5' and 3' untranslated regions contribute to the differential expression of specific HLA-A alleles.

abstract：:The nonobese diabetic (NOD) mouse is a relevant model for studying human insulin-dependent diabetes mellitus (IDDM). The selective destruction of insulin-secreting cells in this model is subsequent to an autoimmune reaction directed towards the beta cells inside the islets of Langerhans of the pancreas. Given the key ...

journal_title：European journal of immunology

authors： Sempé P,Bédossa P,Richard MF,Villà MC,Bach JF,Boitard C

更新日期：1991-05-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:We analyzed the stimulating capacities of malignant B cells from non-Hodgkin's lymphomas (NHL) to induce an allogeneic response in primary mixed lymphocyte reaction (MLR). T cells purified from a single healthy donor (KS) were used to compare the responses induced by either malignant or hyperplastic cells. Malignant B...

journal_title：European journal of immunology

authors： Plumas J,Chaperot L,Jacob MC,Molens JP,Giroux C,Sotto JJ,Bensa JC

更新日期：1995-12-01 00:00:00

abstract：:B cells get help in the antibody response by presenting antigen to helper T (Th) cells. Upon antigen recognition, T cells produce lymphokines that act as growth and differentiation factors for B cells, but resting B cells require additional helper signals that depend on cell contact with an activated Th cell. Like lym...

journal_title：European journal of immunology

authors： Kawakami K,Parker DC

更新日期：1992-01-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates th...

journal_title：European journal of immunology

authors： Youn JI,Gabrilovich DI

更新日期：2010-11-01 00:00:00

abstract：:The recent discovery of IL-17-producing CD4(+) Th subset significantly revised the Th1/Th2 dichotomy model proposed by Mosmann and Coffman almost two decades ago. Th17 cells are involved in the pathogenesis of many human autoimmune diseases. Th17 cells, their developmental pathways and their effector functions, theref...

journal_title：European journal of immunology

authors： Ouyang W,Filvaroff E,Hu Y,Grogan J

更新日期：2009-03-01 00:00:00

abstract：:Cell suspensions enriched for N cells, the effector cell for human natural cell-mediated cytotoxicity, were observed to react strongly with a rabbit antiserum directed against an antigen associated with B cells. Treatment of the effector suspension with the antiserum resulted in inhibition of natural cell-mediated cyt...

journal_title：European journal of immunology

authors： Koide Y,Takasugi M,Biling R

更新日期：1977-10-01 00:00:00

abstract：:Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further the role of this cytokine in resistance to infection and the differentiation of f...

journal_title：European journal of immunology

authors： Mattner F,Magram J,Ferrante J,Launois P,Di Padova K,Behin R,Gately MK,Louis JA,Alber G

更新日期：1996-07-01 00:00:00

abstract：:Cross-linking induced interactions between the membrane form of immunoglobulin (mIg) and the cytoskeletal matrix have been described by several groups. To date, the function of mIgM association with the cytoskeleton is not yet understood. Delineation of the molecular basis of these interactions will be instrumental in...

journal_title：European journal of immunology

authors： Park JY,Jongstra-Bilen J

更新日期：1997-11-01 00:00:00

abstract：:The role of CD8(+) T cells in the development of allergic airway disease is controversial. On the one hand, CD8(+) T cells are known to inhibit the development of airway hyperreactivity (AHR) in murine models of asthma. In humans, IL-10-producing CD8(+) T cells were shown to act as regulatory cells, inhibiting both pr...

journal_title：European journal of immunology

authors： Stock P,Kallinich T,Akbari O,Quarcoo D,Gerhold K,Wahn U,Umetsu DT,Hamelmann E

更新日期：2004-07-01 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in the signaling of a number of cellular responses including activation of T cells. In the present report we have evaluated the effect of increased cAMP levels on PKC activation after stimulation of two distinct receptor systems on normal human T cells. PKC substrate phosphor...

journal_title：European journal of immunology

authors： Friedrich B,Cantrell DA,Gullberg M

更新日期：1989-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after i...

journal_title：European journal of immunology

authors： Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE

更新日期：2013-08-01 00:00:00

abstract：:The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...

journal_title：European journal of immunology

authors： Dabhi VM,Lindahl KF

更新日期：1998-11-01 00:00:00

abstract：:IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell ...

journal_title：European journal of immunology

authors： Mensah-Brown EP,Shahin A,Al-Shamisi M,Wei X,Lukic ML

更新日期：2006-01-01 00:00:00

abstract：:In asymptomatic human immunodeficiency virus-1 infection T cells respond normally to allogeneic dendritic cells (DC), but DC show reduced stimulatory capacity. By contrast in HTLV-1 infection no significant changes in allogeneic stimulation were seen but DC-stimulated activity of autologous T cells. In seeking animal ...

journal_title：European journal of immunology

authors： Gabrilovich DI,Roberts MS,Harvey JJ,Botcherby M,Bedford PA,Knight SC

更新日期：1993-11-01 00:00:00

abstract：:The diversity of the human immune repertoire and how it relates to a functional immune response has not yet been studied in detail in humanized NOD.SCID.gammac(-/-) immunodeficient mice. Here, we used a multiplex PCR on genomic DNA to quantify the combinatorial diversity of all possible V-J rearrangements at the TCR-b...

