytometric analysis of periphe...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830220724

    authors: Thurnher M,Clausen H,Fierz W,Lanzavecchia A,Berger EG

    更新日期:1992-07-01 00:00:00

  • The clonal composition of myelin basic protein-reactive encephalitogenic T cell populations is influenced both by the structure of relevant antigens and the nature of antigen-presenting cells.

    abstract::Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830250114

    authors: Sun D,Hu XZ,Coleclough C

    更新日期:1995-01-01 00:00:00

  • Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn.

    abstract::A major feature of the immature immune system in the newborn is its inability to produce significant levels of immunoglobulins other than IgM in response to antigens. It has recently been demonstrated that interaction of the CD40 molecule on B cells with the CD40 ligand (CD40L) on activated T cells is pivotal for immu...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830240831

    authors: Brugnoni D,Airò P,Graf D,Marconi M,Lebowitz M,Plebani A,Giliani S,Malacarne F,Cattaneo R,Ugazio AG

    更新日期:1994-08-01 00:00:00

  • Kinetics of cellular oncogene expression in mouse lymphocytes. I. Expression of c-myc and c-ras-Ha in T lymphocytes induced by various mitogens.

    abstract::Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830160319

    authors: Schneider-Schaulies J,Hünig T,Schimpl A,Wecker E

    更新日期:1986-03-01 00:00:00

  • Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.

    abstract::To define activation-specific sequences in human T lymphocytes, a cDNA library was constructed by subtractive hybridization using resting and stimulated peripheral blood lymphocyte pairs. Stimulation of peripheral blood lymphocytes was achieved by triggering with mitogenic anti-CD2 (T11) monoclonal antibodies. Differe...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830190614

    authors: Chang HC,Reinherz EL

    更新日期:1989-06-01 00:00:00

  • Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor.

    abstract::A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830261211

    authors: Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

    更新日期:1996-12-01 00:00:00

  • Anti-retroviral effects of type I IFN subtypes in vivo.

    abstract::Type I IFN play a very important role in immunity against viral infections. Murine type I IFN belongs to a multigene family including 14 IFN-alpha subtypes but the biological functions of IFN-alpha subtypes in retroviral infections are unknown. We have used the Friend retrovirus model to determine the anti-viral effec...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200838311

    authors: Gerlach N,Gibbert K,Alter C,Nair S,Zelinskyy G,James CM,Dittmer U

    更新日期:2009-01-01 00:00:00

  • Contrasting efficacy of presentation by major histocompatibility complex class I and class II products when peptides are administered within a common protein carrier, self immunoglobulin.

    abstract::Major histocompatibility complex (MHC) class I and II products are specialized to present antigens via different intracellular processing routes. Peptides originating from proteins in the cytoplasm can gain access to class I peptide-binding grooves, most likely in the rough endoplasmic reticulum. Peptides from protein...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830231104

    authors: Zaghouani H,Kuzu Y,Kuzu H,Brumeanu TD,Swiggard WJ,Steinman RM,Bona CA

    更新日期:1993-11-01 00:00:00

  • Spontaneous or Mycobacterium tuberculosis-induced apoptotic neutrophils exert opposite effects on the dendritic cell-mediated immune response.

    abstract::Polymorphonuclear neutrophils (PMN) modulate the adaptive immune response through interactions with immature dendritic cells (iDC) while spontaneous apoptotic neutrophils PMNapo (PMNapo) may have an inhibitory effect on DC functions. We investigate the effect exerted by PMNapo in DC maturation and the role of Mycobact...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200636771

    authors: Alemán M,de la Barrera S,Schierloh P,Yokobori N,Baldini M,Musella R,Abbate E,Sasiain M

    更新日期:2007-06-01 00:00:00

  • Pertussis toxin can replace T cell receptor signals that induce positive selection of CD8 T cells.

    abstract::CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830271231

    authors: Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

    更新日期:1997-12-01 00:00:00