Macrophage-chemotactic factor-producing T cell hybridomas reactive to phosphorylcholine in I-E-restricted manner.

abstract：:While IL-18 synergizes with IL-12 to induce a Th1 immune response, it also promotes a Th2 response. Here we investigate the modulatory role of IL-18 on the Th1/Th2 cytokine response. The injection of alpha-galactosylceramide (alpha-GalCer), a ligand for NKT cells, elevated mouse serum levels of both IFN-gamma and IL-4...

journal_title：European journal of immunology

authors： Uchida T,Kinoshita M,Fukasawa M,Habu Y,Shinomiya N,Seki S

更新日期：2007-04-01 00:00:00

abstract：:The germ-line V gene segments encoding the subgroups A and G of the BALB/c V kappa 21 family were cloned and assigned to the previously described 30-kb cluster of the V kappa 21 family. Sequence comparison revealed close homology between the two gene segments at the DNA and the predicted amino acid sequence level, ind...

journal_title：European journal of immunology

authors： Alanen A,Weiss S

更新日期：1989-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

journal_title：European journal of immunology

authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

更新日期：2007-02-01 00:00:00

abstract：:Acute and chronic airway inflammations caused by environmental agents including endotoxin represent an increasing health problem. Local TNF production may contribute to lung dysfunction and inflammation, although pulmonary neutrophil recruitment occurs in the absence of TNF. First, we demonstrate that membrane-bound T...

journal_title：European journal of immunology

authors： Togbe D,Grivennikov SI,Noulin N,Couillin I,Maillet I,Jacobs M,Maret M,Fick L,Nedospasov SA,Quesniaux VF,Schnyder B,Schnyder-Candrian S

更新日期：2007-03-01 00:00:00

abstract：:The elevated interleukin (IL)-4 and IgE production in Schistosoma mansoni infection seems to be induced essentially by the egg stage of the parasite. The underlying mechanism, however, is not known. Since basophils from human peripheral blood can produce IL-4, we asked, whether soluble S. mansoni egg antigens (SEA) wo...

journal_title：European journal of immunology

authors： Falcone FH,Dahinden CA,Gibbs BF,Noll T,Amon U,Hebestreit H,Abrahamsen O,Klaucke J,Schlaak M,Haas H

更新日期：1996-05-01 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) induces a strong cytotoxic T lymphocyte (CTL) response in humans following infection. HIV-specific CTL can be detected directly in the blood and lungs of infected patients, and can be expanded in vitro by stimulation with autologous HIV-infected lymphoblasts. Furthermore...

journal_title：European journal of immunology

authors： Chenciner N,Michel F,Dadaglio G,Langlade-Demoyen P,Hoffenbach A,Leroux A,Garcia-Pons F,Rautmann G,Guy B,Guillon JM

更新日期：1989-09-01 00:00:00

abstract：:Nonspecific T cell factors produced by lectin-activated human peripheral blood lymphocytes (PBL) were used to restore the T-dependent B cell response to trinitrophenyl-polyacrylamide (TNP-PAA). Preincubation experiments with the particulate antigen TNP-PAA and/or a soluble TNP-protein conjugate show that a first speci...

journal_title：European journal of immunology

authors： Vazquez A,Gerard JP,Delfraissy JF,Dugas B,Auffredou MT,Crevon MC,Fradelizi D,Galanaud P

更新日期：1986-07-01 00:00:00

abstract：:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...

journal_title：European journal of immunology

authors： Conway de Macario E,Heumann AM,Macario AJ,Biozzi G

更新日期：1979-03-01 00:00:00

abstract：:In this study, we investigated whether the phenotype-related differentiation of human 2H4+ (CD45R) naive cells to 2H4- (CDw29) memory CD4 cells corresponded to modulation of interleukin (IL) 2, IL 4, interferon (IFN)-gamma and granulocyte-monocyte colony-stimulating factor (GM-CSF) gene expression, a phenomenon which ...

journal_title：European journal of immunology

authors： Bettens F,Walker C,Gauchat JF,Gauchat D,Wyss T,Pichler WJ

更新日期：1989-09-01 00:00:00

abstract：:DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...

journal_title：European journal of immunology

authors： Remer KA,Apetrei C,Schwarz T,Linden C,Moll H

更新日期：2007-09-01 00:00:00

abstract：:Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

journal_title：European journal of immunology

authors： Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

更新日期：1993-07-01 00:00:00

abstract：:Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...

journal_title：European journal of immunology

authors： Seyerl M,Blüml S,Kirchberger S,Bochkov VN,Oskolkova O,Majdic O,Stöckl J

更新日期：2008-03-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK ce...

journal_title：European journal of immunology

authors： Colonna M

更新日期：2008-11-01 00:00:00

abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

journal_title：European journal of immunology

authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

更新日期：1993-10-01 00:00:00

abstract：:In hematopoietic stem cell transplantation (HSCT), when no HLA full-matched donor is available, alternative donors could include one HLA-mismatched donor. Recently, the low expressed HLA-C alleles have been identified as permissive mismatches for the best donor choice. Concerning HLA-A, the degree of variability of ex...

