Proliferation of lymphocyte subsets in the adult rat: a comparison of different lymphoid organs.

abstract：:In experimental autoimmune encephalomyelitis (EAE), intravenous transfer of activated CD4(+) myelin-specific T cells is sufficient to induce disease. Transferred T cells access the CNS parenchyma by trafficking across the blood brain barrier (BBB) vascular endothelium into the perivascular space, and then across the g...

journal_title：European journal of immunology

authors： Archambault AS,Sim J,Gimenez MA,Russell JH

更新日期：2005-04-01 00:00:00

abstract：:The immunosuppressor sanglifehrin A (SfA) is a member of a family of immunophilin cyclophilin A-binding molecules and does not inhibit calcineurin activity. Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability. This immunosuppre...

journal_title：European journal of immunology

authors： Sànchez-Tilló E,Wojciechowska M,Comalada M,Farrera C,Lloberas J,Celada A

更新日期：2006-09-01 00:00:00

abstract：:A detailed restriction map of a 430-kb contig comprising the single Ckappa, the 5 Jkappa and the adjoining 22 Vkappa gene segments is presented. The first 12 Vkappa genes following the JkappaCkappa region belong to the Vkappa21 family, the subsequent ones to the closely related families Vkappa8 and Vkappal 9/ 28. Prev...

journal_title：European journal of immunology

authors： Kirschbaum T,Pourrajabi S,Zocher I,Schwendinger J,Heim V,Röschenthaler F,Kirschbaum V,Zachau HG

更新日期：1998-05-01 00:00:00

abstract：:Cells expressing the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and the chemokine C receptor (CCR)4 were consistently detected in the circulation of healthy subjects, whereas numbers of cells expressing CCR3 were much lower. While all CCR4+ cells were T cells, a small proportion of CRT...

journal_title：European journal of immunology

authors： Cosmi L,Annunziato F,Galli MIG,Maggi RME,Nagata K,Romagnani S

更新日期：2000-10-01 00:00:00

abstract：:The lymphoid cell composition of milky spots was analyzed in unprimed mice before and after i.p. immunization with sheep red blood cells. Milky spots contained surface immunoglobulin-positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge the number of lymphocytes i...

journal_title：European journal of immunology

authors： Dux K,Rouse RV,Kyewski B

更新日期：1986-08-01 00:00:00

abstract：:Chronic skin inflammation resulting from a defective epidermal barrier is a hallmark of atopic dermatitis (AD). We previously demonstrated that mice lacking FGF receptors 1 and 2 in keratinocytes (K5-R1/R2 mice) develop an AD-like chronic dermatitis as a result of an impaired epidermal barrier. Here, we show that γδ T...

journal_title：European journal of immunology

authors： Sulcova J,Maddaluno L,Meyer M,Werner S

更新日期：2015-09-01 00:00:00

abstract：:In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...

journal_title：European journal of immunology

authors： Viguier M,Lotteau V,Charron D,Debré P

更新日期：1987-11-01 00:00:00

abstract：:Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

journal_title：European journal of immunology

authors： Webb LM,Walmsley MJ,Feldmann M

更新日期：1996-10-01 00:00:00

abstract：:Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...

journal_title：European journal of immunology

authors： Farber DL,Acuto O,Bottomly K

更新日期：1997-08-01 00:00:00

abstract：:T-cell activation and the subsequent transformation of activated T cells into T-cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T-cell immunology has not been characterized. Here we studied the role of the cell-volume regulating osmolyte transporter Taut for T-cel...

journal_title：European journal of immunology

authors： Kaesler S,Sobiesiak M,Kneilling M,Volz T,Kempf WE,Lang PA,Lang KS,Wieder T,Heller-Stilb B,Warskulat U,Häussinger D,Lang F,Biedermann T

更新日期：2012-04-01 00:00:00

abstract：:Interleukin (IL)-4-transgenic mice were used as a model system to study the consequences of low levels of IL-4 expression for the expression of other cytokines examined by quantitative polymerase chain reaction (PCR). For this purpose, a plasmid was constructed which contains, in tandem array, 5' and 3' primer sequenc...

journal_title：European journal of immunology

authors： Platzer C,Richter G,Uberla K,Müller W,Blöcker H,Diamantstein T,Blankenstein T

更新日期：1992-05-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:Inhibition of growth or eradication of experimentally induced tumors has been shown to be accompanied by infiltration of eosinophils and macrophages into the tumor mass. Since macrophages are important mediators of host antitumor activity, the possibility arises that a collaboration may exist between these two cell ty...

journal_title：European journal of immunology

authors： Spessotto P,Dri P,Bulla R,Zabucchi G,Patriarca P

更新日期：1995-05-01 00:00:00

abstract：:Alpha4-mediated signaling is involved in a variety of functions in mammalian cells. To determine whether this is true for immunocompetent cells, we generated mutant (Lck-alpha4-) mice in which the alpha4 gene was deleted in a T cell-specific manner using the Cre/loxP system. These mice showed impaired early T cell dev...

journal_title：European journal of immunology

authors： Hua DR,Inui S,Yamashita T,Maeda K,Takagi K,Takeda J,Sakaguchi N

更新日期：2003-07-01 00:00:00

abstract：:The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases. However, the relative contributions of these molecules to the development and progression of disease is not known. In the present study...