journal_title：European journal of immunology

authors： Marodon G,Desjardins D,Mercey L,Baillou C,Parent P,Manuel M,Caux C,Bellier B,Pasqual N,Klatzmann D

更新日期：2009-08-01 00:00:00

abstract：:Epidermal keratinocytes differentiate and form a multilayered epidermis, which is the primary barrier between the body and the outer environment. As the epidermis is constantly exposed to a variety of microbial pathogens, its function of resisting microbial pathogens is vital. This characteristic feature is formed dur...

journal_title：European journal of immunology

authors： Sayama K,Komatsuzawa H,Yamasaki K,Shirakata Y,Hanakawa Y,Ouhara K,Tokumaru S,Dai X,Tohyama M,Ten Dijke P,Sugai M,Ichijo H,Hashimoto K

更新日期：2005-06-01 00:00:00

abstract：:We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presentin...

journal_title：European journal of immunology

authors： Darji A,Stockinger B,Wehland J,Chakraborty T,Weiss S

更新日期：1997-07-01 00:00:00

abstract：:Stem cell antigen-1 (Sca1, Ly-6A/E) is a well-established marker of murine hematopoietic stem cells, and also is expressed on memory T cells. It has been suggested that the functional maintenance of T-cell memory requires the expression of Sca1 on a specialized population of memory T cells termed "memory stem cells". ...

journal_title：European journal of immunology

authors： Whitmire JK,Eam B,Whitton JL

更新日期：2009-06-01 00:00:00

abstract：:Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surfact of activating substances. Using sulfated polyanions as model substances, an efficient fluid-phase activation of complement is d...

journal_title：European journal of immunology

authors： Bitter-Suermann D,Burger R,Hadding U

更新日期：1981-04-01 00:00:00

abstract：:The thymus provides the microenvironment in which thymocytes develop into mature T cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T cells is a basic requirement for mature T-cell functions, and those thymocytes that do...

journal_title：European journal of immunology

authors： Szondy Z,Garabuczi É,Tóth K,Kiss B,Köröskényi K

更新日期：2012-07-01 00:00:00

abstract：:MHC-peptide-specific Fab antibodies binding to HLA-A*0201 complexes presenting the wild-type EAAGIGILTV (EAA) or analogue Melan-A 10-mer ELAGIGILTV (ELA) peptide were generated to study efficacy of peptide processing and presentation. None of the selected Fab antibodies detected the naturally processed EAA/HLA-A*0201 ...

journal_title：European journal of immunology

authors： Held G,Wadle A,Dauth N,Stewart-Jones G,Sturm C,Thiel M,Zwick C,Dieckmann D,Schuler G,Hoogenboom HR,Lévy F,Cerundolo V,Pfreundschuh M,Renner C

更新日期：2007-07-01 00:00:00

abstract：:Alpha4-mediated signaling is involved in a variety of functions in mammalian cells. To determine whether this is true for immunocompetent cells, we generated mutant (Lck-alpha4-) mice in which the alpha4 gene was deleted in a T cell-specific manner using the Cre/loxP system. These mice showed impaired early T cell dev...

journal_title：European journal of immunology

authors： Hua DR,Inui S,Yamashita T,Maeda K,Takagi K,Takeda J,Sakaguchi N

更新日期：2003-07-01 00:00:00

abstract：:Spontaneous cytolytic activity of shark peripheral blood leukocytes is observed only during periods of decreased environmental temperature (less than 23 degrees C). The effector cell is adherent to glass and is phagocytic. Leukocytes tested during warmer periods (26-31 degrees C) exhibit no spontaneous activity; howev...

journal_title：European journal of immunology

authors： Pettey CL,McKinney EC

更新日期：1983-02-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

journal_title：European journal of immunology

authors： Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

更新日期：2020-09-01 00:00:00

abstract：:The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function have been identified. E+/UCHT1+ cell...

journal_title：European journal of immunology

authors： Beverley PC,Callard RE

更新日期：1981-04-01 00:00:00

abstract：:Interactions between CD8+ T cells and endothelial cells are important in both protective and pathologic immune responses. Endothelial cells regulate the recruitment of CD8+ T cells into tissues, and the activation of CD8+ T cells by antigen presentation and costimulatory signals. PD-L1 and PD-L2 are recently described...

journal_title：European journal of immunology

authors： Rodig N,Ryan T,Allen JA,Pang H,Grabie N,Chernova T,Greenfield EA,Liang SC,Sharpe AH,Lichtman AH,Freeman GJ

更新日期：2003-11-01 00:00:00

abstract：:The Fc or pFc' fragments of the human IgG were demonstrated to exert different effects on murine T lymphocyte subsets. Thus, murine lymph node (LN) T cells were specifically induced to proliferate in vitro to pFc' after priming in vivo. This proliferation could be inhibited, either by depleting the responding LN popul...

journal_title：European journal of immunology

authors： Baxevanis CN,Ioannides CD,Reclos GJ,Papamichail M

更新日期：1986-08-01 00:00:00

abstract：:Natural killer (NK) cell activity can be stimulated by different surface receptors. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating human NK cell cytotoxicity and cytokine production. Here we show that stimulation of human NK cells by anti...

journal_title：European journal of immunology

authors： Sandusky MM,Messmer B,Watzl C

更新日期：2006-12-01 00:00:00

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00