journal_title：European journal of immunology

authors： René C,Lozano C,Villalba M,Eliaou JF

更新日期：2015-12-01 00:00:00

abstract：:Although most cells of the T cell receptor (TcR) gamma/delta lineage are CD4-CD8-, some gamma/delta cells express CD8. We show here that mouse thymic gamma/delta cells express CD8 following in vitro activation by concanavalin A. Staining with monoclonal and polyclonal antibodies to the CD8 alpha (Ly-2) and CD8 beta (L...

journal_title：European journal of immunology

authors： MacDonald HR,Schreyer M,Howe RC,Bron C

更新日期：1990-04-01 00:00:00

abstract：:Human Vgamma9Vdelta2 T cells contribute to immunity against intracellular pathogens and recognize nonpeptidic antigens, such as the mycobacterial phosphoantigen TUBAg. HIV infection is associated with a polyclonal decrease of peripheral Vgamma9Vdelta2 T cells and we previously reported that the remaining cells show a ...

journal_title：European journal of immunology

authors： Boullier S,Poquet Y,Debord T,Fournie JJ,Gougeon ML

更新日期：1999-01-01 00:00:00

abstract：:Using limiting dilution analysis, we investigated proliferative responses of UCHL1+ and UCHL1- T cell populations to compare the precursor cell frequencies following recall and alloantigen stimulation, and the complexity of cellular interactions within UCHL1+ and UCHL1- populations. We find high frequencies of recall ...

journal_title：European journal of immunology

authors： Merkenschlager M,Terry L,Edwards R,Beverley PC

更新日期：1988-11-01 00:00:00

abstract：:We have explored how IL-15 influences Th1 or Th2 type immune response in vivo. Intraperitoneal application of an IL-15-IgG2b fusion protein (FP) to mice did neither significantly affect the footpad swelling nor the production of hemagglutinizing antibodies in a delayed type hypersensitivity reaction to sheep red blood...

journal_title：European journal of immunology

authors： Rückert R,Herz U,Paus R,Ungureanu D,Pohl T,Renz H,Bulfone-Paus S

更新日期：1998-10-01 00:00:00

abstract：:We analyzed the functional outcome of the interaction between tumor-associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian cancer patients displayed an alternatively activated functional phenotype (M2) characterized by a remarkably high frequency and surface density of membrane-bound...

journal_title：European journal of immunology

authors： Bellora F,Castriconi R,Dondero A,Pessino A,Nencioni A,Liggieri G,Moretta L,Mantovani A,Moretta A,Bottino C

更新日期：2014-06-01 00:00:00

abstract：:Blockade of the immune response, caused by a high dose of Salmonella typhi Vi antigen (200 microgram i.v.) and cyclophosphamide (CY)-induced tolerance to Vi antigen, were analyzed. The results of the study show that blockade of the immune response cannot be attributed to masking of the response resulting from neutrali...

journal_title：European journal of immunology

authors： Prigozhina TB,Fontalin LN

更新日期：1980-08-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:Cycling lymphocytes may express the enzyme telomerase which is involved in maintenance of telomere length and cell proliferation potential. In CD8(+) T cells freshly isolated from peripheral blood, we found that in vivo cycling cells expressed HLA-DR. Furthermore, CD28-positive cells are known to have longer telomeres...

journal_title：European journal of immunology

authors： Speiser DE,Migliaccio M,Pittet MJ,Valmori D,Liénard D,Lejeune F,Reichenbach P,Guillaume P,Lüscher I,Cerottini JC,Romero P

更新日期：2001-02-01 00:00:00

abstract：:Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multip...

journal_title：European journal of immunology

authors： Jones R,Cosway EJ,Willis C,White AJ,Jenkinson WE,Fehling HJ,Anderson G,Withers DR

更新日期：2018-09-01 00:00:00

abstract：:Human T cell clones expressing the T cell receptor (TcR) gamma/delta were isolated from peripheral blood lymphocytes of two unrelated donors. The TcR gamma/delta+ clones derived from one of these donors were all of the Ti gamma A+, delta-TCS1-, BB3+ phenotype indicating the exclusive use of the V gamma 9 and V delta 3...

journal_title：European journal of immunology

authors： Koning F,Knot M,Wassenaar F,Van den Elsen P

更新日期：1989-11-01 00:00:00

abstract：:Lymphocyte proliferation in response to monocytes pulsed with an antigenic extract of Candida albicans was measured in vitro and the effects of modifying major histocompatibility complex (MHC) class II antigen expression at the surface of the antigen-presenting cells was investigated. The study shows that no simple co...

journal_title：European journal of immunology

authors： Rhodes J,Ivanyi J,Cozens P

更新日期：1986-04-01 00:00:00

abstract：:Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...

journal_title：European journal of immunology

authors： Lohoff M,Dirks M,Rohwer P,Röllinghoff M

更新日期：1989-01-01 00:00:00

abstract：:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...

journal_title：European journal of immunology

authors： Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti F

更新日期：1993-01-01 00:00:00