journal_title：European journal of immunology

authors： Probert L,Plows D,Kontogeorgos G,Kollias G

更新日期：1995-06-01 00:00:00

abstract：:Spontaneous cytolytic activity of shark peripheral blood leukocytes is observed only during periods of decreased environmental temperature (less than 23 degrees C). The effector cell is adherent to glass and is phagocytic. Leukocytes tested during warmer periods (26-31 degrees C) exhibit no spontaneous activity; howev...

journal_title：European journal of immunology

authors： Pettey CL,McKinney EC

更新日期：1983-02-01 00:00:00

abstract：:Dendritic cells (DCs) are the key APCs not only for the priming of naïve T cells, but also for the induction and maintenance of peripheral T-cell tolerance. We have recently shown that cognate interactions between Foxp3(+) Tregs and steady-state DCs are crucial to maintain the tolerogenic potential of DCs. Using DIETE...

journal_title：European journal of immunology

authors： Muth S,Schütze K,Hain T,Yagita H,Schild H,Probst HC

更新日期：2014-04-01 00:00:00

abstract：:NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK ce...

journal_title：European journal of immunology

authors： Colonna M

更新日期：2008-11-01 00:00:00

abstract：:In recent years, factors potentially involved in pathogenesis of rheumatoid arthritis have mostly been identified by studying well-defined patient cohorts. Characterization of antibodies from sera of affected patients, family-based heritability studies, genome-wide association scans, the analysis of environmental fact...

journal_title：European journal of immunology

authors： Scherer HU,Burmester GR

更新日期：2009-08-01 00:00:00

abstract：:F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion o...

journal_title：European journal of immunology

authors： Humphrey JH,Grennan D,Sundaram V

更新日期：1984-09-01 00:00:00

abstract：:CD4+CD25(hi)CD127(lo/-) regulatory T cells (Treg) have been implicated in the resolution of asthma-associated inflammation while the opposite role of CD4+ invariant NKT (iNKT) cells has been the subject of recent investigations. Studies here focused on mechanisms of interaction between CD4+ iNKT cells and Treg to furt...

journal_title：European journal of immunology

authors： Nguyen KD,Vanichsarn C,Nadeau KC

更新日期：2008-07-01 00:00:00

abstract：:The expression of interferon (IFN) β is highly induced in immune and nonimmune cells in response to virus infection. This upregulation is mediated at both transcriptional and posttranscriptional levels. Whereas the signaling pathways triggered by innate virus receptors leading to transcription factor activation have b...

journal_title：European journal of immunology

authors： Takeuchi O

更新日期：2015-05-01 00:00:00

abstract：:Genetic and environmental factors both influence autoimmune disease occurrence, but the identity and mechanism of action of environmental factors are poorly understood. Here we show that pinworm-infected neonatal but not adult mice, injected with an ovarian self peptide of the zona pellucida protein 3 (pZP3) in water ...

journal_title：European journal of immunology

authors： Agersborg SS,Garza KM,Tung KS

更新日期：2001-03-01 00:00:00

abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

journal_title：European journal of immunology

authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

更新日期：2011-03-01 00:00:00

abstract：:Cell suspensions enriched for N cells, the effector cell for human natural cell-mediated cytotoxicity, were observed to react strongly with a rabbit antiserum directed against an antigen associated with B cells. Treatment of the effector suspension with the antiserum resulted in inhibition of natural cell-mediated cyt...

journal_title：European journal of immunology

authors： Koide Y,Takasugi M,Biling R

更新日期：1977-10-01 00:00:00

abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...

journal_title：European journal of immunology

authors： Esche C,Cai Q,Peron JM,Hunter O,Subbotin VM,Lotze MT,Shurin MR

更新日期：2000-09-01 00:00:00

abstract：:Human NK cells can be subdivided into CD56(dim) and CD56(bright) NK cells, which exhibit different phenotypical and functional characteristics. As murine NK cells lack CD56 or a distinct correlate, direct comparative studies of NK cells in mice and humans are limited. Although CD27 is currently proposed as a feasible ...

journal_title：European journal of immunology

authors： Marquardt N,Wilk E,Pokoyski C,Schmidt RE,Jacobs R

更新日期：2010-05-01 00:00:00

abstract：:HLA-A2.1-binding peptides (n = 38) were screened for immunogenicity with human peripheral blood mononuclear cells in cytotoxic T lymphocyte (CTL) induction experiments in vitro and with splenocytes from HLA-A2.1/Kb transgenic mice following immunization in vivo. These data were compiled and analyzed to determine the l...

journal_title：European journal of immunology

authors： Wentworth PA,Vitiello A,Sidney J,Keogh E,Chesnut RW,Grey H,Sette A

更新日期：1996-01-01 00:00:00

abstract：:To investigate the role of TCR-pMHC interaction in regulating lung CD8 tissue-resident T cell (TR ) differentiation, polyclonal responses were compared against NP366-374 /Db and PA224-233 /Db , two immunodominant epitopes that arise during influenza A infection in mice. Memory niches distinct from iBALTs develop withi...

journal_title：European journal of immunology

authors： Yoshizawa A,Bi K,Keskin DB,Zhang G,Reinhold B,Reinherz EL

更新日期：2018-01-01 00:00:00

abstract：:Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...

journal_title：European journal of immunology

authors： Lohoff M,Dirks M,Rohwer P,Röllinghoff M

更新日期：1989-01-01 00:00:00