Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma.

abstract：:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...

journal_title：European journal of immunology

authors： Amedei A,Romagnani C,Benagiano M,Azzurri A,Fomia F,Torrente F,Plebani A,D'Elios MM,Del Prete G

更新日期：2001-06-01 00:00:00

abstract：:Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific ...

journal_title：European journal of immunology

authors： Schneider-Schaulies J,Hünig T,Schimpl A,Wecker E

更新日期：1986-03-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

journal_title：European journal of immunology

authors： Richter E,Wick G,Schauenstein K

更新日期：1975-08-01 00:00:00

abstract：:A major contributing factor to the final magnitude and breadth of CD8(+) T-cell responses to complex antigens is immunodomination, where CD8(+) T cells recognizing their cognate ligand inhibit the proliferation of other CD8(+) T cells engaged with the same APC. In this study, we examined how the half-life of cell s...

journal_title：European journal of immunology

authors： Galea I,Stasakova J,Dunscombe MS,Ottensmeier CH,Elliott T,Thirdborough SM

更新日期：2012-01-01 00:00:00

abstract：:Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to stud...

journal_title：European journal of immunology

authors： Li BW,de Bruijn MJ,Tindemans I,Lukkes M,KleinJan A,Hoogsteden HC,Hendriks RW

更新日期：2016-06-01 00:00:00

abstract：:Anti-HLA donor-specific antibodies are deleterious for organ transplant survival. Class I HLA donor-specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti-denatured HLA antibodies (anti-dHLAs). Anti-dHLAs are thought to be unable to recognize native HLA (nHLA...

journal_title：European journal of immunology

authors： Visentin J,Guidicelli G,Moreau JF,Lee JH,Taupin JL

更新日期：2015-07-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) induces a strong cytotoxic T lymphocyte (CTL) response in humans following infection. HIV-specific CTL can be detected directly in the blood and lungs of infected patients, and can be expanded in vitro by stimulation with autologous HIV-infected lymphoblasts. Furthermore...

journal_title：European journal of immunology

authors： Chenciner N,Michel F,Dadaglio G,Langlade-Demoyen P,Hoffenbach A,Leroux A,Garcia-Pons F,Rautmann G,Guy B,Guillon JM

更新日期：1989-09-01 00:00:00

abstract：:Mucosal boosting of BCG-immunised individuals with a subunit tuberculosis (TB) vaccine would be highly desirable, considering that the lungs are the principal port of entry for Mycobacterium tuberculosis (MTB) and the site of the primary infection and reactivation. However, the main roadblock for subunit TB vaccine de...

journal_title：European journal of immunology

authors： Stylianou E,Diogo GR,Pepponi I,van Dolleweerd C,Arias MA,Locht C,Rider CC,Sibley L,Cutting SM,Loxley A,Ma JK,Reljic R

更新日期：2014-02-01 00:00:00

abstract：:Lymph node cells derived from A.TH or A.TL mice primed with beef cytochrome c show striking patterns of reactivity when assayed in vitro for antigen-induced T cell proliferation. Whereas cells from A.TH mice respond specifically to beef cytochrome c or peptides composed of amino acids 1-65 and 81-104, cells from A.TL ...

journal_title：European journal of immunology

authors： Corradin G,Chiller JM

更新日期：1981-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) employs multiple mechanisms to evade the immune system and succeeds to persist lifelong in the host. Human dendritic cells (DC) are the main antigen-presenting cells and play the key role in inducing and maintaining immune responses. Here, we studied the interaction of HCMV with DC. We fou...

journal_title：European journal of immunology

authors： Beck K,Meyer-König U,Weidmann M,Nern C,Hufert FT

更新日期：2003-06-01 00:00:00

abstract：:The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

journal_title：European journal of immunology

authors： Kiely PD,Gillespie KM,Oliveira DB

更新日期：1995-10-01 00:00:00

abstract：:Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103(+) DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tiss...

journal_title：European journal of immunology

authors： Stock AT,Bedoui S

更新日期：2013-06-01 00:00:00

abstract：:Macrophages can be stimulated to produce a relatively large amount of nitric oxide, which is an important component in macrophage-mediated defense mechanisms and regulation of T cell activities. It has been known that T helper (Th) cell activation requires intimate physical interaction between T helper cells and macro...

journal_title：European journal of immunology

authors： Tian L,Noelle RJ,Lawrence DA

更新日期：1995-01-01 00:00:00

abstract：:Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...

journal_title：European journal of immunology

authors： Smith LJ,Sogh JA,Kindt TJ,Mandy WJ

更新日期：1979-01-01 00:00:00

abstract：:Durch Pflanzenkrankheiten entstehen weltweit hohe Ernteverluste. Eine der häufigsten Infektionen in der Familie der Kreuzb&luml;tengewächse wird durch den Pilz Plasmodiophora brassicae verursacht. Die Krankheit äußert sich in Form von Wurzeltumoren, den "Kohlherniegallen". Da es auf verseuchten Böden zu hohen Ernteaus...

journal_title：European journal of immunology

authors： Ludwig-Müller J

更新日期：2000-01-01 00:00:00

abstract：:The class II transactivator (CIITA) has been referred to as the "master control factor" for the expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of CIITA grows, it is becoming increasingly evident that this sobriquet is entirely justified. First, despite extensive investigatio...

journal_title：European journal of immunology

authors： LeibundGut-Landmann S,Waldburger JM,Krawczyk M,Otten LA,Suter T,Fontana A,Acha-Orbea H,Reith W

更新日期：2004-06-01 00:00:00

abstract：:Dendritic cells (DCs) are the key APCs not only for the priming of naïve T cells, but also for the induction and maintenance of peripheral T-cell tolerance. We have recently shown that cognate interactions between Foxp3(+) Tregs and steady-state DCs are crucial to maintain the tolerogenic potential of DCs. Using DIETE...

journal_title：European journal of immunology

authors： Muth S,Schütze K,Hain T,Yagita H,Schild H,Probst HC

更新日期：2014-04-01 00:00:00

abstract：:Stimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of ...

journal_title：European journal of immunology

authors： Gullberg M,Larsson EL

更新日期：1982-12-01 00:00:00

abstract：:Auto-reactive T cells present in healthy subjects remain in a state of unresponsiveness, but may trigger autoimmunity under various situations. Although myelin oligodendrocyte glycoprotein (MOG) is a potential target antigen in multiple sclerosis (MS), MOG-reactive T cell responses are present in the blood of both hea...

journal_title：European journal of immunology

authors： Villoslada P,Abel K,Heald N,Goertsches R,Hauser SL,Genain CP

更新日期：2001-10-01 00:00:00

abstract：:GITR (glucocorticoid-induced TNFR family related gene) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes. Because of a high homology in its cytoplasmic region with other known costimulatory members of the TNFRSF, we investigated whether GITR played a costim...

journal_title：European journal of immunology

authors： Ronchetti S,Zollo O,Bruscoli S,Agostini M,Bianchini R,Nocentini G,Ayroldi E,Riccardi C

更新日期：2004-03-01 00:00:00

abstract：:The germ-line V gene segments encoding the subgroups A and G of the BALB/c V kappa 21 family were cloned and assigned to the previously described 30-kb cluster of the V kappa 21 family. Sequence comparison revealed close homology between the two gene segments at the DNA and the predicted amino acid sequence level, ind...

journal_title：European journal of immunology

authors： Alanen A,Weiss S

更新日期：1989-10-01 00:00:00

abstract：:Many pathogens are initially encountered in the gut, where the decision is made to mount an immune response or induce tolerance. The mesentric lymph node (mLN) has been shown to be involved in immune response and much more in oral tolerance induction. Furthermore, using an in vivo transplantation model, we showed rece...

journal_title：European journal of immunology

authors： Buettner M,Pabst R,Bode U

更新日期：2011-03-01 00:00:00

abstract：:Stimulation of T cells via the T cell receptor (TCR) leads to an increase intracellular in free Ca2+ levels ([Ca2+]i) and the activation of the MAP kinase signaling pathway. This study analyzes for the first time Ca2+ fluxes in naive cytotoxic T cells stimulated with full agonists, partial agonists, or antagonists. Fo...

journal_title：European journal of immunology

authors： Bachmann MF,Mariathasan S,Bouchard D,Speiser DE,Ohashi PS

更新日期：1997-12-01 00:00:00

abstract：:Natural killer (NK) cell activity can be stimulated by different surface receptors. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating human NK cell cytotoxicity and cytokine production. Here we show that stimulation of human NK cells by anti...

journal_title：European journal of immunology

authors： Sandusky MM,Messmer B,Watzl C

更新日期：2006-12-01 00:00:00

abstract：:We have constructed four different deletion mutants of a chimeric mouse-human IgG3 anti-(4-hydroxy-3-nitrophenyl)acetyl/(5-iodo-4 hydroxy-3 nitrophenyl) acetyl (NP/NIP) antibody lacking one or more of the four exons coding for the hinge region. The mutant variants all retained intact hinge region epitopes since they a...

journal_title：European journal of immunology

authors： Sandlie I,Aase A,Westby C,Michaelsen TE

更新日期：1989-09-01 00:00:00

abstract：:The costimulatory receptor OX40 is expressed on activated T cells and regulates T-cell responses. Here, we show the efficacy and mechanism of action of an OX40 blocking antibody using the chronic house dust mite (HDM) mouse model of lung inflammation and in vitro HDM stimulation of cells from HDM allergic human donors...

journal_title：European journal of immunology

authors： Burrows KE,Dumont C,Thompson CL,Catley MC,Dixon KL,Marshall D

更新日期：2015-04-01 00:00:00

abstract：:We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) breaks tolerance induction. The objective of this study was to determine whether GM-CSF breaks established inhalation tolerance. To induce tolerance, BALB/c mice were exposed to aerosolized ovalbumin (OVA) for 10 consecutive days. A co...

journal_title：European journal of immunology

authors： Swirski FK,Gajewska BU,Robbins CS,D'Sa A,Johnson JR,Pouladi MA,Inman MD,Stämpfli MR

更新日期：2004-09-01 00:00:00

abstract：:The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...

journal_title：European journal of immunology

authors： Dabhi VM,Lindahl KF

更新日期：1998-11-01 00:00:00

abstract：:To study allelic exclusion of TcR genes we analyzed two types (I and II) of TcR beta transgenic mice. T cells derived from both types of mice contained similar amounts of transgenic RNA transcripts; however, surface expression of the transgenic beta chain was drastically reduced in type II compared to type I. In type ...

journal_title：European journal of immunology

authors： Pircher H,Ohashi P,Miescher G,Lang R,Zikopoulos A,Bürki K,Mak TW,MacDonald HR,Hengartner H

更新日期：1990-02-01 00:00:00